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  1. Article ; Online: Donor characteristics and intraoperative total nucleated cell count influence hematopoietic progenitor cell yield of healthy donor bone marrow grafts.

    Kalin, Jacob / Nguyen, Anh Thy H / Oshrine, Benjamin

    Pediatric blood & cancer

    2021  Volume 68, Issue 4, Page(s) e28902

    Abstract: Background: Bone marrow graft cell content impacts engraftment potential after allogeneic hematopoietic cell transplantation (alloHCT). Surrogates, such as intraoperative total nucleated cell count (ioTNC), are of unclear utility in predicting final ... ...

    Abstract Background: Bone marrow graft cell content impacts engraftment potential after allogeneic hematopoietic cell transplantation (alloHCT). Surrogates, such as intraoperative total nucleated cell count (ioTNC), are of unclear utility in predicting final graft characteristics. In addition, demographic and clinical factors may influence graft cellular profile and recipient engraftment.
    Procedure: We retrospectively reviewed marrow harvests at our institution performed between 2009 and 2019. During this time, an ioTNC was measured after 50% of the projected final graft volume was collected. Regression models were used to assess associations between ioTNC (cells/µL) and final graft CD34+ (cells/mL), and between graft and donor characteristics and final graft CD34+ (cells/mL).
    Results: Fifty-three marrow harvests and donor-recipient pairs were analyzed. Median (range) donor and recipient ages were 13 (0.7-28) years and 9 (0.2-21) years, respectively. The median ratio of donor/recipient weight was 1.225 kg (range 0.31-7.13). Median total volume of harvested marrow was 15.3 mL/kg (range 4.3-20.4) of donor weight and 19.4 mL/kg (range 4.7-87.4) of recipient weight. Median ioTNC was 20 930/µL (range 6600-44310) or 2.1 × 10
    Conclusions: ioTNC and certain donor characteristics correlate moderately well with marrow product CD34+ cells/mL, potentially informing donor selection and marrow procurement strategies.
    MeSH term(s) Adolescent ; Adult ; Antigens, CD34/analysis ; Bone Marrow Cells/cytology ; Cell Count ; Child ; Child, Preschool ; Donor Selection ; Female ; Graft Survival ; Hematopoietic Stem Cell Transplantation/methods ; Hematopoietic Stem Cells/cytology ; Humans ; Infant ; Male ; Transplantation, Homologous/methods ; Young Adult
    Chemical Substances Antigens, CD34
    Language English
    Publishing date 2021-01-23
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2131448-2
    ISSN 1545-5017 ; 1545-5009
    ISSN (online) 1545-5017
    ISSN 1545-5009
    DOI 10.1002/pbc.28902
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  2. Article ; Online: Le Fort 1 and Bimaxillary Osteotomies Increase the Length of Stay but not Postoperative Morbidity Compared to Mandibular Osteotomies and Single Jaw Procedures.

    Jodeh, Diana S / Nguyen, Anh Thy H / Rottgers, S Alex

    The Journal of craniofacial surgery

    2020  Volume 31, Issue 6, Page(s) 1734–1738

    Abstract: Purpose: The purpose of this study is to examine the association between type of facial osteotomies performed during orthognathic surgery and postoperative outcomes including complications, length of stay, and readmission.: Methods: A retrospective ... ...

    Abstract Purpose: The purpose of this study is to examine the association between type of facial osteotomies performed during orthognathic surgery and postoperative outcomes including complications, length of stay, and readmission.
    Methods: A retrospective review of orthognathic surgery cases from the Pediatric Health Information System (PHIS) database from 2004 to 2014 was undertaken. Osteotomy procedures were classified as Le Fort 1 (LF 1), Mandibular osteotomy, Genioplasty or their combinations. Primary outcome variable was major complications. Secondary outcomes included postoperative LOS > 1 day and 90-day readmission. Random-intercept logistic regression models were utilized to assess the association between the type of osteotomy performed and the outcomes. Bonferroni approach was used to account for multiple comparisons.
    Results: The sample included 5413 patients, with a mean age of 17.1 ± 1.68 years and 60.65% were female. The most common procedures were LF1 (39.4%), followed by bimaxillary surgery (23%). Major complications occurred in 8.57% of patients, postoperative LOS > 1 day in 52.4% and 90-day all-cause readmission in 11.16%. In adjusted analyses comparing LF1 compared to mandibular osteotomies, there were no significant differences for major complications (OR = 0.78), 90-day readmission rate (OR = 0.98). However, LF1 was associated with an increased odds for LOS compared to mandibular osteotomies (OR = 1.42). Addition of osteotomies is associated with a significant increase in LOS (P < 0.001).
    Conclusions: Patients undergoing orthognathic surgery demonstrated increased length of stay for LF1 or bimaxillary osteotomies. Osteotomy type did not impact the odds of readmission or complications. The trends revealed should be helpful for patient counseling.
    MeSH term(s) Adolescent ; Female ; Genioplasty ; Humans ; Jaw Diseases/surgery ; Length of Stay ; Male ; Mandibular Osteotomy ; Morbidity ; Osteotomy, Le Fort ; Retrospective Studies
    Language English
    Publishing date 2020-05-05
    Publishing country United States
    Document type Comparative Study ; Journal Article
    ZDB-ID 1159501-2
    ISSN 1536-3732 ; 1049-2275
    ISSN (online) 1536-3732
    ISSN 1049-2275
    DOI 10.1097/SCS.0000000000006514
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  3. Article ; Online: Preappointment surveys and reminder calls to improve show rate.

    Frye, William S / Cucchiaro, Giovanni / Nguyen, Anh Thy H / Householder, Kym / Kuhn, Bethany

    The American journal of managed care

    2022  Volume 28, Issue 8, Page(s) e296–e300

    Abstract: Objectives: To assess the impact of preappointment surveys and reminder phone calls on show rate and time spent in new patient appointments at a multidisciplinary pediatric chronic pain clinic.: Study design: We examined show rates and appointment ... ...

    Abstract Objectives: To assess the impact of preappointment surveys and reminder phone calls on show rate and time spent in new patient appointments at a multidisciplinary pediatric chronic pain clinic.
    Study design: We examined show rates and appointment length during the 1-year period before and 1-year period after a preappointment survey and phone reminders were implemented. Fisher exact test was used for categorical variables and Student's t test with equal variances was used for continuous variables.
    Methods: The setting was a multidisciplinary pediatric chronic pain management clinic in Florida. Participants were 362 patients scheduled for an initial pain clinic evaluation 1 year prior to and after the implementation of a preappointment survey on August 19, 2019. Our main outcome measures were show rate and appointment length.
    Results: Patients who completed a preappointment survey were significantly more likely to attend their clinic appointment than noncompleters (97.2% vs 36.2%) and spent significantly less time in their appointment.
    Conclusions: With new patients, preappointment surveys can improve clinic show rate and decrease time spent in initial appointments. Clinics may consider policies targeting completion of preappointment surveys to assist with show rate, but they must consider their patients' barriers to completing surveys so access to care is not limited.
    MeSH term(s) Appointments and Schedules ; Child ; Humans ; Patient Compliance ; Reminder Systems ; Surveys and Questionnaires ; Telephone
    Language English
    Publishing date 2022-08-01
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2035781-3
    ISSN 1936-2692 ; 1088-0224 ; 1096-1860
    ISSN (online) 1936-2692
    ISSN 1088-0224 ; 1096-1860
    DOI 10.37765/ajmc.2022.89203
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  4. Article ; Online: Outcomes of Primary Palatoplasty: An Analysis Using the Pediatric Health Information System Database.

    Jodeh, Diana S / Nguyen, Anh Thy H / Rottgers, S Alex

    Plastic and reconstructive surgery

    2019  Volume 143, Issue 2, Page(s) 533–539

    Abstract: Background: Previous attempts at reporting oronasal fistula development and secondary speech surgery following cleft palate surgery have been limited to single-center case series. This limitation can be overcome by querying large databases created by ... ...

    Abstract Background: Previous attempts at reporting oronasal fistula development and secondary speech surgery following cleft palate surgery have been limited to single-center case series. This limitation can be overcome by querying large databases created by health care governing bodies or health care alliances. The authors examined the effect of cleft type and demographic variables on the clinical outcomes.
    Methods: Data from the Pediatric Health Information System database were queried for patients, aged 6 to 18 months, who had undergone primary palatoplasty between 2004 and 2009. Subsequent repair of an oronasal fistula and/or secondary speech surgery between 2004 and 2015 was identified by procedure codes. Logistic regression models were used to assess the associations between cleft type with oronasal fistula and with secondary speech surgery.
    Results: Seven thousand three hundred twenty-five patients were identified, and 6.4 percent (n = 468) had a subsequent repair of an oronasal fistula and 18.5 percent (n = 1355) had a secondary speech operation. Adjusted for age, sex, and race, patients with cleft lip and palate have increased odds of oronasal fistula (OR, 5.60; 95 percent CI, 4.44 to 7.07) and secondary speech surgery (OR, 2.32; 95 percent CI, 2.05 to 2.63).
    Conclusions: Using a large, multi-institution billing database, the authors were able to estimate the prevalence of oronasal fistula and surgically treated velopharyngeal insufficiency following primary palatoplasty in the United States. In addition, the authors demonstrated that patients with isolated cleft palate develop fewer oronasal fistulas and require less secondary speech surgery than patients with cleft lip and palate.
    Clinical question/level of evidence: Risk, III.
    MeSH term(s) Cleft Lip/surgery ; Cleft Palate/surgery ; Female ; Health Information Systems/statistics & numerical data ; Humans ; Infant ; Male ; Nose Diseases/epidemiology ; Nose Diseases/etiology ; Nose Diseases/surgery ; Oral Fistula/epidemiology ; Oral Fistula/etiology ; Oral Fistula/surgery ; Oral Surgical Procedures/adverse effects ; Oral Surgical Procedures/methods ; Postoperative Complications/epidemiology ; Postoperative Complications/etiology ; Prevalence ; Reconstructive Surgical Procedures/adverse effects ; Reconstructive Surgical Procedures/methods ; Retrospective Studies ; United States/epidemiology ; Velopharyngeal Insufficiency/epidemiology ; Velopharyngeal Insufficiency/etiology ; Velopharyngeal Insufficiency/surgery
    Language English
    Publishing date 2019-01-24
    Publishing country United States
    Document type Journal Article
    ZDB-ID 208012-6
    ISSN 1529-4242 ; 0032-1052 ; 0096-8501
    ISSN (online) 1529-4242
    ISSN 0032-1052 ; 0096-8501
    DOI 10.1097/PRS.0000000000005210
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  5. Article ; Online: Online educational curriculum in pediatric epilepsy: A pilot study.

    Winesett, Steven Parrish / Amankwah, Ernest K / Nguyen, Anh Thy H / Sibinga, Erica

    Journal of the American Association of Nurse Practitioners

    2020  Volume 33, Issue 11, Page(s) 999–1006

    Abstract: Abstract: Recent projections suggest that increasing numbers of nurse practitioners (NPs) and physician assistants (PAs) will be needed to meet the increasing need for pediatric neurology expertise. This pilot study assessed feasibility and preliminary ... ...

    Abstract Abstract: Recent projections suggest that increasing numbers of nurse practitioners (NPs) and physician assistants (PAs) will be needed to meet the increasing need for pediatric neurology expertise. This pilot study assessed feasibility and preliminary effectiveness of an online curriculum designed to impact knowledge, skills, attitudes, and behaviors of NPs/PAs treating patients with pediatric epilepsy. Ten-session online curriculum was developed using previous experience and published recommendations to improve knowledge, electroencephalogram (EEG) skills, attitudes, and behaviors related to treating patients with pediatric epilepsy. Participants were NPs and PAs recruited from regional pediatric neurology practices. Three successive 10-week courses were provided. Attendance and completion were used to assess feasibility. Knowledge, EEG skills, attitudes, and behaviors were evaluated using pretest versus posttest questionnaires and compared analytically using a paired t-test and McNemar test. Twenty-nine NPs/PAs started the course, with typical attendance ∼85%. Twenty-two participants (76%) completed the course. Completers showed significant improvements in medication knowledge (premedication: mean = 74.6, SD = 16.4; postmedication: mean: 88.3, SD = 14.0; p = .001), EEG skills (premedication: mean = 44.8, SD = 24.4; postmedication: mean: 77.3, SD = 19.8; p < .001), and several measures of attitude and behavior. This pilot study shows feasibility and potential educational benefit of a 10-hour online course on pediatric epilepsy and may provide a convenient and effective option for continuing education for hard-to-reach students.
    MeSH term(s) Child ; Curriculum ; Epilepsy/therapy ; Humans ; Nurse Practitioners ; Physician Assistants ; Pilot Projects
    Language English
    Publishing date 2020-10-07
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2716317-9
    ISSN 2327-6924 ; 1745-7599 ; 2327-6886 ; 1041-2972
    ISSN (online) 2327-6924 ; 1745-7599
    ISSN 2327-6886 ; 1041-2972
    DOI 10.1097/JXX.0000000000000492
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  6. Article ; Online: Prevalence of Vision Loss and Associations With Age-Related Eye Diseases Among Nursing Home Residents Aged ≥65 Years.

    Monaco, William A / Crews, John E / Nguyen, Anh Thy H / Arif, Areeb

    Journal of the American Medical Directors Association

    2020  Volume 22, Issue 6, Page(s) 1156–1161

    Abstract: Objectives: To examine data from Delaware nursing homes to determine prevalence of age-related eye diseases (AREDs), vision impairment, and blindness and to compare the findings with the results of 11 US investigations of vision and eye health in ... ...

    Abstract Objectives: To examine data from Delaware nursing homes to determine prevalence of age-related eye diseases (AREDs), vision impairment, and blindness and to compare the findings with the results of 11 US investigations of vision and eye health in nursing homes.
    Design: This is a cross-sectional, retrospective study of nursing home patients.
    Setting and participants: Twenty nursing homes in Delaware participated in the study, yielding comprehensive eye examination records for 2019 study participants.
    Methods: Summary statistics and regression analyses.
    Results: The overall prevalence of vision impairment or blindness was 63.8% and was above 60% for each age, sex, and race category. Prevalence of vision impairment or blindness was 68.4% among patients with cataracts, 69.4% among patients with macular degeneration, 70.5% among patients with glaucoma, and 68.4% among patients with diabetic retinopathy. Prevalence of blindness was 14.1%. Among patients with AREDs, prevalence of blindness ranged from 15.0% for patients with cataracts to 22.6% for patients with diabetic retinopathy. When compared with other investigations, we found wide variation in vision and eye factors reported and wide variation in the prevalence of those factors. Only 4 studies diagnosed both AREDs and visual function. Seven studies reported AREDs, and 7 reported vision impairment and/or blindness. Vision impairment or blindness ranged from 29% to 67%; cataract ranged from 32% to 83%; macular degeneration ranged from 4.6% to 70.7%. Glaucoma ranged from 5.3% to 41.4%; diabetic retinopathy ranged from 1.7% to 3.1%.
    Conclusions and implications: Comprehensive eye examinations showed that vision impairment and blindness affected 63.8% of nursing home residents. Compared with other studies, there was a wide range of vision factors reported and wide variation in the prevalence of vision impairment or blindness and AREDs. This investigation suggests the importance of eye care in nursing homes and the importance of reporting standard vision and eye health factors to inform policy and practice.
    MeSH term(s) Aged ; Blindness/epidemiology ; Cross-Sectional Studies ; Humans ; Nursing Homes ; Prevalence ; Retrospective Studies ; Vision Disorders/epidemiology
    Language English
    Publishing date 2020-10-09
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2171030-2
    ISSN 1538-9375 ; 1525-8610
    ISSN (online) 1538-9375
    ISSN 1525-8610
    DOI 10.1016/j.jamda.2020.08.036
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  7. Article: Airway Management for Initial PEG Insertion in the Pediatric Endoscopy Unit: A Retrospective Evaluation of 168 Patients.

    Peck, Jacquelin / Nguyen, Anh Thy H / Dey, Aditi / Amankwah, Ernest K / Rehman, Mohamed / Wilsey, Michael

    Pediatric gastroenterology, hepatology & nutrition

    2021  Volume 24, Issue 1, Page(s) 100–108

    Abstract: Purpose: Percutaneous endoscopic gastrostomy (PEG) tube placements are commonly performed pediatric endoscopic procedures. Because of underlying disease, these patients are at increased risk for airway-related complications. This study compares patient ... ...

    Abstract Purpose: Percutaneous endoscopic gastrostomy (PEG) tube placements are commonly performed pediatric endoscopic procedures. Because of underlying disease, these patients are at increased risk for airway-related complications. This study compares patient characteristics and complications following initial PEG insertion with general endotracheal anesthesia (GETA) vs. anesthesia-directed deep sedation with a natural airway (ADDS).
    Methods: All patients 6 months to 18 years undergoing initial PEG insertion within the endoscopy suite were considered for inclusion in this retrospective cohort study. Selection of GETA vs. ADDS was made by the anesthesia attending after discussion with the gastroenterologist.
    Results: This study included 168 patients (GETA n=38, ADDS n=130). Cohorts had similar characteristics with respect to sex, race, and weight. Compared to ADDS, GETA patients were younger (1.5 years vs. 2.9 years,
    Conclusion: Study results indicate that younger and higher risk patients are more likely to undergo GETA. Children selected for GETA experienced longer room times, anesthesia times, and hospital length of stay.
    Language English
    Publishing date 2021-01-08
    Publishing country Korea (South)
    Document type Journal Article
    ZDB-ID 3032413-0
    ISSN 2234-8840 ; 2234-8646
    ISSN (online) 2234-8840
    ISSN 2234-8646
    DOI 10.5223/pghn.2021.24.1.100
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  8. Article ; Online: Corticosteroids for Acute Orbital Cellulitis.

    Leszczynska, Maria Anna / Sochet, Anthony Alexander / Nguyen, Anh Thy H / Mateus, Jazmine / Morrison, John Michael

    Pediatrics

    2021  Volume 148, Issue 5

    Abstract: Objectives: Standard treatment of children hospitalized for acute orbital cellulitis includes systemic antibiotics. Recent data from single-center studies suggest the addition of systemic corticosteroids may hasten clinical improvement and reduce ... ...

    Abstract Objectives: Standard treatment of children hospitalized for acute orbital cellulitis includes systemic antibiotics. Recent data from single-center studies suggest the addition of systemic corticosteroids may hasten clinical improvement and reduce hospital length of stay (LOS). We investigate the potential relationship between corticosteroid exposure and duration of hospitalization for pediatric orbital cellulitis.
    Methods: Using Pediatric Health Information System registry data from 51 children's facilities, we performed a retrospective cohort study of children hospitalized for orbital cellulitis <18 years of age from 2007 to 2018. The primary study outcome was hospital LOS. Secondary outcomes included frequency of surgical interventions, PICU admission, and 30-day related-cause readmission.
    Results: Of the 5645 children included for study, 1347 (24%) were prescribed corticosteroids within 2 days of admission. Corticosteroid prescription was not associated with LOS in analyses adjusted for age; presence of meningitis, abscess, or vision issues; and operative episode and PICU admission within 2 days (
    Conclusions: In this database query, we were not able to detect a reduction in LOS associated with corticosteroid exposure during hospitalization for orbital cellulitis. Corticosteroid prescription was associated with PICU admission and operative episodes after 2 days of hospitalization. Before the adoption of routine corticosteroid use, prospective, randomized control trials are needed.
    MeSH term(s) Acute Disease ; Adolescent ; Adrenal Cortex Hormones/therapeutic use ; Child ; Child, Preschool ; Confidence Intervals ; Humans ; Infant ; Infant, Newborn ; Intensive Care Units, Pediatric/statistics & numerical data ; Length of Stay ; Odds Ratio ; Orbital Cellulitis/drug therapy ; Patient Readmission/statistics & numerical data ; Registries ; Retrospective Studies ; Surgical Procedures, Operative/statistics & numerical data
    Chemical Substances Adrenal Cortex Hormones
    Language English
    Publishing date 2021-10-25
    Publishing country United States
    Document type Journal Article ; Multicenter Study
    ZDB-ID 207677-9
    ISSN 1098-4275 ; 0031-4005
    ISSN (online) 1098-4275
    ISSN 0031-4005
    DOI 10.1542/peds.2021-050677
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  9. Article ; Online: Multicenter Comparison of Laparoscopic Versus Open Repair of Duodenal Atresia in Neonates.

    Williams, Sacha A / Nguyen, Anh Thy H / Chang, Henry / Danielson, Paul D / Chandler, Nicole M

    Journal of laparoendoscopic & advanced surgical techniques. Part A

    2021  Volume 32, Issue 2, Page(s) 226–230

    Abstract: Introduction: ...

    Abstract Introduction:
    MeSH term(s) Duodenal Obstruction/etiology ; Duodenal Obstruction/surgery ; Female ; Humans ; Infant, Newborn ; Intestinal Atresia/surgery ; Laparoscopy ; Length of Stay ; Male ; Postoperative Complications/epidemiology ; Retrospective Studies ; Treatment Outcome
    Language English
    Publishing date 2021-11-09
    Publishing country United States
    Document type Comparative Study ; Journal Article ; Multicenter Study
    ZDB-ID 1381909-4
    ISSN 1557-9034 ; 1092-6429
    ISSN (online) 1557-9034
    ISSN 1092-6429
    DOI 10.1089/lap.2021.0557
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  10. Article ; Online: Does speed matter? A look at NSQIP-P outcomes based on operative time.

    Bludevich, Bryce M / Danielson, Paul D / Snyder, Christopher W / Nguyen, Anh Thy H / Chandler, Nicole M

    Journal of pediatric surgery

    2021  Volume 56, Issue 6, Page(s) 1107–1113

    Abstract: Background: Appendicitis is a common pediatric surgical condition, comprising a large burden of healthcare costs. We aimed to determine if prolonged operative times were associated with increased 30-day complication rates when adjusting for pre- ... ...

    Abstract Background: Appendicitis is a common pediatric surgical condition, comprising a large burden of healthcare costs. We aimed to determine if prolonged operative times were associated with increased 30-day complication rates when adjusting for pre-operative risk factors.
    Methods: Patients <18 years old, diagnosed intraoperatively with acute uncomplicated appendicitis and undergoing laparoscopic appendectomy were identified from the NSQIP-P 2012-2018 databases. The primary outcome, "infectious post-operative complications", is a composite of sepsis, deep incisional surgical site infections, wound disruptions, superficial, and organ space infections within 30-days of the operation. Secondary outcomes included return to the operating room and unplanned readmissions within 30 days. Logistic regression models were used to assess associations between operative time and each outcome. A Receiver Operating Characteristic (ROC) curve was generated from the predicted probabilities of the multivariate model for infectious post-operative complications to examine operative times.
    Results: Between 2012 and 2018, 27,763 pediatric patients with acute uncomplicated appendicitis underwent a laparoscopic appendectomy. Over half the population was male (61%) with a median operative time of 39 min (IQR 29-52 min). Infectious post-operative complication rate was 2.8% overall and was highest (8%) among patients with operative time ≥ 90 min (Fig. 1). Unplanned readmission occurred in 2.9% of patients, with 0.7% returning to the operating room. Each 30-min increase in operating time was associated with a 24% increase in odds of an infectious post-operative complication (OR=1.24, 95% CI=1.17-1.31) in adjusted models. Operative time thresholds predicted with ROC analysis were most meaningful in younger patients with higher ASA class and pre-operative SIRS/Sepsis/Septic shock. Longer operative times were also associated with higher odds of unplanned readmission (OR=1.11, 95% CI=1.05-1.18) and return to the operating room (OR=1.13, 95% CI=1.02-1.24) in adjusted models.
    Conclusion: There is a risk-adjusted association between prolonged operative time and the occurrence of infectious post-operative complications. Infectious postoperative complications increase healthcare spending and are currently an area of focus in healthcare value models. Future studies should focus on addressing laparoscopic appendectomy operative times longer than 60 min, with steps such as continuation of antibiotics, shifting roles between attending and resident surgeons, and simulation training.
    Level of evidence: Level III, retrospective comparative study.
    MeSH term(s) Adolescent ; Appendectomy/adverse effects ; Appendicitis/surgery ; Child ; Humans ; Laparoscopy ; Male ; Operative Time ; Postoperative Complications/epidemiology ; Postoperative Complications/etiology ; Retrospective Studies
    Language English
    Publishing date 2021-02-23
    Publishing country United States
    Document type Journal Article
    ZDB-ID 80165-3
    ISSN 1531-5037 ; 0022-3468
    ISSN (online) 1531-5037
    ISSN 0022-3468
    DOI 10.1016/j.jpedsurg.2021.02.033
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