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  1. Article ; Online: Clinical Features and CD4+ T Cells Count in AIDS Patients with CMV Retinitis: Correlation with Mortality.

    Agrawal, Rupesh / Gunasekeran, Dinesh V / Xu, Yanping / Leo, Yee-Sin / Ng, Oon T / Wong, Chen Seong / Testi, Ilaria / Ding, Jianbin / Banu, Imrana / Teoh, Stephen C

    Ocular immunology and inflammation

    2020  Volume 30, Issue 1, Page(s) 42–47

    Abstract: Purpose: To explore the all-cause mortality in patients with acquired immune deficiency syndrome (AIDS) and Cytomegalovirus (CMV) retinitis.: Methods: A retrospective cohort study of patients with CMV retinitis (CMVR) presented to a tertiary referral ...

    Abstract Purpose: To explore the all-cause mortality in patients with acquired immune deficiency syndrome (AIDS) and Cytomegalovirus (CMV) retinitis.
    Methods: A retrospective cohort study of patients with CMV retinitis (CMVR) presented to a tertiary referral center in Singapore from January 1, 2004, through December 31, 2015.
    Results: A total of 144 patients were studied (87 survived, 11 lost to follow up, 46 died). Patients with bilateral CMVR and six-month follow up CD4 + T cell count < 50 cells/mm
    Conclusion: Bilateral ocular involvement and lack of immune recovery in patients with AIDS and CMVR are associated with shorter survival time.
    MeSH term(s) AIDS-Related Opportunistic Infections/diagnosis ; AIDS-Related Opportunistic Infections/drug therapy ; Acquired Immunodeficiency Syndrome/complications ; Acquired Immunodeficiency Syndrome/drug therapy ; CD4 Lymphocyte Count ; CD4-Positive T-Lymphocytes ; Cytomegalovirus Retinitis/complications ; Cytomegalovirus Retinitis/diagnosis ; Cytomegalovirus Retinitis/drug therapy ; Humans ; Retrospective Studies
    Language English
    Publishing date 2020-07-09
    Publishing country England
    Document type Journal Article
    ZDB-ID 1193873-0
    ISSN 1744-5078 ; 0927-3948
    ISSN (online) 1744-5078
    ISSN 0927-3948
    DOI 10.1080/09273948.2020.1772312
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 4004: Show issues Location:
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  2. Article ; Online: Survival after long-term ART exposure: findings from an Asian patient population retained in care beyond 5 years on ART.

    Bijker, Rimke / Kiertiburanakul, Sasisopin / Kumarasamy, Nagalingeswaran / Pujari, Sanjay / Sun, Ly P / Ng, Oon T / Lee, Man P / Choi, Jun Y / Nguyen, Kinh V / Chan, Yu J / Merati, Tuti P / Cuong, Do D / Ross, Jeremy / Jiamsakul, Awachana

    Antiviral therapy

    2020  Volume 25, Issue 3, Page(s) 131–142

    Abstract: Background: This study investigated survival in people living with HIV being followed-up from 5 and 10 years after antiretroviral therapy (ART) initiation in a multi-country Asian cohort.: Methods: We included patients in follow-up >5 years after ART ...

    Abstract Background: This study investigated survival in people living with HIV being followed-up from 5 and 10 years after antiretroviral therapy (ART) initiation in a multi-country Asian cohort.
    Methods: We included patients in follow-up >5 years after ART initiation. Factors associated with mortality beyond 5 and 10 years on ART were analysed using competing risk regression with time-updated variables.
    Results: Of 13,495 patients retained after 5 years on ART, 279 subsequently died (0.56/100 person-years). Increased mortality was associated with age >50 years (sub-hazard ratio [sHR] 2.24, 95% CI 1.58, 3.15, compared with ≤40 years), HIV exposure through injecting drug use (sHR 2.17, 95% CI 1.32, 3.56), HIV viral load ≥1,000 copies/ml: sHR 1.52, 95% CI 1.05, 2.21, compared with <400), regimen (second-line regimen: sHR 2.11, 95% CI 1.52, 2.94, and third-line regimen: sHR 2.82, 95% CI 2.00, 3.98, compared with first-line regimen), HBV coinfection (sHR 2.23, 95% CI 1.49, 3.33), fasting plasma glucose ≥126 mg/dl (sHR 1.98, 95% CI 1.22, 3.21, compared with <100 mg/dl) and estimated glomerular filtration rate <60 ml/min/1.73 m
    Conclusions: Next to preventing ART failure, HIV programmes should carefully monitor and treat comorbidities, including hepatitis, kidney disease and diabetes, to optimize survival after long-term ART exposure.
    MeSH term(s) Adult ; Age Factors ; Anti-HIV Agents/therapeutic use ; Female ; HIV Infections/drug therapy ; HIV Infections/mortality ; Humans ; Male ; Middle Aged ; Prospective Studies ; Risk Factors ; Thailand/epidemiology ; Time Factors ; Viral Load
    Chemical Substances Anti-HIV Agents
    Language English
    Publishing date 2020-05-04
    Publishing country England
    Document type Journal Article ; Observational Study ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 1339842-8
    ISSN 2040-2058 ; 1359-6535
    ISSN (online) 2040-2058
    ISSN 1359-6535
    DOI 10.3851/IMP3358
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  3. Article ; Online: Trends in CD4 cell count response to first-line antiretroviral treatment in HIV-positive patients from Asia, 2003-2013: TREAT Asia HIV Observational Database Low Intensity Transfer.

    De La Mata, Nicole L / Ly, Penh S / Ng, Oon T / Nguyen, Kinh V / Merati, Tuti P / Pham, Thuy T / Lee, Man P / Choi, Jun Y / Sohn, Annette H / Law, Matthew G / Kumarasamy, Nagalingeswaran

    International journal of STD & AIDS

    2017  Volume 28, Issue 13, Page(s) 1282–1291

    Abstract: Antiretroviral treatment (ART) guidelines have changed over the past decade, recommending earlier initiation and more tolerable regimens. The study objective was to examine the CD4 response to ART, depending on the year of ART initiation, in HIV-positive ...

    Abstract Antiretroviral treatment (ART) guidelines have changed over the past decade, recommending earlier initiation and more tolerable regimens. The study objective was to examine the CD4 response to ART, depending on the year of ART initiation, in HIV-positive patients in the Asia-Pacific. We included HIV-positive adult patients who initiated ART between 2003 and 2013 in our regional cohort from eight urban referral centres in seven countries within Asia. We used mixed-effects linear regression models to evaluate differences in CD4 response by year of ART initiation during 36 months of follow-up, adjusted a priori for other covariates. Overall, 16,962 patients were included. Patients initiating in 2006-9 and 2010-13 had an estimated mean CD4 cell count increase of 8 and 15 cells/µl, respectively, at any given time during the 36-month follow-up, compared to those in 2003-5. The median CD4 cell count at ART initiation also increased from 96 cells/µl in 2003-5 to 173 cells/µl in 2010-13. Our results suggest that the CD4 response to ART is modestly higher for those initiating ART in more recent years. Moreover, fewer patients are presenting with lower absolute CD4 cell counts over time. This is likely to reduce their risk of opportunistic infections and future non-AIDS defining cancers.
    MeSH term(s) Adult ; Anti-HIV Agents/administration & dosage ; Anti-HIV Agents/therapeutic use ; Antiretroviral Therapy, Highly Active/methods ; Antiretroviral Therapy, Highly Active/trends ; Asia ; CD4 Lymphocyte Count/statistics & numerical data ; Drug Administration Schedule ; Female ; HIV Infections/drug therapy ; HIV Infections/immunology ; HIV Infections/virology ; Humans ; Male ; Middle Aged ; Time Factors ; Viral Load
    Chemical Substances Anti-HIV Agents
    Language English
    Publishing date 2017-03-21
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 1018089-8
    ISSN 1758-1052 ; 0956-4624
    ISSN (online) 1758-1052
    ISSN 0956-4624
    DOI 10.1177/0956462417699538
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    Zs.A 2829: Show issues Location:
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  4. Article ; Online: Loss to Follow-up Trends in HIV-Positive Patients Receiving Antiretroviral Treatment in Asia From 2003 to 2013.

    De La Mata, Nicole L / Ly, Penh S / Nguyen, Kinh V / Merati, Tuti P / Pham, Thuy T / Lee, Man P / Choi, Jun Y / Ross, Jeremy / Law, Matthew G / Ng, Oon T

    Journal of acquired immune deficiency syndromes (1999)

    2017  Volume 74, Issue 5, Page(s) 555–562

    Abstract: Introduction: Over time, there has been a substantial improvement in antiretroviral treatment (ART) programs, including expansion of services and increased patient engagement. We describe time trends in, and factors associated with, loss to follow-up ( ... ...

    Abstract Introduction: Over time, there has been a substantial improvement in antiretroviral treatment (ART) programs, including expansion of services and increased patient engagement. We describe time trends in, and factors associated with, loss to follow-up (LTFU) in HIV-positive patients receiving ART in Asia.
    Methods: Analysis included HIV-positive adults initiating ART in 2003-2013 at 7 ART programs in Asia. Patients LTFU had not attended the clinic for ≥180 days, had not died, or transferred to another clinic. Patients were censored at recent clinic visit, follow-up to January 2014. We used cumulative incidence to compare LTFU and mortality between years of ART initiation. Factors associated with LTFU were evaluated using a competing risks regression model, adjusted for clinical site.
    Results: A total of 8305 patients were included. There were 743 patients LTFU and 352 deaths over 26,217 person-years (pys), a crude LTFU, and mortality rate of 2.83 (2.64-3.05) per 100 pys and 1.34 (1.21-1.49) per 100 pys, respectively. At 24 months, the cumulative LTFU incidence increased from 4.3% (2.9%-6.1%) in 2003-05 to 8.1% (7.1%-9.2%) in 2006-09 and then decreased to 6.7% (5.9%-7.5%) in 2010-13. Concurrently, the cumulative mortality incidence decreased from 6.2% (4.5%-8.2%) in 2003-05 to 3.3% (2.8%-3.9%) in 2010-13. The risk of LTFU reduced in 2010-13 compared with 2006-09 (adjusted subhazard ratio = 0.73, 0.69-0.99).
    Conclusions: LTFU rates in HIV-positive patients receiving ART in our clinical sites have varied by the year of ART initiation, with rates declining in recent years whereas mortality rates have remained stable. Further increases in site-level resources are likely to contribute to additional reductions in LTFU for patients initiating in subsequent years.
    MeSH term(s) Adult ; Aged ; Anti-Retroviral Agents/therapeutic use ; Asia ; Female ; HIV Infections/drug therapy ; HIV Infections/mortality ; Humans ; Incidence ; Lost to Follow-Up ; Male ; Middle Aged ; Risk Assessment ; Young Adult
    Chemical Substances Anti-Retroviral Agents
    Language English
    Publishing date 2017-01-27
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 645053-2
    ISSN 1944-7884 ; 1077-9450 ; 0897-5965 ; 0894-9255 ; 1525-4135
    ISSN (online) 1944-7884 ; 1077-9450
    ISSN 0897-5965 ; 0894-9255 ; 1525-4135
    DOI 10.1097/QAI.0000000000001293
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  5. Article ; Online: Diabetes mellitus burden among people living with HIV from the Asia-Pacific region.

    Han, Win M / Jiamsakul, Awachana / Kiertiburanakul, Sasisopin / Ng, Oon T / Sim, Benedict Lh / Sun, Ly P / Van Nguyen, Kinh / Choi, Jun Y / Lee, Man P / Wong, Wing W / Kamarulzaman, Adeeba / Kumarasamy, Nagalingeswaran / Zhang, Fujie / Tanuma, Junko / Do, Cuong D / Chaiwarith, Romanee / Merati, Tuti P / Yunihastuti, Evy / Pujari, Sanjay /
    Ditangco, Rossana / Khusuwan, Suwimon / Ross, Jeremy / Avihingsanon, Anchalee

    Journal of the International AIDS Society

    2018  Volume 22, Issue 1, Page(s) e25236

    Abstract: Introduction: Comorbidities including diabetes mellitus (DM) among people living with HIV (PLHIV) are of increasing clinical concerns in combination antiretroviral therapy (cART) era. We aimed to determine the incidence and risk factors of new-onset DM ... ...

    Abstract Introduction: Comorbidities including diabetes mellitus (DM) among people living with HIV (PLHIV) are of increasing clinical concerns in combination antiretroviral therapy (cART) era. We aimed to determine the incidence and risk factors of new-onset DM among PLHIV in Asian settings.
    Methods: PLHIV from a regional observational cohort without DM prior to antiretroviral therapy (ART) initiation were included in the analysis. DM was defined as having a fasting blood glucose ≥126 mg/dL, glycated haemoglobin ≥6.5%, a two-hour plasma glucose ≥200 mg/dL, or a random plasma glucose ≥200 mg/dL. A Cox regression model, stratified by site, was used to identify risk factors associated with DM.
    Results and discussion: Of the 1927 participants included, 127 were diagnosed with DM after ART initiation. Median follow-up time from ART initiation to DM diagnosis was 5.9 years (interquartile range (IQR): 2.8 to 8.9 years). The crude incidence rate of DM was 1.08 per 100 person-years (100 PYS), 95% confidence interval (CI) (0.9 to 1.3). In the multivariate analysis, later years of follow-up (2011 to 2013: HR = 2.34, 95% CI 1.14 to 4.79, p = 0.02; and 2014 to 2017: HR = 7.20, 95% CI 3.27 to 15.87, p < 0.001) compared to <2010, older age (41 to 50 years: HR = 2.46, 95% CI 1.39 to 4.36, p  = 0.002; and >50 years: HR = 4.19, 95% CI 2.12 to 8.28, p < 0.001) compared to <30 years, body mass index (BMI) >30 kg/m
    Conclusions: Type 2 DM in HIV-infected Asians was associated with later years of follow-up, high blood pressure, obesity and older age. This highlights the importance of monitoring and routine screening for non-communicable diseases including DM as PLHIV age.
    MeSH term(s) Adult ; Anti-HIV Agents/therapeutic use ; Anti-Retroviral Agents/therapeutic use ; Asia/epidemiology ; Blood Glucose/metabolism ; Cohort Studies ; Diabetes Mellitus/epidemiology ; Diabetes Mellitus/etiology ; Diabetes Mellitus/metabolism ; Female ; Glycated Hemoglobin/metabolism ; HIV Infections/complications ; HIV Infections/drug therapy ; Humans ; Male ; Middle Aged ; Risk Factors
    Chemical Substances Anti-HIV Agents ; Anti-Retroviral Agents ; Blood Glucose ; Glycated Hemoglobin A ; hemoglobin A1c protein, human
    Language English
    Publishing date 2018-10-24
    Publishing country Switzerland
    Document type Journal Article ; Observational Study ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 2467110-1
    ISSN 1758-2652 ; 1758-2652
    ISSN (online) 1758-2652
    ISSN 1758-2652
    DOI 10.1002/jia2.25236
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  6. Article ; Online: Immunodeficiency at the start of combination antiretroviral therapy in low-, middle-, and high-income countries.

    Avila, Dorita / Althoff, Keri N / Mugglin, Catrina / Wools-Kaloustian, Kara / Koller, Manuel / Dabis, François / Nash, Denis / Gsponer, Thomas / Sungkanuparph, Somnuek / McGowan, Catherine / May, Margaret / Cooper, David / Chimbetete, Cleophas / Wolff, Marcelo / Collier, Ann / McManus, Hamish / Davies, Mary-Ann / Costagliola, Dominique / Crabtree-Ramirez, Brenda /
    Chaiwarith, Romanee / Cescon, Angela / Cornell, Morna / Diero, Lameck / Phanuphak, Praphan / Sawadogo, Adrien / Ehmer, Jochen / Eholie, Serge P / Li, Patrick C K / Fox, Matthew P / Gandhi, Neel R / González, Elsa / Lee, Christopher K C / Hoffmann, Christopher J / Kambugu, Andrew / Keiser, Olivia / Ditangco, Rossana / Prozesky, Hans / Lampe, Fiona / Kumarasamy, Nagalingeswaran / Kitahata, Mari / Lugina, Emmanuel / Lyamuya, Rita / Vonthanak, Saphonn / Fink, Valeria / d'Arminio Monforte, Antonella / Luz, Paula Mendes / Chen, Yi-Ming A / Minga, Albert / Casabona, Jordi / Mwango, Albert / Choi, Jun Y / Newell, Marie-Louise / Bukusi, Elizabeth A / Ngonyani, Kapella / Merati, Tuti P / Otieno, Juliana / Bosco, Mwebesa B / Phiri, Sam / Ng, Oon T / Anastos, Kathryn / Rockstroh, Jürgen / Santos, Ignacio / Oka, Shinichi / Somi, Geoffrey / Stephan, Christoph / Teira, Ramon / Wabwire, Deo / Wandeler, Gilles / Boulle, Andrew / Reiss, Peter / Wood, Robin / Chi, Benjamin H / Williams, Carolyn / Sterne, Jonathan A / Egger, Matthias

    Journal of acquired immune deficiency syndromes (1999)

    2013  Volume 65, Issue 1, Page(s) e8–16

    Abstract: Objective: To describe the CD4 cell count at the start of combination antiretroviral therapy (cART) in low-income (LIC), lower middle-income (LMIC), upper middle-income (UMIC), and high-income (HIC) countries.: Methods: Patients aged 16 years or ... ...

    Abstract Objective: To describe the CD4 cell count at the start of combination antiretroviral therapy (cART) in low-income (LIC), lower middle-income (LMIC), upper middle-income (UMIC), and high-income (HIC) countries.
    Methods: Patients aged 16 years or older starting cART in a clinic participating in a multicohort collaboration spanning 6 continents (International epidemiological Databases to Evaluate AIDS and ART Cohort Collaboration) were eligible. Multilevel linear regression models were adjusted for age, gender, and calendar year; missing CD4 counts were imputed.
    Results: In total, 379,865 patients from 9 LIC, 4 LMIC, 4 UMIC, and 6 HIC were included. In LIC, the median CD4 cell count at cART initiation increased by 83% from 80 to 145 cells/μL between 2002 and 2009. Corresponding increases in LMIC, UMIC, and HIC were from 87 to 155 cells/μL (76% increase), 88 to 135 cells/μL (53%), and 209 to 274 cells/μL (31%). In 2009, compared with LIC, median counts were 13 cells/μL [95% confidence interval (CI): -56 to +30] lower in LMIC, 22 cells/μL (-62 to +18) lower in UMIC, and 112 cells/μL (+75 to +149) higher in HIC. They were 23 cells/μL (95% CI: +18 to +28 cells/μL) higher in women than men. Median counts were 88 cells/μL (95% CI: +35 to +141 cells/μL) higher in countries with an estimated national cART coverage >80%, compared with countries with <40% coverage.
    Conclusions: Median CD4 cell counts at the start of cART increased 2000-2009 but remained below 200 cells/μL in LIC and MIC and below 300 cells/μL in HIC. Earlier start of cART will require substantial efforts and resources globally.
    MeSH term(s) Adolescent ; Adult ; Age Factors ; Anti-HIV Agents/therapeutic use ; CD4 Lymphocyte Count/statistics & numerical data ; Developed Countries/statistics & numerical data ; Developing Countries/statistics & numerical data ; Female ; HIV Infections/drug therapy ; HIV Infections/immunology ; Humans ; Male ; Sex Factors ; Young Adult
    Chemical Substances Anti-HIV Agents
    Language English
    Publishing date 2013-12-24
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, P.H.S.
    ZDB-ID 645053-2
    ISSN 1944-7884 ; 1077-9450 ; 0897-5965 ; 0894-9255 ; 1525-4135
    ISSN (online) 1944-7884 ; 1077-9450
    ISSN 0897-5965 ; 0894-9255 ; 1525-4135
    DOI 10.1097/QAI.0b013e3182a39979
    Database MEDical Literature Analysis and Retrieval System OnLINE

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