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  1. AU="Ngo, Lena"
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  1. Article ; Online: Chronic nicotine exposure is associated with electrophysiological and sympathetic remodeling in the intact rabbit heart.

    Guevara, Amanda / Smith, Charlotte E R / Caldwell, Jessica L / Ngo, Lena / Mott, Lilian R / Lee, I-Ju / Tapa, Srinivas / Wang, Zhen / Wang, Lianguo / Woodward, William R / Ng, G Andre / Habecker, Beth A / Ripplinger, Crystal M

    American journal of physiology. Heart and circulatory physiology

    2024  Volume 326, Issue 6, Page(s) H1337–H1349

    Abstract: Nicotine is the primary addictive component of tobacco products. Through its actions on the heart and autonomic nervous system, nicotine exposure is associated with electrophysiological changes and increased arrhythmia susceptibility. To assess the ... ...

    Abstract Nicotine is the primary addictive component of tobacco products. Through its actions on the heart and autonomic nervous system, nicotine exposure is associated with electrophysiological changes and increased arrhythmia susceptibility. To assess the underlying mechanisms, we treated rabbits with transdermal nicotine (NIC, 21 mg/day) or control (CT) patches for 28 days before performing dual optical mapping of transmembrane potential (RH237) and intracellular Ca
    MeSH term(s) Animals ; Nicotine/toxicity ; Nicotine/adverse effects ; Rabbits ; Heart Rate/drug effects ; Action Potentials/drug effects ; Heart/innervation ; Heart/drug effects ; Sympathetic Nervous System/drug effects ; Sympathetic Nervous System/physiopathology ; Male ; Nicotinic Agonists/toxicity ; Nicotinic Agonists/administration & dosage ; Calcium Signaling/drug effects ; Arrhythmias, Cardiac/chemically induced ; Arrhythmias, Cardiac/physiopathology ; Arrhythmias, Cardiac/metabolism ; Transdermal Patch ; Isolated Heart Preparation ; Administration, Cutaneous ; Norepinephrine/metabolism
    Chemical Substances Nicotine (6M3C89ZY6R) ; Nicotinic Agonists ; Norepinephrine (X4W3ENH1CV)
    Language English
    Publishing date 2024-03-29
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 603838-4
    ISSN 1522-1539 ; 0363-6135
    ISSN (online) 1522-1539
    ISSN 0363-6135
    DOI 10.1152/ajpheart.00749.2023
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Uc I Zs.89: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  2. Article ; Online: The Development and Implementation of the Fast-Pace Assessment Framework and Tiered Analgesic Orders for Opioid Optimization.

    Bazinski, Marilyn / Lau, Catherine / Clemons, Brooke / Purser, Lisa / Kangwankij, Amy / Ngo, Lena / Lang, Michael / Besen, Brianna / Gross, Kendall / Borucki, Amber / Behrends, Matthias / Miaskowski, Christine / Schell-Chaple, Hildy

    Pain management nursing : official journal of the American Society of Pain Management Nurses

    2024  

    Abstract: Background: Within the context of the opioid epidemic, changes needed to be made in the prescription and administration of analgesics. The purpose of this paper is to describe the development and implementation of a project that utilized a holistic pain ...

    Abstract Background: Within the context of the opioid epidemic, changes needed to be made in the prescription and administration of analgesics. The purpose of this paper is to describe the development and implementation of a project that utilized a holistic pain assessment framework and introduced new order sets to guide the integration of nonopioid, opioid, and co-analgesics in a quaternary care medical center.
    Methods: An interdisciplinary team updated policies and procedures for pain assessment and opioid administration and created new analgesic order sets for both adult and pediatric patients. Following requisite approvals, these order sets were integrated into the electronic health record. Education of clinicians, patients, and caregivers was provided to facilitate implementation of these new clinical practices.
    Results: Prescribers' levels of adherence with the use of the pain order sets ranged from 80% to 90% and no adverse effects were reported. Education of nursing staff was incorporated into hospital orientation. Ongoing evaluations are providing insights into how the new policies and procedures can be optimized to ensure reliable, safe, and effective pain management.
    Conclusions: Since the implementation of the opioid optimization project, adherence with the tiered, multimodal approach to analgesic prescribing is high. Next steps include both qualitative and quantitative evaluations of the benefits and challenges associated with this practice change. For example, systems will be developed to monitor nurses' adherence with the implementation of the pain order sets and the use of both pharmacologic and nonpharmacologic pain management interventions.
    Language English
    Publishing date 2024-03-23
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2213260-0
    ISSN 1532-8635 ; 1524-9042
    ISSN (online) 1532-8635
    ISSN 1524-9042
    DOI 10.1016/j.pmn.2024.01.003
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6269: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 514: Show issues

    Order via subito

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  3. Article ; Online: Whole-heart multiparametric optical imaging reveals sex-dependent heterogeneity in cAMP signaling and repolarization kinetics.

    Caldwell, Jessica L / Lee, I-Ju / Ngo, Lena / Wang, Lianguo / Bahriz, Sherif / Xu, Bing / Bers, Donald M / Navedo, Manuel F / Bossuyt, Julie / Xiang, Yang K / Ripplinger, Crystal M

    Science advances

    2023  Volume 9, Issue 3, Page(s) eadd5799

    Abstract: Cyclic adenosine 3',5'-monophosphate (cAMP) is a key second messenger in cardiomyocytes responsible for transducing autonomic signals into downstream electrophysiological responses. Previous studies have shown intracellular heterogeneity and ... ...

    Abstract Cyclic adenosine 3',5'-monophosphate (cAMP) is a key second messenger in cardiomyocytes responsible for transducing autonomic signals into downstream electrophysiological responses. Previous studies have shown intracellular heterogeneity and compartmentalization of cAMP signaling. However, whether cAMP signaling occurs heterogeneously throughout the intact heart and how this drives sex-dependent functional responses are unknown. Here, we developed and validated a novel cardiac-specific fluorescence resonance energy transfer-based cAMP reporter mouse and a combined voltage-cAMP whole-heart imaging system. We showed that in male hearts, cAMP was uniformly activated in response to pharmacological β-adrenergic stimulation. In contrast, female hearts showed that cAMP levels decayed faster in apical versus basal regions, which was associated with nonuniform action potential changes and notable changes in the direction of repolarization. Apical phosphodiesterase (PDE) activity was higher in female versus male hearts, and PDE inhibition prevented repolarization changes in female hearts. Thus, our imaging approach revealed sex-dependent regional breakdown of cAMP and associated electrophysiological differences.
    MeSH term(s) Mice ; Male ; Female ; Animals ; Cyclic AMP/metabolism ; Kinetics ; Signal Transduction ; Myocytes, Cardiac/metabolism ; Optical Imaging
    Chemical Substances Cyclic AMP (E0399OZS9N)
    Language English
    Publishing date 2023-01-20
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2810933-8
    ISSN 2375-2548 ; 2375-2548
    ISSN (online) 2375-2548
    ISSN 2375-2548
    DOI 10.1126/sciadv.add5799
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  4. Article: Chronic nicotine exposure is associated with electrophysiological and sympathetic remodeling in the intact rabbit heart.

    Guevara, Amanda / Smith, Charlotte E R / Caldwell, Jessica L / Ngo, Lena / Mott, Lilian R / Lee, I-Ju / Tapa, Inivas / Wang, Zhen / Wang, Lianguo / Woodward, William R / Ng, G Andre / Habecker, Beth A / Ripplinger, Crystal M

    bioRxiv : the preprint server for biology

    2023  

    Abstract: Nicotine is the primary addictive component in tobacco products. Through its actions on the heart and autonomic nervous system, nicotine exposure is associated with electrophysiological changes and increased arrhythmia susceptibility. However, the ... ...

    Abstract Nicotine is the primary addictive component in tobacco products. Through its actions on the heart and autonomic nervous system, nicotine exposure is associated with electrophysiological changes and increased arrhythmia susceptibility. However, the underlying mechanisms are unclear. To address this, we treated rabbits with transdermal nicotine (NIC, 21 mg/day) or control (CT) patches for 28 days prior to performing dual optical mapping of transmembrane potential (RH237) and intracellular Ca
    New & noteworthy: Here we show that chronic nicotine exposure was associated with increased heart rate, lower threshold for alternans and reduced sympathetic electrophysiological responses in the intact rabbit heart. We suggest that this was due to the sympathetic hypo-innervation of the myocardium and diminished β- adrenergic responsiveness observed following nicotine treatment. Though these differences did not result in increased arrhythmia propensity in our study, we hypothesize that prolonged nicotine exposure may exacerbate this pro-arrhythmic remodeling.
    Language English
    Publishing date 2023-11-23
    Publishing country United States
    Document type Preprint
    DOI 10.1101/2023.11.23.567754
    Database MEDical Literature Analysis and Retrieval System OnLINE

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