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  1. Article ; Online: Willingness to Donate Hair Samples for Research Among People Living with HIV/AIDS Attending a Tertiary Health Facility in Ibadan, Nigeria.

    Nwogu, Jacinta N / Babalola, Chinedum P / Ngene, Samuel O / Taiwo, Babafemi O / Berzins, Baiba / Gandhi, Monica

    AIDS research and human retroviruses

    2019  Volume 35, Issue 7, Page(s) 642–648

    Abstract: The use of hair samples in biomedical research is a rapidly growing field. High acceptability rates for hair collection have been demonstrated in multiple settings. Each setting may have unique issues and, to our knowledge, no previous study has assessed ...

    Abstract The use of hair samples in biomedical research is a rapidly growing field. High acceptability rates for hair collection have been demonstrated in multiple settings. Each setting may have unique issues and, to our knowledge, no previous study has assessed the acceptability of hair sampling for HIV-related research in Nigeria. This study aimed to assess the willingness to donate hair for research among people living with HIV (PLWH). A cross-sectional study was conducted among 381 PLWH in a tertiary institution in Southwest Nigeria, using convenience sampling. An interviewer-administered questionnaire was used to collect data from consenting participants, including a question on willingness to donate hair for research. The mean age of respondents was 42.1 ± 10.5 years and more than three-quarters of the respondents were females. Two hundred and eighty-eight (75.8%) respondents had at least a tertiary education. Only 51.4% of the respondents were willing to donate their hair for research. Possible sample diversion for rituals was the major (60.5%) reason cited for unwillingness to donate hair. In multivariate analysis, respondents with primary education or less exhibited a trend toward being more willing to donate hair than those with secondary education or more (
    MeSH term(s) Adult ; Biomedical Research ; Cross-Sectional Studies ; Female ; HIV Infections/epidemiology ; HIV Infections/psychology ; Hair ; Health Knowledge, Attitudes, Practice ; Humans ; Male ; Middle Aged ; Nigeria/epidemiology ; Surveys and Questionnaires ; Tertiary Care Centers ; Tissue and Organ Procurement/statistics & numerical data
    Language English
    Publishing date 2019-05-29
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 639130-8
    ISSN 1931-8405 ; 0889-2229
    ISSN (online) 1931-8405
    ISSN 0889-2229
    DOI 10.1089/AID.2018.0242
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1928: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  2. Article ; Online: Breast Cancer Genetics Knowledge and Testing Intentions among Nigerian Professional Women.

    Ngene, Samuel O / Adedokun, Babatunde / Adejumo, Prisca / Olopade, Olufunmilayo

    Journal of genetic counseling

    2017  Volume 27, Issue 4, Page(s) 863–873

    Abstract: Genetic testing services for breast cancer are well established in developed countries compared to African populations that bear a disproportionate burden of breast cancer (BC). The objective of this study is to examine the knowledge of professional ... ...

    Abstract Genetic testing services for breast cancer are well established in developed countries compared to African populations that bear a disproportionate burden of breast cancer (BC). The objective of this study is to examine the knowledge of professional Nigerian women about BC genetics and their intentions to utilize genetic testing services when it is made available in Nigeria. In this study, 165 lecturers and 189 bankers were recruited and studied using a validated self-administered questionnaire. The respondents' mean age was 34.9 years (SD = 10.9), 6.5% had family history of BC, and 84.7% had limited knowledge of breast cancer genetics. The proportion of women with genetic testing intentions for breast cancer was 87.3%. Health care access (OR = 2.35, 95% CI, 1.07-5.13), religion (OR = 3.51, 95% CI, 1.03-11.92), and perceived personal risk if a close relative had breast cancer (OR = 2.31, 95% CI, 1.05-5.08) independently predicted testing intentions. The genetic testing intentions for BC were high despite limited knowledge about breast cancer genetics. Promotion of BC genetics education as well as efforts to make BC genetic testing services available in Nigeria at reduced cost remains essential.
    MeSH term(s) Adult ; Breast Neoplasms/diagnosis ; Breast Neoplasms/genetics ; Breast Neoplasms/psychology ; Cross-Sectional Studies ; Female ; Genetic Predisposition to Disease ; Genetic Testing ; Health Knowledge, Attitudes, Practice ; Humans ; Middle Aged ; Nigeria ; Occupations ; Risk Factors ; Surveys and Questionnaires ; Women, Working/psychology
    Language English
    Publishing date 2017-12-19
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1117799-8
    ISSN 1573-3599 ; 1059-7700
    ISSN (online) 1573-3599
    ISSN 1059-7700
    DOI 10.1007/s10897-017-0194-4
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4263: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  3. Article ; Online: Comparison of efavirenz levels in blood and hair with pharmacy refills as measures of adherence and predictors of viral suppression among people living with HIV in Nigeria.

    Nwogu, Jacinta N / Ngene, Samuel O / Babalola, Chinedum P / Olagunju, Adeniyi / Owen, Andrew / Khoo, Saye H / Kotila, Olayinka A / Berzins, Baiba / Okochi, Hideaki / Tallerico, Regina / Gandhi, Monica / Taiwo, Babafemi

    AIDS research and therapy

    2022  Volume 19, Issue 1, Page(s) 35

    Abstract: Background: Strategies to support adherence are constrained by the lack of tools to objectively monitor medication intake in low-resource settings. Pharmacologic measures are objective, but pharmacy refill data is more accessible and cost-efficient. ... ...

    Abstract Background: Strategies to support adherence are constrained by the lack of tools to objectively monitor medication intake in low-resource settings. Pharmacologic measures are objective, but pharmacy refill data is more accessible and cost-efficient. This study compared short-term and long-term efavirenz (EFV) drug levels with pharmacy refill adherence data (PRA) and evaluated their ability to predict viral suppression among people living with HIV in Nigeria.
    Methods: Paired hair and dried blood spot (DBS) samples were obtained from 91 adults living with HIV receiving 600 mg EFV-based antiretroviral therapy (ART) and EFV concentrations were measured via validated methods using liquid-chromatography-mass-spectrometry. PRA was estimated from pharmacy records, based on the number of days a patient collected medication before or after the scheduled pick-up date. PRA was categorized into ≤ 74%, 75-94% and ≥ 95%, defined as poor, medium and high adherence, respectively. HIV viral loads closest to the hair sampling time (within 6 months) were also abstracted. Receiver Operating Characteristics (ROC) curve analyses compared the ability of adherence metrics to predict viral suppression.
    Results: Based on PRA, 81% of participants had high adherence while 11% and 8% had medium and poor adherence, respectively. The median (IQR) EFV concentrations were 6.85 ng/mg (4.56-10.93) for hair and 1495.6 ng/ml (1050.7-2365.8) for DBS. Of the three measures of adherence, hair EFV concentration had the highest Area Under Curve (AUC) to predict viral suppression. Correlations between EFV concentrations in DBS and hair with PRA were positive (r = 0.12, P = 0.27 and r = 0.21, P = 0.05, respectively) but not strong.
    Conclusions: EFV concentrations in hair were the strongest predictor of viral suppression and only weakly correlated with pharmacy refill adherence data in Nigeria. This study suggests that resource-limited settings may benefit from objective adherence metrics to monitor and support adherence.
    MeSH term(s) Adult ; Alkynes ; Anti-HIV Agents/analysis ; Anti-HIV Agents/therapeutic use ; Benzoxazines ; Cyclopropanes ; HIV Infections/drug therapy ; Hair/chemistry ; Humans ; Nigeria ; Pharmacy
    Chemical Substances Alkynes ; Anti-HIV Agents ; Benzoxazines ; Cyclopropanes ; efavirenz (JE6H2O27P8)
    Language English
    Publishing date 2022-07-10
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 2173450-1
    ISSN 1742-6405 ; 1742-6405
    ISSN (online) 1742-6405
    ISSN 1742-6405
    DOI 10.1186/s12981-022-00462-3
    Database MEDical Literature Analysis and Retrieval System OnLINE

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