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  1. Book: Oogenesis

    Nezis, Ioannis P.

    methods and protocols

    (Methods in molecular biology ; 1457 ; Springer protocols)

    2016  

    Author's details ed. by Ioannis P. Nezis
    Series title Methods in molecular biology ; 1457
    Springer protocols
    Collection
    Keywords chicken ; mosquitos ; mouse ; oogenesis ; plants
    Language English
    Size X, 277 S. : Ill., 25.4 cm x 17.8 cm, 0 g
    Publisher Humana
    Publishing place New York, NY
    Publishing country United States
    Document type Book
    HBZ-ID HT019098947
    ISBN 978-1-4939-3793-6 ; 1-4939-3793-6 ; 9781493937950 ; 1493937952
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    Zs A 7042 -1457- verfügbar in Königswinter Königswinter

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  2. Article ; Online: Label-free quantitative proteomic analysis of adult

    Zhang, Yan / Nezis, Ioannis P

    STAR protocols

    2022  Volume 3, Issue 4, Page(s) 101830

    Abstract: LIR motif-containing proteins (LIRCPs) bind to LDS (LIR motif docking site) of Atg8-family proteins. In this protocol, we describe steps to ... ...

    Abstract LIR motif-containing proteins (LIRCPs) bind to LDS (LIR motif docking site) of Atg8-family proteins. In this protocol, we describe steps to identify
    MeSH term(s) Animals ; Drosophila/genetics ; Chromatography, Liquid/methods ; Proteomics/methods ; Tandem Mass Spectrometry/methods ; Autophagy-Related Protein 8 Family/metabolism ; Proteins
    Chemical Substances Autophagy-Related Protein 8 Family ; Proteins
    Language English
    Publishing date 2022-11-11
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 2666-1667
    ISSN (online) 2666-1667
    DOI 10.1016/j.xpro.2022.101830
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: A yeast two-hybrid screening identifies novel Atg8a interactors in

    Tsapras, Panagiotis / Nezis, Ioannis P

    Autophagy

    2022  Volume 18, Issue 5, Page(s) 1211–1212

    Abstract: Macroautophagy/autophagy-related protein Atg8/LC3 is important for autophagosome biogenesis and required for selective degradation of various substrates. In our recent study, we performed a yeast two-hybrid screening to identify proteins that interact ... ...

    Abstract Macroautophagy/autophagy-related protein Atg8/LC3 is important for autophagosome biogenesis and required for selective degradation of various substrates. In our recent study, we performed a yeast two-hybrid screening to identify proteins that interact with Atg8a, the
    MeSH term(s) Animals ; Ankyrins/metabolism ; Autophagy/physiology ; Autophagy-Related Protein 8 Family/genetics ; Autophagy-Related Protein 8 Family/metabolism ; Drosophila/metabolism ; Drosophila Proteins/genetics ; Drosophila Proteins/metabolism ; Intracellular Signaling Peptides and Proteins/metabolism ; MAP Kinase Kinase Kinases/metabolism ; Macroautophagy ; Mammals/metabolism ; Microtubule-Associated Proteins/metabolism ; Saccharomyces cerevisiae/metabolism
    Chemical Substances Ank2 protein, Drosophila ; Ankyrins ; Autophagy-Related Protein 8 Family ; Drosophila Proteins ; Intracellular Signaling Peptides and Proteins ; Microtubule-Associated Proteins ; SH3PX1 protein, Drosophila ; MAP Kinase Kinase Kinases (EC 2.7.11.25) ; TAK1 protein, Drosophila (EC 2.7.11.25)
    Language English
    Publishing date 2022-02-28
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2454135-7
    ISSN 1554-8635 ; 1554-8627
    ISSN (online) 1554-8635
    ISSN 1554-8627
    DOI 10.1080/15548627.2022.2045535
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6741: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  4. Article ; Online: Impact of Autophagy Impairment on Experience- and Diet-Related Synaptic Plasticity.

    Lalo, Ulyana / Nezis, Ioannis P / Pankratov, Yuriy

    International journal of molecular sciences

    2022  Volume 23, Issue 16

    Abstract: The beneficial effects of diet and exercise on brain function are traditionally attributed to the enhancement of autophagy, which plays a key role in neuroprotection via the degradation of potentially harmful intracellular structures. The molecular ... ...

    Abstract The beneficial effects of diet and exercise on brain function are traditionally attributed to the enhancement of autophagy, which plays a key role in neuroprotection via the degradation of potentially harmful intracellular structures. The molecular machinery of autophagy has also been suggested to influence synaptic signaling via interaction with trafficking and endocytosis of synaptic vesicles and proteins. Still, the role of autophagy in the regulation of synaptic plasticity remains elusive, especially in the mammalian brain. We explored the impact of autophagy on synaptic transmission and homeostatic and acute synaptic plasticity using transgenic mice with induced deletion of the Beclin1 protein. We observed down-regulation of glutamatergic and up-regulation of GABAergic synaptic currents and impairment of long-term plasticity in the neocortex and hippocampus of Beclin1-deficient mice. Beclin1 deficiency also significantly reduced the effects of environmental enrichment, caloric restriction and its pharmacological mimetics (metformin and resveratrol) on synaptic transmission and plasticity. Taken together, our data strongly support the importance of autophagy in the regulation of excitatory and inhibitory synaptic transmission and synaptic plasticity in the neocortex and hippocampus. Our results also strongly suggest that the positive modulatory actions of metformin and resveratrol in acute and homeostatic synaptic plasticity, and therefore their beneficial effects on brain function, occur via the modulation of autophagy.
    MeSH term(s) Animals ; Autophagy ; Beclin-1/metabolism ; Diet ; Hippocampus/metabolism ; Mammals/metabolism ; Metformin/pharmacology ; Mice ; Neuronal Plasticity ; Resveratrol/pharmacology ; Synapses/metabolism ; Synaptic Transmission
    Chemical Substances Beclin-1 ; Metformin (9100L32L2N) ; Resveratrol (Q369O8926L)
    Language English
    Publishing date 2022-08-17
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms23169228
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Selective autophagic degradation of the IKK complex in

    Jacomin, Anne-Claire / Nezis, Ioannis P

    Molecular & cellular oncology

    2019  Volume 7, Issue 1, Page(s) 1682309

    Abstract: Implication of autophagy in the downregulation of immune signaling pathways through the degradation of their components constitutes an emerging field of investigation. Our work showed that the selective interaction ... ...

    Abstract Implication of autophagy in the downregulation of immune signaling pathways through the degradation of their components constitutes an emerging field of investigation. Our work showed that the selective interaction of
    Language English
    Publishing date 2019-11-06
    Publishing country United States
    Document type Journal Article
    ISSN 2372-3556
    ISSN 2372-3556
    DOI 10.1080/23723556.2019.1682309
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  6. Book: Oogenesis

    Nezis, Ioannis P.

    methods and protocols

    (Methods in molecular biology, ; 1457 ; Springer protocols)

    2016  

    Author's details edited by Ioannis P. Nezis
    Series title Methods in molecular biology, ; 1457
    Springer protocols
    MeSH term(s) Oogenesis/physiology.
    Keywords Oogenesis ; oogenesis. ; physiology.
    Language English
    Size x, 277 pages :, illustrations (chiefly color), still color photographic images ;, 26 cm
    Publisher Humana Press
    Publishing place New York, NY
    Document type Book
    ISBN 9781493937936 ; 1493937936 ; 9781493937950 ; 1493937952 ; 1493937936 ; 9781493937936 ; 1493937952 ; 9781493937950
    Database NAL-Catalogue (AGRICOLA)

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    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  7. Book: Oogenesis

    Nezis, Ioannis P

    methods and protocols

    (Methods in molecular biology, ; 1457 ; Springer protocols)

    2016  

    Author's details edited by Ioannis P. Nezis
    Series title Methods in molecular biology, ; 1457
    Springer protocols
    MeSH term(s) Oogenesis/physiology
    Language English
    Size x, 277 pages :, illustrations (mostly color), still color photographic images ;, 26 cm.
    Document type Book
    ISBN 9781493937936 ; 1493937936 ; 9781493937950 ; 1493937952
    Database Catalogue of the US National Library of Medicine (NLM)

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    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  8. Article ; Online: Assays to Monitor Aggrephagy in Drosophila Brain.

    Jacomin, Anne-Claire / Nezis, Ioannis P

    Methods in molecular biology (Clifton, N.J.)

    2018  Volume 1854, Page(s) 147–157

    Abstract: Accumulation of ubiquitinated protein aggregates is a hallmark of most aging-related neurodegenerative disorders. Autophagy has been found to be involved in the selective clearance of these protein aggregates, and this process is called aggrephagy. Here ... ...

    Abstract Accumulation of ubiquitinated protein aggregates is a hallmark of most aging-related neurodegenerative disorders. Autophagy has been found to be involved in the selective clearance of these protein aggregates, and this process is called aggrephagy. Here we provide two protocols for the investigation of protein aggregation and their removal by autophagy using western blotting and immunofluorescence techniques in Drosophila brain. Investigating the role of aggrephagy at the cellular and organismal level is important for the development of therapeutic interventions against aging-related diseases.
    MeSH term(s) Aging/metabolism ; Animals ; Autophagy ; Brain/metabolism ; Brain/pathology ; Drosophila ; Humans ; Microscopy, Fluorescence ; Neurodegenerative Diseases/metabolism ; Protein Aggregates ; Protein Aggregation, Pathological/metabolism ; Ubiquitination
    Chemical Substances Protein Aggregates
    Language English
    Publishing date 2018-06-04
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 1940-6029
    ISSN (online) 1940-6029
    DOI 10.1007/7651_2018_157
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

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    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  9. Article: Editorial: Autophagy: From Big Data to Physiological Significance.

    Sarkar, Sovan / Vaccaro, Maria I / Nezis, Ioannis P

    Frontiers in cell and developmental biology

    2020  Volume 7, Page(s) 376

    Language English
    Publishing date 2020-01-10
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2737824-X
    ISSN 2296-634X
    ISSN 2296-634X
    DOI 10.3389/fcell.2019.00376
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Caspase involvement in autophagy.

    Tsapras, Panagiotis / Nezis, Ioannis P

    Cell death and differentiation

    2017  Volume 24, Issue 8, Page(s) 1369–1379

    Abstract: Caspases are a family of cysteine proteases widely known as the principal mediators of the apoptotic cell death response, but considerably less so as the contributors to the regulation of pathways outside cellular demise. In regards to autophagy, the ... ...

    Abstract Caspases are a family of cysteine proteases widely known as the principal mediators of the apoptotic cell death response, but considerably less so as the contributors to the regulation of pathways outside cellular demise. In regards to autophagy, the modulatory roles of caspases have only recently begun to be adequately described. In contrast to apoptosis, autophagy promotes cell survival by providing energy and nutrients through the lysosomal degradation of cytoplasmic constituents. Under basal conditions autophagy and apoptosis cross-regulate each other through an elaborate network of interconnections which also includes the interplay between autophagy-related proteins (ATGs) and caspases. In this review we focus on the effects of this crosstalk at the cellular level, as we aim to concentrate the main observations from research conducted so far on the fine-tuning of autophagy by caspases. Several members of this protease-family have been found to directly interact with key ATGs involved in different tiers across the autophagic cascade. Therefore, we firstly outline the core mechanism of macroautophagy in brief. In an effort to emphasize the importance of the intricate cross-regulation of ATGs and caspases, we also present examples of autophagy's contribution to apoptotic cell death during development.
    MeSH term(s) Animals ; Apoptosis/genetics ; Autophagy/genetics ; Autophagy-Related Proteins/genetics ; Autophagy-Related Proteins/metabolism ; Caspases/genetics ; Caspases/metabolism ; Eukaryotic Cells/cytology ; Eukaryotic Cells/enzymology ; Gene Expression Regulation, Developmental ; Humans ; Lysosomes/enzymology ; Microtubule-Associated Proteins/genetics ; Microtubule-Associated Proteins/metabolism ; Proteolysis ; Signal Transduction
    Chemical Substances Autophagy-Related Proteins ; Microtubule-Associated Proteins ; Caspases (EC 3.4.22.-)
    Language English
    Publishing date 2017-06-02
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 1225672-9
    ISSN 1476-5403 ; 1350-9047
    ISSN (online) 1476-5403
    ISSN 1350-9047
    DOI 10.1038/cdd.2017.43
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4230: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MG 80: Show issues

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