LIVIVO - The Search Portal for Life Sciences

zur deutschen Oberfläche wechseln
Advanced search

Search results

Result 1 - 3 of total 3

Search options

  1. Article: Identification of predictors for persistence of immediate-type egg allergy in Chinese children.

    Ngai, Noelle Anne / Leung, Agnes Sze Yin / Leung, Jonathan Chi Ho / Chan, Oi Man / Leung, Ting Fan

    Asia Pacific allergy

    2021  Volume 11, Issue 4, Page(s) e41

    Abstract: Background: Egg allergy is one of the most common food allergies in childhood with increasing prevalence in Hong Kong. While ample studies were published on its optimal diagnosis, there was limited data on predictors for the natural history of egg ... ...

    Abstract Background: Egg allergy is one of the most common food allergies in childhood with increasing prevalence in Hong Kong. While ample studies were published on its optimal diagnosis, there was limited data on predictors for the natural history of egg allergy in Asian populations.
    Objective: This study aimed to characterize the clinical course and outcome of children with egg allergy and identify its prognostic factors.
    Methods: All Chinese children with immediate-type egg allergy being followed since ≥3 years old in allergy clinic of our university-affiliated teaching hospital were reviewed to determine if they outgrew egg allergy at the latest follow-up. The predictive values of clinical and atopic factors for resolution of egg allergy were analyzed on Kaplan-Meier curves, and factors independently associated with persistent egg allergy was analyzed by logistic regression.
    Results: Seventy-six patients with median (interquartile range) age 8.9 years (6.3-13.0 years) were recruited. They initially presented with egg-allergic reactions at 1.0 years (0.7-1.7 years). Fifty-four children (71%) were able to tolerate egg at a median of 36 months from initial reaction. Patients with concomitant peanut allergy and those with initial reaction at ≥1 year old were more likely to have persistent egg allergy (
    Conclusion: Most Chinese children with immediate-type egg allergy can tolerate egg in long run. SPT wheal size to egg, concomitant peanut allergy and initial presentation after infancy may predict egg allergy persistence.
    Language English
    Publishing date 2021-10-25
    Publishing country Korea (South)
    Document type Journal Article
    ZDB-ID 2614800-6
    ISSN 2233-8268 ; 2233-8276
    ISSN (online) 2233-8268
    ISSN 2233-8276
    DOI 10.5415/apallergy.2021.11.e41
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  2. Article ; Online: Prospective study of disease persistence and lung function trajectories of childhood asthma.

    Tang, Man Fung / Leung, Agnes Sze Yin / Ngai, Noelle Anne / Chan, Oi Man / Wong, Gary Wing Kin / Leung, Ting Fan

    Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology

    2022  Volume 33, Issue 2, Page(s) e13726

    Abstract: Background: A proportion of asthmatic children outgrow their disease by adulthood, but there are limited data on predictors for asthma persistence. This prospective study characterized the trajectory of spirometric indices and identified predictors for ... ...

    Abstract Background: A proportion of asthmatic children outgrow their disease by adulthood, but there are limited data on predictors for asthma persistence. This prospective study characterized the trajectory of spirometric indices and identified predictors for the persistence of childhood asthma.
    Methods: Chinese asthmatic children aged 6-15 years from pediatric allergy clinic underwent annual visits for ≥5 years and until their adulthood. Pre-bronchodilator spirometry and anti-asthma medications were recorded at baseline and then at least annually. Asthma resolution was defined when patients were free from asthma symptoms and use of anti-asthma drugs for ≥2 years. Logistic regression was used to identify predictors for asthma persistence. Generalized estimating equation was used to analyze longitudinal changes in lung function parameters in relation to asthma persistence.
    Results: 181 asthmatic children aged [mean (SD)] 10.0 (2.7) years were followed for [mean (SD)] 12.5 (2.8) years. One third of them outgrew asthma during follow-up. Female was 3.36 times more likely to have persistent asthma. Inhaled corticosteroid (ICS) treatment ever and frequent asthma exacerbation (AE) predicted asthma persistence with respective odds ratios of 3.19 (95% confidence interval [CI] 1.44-7.09) and 3.05 (95% CI 1.39-6.68). Persistent asthma was inversely associated with baseline forced expiratory volume in 1-second (FEV
    Conclusions: Female, ICS ever, and frequent AE predicted persistent asthma. Patients with persistent asthma had lower forced expiratory indices and poorer lung function growth into adulthood.
    MeSH term(s) Administration, Inhalation ; Adolescent ; Adrenal Cortex Hormones/adverse effects ; Adrenal Cortex Hormones/therapeutic use ; Adult ; Aged ; Anti-Asthmatic Agents/adverse effects ; Anti-Asthmatic Agents/therapeutic use ; Asthma/diagnosis ; Asthma/drug therapy ; Asthma/epidemiology ; Child ; Female ; Forced Expiratory Volume ; Humans ; Lung ; Prospective Studies
    Chemical Substances Adrenal Cortex Hormones ; Anti-Asthmatic Agents
    Language English
    Publishing date 2022-02-24
    Publishing country England
    Document type Journal Article
    ZDB-ID 1057059-7
    ISSN 1399-3038 ; 0905-6157 ; 0906-5784
    ISSN (online) 1399-3038
    ISSN 0905-6157 ; 0906-5784
    DOI 10.1111/pai.13726
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  3. Article ; Online: Real-World Sensitization and Tolerance Pattern to Seafood in Fish-Allergic Individuals.

    Leung, Agnes S Y / Wai, Christine Y Y / Leung, Nicki Y H / Ngai, Noelle Anne / Chua, Gilbert T / Ho, Po Ki / Lam, Ivan C S / Cheng, James W C H / Chan, Oi Man / Li, Pui Fung / Au, Ann W S / Leung, Chloris H W / Cheng, Nam Sze / Tang, Man Fung / Fong, Brian L Y / Rosa Duque, Jaime S / Wong, Joshua S C / Luk, David C K / Ho, Marco H K /
    Kwan, Mike Y W / Yau, Yat Sun / Lee, Qun Ui / Chan, Wai Hung / Wong, Gary W K / Leung, Ting Fan

    The journal of allergy and clinical immunology. In practice

    2023  Volume 12, Issue 3, Page(s) 633–642.e9

    Abstract: Background: Seafood is a common cause of food allergy and anaphylaxis, but there are limited published real-world data describing the clinical presentation of fish and shellfish allergies.: Objective: This study aimed to examine the clinical ... ...

    Abstract Background: Seafood is a common cause of food allergy and anaphylaxis, but there are limited published real-world data describing the clinical presentation of fish and shellfish allergies.
    Objective: This study aimed to examine the clinical characteristics, immunological profile, and tolerance pattern to fish, crustaceans, and mollusks in fish-allergic individuals.
    Methods: Patients presenting with IgE-mediated fish allergy between 2016 and 2021 were recruited. A comprehensive sensitization profile including specific IgE and skin prick test to various fish and shellfish species and a detailed clinical history including individuals' recent seafood consumption were evaluated.
    Results: A total of 249 fish-allergic individuals (aged 4.2 ± 5.8 years) were recruited from 6 allergy clinics in Hong Kong, and they had experienced their fish-allergic reaction 2.2 ± 3.4 years before enrollment. Seventy-five subjects (30%) reacted to either grass carp, salmon, grouper, or cod in oral food challenges. We identified an IgE sensitization gradient that corresponded to the level of β-parvalbumin in fish. In total, 40% of fish-allergic individuals reported tolerance to 1 or more types of fish, more commonly to fish with a lower β-parvalbumin level such as tuna and salmon, compared with β-parvalbumin-rich fish such as catfish and grass carp. Despite fish and shellfish cosensitization, 41% of individuals reported tolerance to crustaceans, mollusks, or both, whereas shellfish avoidance occurred in half of the fish-allergic individuals, of whom 33% lacked shellfish sensitization.
    Conclusions: Fish allergy commonly presents in early childhood. A considerable proportion of fish-allergic patients are selectively tolerant to certain fish, typically those with lower levels of β-parvalbumin. There is an unmet need to promote precision medicine for seafood allergies.
    MeSH term(s) Animals ; Humans ; Child, Preschool ; Parvalbumins ; Fishes ; Food Hypersensitivity ; Seafood ; Allergens ; Immunoglobulin E
    Chemical Substances Parvalbumins ; Allergens ; Immunoglobulin E (37341-29-0)
    Language English
    Publishing date 2023-10-05
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2843237-X
    ISSN 2213-2201 ; 2213-2198
    ISSN (online) 2213-2201
    ISSN 2213-2198
    DOI 10.1016/j.jaip.2023.09.038
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

To top