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  1. Article ; Online: Erratum to "A potpourri of summer allergic environmental disorders" [Ann Allergy Asthma Immunol 130 (2023) 415-418].

    Nguyen, Ashley T / Settipane, Russell A

    Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology

    2023  Volume 130, Issue 6, Page(s) 823

    Language English
    Publishing date 2023-06-02
    Publishing country United States
    Document type Published Erratum
    ZDB-ID 1228189-x
    ISSN 1534-4436 ; 0003-4738 ; 1081-1206
    ISSN (online) 1534-4436
    ISSN 0003-4738 ; 1081-1206
    DOI 10.1016/j.anai.2023.04.001
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Calling a Death for the First Time.

    Nguyen, Ashley T

    Academic medicine : journal of the Association of American Medical Colleges

    2020  Volume 95, Issue 8, Page(s) 1134–1135

    MeSH term(s) Death ; Family ; Humans ; Internship and Residency
    Language English
    Publishing date 2020-02-26
    Publishing country United States
    Document type Letter ; Personal Narrative
    ZDB-ID 96192-9
    ISSN 1938-808X ; 1040-2446
    ISSN (online) 1938-808X
    ISSN 1040-2446
    DOI 10.1097/ACM.0000000000003233
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  3. Article ; Online: It's Never the Right Time to Say Goodbye…Until It Is: Transitioning from Pediatric to Adult Primary Care.

    Nguyen, Ashley T / Lewis, Carol / Geary, Megan

    Rhode Island medical journal (2013)

    2022  Volume 105, Issue 10, Page(s) 74–75

    MeSH term(s) Adult ; Child ; Humans ; Primary Health Care
    Language English
    Publishing date 2022-12-01
    Publishing country United States
    Document type Journal Article
    ZDB-ID 419430-5
    ISSN 2327-2228 ; 0363-7913
    ISSN (online) 2327-2228
    ISSN 0363-7913
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  4. Article ; Online: Depletion of

    Neelamraju, Yaseswini / Gjini, Evisa / Chhangawala, Sagar / Fan, Hao / He, Shuning / Jing, Chang-Bin / Nguyen, Ashley T / Prajapati, Subhash / Sheridan, Caroline / Houvras, Yariv / Melnick, Ari / Look, A Thomas / Garrett-Bakelman, Francine E

    Frontiers in hematology

    2023  Volume 2

    Abstract: Introduction: Myelodysplastic syndrome (MDS) is a heterogeneous group of clonal hematopoietic disorders characterized by ineffective hematopoiesis, cytopenias, and dysplasia. The gene encoding ten-eleven translocation 2 (: Methods: In the current ... ...

    Abstract Introduction: Myelodysplastic syndrome (MDS) is a heterogeneous group of clonal hematopoietic disorders characterized by ineffective hematopoiesis, cytopenias, and dysplasia. The gene encoding ten-eleven translocation 2 (
    Methods: In the current study, we collected progenitor cells from the kidney marrows of the adult
    Results and discussion: A global increase in DNA methylation of gene promoter regions and CpG islands was observed in
    Language English
    Publishing date 2023-09-14
    Publishing country Switzerland
    Document type Journal Article
    ISSN 2813-3935
    ISSN (online) 2813-3935
    DOI 10.3389/frhem.2023.1235170
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  5. Article ; Online: Disruption of

    Gjini, Evisa / Jing, Chang-Bin / Nguyen, Ashley T / Reyon, Deepak / Gans, Emma / Kesarsing, Michiel / Peterson, Joshua / Pozdnyakova, Olga / Rodig, Scott J / Mansour, Marc R / Joung, Keith / Look, A Thomas

    Disease models & mechanisms

    2019  Volume 12, Issue 5

    Abstract: Somatic loss-of-function mutations of the additional sex combs-like transcriptional regulator 1 ( ...

    Abstract Somatic loss-of-function mutations of the additional sex combs-like transcriptional regulator 1 (
    MeSH term(s) Animals ; Apoptosis ; Base Sequence ; Bone Marrow Neoplasms/pathology ; Cell Survival ; Embryo, Nonmammalian/metabolism ; Gene Editing ; Hematopoietic Stem Cells/metabolism ; Leukemia, Myeloid, Acute/pathology ; Mutation/genetics ; Organogenesis ; Repressor Proteins/metabolism ; Up-Regulation/genetics ; Zebrafish/embryology ; Zebrafish/metabolism ; Zebrafish Proteins/metabolism
    Chemical Substances Repressor Proteins ; Zebrafish Proteins ; asxl1 protein, zebrafish
    Language English
    Publishing date 2019-05-07
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ISSN 1754-8411
    ISSN (online) 1754-8411
    DOI 10.1242/dmm.035790
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: A zebrafish model of myelodysplastic syndrome produced through tet2 genomic editing.

    Gjini, Evisa / Mansour, Marc R / Sander, Jeffry D / Moritz, Nadine / Nguyen, Ashley T / Kesarsing, Michiel / Gans, Emma / He, Shuning / Chen, Si / Ko, Myunggon / Kuang, You-Yi / Yang, Song / Zhou, Yi / Rodig, Scott / Zon, Leonard I / Joung, J Keith / Rao, Anjana / Look, A Thomas

    Molecular and cellular biology

    2015  Volume 35, Issue 5, Page(s) 789–804

    Abstract: The ten-eleven translocation 2 gene (TET2) encodes a member of the TET family of DNA methylcytosine oxidases that converts 5-methylcytosine (5mC) to 5-hydroxymethylcytosine (5hmC) to initiate the demethylation of DNA within genomic CpG islands. Somatic ... ...

    Abstract The ten-eleven translocation 2 gene (TET2) encodes a member of the TET family of DNA methylcytosine oxidases that converts 5-methylcytosine (5mC) to 5-hydroxymethylcytosine (5hmC) to initiate the demethylation of DNA within genomic CpG islands. Somatic loss-of-function mutations of TET2 are frequently observed in human myelodysplastic syndrome (MDS), which is a clonal malignancy characterized by dysplastic changes of developing blood cell progenitors, leading to ineffective hematopoiesis. We used genome-editing technology to disrupt the zebrafish Tet2 catalytic domain. tet2(m/m) (homozygous for the mutation) zebrafish exhibited normal embryonic and larval hematopoiesis but developed progressive clonal myelodysplasia as they aged, culminating in myelodysplastic syndromes (MDS) at 24 months of age, with dysplasia of myeloid progenitor cells and anemia with abnormal circulating erythrocytes. The resultant tet2(m/m) mutant zebrafish lines show decreased levels of 5hmC in hematopoietic cells of the kidney marrow but not in other cell types, most likely reflecting the ability of other Tet family members to provide this enzymatic activity in nonhematopoietic tissues but not in hematopoietic cells. tet2(m/m) zebrafish are viable and fertile, providing an ideal model to dissect altered pathways in hematopoietic cells and, for small-molecule screens in embryos, to identify compounds with specific activity against tet2 mutant cells.
    MeSH term(s) Animals ; Catalytic Domain ; Cell Differentiation ; CpG Islands ; DNA-Binding Proteins/metabolism ; Dioxygenases/genetics ; Dioxygenases/physiology ; Disease Models, Animal ; Flow Cytometry ; Gene Expression Regulation ; Genotype ; Hematopoiesis/genetics ; Hematopoietic Stem Cells/cytology ; Humans ; In Situ Hybridization ; Kidney/metabolism ; Mutation ; Myelodysplastic Syndromes/metabolism ; Stem Cells/cytology ; Zebrafish ; Zebrafish Proteins/genetics ; Zebrafish Proteins/physiology
    Chemical Substances DNA-Binding Proteins ; Zebrafish Proteins ; TET2 protein, zebrafish (EC 1.-) ; Dioxygenases (EC 1.13.11.-)
    Language English
    Publishing date 2015-03
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 779397-2
    ISSN 1098-5549 ; 0270-7306
    ISSN (online) 1098-5549
    ISSN 0270-7306
    DOI 10.1128/MCB.00971-14
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 1666: Show issues Location:
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  7. Article ; Online: A Zebrafish Model of Myelodysplastic Syndrome Produced through tet2 Genomic Editing

    Gjini, Evisa / Mansour, Marc R. / Sander, Jeffry D. / Moritz, Nadine / Nguyen, Ashley T. / Kesarsing, Michiel / Gans, Emma / He, Shuning / Chen, Si / Ko, Myunggon / Kuang, You-Yi / Yang, Song / Zhou, Yi / Rodig, Scott / Zon, Leonard I. / Joung, J. Keith / Rao, Anjana / Look, A. Thomas

    Molecular and Cellular Biology. 2015 Mar. 1, v. 35, no. 5 p.789-804

    2015  

    Abstract: The ten-eleven translocation 2 gene (TET2) encodes a member of the TET family of DNA methylcytosine oxidases that converts 5-methylcytosine (5mC) to 5-hydroxymethylcytosine (5hmC) to initiate the demethylation of DNA within genomic CpG islands. Somatic ... ...

    Abstract The ten-eleven translocation 2 gene (TET2) encodes a member of the TET family of DNA methylcytosine oxidases that converts 5-methylcytosine (5mC) to 5-hydroxymethylcytosine (5hmC) to initiate the demethylation of DNA within genomic CpG islands. Somatic loss-of-function mutations of TET2 are frequently observed in human myelodysplastic syndrome (MDS), which is a clonal malignancy characterized by dysplastic changes of developing blood cell progenitors, leading to ineffective hematopoiesis. We used genome-editing technology to disrupt the zebrafish Tet2 catalytic domain. tet2ᵐ/ᵐ (homozygous for the mutation) zebrafish exhibited normal embryonic and larval hematopoiesis but developed progressive clonal myelodysplasia as they aged, culminating in myelodysplastic syndromes (MDS) at 24 months of age, with dysplasia of myeloid progenitor cells and anemia with abnormal circulating erythrocytes. The resultant tet2ᵐ/ᵐ mutant zebrafish lines show decreased levels of 5hmC in hematopoietic cells of the kidney marrow but not in other cell types, most likely reflecting the ability of other Tet family members to provide this enzymatic activity in nonhematopoietic tissues but not in hematopoietic cells. tet2ᵐ/ᵐ zebrafish are viable and fertile, providing an ideal model to dissect altered pathways in hematopoietic cells and, for small-molecule screens in embryos, to identify compounds with specific activity against tet2 mutant cells.
    Keywords 5-methylcytosine ; DNA ; Danio rerio ; active sites ; anemia ; demethylation ; enzyme activity ; erythrocytes ; gene editing ; genes ; genomics ; hematopoiesis ; homozygosity ; humans ; kidneys ; larvae ; loss-of-function mutation ; models ; mutants ; oxidoreductases
    Language English
    Dates of publication 2015-0301
    Size p. 789-804.
    Publishing place Taylor & Francis
    Document type Article ; Online
    ZDB-ID 779397-2
    ISSN 1098-5549 ; 0270-7306
    ISSN (online) 1098-5549
    ISSN 0270-7306
    DOI 10.1128/MCB.00971-14
    Database NAL-Catalogue (AGRICOLA)

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