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  1. Article ; Online: Combined accelerated collagen crosslinking and sub-Bowman's keratomileusis in high myopic eyes: a comparison between total ultraviolet energy dose.

    Wan, Kelvin H / Chan, Tommy Cy / Kwok, Peter Sk / Ng, Alex Lk

    Seminars in ophthalmology

    2022  Volume 37, Issue 5, Page(s) 676–681

    Abstract: Aim: To compare the safety, efficacy, and predictability outcomes of combined sub-Bowman's keratomileusis (thin flap laser in situ keratomileusis [LASIK]) and accelerated crosslinking (CXL) using two different irradiation durations.: Methods: A ... ...

    Abstract Aim: To compare the safety, efficacy, and predictability outcomes of combined sub-Bowman's keratomileusis (thin flap laser in situ keratomileusis [LASIK]) and accelerated crosslinking (CXL) using two different irradiation durations.
    Methods: A retrospective comparative study of patients with percent tissue altered ≥35%, undergoing simultaneous CXL during sub-Bowman's keratomileusis were recruited. Following riboflavin application, they underwent ultraviolet-A (UVA) irradiation (18 mW/cm
    Results: The baseline characteristics were similar between the 40 eyes/patients treated using the 2-min protocol and the 33 eyes/patients treated with the 3-min protocol (
    Conclusions: A comparable volume of crosslinked corneal tissue can be achieved by using a shorter UVA irradiation duration. Additional duration of UVA irradiation could lead to delay in visual rehabilitation after simultaneous sub-Bowman's keratomileusis and CXL.
    MeSH term(s) Collagen/metabolism ; Humans ; Keratomileusis, Laser In Situ/methods ; Lasers, Excimer/therapeutic use ; Myopia/surgery ; Photosensitizing Agents/therapeutic use ; Refraction, Ocular ; Retrospective Studies ; Ultraviolet Rays
    Chemical Substances Photosensitizing Agents ; Collagen (9007-34-5)
    Language English
    Publishing date 2022-04-27
    Publishing country England
    Document type Comparative Study ; Journal Article
    ZDB-ID 632820-9
    ISSN 1744-5205 ; 0882-0538
    ISSN (online) 1744-5205
    ISSN 0882-0538
    DOI 10.1080/08820538.2022.2070026
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Combined 0.01% atropine with orthokeratology in childhood myopia control (AOK) study: A 2-year randomized clinical trial.

    Tan, Qi / Ng, Alex Lk / Cheng, George Pm / Woo, Victor Cp / Cho, Pauline

    Contact lens & anterior eye : the journal of the British Contact Lens Association

    2022  Volume 46, Issue 1, Page(s) 101723

    Abstract: Background: To investigate whether combining 0.01% atropine with orthokeratology (AOK) has a better effect in retarding axial elongation, compared with orthokeratology alone (OK) over two years.: Methods: A total of 96 Chinese children aged six to < ... ...

    Abstract Background: To investigate whether combining 0.01% atropine with orthokeratology (AOK) has a better effect in retarding axial elongation, compared with orthokeratology alone (OK) over two years.
    Methods: A total of 96 Chinese children aged six to < 11 years with myopia (1.00 - 4.00 D, inclusive) were randomized into either the AOK or OK group in a 1:1 ratio. Axial length (the primary outcome), and secondary outcomes (e.g. pupil size and choroidal thickness) were measured at 1-month and at 6-monthly intervals after commencement of treatment.
    Results: Both intention-to-treat and per-protocol analyses showed significantly slower axial elongation in the AOK group than OK group over two years (P = 0.008, P < 0.001, respectively). AOK subjects had statistically slower axial elongation (adjusted mean [standard error], 0.17 [0.03] mm vs 0.34 [0.03] mm, P < 0.001), larger increase in mesopic (0.70 [0.09] mm vs 0.31 [0.09] mm, P = 0.003) and photopic pupil size (0.78 [0.07] mm vs 0.23 [0.07] mm, P < 0.001), and greater thickening of the choroid (22.6 [3.5] µm vs -9.0 [3.5] µm, P < 0.001) than OK subjects over two years. Except for a higher incidence of photophobia in the AOK group (P = 0.006), there were no differences in the incidence of any other symptom or adverse events between the two groups. Slower axial elongation was associated with a larger increase in the photopic pupil size and a greater thickening in the choroid in the AOK group.
    Conclusions: Slower axial elongation following 2-year AOK treatment may result from increased pupil dilation and a thickening in the choroid observed in the AOK group.
    MeSH term(s) Child ; Humans ; Atropine ; Orthokeratologic Procedures/methods ; Axial Length, Eye ; Myopia/diagnosis ; Myopia/therapy ; Refraction, Ocular
    Chemical Substances Atropine (7C0697DR9I)
    Language English
    Publishing date 2022-05-31
    Publishing country England
    Document type Randomized Controlled Trial ; Journal Article
    ZDB-ID 2004847-6
    ISSN 1476-5411 ; 1367-0484
    ISSN (online) 1476-5411
    ISSN 1367-0484
    DOI 10.1016/j.clae.2022.101723
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: One-year results of 0.01% atropine with orthokeratology (AOK) study: a randomised clinical trial.

    Tan, Qi / Ng, Alex Lk / Choy, Bonnie Nk / Cheng, George Pm / Woo, Victor Cp / Cho, Pauline

    Ophthalmic & physiological optics : the journal of the British College of Ophthalmic Opticians (Optometrists)

    2020  Volume 40, Issue 5, Page(s) 557–566

    Abstract: Purpose: To report the 1-year results of an investigation into whether there is an additive effect between 0.01% atropine and orthokeratology (ortho-k), in a single-masked, two-arm, randomised controlled trial: Combined Atropine with Orthokeratology ( ... ...

    Abstract Purpose: To report the 1-year results of an investigation into whether there is an additive effect between 0.01% atropine and orthokeratology (ortho-k), in a single-masked, two-arm, randomised controlled trial: Combined Atropine with Orthokeratology (AOK) for myopia control study (ClinicalTrials.gov number: NCT02955927).
    Methods: Chinese children aged between 6 and 11 years with 1.00-4.00 D of myopia, astigmatism <2.50 D, and no more than 1.00 D anisometropia, were randomly assigned either to an AOK group or ortho-k only (OK) group at a 1:1 ratio. Subjects in the AOK group instilled one drop of 0.01% atropine into each eye, 10 min before nightly wear of ortho-k lenses. The primary outcome, axial elongation, was examined at 6-monthly intervals, along with secondary outcomes including best-corrected visual acuity (BCVA), manifest refraction, accommodation, pupil size, and corneal topography.
    Results: 29 AOK and 30 OK subjects completed the 1-year visit. The overall axial elongation rate was significantly slower in the AOK group than in the OK group (mean (S.D.), 0.07 (0.16) mm vs 0.16 (0.15) mm, respectively; p = 0.03). A significant between-group difference in axial elongation was observed over the first 6-month period only (p < 0.001), but not over the second period (p = 0.818). At the 1-year visit, increases in mean (S.D.) mesopic and photopic pupil sizes in the AOK group were 0.64 (0.48) mm and 0.36 (0.34) mm, respectively, which were significantly higher than 0.10 (0.50) mm and 0.02 (0.28) mm in the OK group (p < 0.001). At the 6-month visit, a significant moderate negative correlation was found between axial elongation and the increase in photopic pupil size (r = -0.42, p = 0.02) in the AOK group.
    Conclusions: There is an additive effect between 0.01% atropine and ortho-k over one year, with mean axial elongation in the AOK group 0.09 mm slower than that in the OK group. It appears that the additive effect was only during the first six months; a second-year investigation is warranted to determine whether the effect is sustained over time.
    MeSH term(s) Accommodation, Ocular ; Atropine/administration & dosage ; Child ; Cornea/pathology ; Corneal Topography ; Dose-Response Relationship, Drug ; Female ; Follow-Up Studies ; Humans ; Male ; Mydriatics/administration & dosage ; Myopia/diagnosis ; Myopia/physiopathology ; Myopia/therapy ; Ophthalmic Solutions ; Orthokeratologic Procedures/methods ; Refraction, Ocular/physiology ; Time Factors ; Visual Acuity
    Chemical Substances Mydriatics ; Ophthalmic Solutions ; Atropine (7C0697DR9I)
    Language English
    Publishing date 2020-08-10
    Publishing country England
    Document type Journal Article ; Randomized Controlled Trial ; Research Support, Non-U.S. Gov't
    ZDB-ID 604564-9
    ISSN 1475-1313 ; 0275-5408
    ISSN (online) 1475-1313
    ISSN 0275-5408
    DOI 10.1111/opo.12722
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Repeatability of pupil size measurements with NIDEK OPD-Scan III in myopic children.

    Tan, Qi / Ng, Alex Lk / Cheng, George Pm / Woo, Victor Cp / Cho, Pauline

    Ophthalmic & physiological optics : the journal of the British College of Ophthalmic Opticians (Optometrists)

    2020  Volume 41, Issue 2, Page(s) 431–436

    Abstract: Objective: To investigate the repeatability of pupil size measurements, determined from the NIDEK OPD-Scan III, of myopic eyes in children wearing single-vision spectacles (SVS), undergoing orthokeratology (OK) and receiving combined treatment of 0.01% ... ...

    Abstract Objective: To investigate the repeatability of pupil size measurements, determined from the NIDEK OPD-Scan III, of myopic eyes in children wearing single-vision spectacles (SVS), undergoing orthokeratology (OK) and receiving combined treatment of 0.01% atropine and orthokeratology (AOK).
    Methods: A single examiner took two sets of mesopic pupil size measurements from the right eyes of 80 children (SVS:16, OK: 34, AOK: 30) (mesopic 1 and mesopic 2) and two sets of photopic (photopic 1 and photopic 2) pupil size measurements (internal light source) using the NIDEK OPD-Scan III. Each set was taken at a single visit, 15 min apart. Subjects in the OK and AOK groups had undergone treatment for at least 6 months, and the SVS subjects had no previous myopia treatment other than wearing spectacles. Repeatability of measurements was analysed using intraclass correlation coefficient (ICC), Bland-Altman (BA) plot, and coefficient of repeatability (CoR).
    Results: Mesopic 1 and 2 values were not significantly different among the three groups (p = 0.56, 0.77), hence the data were pooled for each set of measurements (mean [±S.D.] values were 7.09 ± 0.61 and 7.12 ± 0.61 mm, respectively) for further analyses. ICC for repeated mesopic pupil size measurements was 0.98 (95% CI, 0.98-0.99). No significant correlation was found between the means of the mesopic 1 and 2 measurements and their differences (Pearson's r = -0.02, p = 0.83). A BA plot also demonstrated narrow 95% limits of agreement, with a CoR of 0.28 mm. Mean photopic 1 and 2 measurements for the AOK group (3.74 ± 0.46; 3.73 ± 0.43 mm, respectively) were significantly larger (p = 0.01; 0.009) than those of the SVS and OK groups, but no significant difference was found between the latter two groups (p > 0.05). Hence, photopic 1 and 2 measurements for the SVS and OK groups were pooled (SVS-OK) for further analyses. ICC for repeatability of the photopic measurements was 0.98 (95% CI, 0.96 to 0.99) for the SVS-OK and AOK groups. The differences between photopic 1 and 2 measurements were not significantly correlated with their means, either in the AOK group (Pearson's r = -0.25, p = 0.19), or in the pooled SVS-OK group (Pearson's r = -0.04, p = 0.78). BA plots also showed narrow 95% limits of agreement, and CoR was 0.25 mm and 0.23 mm in the AOK and pooled SVS-OK groups, respectively.
    Conclusion: Mesopic and photopic pupil size measurement using the NIDEK OPD-Scan III was highly repeatable and suitable for use on children.
    MeSH term(s) Adolescent ; Axial Length, Eye/diagnostic imaging ; Child ; Cross-Sectional Studies ; Diagnostic Techniques, Ophthalmological ; Female ; Follow-Up Studies ; Humans ; Light ; Male ; Myopia/diagnosis ; Myopia/physiopathology ; Myopia/therapy ; Pupil ; Refraction, Ocular/physiology ; Retrospective Studies
    Language English
    Publishing date 2020-12-08
    Publishing country England
    Document type Journal Article
    ZDB-ID 604564-9
    ISSN 1475-1313 ; 0275-5408
    ISSN (online) 1475-1313
    ISSN 0275-5408
    DOI 10.1111/opo.12774
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Combined Atropine with Orthokeratology for Myopia Control: Study Design and Preliminary Results.

    Tan, Qi / Ng, Alex Lk / Cheng, George Pm / Woo, Victor Cp / Cho, Pauline

    Current eye research

    2019  Volume 44, Issue 6, Page(s) 671–678

    Abstract: ... ...

    Abstract Purpose
    MeSH term(s) Atropine/therapeutic use ; Axial Length, Eye/physiopathology ; Child ; Combined Modality Therapy ; Corneal Topography ; Double-Blind Method ; Female ; Humans ; Male ; Muscarinic Antagonists/therapeutic use ; Myopia/physiopathology ; Myopia/therapy ; Orthokeratologic Procedures/methods ; Prospective Studies ; Refraction, Ocular/physiology ; Refractive Errors/physiopathology ; Research Design ; Treatment Outcome ; Visual Acuity/physiology
    Chemical Substances Muscarinic Antagonists ; Atropine (7C0697DR9I)
    Language English
    Publishing date 2019-01-24
    Publishing country England
    Document type Journal Article ; Randomized Controlled Trial ; Research Support, Non-U.S. Gov't
    ZDB-ID 82079-9
    ISSN 1460-2202 ; 0271-3683
    ISSN (online) 1460-2202
    ISSN 0271-3683
    DOI 10.1080/02713683.2019.1568501
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Epidemiological factors associated with health knowledge of three common eye diseases: A community-based pilot survey in Hong Kong.

    Wong, Perseus Wf / Lau, Jordy Kp / Choy, Bonnie Nk / Shih, Kendrick C / Ng, Alex Lk / Chan, Jonathan Ch / Wong, Ian Yh

    SAGE open medicine

    2020  Volume 8, Page(s) 2050312120943044

    Abstract: Objectives: To assess the proportions of respondents in the general community having heard or awareness, and their knowledge level, of three common eye diseases: age-related macular degeneration, cataract, and glaucoma. We also attempted to assess for ... ...

    Abstract Objectives: To assess the proportions of respondents in the general community having heard or awareness, and their knowledge level, of three common eye diseases: age-related macular degeneration, cataract, and glaucoma. We also attempted to assess for risk factors that may be associated with any variations, which will help identify the areas of inadequate knowledge and demographics of potential audiences for focused health education.
    Methods: We conducted a community-based pilot survey for the residents from a southern suburb of Hong Kong in early 2016, by inviting all aged 50 or above to complete a standardized questionnaire in the local community hall.
    Results: Most of the 222 respondents have heard, or awareness, of cataract (92.79% or 81.98%, respectively), followed by glaucoma (86.94% or 52.70%, respectively), and age-related macular degeneration (51.35% or 29.28%, respectively). The results of Cronbach's alpha (α > 0.7) and Spearman's correlation coefficient (p < 0.01) suggested that the internal consistency, convergent and discriminant validities of the questionnaire were acceptable for the study population. Compared to a previous Hong Kong survey in 2002, the proportions of having heard of the three eye diseases were greater, but the overall knowledge remained limited. From a maximum knowledge score of 29, the median scores for age-related macular degeneration, cataract, and glaucoma were 9, 13, and 14, respectively. Except for the treatment of cataract, the knowledge level in most areas was low. Sociodemographic factors and medical history, rather than behavioral factors, were more likely to be associated with having a higher knowledge level. Subjects with family or friends with a history of glaucoma or age-related macular degeneration were more aware and knowledgeable, but not for subjects who were current and past smokers or alcohol drinkers. For age-related macular degeneration, gender modified the effect between age and knowledge level, while age was a confounder of having medical history, and having heard or awareness, of the disease.
    Conclusion: Despite a larger proportion of the community having heard or awareness since 15 years ago, much effort remains for improving health knowledge of these three eye diseases in Hong Kong. We recommend targeting respondents with higher lifestyle risks, such as current and past smokers or alcohol drinkers, as a focused audience, and utilizing family members, relatives, or friends as another way of distributing health information.
    Language English
    Publishing date 2020-07-20
    Publishing country England
    Document type Journal Article
    ZDB-ID 2735399-0
    ISSN 2050-3121
    ISSN 2050-3121
    DOI 10.1177/2050312120943044
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: Changes in Corneal Volume at Different Areas and Its Correlation with Corneal Biomechanics after SMILE and FS-LASIK Surgery.

    Wei, Pinghui / Cheng, George Pm / Zhang, Jiamei / Ng, Alex Lk / Chan, Tommy Cy / Jhanji, Vishal / Wang, Yan

    Journal of ophthalmology

    2020  Volume 2020, Page(s) 1713979

    Abstract: Purpose: To investigate the variations of corneal volume (CV) after small incision lenticule extraction (SMILE) and femtosecond laser-assisted laser in situ keratomileusis (FS-LASIK) and analyze the influences of biomechanical properties on the changes ... ...

    Abstract Purpose: To investigate the variations of corneal volume (CV) after small incision lenticule extraction (SMILE) and femtosecond laser-assisted laser in situ keratomileusis (FS-LASIK) and analyze the influences of biomechanical properties on the changes of refraction and CV.
    Methods: Ninety-seven eyes of 97 patients undergoing SMILE and FS-LASIK were included in this retrospective study. CV was measured with Scheimpflug-based corneal topography at preoperatively and at day 1, week 1, and months 1 and 3 postoperatively. CV measured within 5 mm diameter was defined as central region volume (CV5) and between 5 mm and 10 mm diameter was defined as peripheral region volume (CV5-10). An Ocular Response Analyzer (ORA) was used to assess corneal biomechanical properties including corneal hysteresis (CH) and corneal resistant factor (CRF). The reduction of study parameters (△) were calculated by subtracting the preoperative value at various time points from the postoperative values.
    Results: CV had significant reduction after the SMILE and FS-LASIK procedure (
    Conclusions: Dynamic changes in corneal volume were found after SMILE and FS-LASIK surgery. The central region significantly increased after SMILE, while both central and peripheral regions increased following FS-LASIK in the early postoperative period. SMILE was associated with less change in biomechanical properties per unit of reduction in CV compared with FS-LASIK.
    Language English
    Publishing date 2020-04-27
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2546525-9
    ISSN 2090-0058 ; 2090-004X
    ISSN (online) 2090-0058
    ISSN 2090-004X
    DOI 10.1155/2020/1713979
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Dietary Habits, Fatty Acids and Carotenoid Levels Are Associated with Neovascular Age-Related Macular Degeneration in Chinese.

    Ng, Alex Lk / Leung, Ho Hang / Kawasaki, Ryo / Ho, Wing-Lau / Chow, Loraine Lw / Chow, Sharon Sw / Lee, Jetty Chung-Yung / Wong, Ian Yh

    Nutrients

    2019  Volume 11, Issue 8

    Abstract: The role of diet and circulatory carotenoids and docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA) are implicated in age-related macular degeneration (AMD) but not well studied in Chinese. However, other fatty acids were not comprehensively ... ...

    Abstract The role of diet and circulatory carotenoids and docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA) are implicated in age-related macular degeneration (AMD) but not well studied in Chinese. However, other fatty acids were not comprehensively evaluated if it had additional consequence on AMD. This study investigated the relationship among dietary habits, fatty acids levels, carotenoids and AMD in Hong Kong Chinese adults. In this cross-sectional case-controlled study, plasma fatty acids including, saturated fatty acids (SFA), monounsaturated fatty acids (MUFA) and polyunsaturated fatty acids (PUFA), and carotenoids levels were quantified between patients with neovascular AMD (
    MeSH term(s) Aged ; Aged, 80 and over ; Biomarkers/blood ; Carotenoids/administration & dosage ; Carotenoids/blood ; Case-Control Studies ; Cross-Sectional Studies ; Diet/adverse effects ; Fatty Acids/administration & dosage ; Fatty Acids/blood ; Feeding Behavior ; Female ; Hong Kong/epidemiology ; Humans ; Macular Degeneration/diagnosis ; Macular Degeneration/epidemiology ; Macular Degeneration/pathology ; Macular Degeneration/prevention & control ; Male ; Middle Aged ; Neovascularization, Pathologic ; Nutritional Status ; Nutritive Value ; Protective Factors ; Risk Assessment ; Risk Factors
    Chemical Substances Biomarkers ; Fatty Acids ; Carotenoids (36-88-4)
    Language English
    Publishing date 2019-07-25
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2518386-2
    ISSN 2072-6643 ; 2072-6643
    ISSN (online) 2072-6643
    ISSN 2072-6643
    DOI 10.3390/nu11081720
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  9. Article: Review on the Management of Primary Congenital Glaucoma.

    Yu Chan, Julia Yan / Choy, Bonnie Nk / Ng, Alex Lk / Shum, Jennifer Wh

    Journal of current glaucoma practice

    2016  Volume 9, Issue 3, Page(s) 92–99

    Abstract: Despite being documented in medical history from over 2400 years ago, primary congenital glaucoma (PCG), being a disease with low incidence rate, remains a challenge to ophthalmologists. The article provides a broad overview on the pathophysiology and ... ...

    Abstract Despite being documented in medical history from over 2400 years ago, primary congenital glaucoma (PCG), being a disease with low incidence rate, remains a challenge to ophthalmologists. The article provides a broad overview on the pathophysiology and diagnostic approach to PCG with major emphasis on the treatment options of PCG. While reviewing on the well-established treatment options, namely goniotomy, trabeculo-tomy and combined trabeculotomy-trabeculectomy, emphasis has also been made to recent updates on secondary treatments: trabeculectomy, antimetabolites, glaucoma-drainage devices and cyclodestructive procedures. It is, however, important to note that the rarity of PCG places limitations on study design, most studies are, thus, retrospective, nonrandomized and have different definitions of surgical success. Ophthalmologists need to interpret the results with critical thinking and formulate individual treatment plans for each patient. How to cite this article: Yu Chan JY, Choy BNK, Alex LK Ng, Shum JWH. Review on the Management of Primary Congenital Glaucoma. J Curr Glaucoma Pract 2015;9(3):92-99.
    Language English
    Publishing date 2016-02-02
    Publishing country India
    Document type Journal Article ; Review
    ISSN 0974-0333
    ISSN 0974-0333
    DOI 10.5005/jp-journals-10008-1192
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  10. Article: Dietary Habits, Fatty Acids and Carotenoid Levels Are Associated with Neovascular Age-Related Macular Degeneration in Chinese

    Ng, Alex L.-K / Leung, Ho Hang / Kawasaki, Ryo / Ho, Wing-Lau / Chow, Loraine L.-W / Chow, Sharon S.-W / Lee, Jetty Chung-Yung / Wong, Ian Y.-H

    Nutrients. 2019 July 25, v. 11, no. 8

    2019  

    Abstract: The role of diet and circulatory carotenoids and docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA) are implicated in age-related macular degeneration (AMD) but not well studied in Chinese. However, other fatty acids were not comprehensively ... ...

    Abstract The role of diet and circulatory carotenoids and docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA) are implicated in age-related macular degeneration (AMD) but not well studied in Chinese. However, other fatty acids were not comprehensively evaluated if it had additional consequence on AMD. This study investigated the relationship among dietary habits, fatty acids levels, carotenoids and AMD in Hong Kong Chinese adults. In this cross-sectional case-controlled study, plasma fatty acids including, saturated fatty acids (SFA), monounsaturated fatty acids (MUFA) and polyunsaturated fatty acids (PUFA), and carotenoids levels were quantified between patients with neovascular AMD (n = 99) and age-gender-matched controls (n = 198). A food frequency questionnaire was also conducted. Low blood carotenoid levels and omega-3 PUFAs namely DHA, EPA and α-linolenic acid increased the odds ratio of developing neovascular AMD. High blood omega-6 PUFAs specifically arachidonic acid and eicosadienoic acid, oleic acid (a MUFA) and SFA levels increased the odds ratio of having neovascular AMD. Neovascular AMD group had significantly less omega-3 PUFA rich food (vegetables, nuts, seafood) intake and higher SFA (meat) intake than controls. In short, neovascular AMD was associated with lower circulatory levels of carotenoids and omega-3 PUFAs, and higher level of omega-6 PUFAs, oleic acid and SFAs in the Hong Kong Chinese population. These findings enhance the understandings of dietary impacts on neovascular AMD and provide a context for future nutritional intervention studies.
    Keywords adults ; alpha-linolenic acid ; arachidonic acid ; blood ; carotenoids ; docosahexaenoic acid ; eating habits ; eicosapentaenoic acid ; food frequency questionnaires ; macular degeneration ; meat ; nutritional intervention ; nuts ; odds ratio ; oleic acid ; omega-3 fatty acids ; omega-6 fatty acids ; patients ; saturated fatty acids ; seafoods ; vegetables ; China
    Language English
    Dates of publication 2019-0725
    Publishing place Multidisciplinary Digital Publishing Institute
    Document type Article
    ZDB-ID 2518386-2
    ISSN 2072-6643
    ISSN 2072-6643
    DOI 10.3390/nu11081720
    Database NAL-Catalogue (AGRICOLA)

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