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  1. Article ; Online: Short Antiangiogenic MMP-2 Peptide-Decorated Conjugated Linoleic Acid-Coated SPIONs for Targeted Paclitaxel Delivery in an A549 Cell Xenograft Mouse Tumor Model.

    Ngema, Lindokuhle M / Adeyemi, Samson A / Marimuthu, Thashree / Ubanako, Philemon N / Ngwa, Wilfred / Choonara, Yahya E

    ACS omega

    2023  Volume 9, Issue 1, Page(s) 700–713

    Abstract: The design of targeted antiangiogenic nanovectors for the delivery of anticancer drugs presents a viable approach for effective management of nonsmall-cell lung carcinoma (NSCLC). Herein, we report on the fabrication of a targeted delivery nanosystem for ...

    Abstract The design of targeted antiangiogenic nanovectors for the delivery of anticancer drugs presents a viable approach for effective management of nonsmall-cell lung carcinoma (NSCLC). Herein, we report on the fabrication of a targeted delivery nanosystem for paclitaxel (PTX) functionalized with a short antimatrix metalloproteinase 2 (MMP-2) CTT peptide for selective MMP-2 targeting and effective antitumor activity in NSCLC. The fabrication of the targeted nanosystem (CLA-coated PTX-SPIONs@CTT) involved coating of superparamagnetic iron-oxide nanoparticles (SPIONs) with conjugated linoleic acid (CLA) via chemisorption, onto which PTX was adsorbed, and subsequent surface functionalization with carboxylic acid groups for conjugation of the CTT peptide. CLA-coated PTX SPIONs@CTT had a mean particle size of 99.4 nm and a PTX loading efficiency of ∼98.5%. The nanosystem exhibited a site-specific in vitro PTX release and a marked antiproliferative action on lung adenocarcinoma cells. The CTT-functionalized nanosystem significantly inhibited MMP-2 secretion by almost 70% from endothelial cells, indicating specific anti-MMP-2 activity. Treatment of tumor-bearing mice with subcutaneous injection of the CTT-functionalized nanosystem resulted in 69.7% tumor inhibition rate, and the administration of the nanosystem subcutaneously prolonged the half-life of PTX and circulation time in vivo. As such, CLA-coated PTX-SPIONs@CTT presents with potential for application as a targeted nanomedicine in NSCLC management.
    Language English
    Publishing date 2023-12-22
    Publishing country United States
    Document type Journal Article
    ISSN 2470-1343
    ISSN (online) 2470-1343
    DOI 10.1021/acsomega.3c06489
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Surface Immobilization of Anti-VEGF Peptide on SPIONs for Antiangiogenic and Targeted Delivery of Paclitaxel in Non-Small-Cell Lung Carcinoma.

    Ngema, Lindokuhle M / Adeyemi, Samson A / Marimuthu, Thashree / Ubanako, Philemon N / Ngwa, Wilfred / Choonara, Yahya E

    ACS applied bio materials

    2023  Volume 6, Issue 7, Page(s) 2747–2759

    Abstract: A design has been established for the surface decoration of superparamagnetic iron oxide nanoparticles (SPIONs) with anti-vascular endothelial growth factor peptide, HRH, to formulate a targeted paclitaxel (PTX) delivery nanosystem with notable tumor ... ...

    Abstract A design has been established for the surface decoration of superparamagnetic iron oxide nanoparticles (SPIONs) with anti-vascular endothelial growth factor peptide, HRH, to formulate a targeted paclitaxel (PTX) delivery nanosystem with notable tumor targetability and antiangiogenic activity. The design methodology included (i) tandem surface functionalization
    MeSH term(s) Humans ; Mice ; Animals ; Paclitaxel/pharmacology ; Paclitaxel/therapeutic use ; Carcinoma, Non-Small-Cell Lung/drug therapy ; Vascular Endothelial Growth Factor A ; Endothelial Cells ; Lung Neoplasms/drug therapy ; Cell Line, Tumor ; Peptides/chemistry ; Magnetic Iron Oxide Nanoparticles
    Chemical Substances Paclitaxel (P88XT4IS4D) ; Vascular Endothelial Growth Factor A ; Peptides
    Language English
    Publishing date 2023-06-29
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 2576-6422
    ISSN (online) 2576-6422
    DOI 10.1021/acsabm.3c00224
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Recent Innovations and Nano-Delivery of Actinium-225: A Narrative Review.

    Mdanda, Sipho / Ngema, Lindokuhle M / Mdlophane, Amanda / Sathekge, Mike M / Zeevaart, Jan Rijn

    Pharmaceutics

    2023  Volume 15, Issue 6

    Abstract: The actinium-225 ( ...

    Abstract The actinium-225 (
    Language English
    Publishing date 2023-06-13
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2527217-2
    ISSN 1999-4923
    ISSN 1999-4923
    DOI 10.3390/pharmaceutics15061719
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: A review on engineered magnetic nanoparticles in Non-Small-Cell lung carcinoma targeted therapy.

    Ngema, Lindokuhle M / Adeyemi, Samson A / Marimuthu, Thashree / Choonara, Yahya E

    International journal of pharmaceutics

    2021  Volume 606, Page(s) 120870

    Abstract: There are growing appeals forthe design of efficacious treatment options for non-small-cell lung carcinoma (NSCLC) as it accrues to ~ 85% cases of lung cancer. Although platinum-based doublet chemotherapy has been the main therapeutic intervention in ... ...

    Abstract There are growing appeals forthe design of efficacious treatment options for non-small-cell lung carcinoma (NSCLC) as it accrues to ~ 85% cases of lung cancer. Although platinum-based doublet chemotherapy has been the main therapeutic intervention in NSCLC management, this leads to myriad of problems including intolerability to the doublet regimens and detrimental side effects due to high doses. A new approach is therefore needed and warrants the design of targeted drug delivery systems that can halt tumor proliferation and metastasis by targeting key molecules, while exhibiting minimal side effects and toxicity. This review aims to explore the rational design of magnetic nanoparticles for the development of tumor-targeting systems for NSCLC. In the review, we explore the anticancer merits of conjugated linoleic acid (CLA) and provide a concise incursion into its application for the invention of functionalized magnetic nanoparticles in the targeted treatment of NSCLC. Recent nanoparticle-based targeted chemotherapies for targeting angiogenesis biomarkers in NSCLC will also be reviewed to further highlight versatility of magnetic nanoparticles. These developments through molecular tuning at the nanoscale and supported by comprehensive pre-clinical studies could lead to the establishment of precise nanosystems for tumor-homing cancer therapy.
    MeSH term(s) Carcinoma, Non-Small-Cell Lung/drug therapy ; Humans ; Lung Neoplasms/drug therapy ; Magnetite Nanoparticles ; Nanoparticles
    Chemical Substances Magnetite Nanoparticles
    Language English
    Publishing date 2021-07-08
    Publishing country Netherlands
    Document type Journal Article ; Review
    ZDB-ID 428962-6
    ISSN 1873-3476 ; 0378-5173
    ISSN (online) 1873-3476
    ISSN 0378-5173
    DOI 10.1016/j.ijpharm.2021.120870
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Synthesis of Novel Conjugated Linoleic Acid (CLA)-Coated Superparamagnetic Iron Oxide Nanoparticles (SPIONs) for the Delivery of Paclitaxel with Enhanced In Vitro Anti-Proliferative Activity on A549 Lung Cancer Cells.

    Ngema, Lindokuhle M / Adeyemi, Samson A / Marimuthu, Thashree / Ubanako, Philemon / Wamwangi, Daniel / Choonara, Yahya E

    Pharmaceutics

    2022  Volume 14, Issue 4

    Abstract: The application of Superparamagnetic Iron Oxide Nanoparticles (SPIONs) as a nanomedicine for Non-Small Cell Lung Carcinoma (NSCLC) can provide effective delivery of anticancer drugs with minimal side-effects. SPIONs have the flexibility to be modified to ...

    Abstract The application of Superparamagnetic Iron Oxide Nanoparticles (SPIONs) as a nanomedicine for Non-Small Cell Lung Carcinoma (NSCLC) can provide effective delivery of anticancer drugs with minimal side-effects. SPIONs have the flexibility to be modified to achieve enhanced oading of hydrophobic anticancer drugs such as paclitaxel (PTX). The purpose of this study was to synthesize novel
    Language English
    Publishing date 2022-04-11
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2527217-2
    ISSN 1999-4923
    ISSN 1999-4923
    DOI 10.3390/pharmaceutics14040829
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Patient reported outcomes following whole brain radiotherapy in patients with brain metastases in NSIA-LUTH Cancer Center.

    Adegboyega, Bolanle / Joseph, Adedayo / Alabi, Adewumi / Omomila, John / Ngema, Lindokuhle M / Ainsworth, Victoria / Chin, Jennifer / Evbuomwan, Moses O / Ngwa, Wilfred

    BMC cancer

    2023  Volume 23, Issue 1, Page(s) 1233

    Abstract: Background: Brain metastases (BM) are a common complication in advanced cancer patients, and extremely challenging to treat. Consequently, whole brain radiotherapy (WBRT) remains the standard palliative intervention for patients with BM. The present ... ...

    Abstract Background: Brain metastases (BM) are a common complication in advanced cancer patients, and extremely challenging to treat. Consequently, whole brain radiotherapy (WBRT) remains the standard palliative intervention for patients with BM. The present study set to evaluate the clinical benefits of WBRT by assessing the quality of life (QoL) in WBRT-treated patients with BM, in Nigeria.
    Methods: This was a prospective, longitudinal, hospital-based single-centre study. Consecutive sampling methodology was used to recruit 52 patients with BM undergoing WBRT. Patients were followed up on days 7, 30, 90 and 180 after WBRT. The EORTC QLQ-C15-PAL and EORTC QLQ-BN20 were employed to report patients' responses. The likert scale responses were linearly converted into 0 - 100 scores, and the descriptive analysis was conducted using IBM SPSS Statistics 29.0, at 95% confidence interval, using the two-tailed t-test for continuous variables or the chi-square test for categorical values. The overall survival was calculated with the Kaplan Maier method and the difference tested with Log-rank method, considering the interval from the baseline until death or end of the study.
    Results: The study cohort was predominantly females (82.7%), and accordingly, 65.4% of the respondents had a breast primary tumor. A goodness-of-fit test yielded non-significant Chi square Pearson (p = 0.325) and Deviance (p = 1.000) residuals, indicating the best fit. The median overall survival was 180 days (~ 6 months). A total of 20 patients (38%) that survived up to 180 days reported alleviated symptoms and better functioning. A significant improvement in physical functioning (p < 0.001) and emotional functioning (p = 0.031) was reported at 180 days post WBRT, compared to baseline.
    Conclusions: WBRT is an effective palliative intervention in patients with BM, resulting in improved QoL. More than 50% of patients that survived ~ 3 months reported alleviation of pain, and 38% of patients that survived for ~ 6 months reported a significantly improved functioning. This demonstrated the clinical benefits of WBRT in palliative care and will add to the body of data on the use of WBRT, from Africa.
    MeSH term(s) Female ; Humans ; Male ; Quality of Life ; Prospective Studies ; Brain Neoplasms/secondary ; Cranial Irradiation/adverse effects ; Cranial Irradiation/methods ; Patient Reported Outcome Measures ; Brain ; Nigeria/epidemiology
    Language English
    Publishing date 2023-12-14
    Publishing country England
    Document type Journal Article
    ZDB-ID 2041352-X
    ISSN 1471-2407 ; 1471-2407
    ISSN (online) 1471-2407
    ISSN 1471-2407
    DOI 10.1186/s12885-023-11675-8
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: Pre-Clinical Investigations of the Pharmacodynamics of Immunogenic Smart Radiotherapy Biomaterials (iSRB).

    Moreau, Michele / Acter, Shahinur / Ngema, Lindokuhle M / Bih, Noella / Sy, Gnagna / Keno, Lensa S / Chow, Kwok Fan / Sajo, Erno / Nebangwa, Oscar / Walker, Jacques / Oh, Philmo / Broyles, Eric / Ngwa, Wilfred / Yasmin-Karim, Sayeda

    Pharmaceutics

    2023  Volume 15, Issue 12

    Abstract: The use of an immunogenic smart radiotherapy biomaterial (iSRB) for the delivery of anti-CD40 is effective in treating different cancers in animal models. This study further characterizes the use of iSRBs to evaluate any associated toxicity in healthy ... ...

    Abstract The use of an immunogenic smart radiotherapy biomaterial (iSRB) for the delivery of anti-CD40 is effective in treating different cancers in animal models. This study further characterizes the use of iSRBs to evaluate any associated toxicity in healthy C57BL6 mice. iSRBs were fabricated using a poly-lactic-co-glycolic-acid (PLGA) polymer mixed with titanium dioxide (TiO
    Language English
    Publishing date 2023-12-14
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2527217-2
    ISSN 1999-4923
    ISSN 1999-4923
    DOI 10.3390/pharmaceutics15122778
    Database MEDical Literature Analysis and Retrieval System OnLINE

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