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  1. Article: Rebalancing of the skin microbiome with an emollient 'plus' for effective management of atopic dermatitis: A mini review.

    Ch'ng, C C

    The Medical journal of Malaysia

    2024  Volume 79, Issue 2, Page(s) 203–205

    Abstract: A balanced and diverse skin microbiome is pivotal for healthy skin. Dysregulation of the skin microbiome could disrupt the skin barrier function and result in the development of atopic dermatitis (AD), a common chronic and relapsing inflammatory skin ... ...

    Abstract A balanced and diverse skin microbiome is pivotal for healthy skin. Dysregulation of the skin microbiome could disrupt the skin barrier function and result in the development of atopic dermatitis (AD), a common chronic and relapsing inflammatory skin disorder. Given the role that the skin microbiome plays in the initiation and maintenance of AD, maintaining a healthy skin microbiome is crucial for effective disease management. Specifically, current guidelines recommend emollients as the treatment mainstay in maintaining a functional skin barrier across disease severity. Emollient 'plus' or therapeutic moisturisers have recently emerged as the next-generation emollients that specifically aim to rebalance the skin microbiome and subsequently improve AD lesions. This article provides a quick overview of an emollient 'plus' or therapeutic moisturiser, discussing the clinical efficacy and tolerability of Lipikar Baume AP+M as a companion in AD management.
    MeSH term(s) Humans ; Dermatitis, Atopic/drug therapy ; Emollients/therapeutic use ; Skin/pathology ; Treatment Outcome ; Sulfadiazine/therapeutic use ; Microbiota
    Chemical Substances Emollients ; Sulfadiazine (0N7609K889)
    Language English
    Publishing date 2024-03-30
    Publishing country Malaysia
    Document type Review ; Journal Article
    ZDB-ID 604286-7
    ISSN 0300-5283
    ISSN 0300-5283
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1206: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  2. Article: Parasite proteostasis and artemisinin resistance.

    Rosenthal, Melissa / Ng, Caroline

    Research square

    2023  

    Abstract: The continued emergence and spread of resistance to artemisinins, the cornerstone of first line antimalarials, threatens significant gains made toward malaria elimination. Mutations in Kelch13 have been proposed to mediate artemisinin resistance by ... ...

    Abstract The continued emergence and spread of resistance to artemisinins, the cornerstone of first line antimalarials, threatens significant gains made toward malaria elimination. Mutations in Kelch13 have been proposed to mediate artemisinin resistance by either reducing artemisinin activation via reduced parasite hemoglobin digestion or by enhancing the parasite stress response. Here, we explored the involvement of the parasite unfolded protein response (UPR) and ubiquitin proteasome system (UPS), vital to maintaining parasite proteostasis, in the context of artemisinin resistance. Our data show that perturbing parasite proteostasis kills parasites, early parasite UPR signaling dictate DHA survival outcomes, and DHA susceptibility correlates with impairment of proteasome-mediated protein degradation. These data provide compelling evidence toward targeting the UPR and UPS to overcome existing artemisinin resistance.
    Language English
    Publishing date 2023-05-15
    Publishing country United States
    Document type Preprint
    DOI 10.21203/rs.3.rs-2926003/v1
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Case 3: Acute Right Lower Quadrant Abdominal Pain in a 2-year-old.

    Mehta, Sagar D / Ng, Carrie

    Pediatrics in review

    2023  Volume 44, Issue 12, Page(s) 697–700

    MeSH term(s) Humans ; Child, Preschool ; Abdominal Pain/etiology ; Appendicitis/complications ; Appendicitis/diagnosis ; Appendicitis/surgery
    Language English
    Publishing date 2023-11-29
    Publishing country United States
    Document type Journal Article
    ZDB-ID 774515-1
    ISSN 1526-3347 ; 0191-9601
    ISSN (online) 1526-3347
    ISSN 0191-9601
    DOI 10.1542/pir.2023-005993
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.B 2595: Show issues Location:
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    Zs.MO 53: Show issues

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  4. Article ; Online: Common maternal health problems and their correlates in early post-partum mothers.

    Ng, Christine / Szücs, Anna / Goh, Lay Hoon

    Women's health (London, England)

    2024  Volume 20, Page(s) 17455057241227879

    Abstract: Background: Mothers experience a wide range of maternal health problems after childbirth, which in turn, affect their well-being and ability to care for their newborn. These problems may be influenced by factors such as mode of delivery or socio- ... ...

    Abstract Background: Mothers experience a wide range of maternal health problems after childbirth, which in turn, affect their well-being and ability to care for their newborn. These problems may be influenced by factors such as mode of delivery or socio-economic status.
    Objective: This study aims to investigate the prevalence of common maternal health problems and their correlates in a public primary healthcare institution in Singapore.
    Design: This was a cross-sectional study, based on a self-administered questionnaire.
    Methods: A total of 373 mothers (mean age 31.9 years) who accompanied their infants for their 4- to 8-week development assessments at a public primary care clinic in Singapore completed a self-administered questionnaire from June 2021 to December 2021. The questionnaire assessed demographic factors, mode of delivery, number of children, number of individuals providing significant help, and the frequency of common physical and mental maternal health problems using a 5-point Likert-type scale.
    Results: The five most common maternal health problems were fatigue (77.7%), lower back pain (59.3%), Caesarean wound pain (54.3%), upper back pain (53.0%) and vaginal pain (41.2%). The prevalence of depression and anxiety was 22.0% and 11.3%, respectively. With respect to the symptoms' correlates, pain on passing urine was more frequent after assisted vaginal deliveries than all other forms of deliveries (all pairwise
    Conclusion: Mothers experienced a high prevalence of maternal health problems in multiple domains during the first 8 weeks after childbirth. Mode of delivery and number of children were associated with increased prevalence of certain problems. Mothers' physical and mental well-being should be investigated early after delivery and addressed with adequate treatments and resources.
    MeSH term(s) Pregnancy ; Female ; Infant, Newborn ; Child ; Humans ; Adult ; Cross-Sectional Studies ; Maternal Health ; Mothers ; Postpartum Period ; Pain
    Language English
    Publishing date 2024-01-29
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2274503-8
    ISSN 1745-5065 ; 1745-5057
    ISSN (online) 1745-5065
    ISSN 1745-5057
    DOI 10.1177/17455057241227879
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6629: Show issues Location:
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    ab Jg. 2022: Lesesaal (EG)

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  5. Article: Multisystemic smooth muscle dysfunction syndrome: the first local case report.

    Ng, C H / Chiang, G P K / Tsui, K W

    Hong Kong medical journal = Xianggang yi xue za zhi

    2024  Volume 30, Issue 1, Page(s) 63–65

    MeSH term(s) Humans ; Ductus Arteriosus, Patent ; Muscle, Smooth
    Language English
    Publishing date 2024-02-08
    Publishing country China
    Document type Case Reports
    ZDB-ID 1239255-8
    ISSN 1024-2708
    ISSN 1024-2708
    DOI 10.12809/hkmj2210382
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4347: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  6. Article ; Online: Workplace violence in medical radiation science: A systematic review.

    Shah, K A / Ng, C K C

    Radiography (London, England : 1995)

    2024  Volume 30, Issue 2, Page(s) 440–447

    Abstract: Introduction: According to World Health Organization (WHO), workplace violence (WPV) is a significant issue in healthcare. However, no systematic review on WPV in medical radiation science (MRS) has been published yet. The purpose of this paper is to ... ...

    Abstract Introduction: According to World Health Organization (WHO), workplace violence (WPV) is a significant issue in healthcare. However, no systematic review on WPV in medical radiation science (MRS) has been published yet. The purpose of this paper is to systematically review prevalence of WPV in MRS and its risk factors.
    Methods: Electronic scholarly publication databases, namely EBSCOhost/Cumulative Index of Nursing and Allied Health Literature Ultimate, PubMed/Medline, ScienceDirect, Scopus, and Wiley Online Library were used for literature search to identify articles about WPV in MRS published over last 10 years as per preferred reporting items for systematic reviews and meta-analyses guidelines. To facilitate comparisons of the WPV prevalence and relative importance of individual risk factors across the included studies, their reported absolute figures of findings were used to synthesize respective percentages (if not stated).
    Results: Twelve papers met the selection criteria and were included. This review shows that the WPV prevalence were 69.2-100 % (whole career) and 46.1-83.0 % (last 12 months) in diagnostic radiography, 63.0-84.0 % (whole career) in radiation therapy, 57.6 % in medical sonography (last 12 months), and 46.8 % (last 6 months) in nuclear medicine. The identified WPV risk factors included intoxicated patients, staff stress, feeling of inadequacy resulting in self-protection, more vulnerable practitioners (female, <40 years old and <5-year experience), working in radiation therapy treatment room, emergency department, examination room, general radiography, public hospital, and non-examination and waiting areas, long patient waiting time, night shift, overcrowding environment, unable to meet patients'/family members' expectations, miscommunication, patient handling, inadequate staff and security measures, interaction with colleagues, and lone working.
    Conclusion: The WPV risk in diagnostic radiography and radiation therapy appears extremely high as a result of the aforementioned risk factors. Nevertheless, these study findings should be used with caution due to potential non-response bias.
    Implications for practice: A WPV policy should be developed in every clinical workplace. Even if such policy is available, its enforcement including policy awareness boosting, and encouraging incident reporting and support seeking will be essential for reducing WPV. More survey studies based on WHO WPV questionnaire should be conducted for strengthening evidence base.
    MeSH term(s) Humans ; Risk Factors ; Workplace ; Workplace Violence/prevention & control ; Radiology
    Language English
    Publishing date 2024-01-09
    Publishing country Netherlands
    Document type Journal Article ; Systematic Review
    ZDB-ID 1289102-2
    ISSN 1532-2831 ; 1078-8174
    ISSN (online) 1532-2831
    ISSN 1078-8174
    DOI 10.1016/j.radi.2023.12.018
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4438: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  7. Article ; Online: Evaluating contamination of seafood purchased from U.S. retail stores by persistent environmental pollutants, pesticides and veterinary drugs.

    Bedi, Megha / Sapozhnikova, Yelena / Ng, Carla

    Food additives & contaminants. Part A, Chemistry, analysis, control, exposure & risk assessment

    2024  Volume 41, Issue 3, Page(s) 325–338

    Abstract: Studies have reported health risks associated with seafood contamination, but few data exist on levels in commercially available seafood in the US. To better understand, the magnitude of foodborne exposure and identify vulnerable populations in the US, ... ...

    Abstract Studies have reported health risks associated with seafood contamination, but few data exist on levels in commercially available seafood in the US. To better understand, the magnitude of foodborne exposure and identify vulnerable populations in the US, we measured concentrations of veterinary drugs, persistent organic pollutants (POPs) (polycyclic aromatic hydrocarbons [PAHs], polybrominated diphenyl ethers [PBDEs] and polychlorinated biphenyls [PCBs]), and legacy and current-use pesticides in 46 seafood samples purchased from retail outlets. Measured levels were used to estimate risk based on available maximum residue limits (MRLs) and toxic equivalence (TEQ) factors for analytes. Only seventeen of the 445 analytes were detected, at low substance frequencies. However, half of the samples tested positive for one or more analyte, with total concentrations ranging from below the limit of detection (LOD) to as high as 156 µg/kg wet weight. Based on the risk assessment for individual pesticides and veterinary drugs, the hazard quotients (HQ) were all <1, indicating no risk. However, for the sum of PCB126 and PCB167, two dioxin-like PCBs detected in our samples, the TEQ was nearly two orders of magnitude higher than the WHO limits in one catfish sample. Moreover, vulnerable groups with higher rates of consumption of specific fish types may face higher risks.
    MeSH term(s) Animals ; Environmental Pollutants ; Polychlorinated Biphenyls ; Veterinary Drugs ; Pesticides ; Seafood
    Chemical Substances Environmental Pollutants ; Polychlorinated Biphenyls (DFC2HB4I0K) ; Veterinary Drugs ; Pesticides
    Language English
    Publishing date 2024-02-05
    Publishing country England
    Document type Journal Article
    ZDB-ID 2462951-0
    ISSN 1944-0057 ; 1944-0049
    ISSN (online) 1944-0057
    ISSN 1944-0049
    DOI 10.1080/19440049.2024.2310128
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  8. Article ; Online: Investigation of fatigue crack closure effect on the evaluation of edge cracks with the fundamental mode of edge waves.

    Zhu, Hankai / Kotousov, Andrei / Tai Ng, Ching

    Ultrasonics

    2024  Volume 138, Page(s) 107266

    Abstract: Fatigue cracks often initiate and propagate from edges of structural components. Detection and evaluation of edge cracks could be very challenging, specifically, due to the crack closure phenomenon, which makes fatigue cracks to be partially closed when ... ...

    Abstract Fatigue cracks often initiate and propagate from edges of structural components. Detection and evaluation of edge cracks could be very challenging, specifically, due to the crack closure phenomenon, which makes fatigue cracks to be partially closed when the applied loading is removed; this usually corresponds to maintenance and NDE inspection conditions. Despite that fatigue crack closure is well investigated, past experimental and theoretical studies related to guided wave-based NDEs largely ignored this phenomenon. In this article, the fundamental symmetric mode of edge waves (ES
    Language English
    Publishing date 2024-02-16
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 200839-7
    ISSN 1874-9968 ; 0041-624X
    ISSN (online) 1874-9968
    ISSN 0041-624X
    DOI 10.1016/j.ultras.2024.107266
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    In stock of ZB MED Cologne/Königswinter

    Zs.B 1133: Show issues Location:
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  9. Article ; Online: A review of the impact of the COVID-19 pandemic on pre-registration medical radiation science education.

    Ng, C K C

    Radiography (London, England : 1995)

    2021  Volume 28, Issue 1, Page(s) 222–231

    Abstract: Objective: The COVID-19 pandemic has changed traditional ways to provide pre-registration medical radiation science (MRS) (medical imaging and radiation therapy) education. This literature review explores the published pre-registration MRS education ... ...

    Abstract Objective: The COVID-19 pandemic has changed traditional ways to provide pre-registration medical radiation science (MRS) (medical imaging and radiation therapy) education. This literature review explores the published pre-registration MRS education curriculum adaptations implemented in response to the pandemic and effects of the adaptations on stakeholders.
    Key findings: Eleven articles were identified through a systematic literature search. The included articles covered the pre-registration MRS curriculum adaptations implemented in response to the pandemic in 12 countries of five continents. Through changing content delivery and assessment modes from face-to-face to online, non-practical classes and academic assessments could continue without significant interruptions. However, cancellation/postponement of practical classes and clinical placements was common during COVID-19 lockdown. Simulated learning was used by some institutions to replace some practical classes and placements. Among the stakeholders of MRS education (students, academics and clinical educators), the students were most affected. The main impacts were negative psychological effects and learning experiences. For the academics, they had common concerns about online learning quality and assessment integrity.
    Conclusion: This review of the early publications in the first year of the pandemic provides an illustration of the MRS curriculum adaptations implemented in five continents covering both English and non-English speaking countries and their effects on the stakeholders as yet. It is expected that more articles on this area will be published over time and hence allowing a more comprehensive review in the future.
    Implications for practice: The included articles show provision of wellbeing support, good planning of online content delivery based on sound pedagogical approaches, implementation of computer-based simulation tools suitable for home-based learning environment and use of authentic online assessments would address the impacts on the students and academics.
    MeSH term(s) COVID-19 ; Communicable Disease Control ; Education, Medical ; Humans ; Pandemics ; SARS-CoV-2
    Language English
    Publishing date 2021-08-04
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 1289102-2
    ISSN 1532-2831 ; 1078-8174
    ISSN (online) 1532-2831
    ISSN 1078-8174
    DOI 10.1016/j.radi.2021.07.026
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4438: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  10. Article ; Online: Taking a stand for operative vaginal delivery.

    Ng, Christopher

    CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne

    2018  Volume 190, Issue 24, Page(s) E732–E733

    MeSH term(s) Delivery, Obstetric ; Female ; Humans ; Infant, Newborn ; Obstetrical Forceps ; Pregnancy
    Language English
    Publishing date 2018-03-21
    Publishing country Canada
    Document type Journal Article ; Comment
    ZDB-ID 215506-0
    ISSN 1488-2329 ; 0008-4409 ; 0820-3946
    ISSN (online) 1488-2329
    ISSN 0008-4409 ; 0820-3946
    DOI 10.1503/cmaj.180668
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Ua VI Zs.136: Show issues Location:
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