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  1. Article ; Online: Author Correction: Modeling idiopathic autism in forebrain organoids reveals an imbalance of excitatory cortical neuron subtypes during early neurogenesis.

    Jourdon, Alexandre / Wu, Feinan / Mariani, Jessica / Capauto, Davide / Norton, Scott / Tomasini, Livia / Amiri, Anahita / Suvakov, Milovan / Schreiner, Jeremy D / Jang, Yeongjun / Panda, Arijit / Nguyen, Cindy Khanh / Cummings, Elise M / Han, Gloria / Powell, Kelly / Szekely, Anna / McPartland, James C / Pelphrey, Kevin / Chawarska, Katarzyna /
    Ventola, Pamela / Abyzov, Alexej / Vaccarino, Flora M

    Nature neuroscience

    2023  Volume 26, Issue 11, Page(s) 2035

    Language English
    Publishing date 2023-09-06
    Publishing country United States
    Document type Published Erratum
    ZDB-ID 1420596-8
    ISSN 1546-1726 ; 1097-6256
    ISSN (online) 1546-1726
    ISSN 1097-6256
    DOI 10.1038/s41593-023-01447-9
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Modeling idiopathic autism in forebrain organoids reveals an imbalance of excitatory cortical neuron subtypes during early neurogenesis.

    Jourdon, Alexandre / Wu, Feinan / Mariani, Jessica / Capauto, Davide / Norton, Scott / Tomasini, Livia / Amiri, Anahita / Suvakov, Milovan / Schreiner, Jeremy D / Jang, Yeongjun / Panda, Arijit / Nguyen, Cindy Khanh / Cummings, Elise M / Han, Gloria / Powell, Kelly / Szekely, Anna / McPartland, James C / Pelphrey, Kevin / Chawarska, Katarzyna /
    Ventola, Pamela / Abyzov, Alexej / Vaccarino, Flora M

    Nature neuroscience

    2023  Volume 26, Issue 9, Page(s) 1505–1515

    Abstract: Idiopathic autism spectrum disorder (ASD) is highly heterogeneous, and it remains unclear how convergent biological processes in affected individuals may give rise to symptoms. Here, using cortical organoids and single-cell transcriptomics, we modeled ... ...

    Abstract Idiopathic autism spectrum disorder (ASD) is highly heterogeneous, and it remains unclear how convergent biological processes in affected individuals may give rise to symptoms. Here, using cortical organoids and single-cell transcriptomics, we modeled alterations in the forebrain development between boys with idiopathic ASD and their unaffected fathers in 13 families. Transcriptomic changes suggest that ASD pathogenesis in macrocephalic and normocephalic probands involves an opposite disruption of the balance between excitatory neurons of the dorsal cortical plate and other lineages such as early-generated neurons from the putative preplate. The imbalance stemmed from divergent expression of transcription factors driving cell fate during early cortical development. While we did not find genomic variants in probands that explained the observed transcriptomic alterations, a significant overlap between altered transcripts and reported ASD risk genes affected by rare variants suggests a degree of gene convergence between rare forms of ASD and the developmental transcriptome in idiopathic ASD.
    MeSH term(s) Male ; Humans ; Autistic Disorder/genetics ; Autism Spectrum Disorder/pathology ; Neurons/metabolism ; Neurogenesis ; Prosencephalon/metabolism ; Organoids/metabolism
    Language English
    Publishing date 2023-08-10
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 1420596-8
    ISSN 1546-1726 ; 1097-6256
    ISSN (online) 1546-1726
    ISSN 1097-6256
    DOI 10.1038/s41593-023-01399-0
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Effects of Collateral Status on Infarct Distribution Following Endovascular Therapy in Large Vessel Occlusion Stroke.

    Al-Dasuqi, Khalid / Payabvash, Seyedmehdi / Torres-Flores, Gerardo A / Strander, Sumita M / Nguyen, Cindy Khanh / Peshwe, Krithika U / Kodali, Sreeja / Silverman, Andrew / Malhotra, Ajay / Johnson, Michele H / Matouk, Charles C / Schindler, Joseph L / Sansing, Lauren H / Falcone, Guido J / Sheth, Kevin N / Petersen, Nils H

    Stroke

    2020  Volume 51, Issue 9, Page(s) e193–e202

    Abstract: Background and purpose: We aim to examine effects of collateral status and post-thrombectomy reperfusion on final infarct distribution and early functional outcome in patients with anterior circulation large vessel occlusion ischemic stroke.: Methods!# ...

    Abstract Background and purpose: We aim to examine effects of collateral status and post-thrombectomy reperfusion on final infarct distribution and early functional outcome in patients with anterior circulation large vessel occlusion ischemic stroke.
    Methods: Patients with large vessel occlusion who underwent endovascular intervention were included in this study. All patients had baseline computed tomography angiography and follow-up magnetic resonance imaging. Collateral status was graded according to the criteria proposed by Miteff et al and reperfusion was assessed using the modified Thrombolysis in Cerebral Infarction (mTICI) system. We applied a multivariate voxel-wise general linear model to correlate the distribution of final infarction with collateral status and degree of reperfusion. Early favorable outcome was defined as a discharge modified Rankin Scale score ≤2.
    Results: Of the 283 patients included, 129 (46%) had good, 97 (34%) had moderate, and 57 (20%) had poor collateral status. Successful reperfusion (mTICI 2b/3) was achieved in 206 (73%) patients. Poor collateral status was associated with infarction of middle cerebral artery border zones, whereas worse reperfusion (mTICI scores 0-2a) was associated with infarction of middle cerebral artery territory deep white matter tracts and the posterior limb of the internal capsule. In multivariate regression models, both mTICI (
    Conclusions: In this cohort of patients with large vessel occlusion stroke, both the collateral status and endovascular reperfusion were strongly associated with middle cerebral artery territory final infarct volumes. Our findings suggesting that baseline collateral status predominantly affected middle cerebral artery border zones infarction, whereas higher mTICI preserved deep white matter and internal capsule from infarction; may explain why reperfusion success-but not collateral status-was among the independent predictors of favorable outcome at discharge. Infarction of the lentiform nuclei was observed regardless of collateral status or reperfusion success.
    MeSH term(s) Aged ; Aged, 80 and over ; Arterial Occlusive Diseases/pathology ; Arterial Occlusive Diseases/therapy ; Cerebral Infarction/pathology ; Cerebral Infarction/therapy ; Cohort Studies ; Collateral Circulation ; Computed Tomography Angiography ; Endovascular Procedures/methods ; Female ; Humans ; Infarction, Middle Cerebral Artery/pathology ; Infarction, Middle Cerebral Artery/therapy ; Linear Models ; Magnetic Resonance Angiography ; Male ; Middle Aged ; Reperfusion ; Retrospective Studies ; Stroke/therapy ; Thrombectomy ; Treatment Outcome ; White Matter/pathology
    Language English
    Publishing date 2020-08-12
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 80381-9
    ISSN 1524-4628 ; 0039-2499 ; 0749-7954
    ISSN (online) 1524-4628
    ISSN 0039-2499 ; 0749-7954
    DOI 10.1161/STROKEAHA.120.029892
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Direct carotid puncture for mechanical thrombectomy in acute ischemic stroke patients with prohibitive vascular access.

    Cord, Branden J / Kodali, Sreeja / Strander, Sumita / Silverman, Andrew / Wang, Anson / Chouairi, Fouad / Koo, Andrew B / Nguyen, Cindy Khanh / Peshwe, Krithika / Kimmel, Alexandra / Porto, Carl M / Hebert, Ryan M / Falcone, Guido J / Sheth, Kevin N / Sansing, Lauren H / Schindler, Joseph L / Matouk, Charles C / Petersen, Nils H

    Journal of neurosurgery

    2020  Volume 135, Issue 1, Page(s) 53–63

    Abstract: Objective: While the benefit of mechanical thrombectomy (MT) for patients with anterior circulation acute ischemic stroke with large-vessel occlusion (AIS-LVO) has been clearly established, difficult vascular access may make the intervention impossible ... ...

    Abstract Objective: While the benefit of mechanical thrombectomy (MT) for patients with anterior circulation acute ischemic stroke with large-vessel occlusion (AIS-LVO) has been clearly established, difficult vascular access may make the intervention impossible or unduly prolonged. In this study, the authors evaluated safety as well as radiographic and functional outcomes in stroke patients treated with MT via direct carotid puncture (DCP) for prohibitive vascular access.
    Methods: The authors retrospectively studied patients from their prospective AIS-LVO database who underwent attempted MT between 2015 and 2018. Patients with prohibitive vascular access were divided into two groups: 1) aborted MT (abMT) after failed transfemoral access and 2) attempted MT via DCP. Functional outcome was assessed using the modified Rankin Scale at 3 months. Associations with outcome were analyzed using ordinal logistic regression.
    Results: Of 352 consecutive patients with anterior circulation AIS-LVO who underwent attempted MT, 37 patients (10.5%) were deemed to have prohibitive vascular access (mean age [± SD] 82 ± 11 years, mean National Institutes of Health Stroke Scale [NIHSS] score 17 ± 5, with females accounting for 75% of the patients). There were 20 patients in the DCP group and 17 in the abMT group. The two groups were well matched for the known predictors of clinical outcome: age, sex, and admission NIHSS score. Direct carotid access was successfully obtained in 19 of 20 patients. Successful reperfusion (thrombolysis in cerebral infarction score 2b or 3) was achieved in 16 (84%) of 19 patients in the DCP group. Carotid access complications included an inability to catheterize the carotid artery in 1 patient, neck hematomas in 4 patients, non-flow-limiting common carotid artery (CCA) dissections in 2 patients, and a delayed, fatal carotid blowout in 1 patient. The neck hematomas and non-flow-limiting CCA dissections did not require any subsequent interventions and remained clinically silent. Compared with the abMT group, patients in the DCP group had smaller infarct volumes (11 vs 48 ml, p = 0.04), a greater reduction in NIHSS score (-4 vs +2.9, p = 0.03), and better functional outcome (shift analysis for 3-month modified Rankin Scale score: adjusted OR 5.2, 95% CI 1.02-24.5; p = 0.048).
    Conclusions: DCP for emergency MT in patients with anterior circulation AIS-LVO and prohibitive vascular access is safe and effective and is associated with higher recanalization rates, smaller infarct volumes, and improved functional outcome compared with patients with abMT after failed transfemoral access. DCP should be considered in this patient population.
    Language English
    Publishing date 2020-08-14
    Publishing country United States
    Document type Journal Article
    ZDB-ID 3089-2
    ISSN 1933-0693 ; 0022-3085
    ISSN (online) 1933-0693
    ISSN 0022-3085
    DOI 10.3171/2020.5.JNS192737
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Blood Pressure Trajectory Groups and Outcome After Endovascular Thrombectomy: A Multicenter Study.

    Petersen, Nils H / Kodali, Sreeja / Meng, Can / Li, Fangyong / Nguyen, Cindy Khanh / Peshwe, Krithika U / Strander, Sumita / Silverman, Andrew / Kimmel, Alexandra / Wang, Anson / Anadani, Mohammad / Almallouhi, Eyad / Spiotta, Alejandro M / Kim, Joon-Tae / Giles, James A / Keyrouz, Salah G / Farooqui, Mudassir / Zevallos, Cynthia / Maier, Ilko L /
    Psychogios, Marios-Nikos / Liman, Jan / Riou-Comte, Nolwenn / Richard, Sébastien / Gory, Benjamin / Quintero Wolfe, Stacey / Brown, Patrick A / Fargen, Kyle M / Mistry, Eva A / Fakhri, Hiba / Mistry, Akshitkumar M / Wong, Ka-Ho / de Havenon, Adam / Nascimento, Fábio A / Kan, Peter / Matouk, Charles / Ortega-Gutiérrez, Santiago / Sheth, Kevin N

    Stroke

    2021  Volume 53, Issue 4, Page(s) 1216–1225

    Abstract: Background: Elevated blood pressure after endovascular thrombectomy (EVT) has been associated with an increased risk of hemorrhagic transformation and poor functional outcomes. However, the optimal hemodynamic management after EVT remains unknown, and ... ...

    Abstract Background: Elevated blood pressure after endovascular thrombectomy (EVT) has been associated with an increased risk of hemorrhagic transformation and poor functional outcomes. However, the optimal hemodynamic management after EVT remains unknown, and the blood pressure course in the acute phase of ischemic stroke has not been well characterized. This study aimed to identify patient subgroups with distinct blood pressure trajectories after EVT and study their association with radiographic and functional outcomes.
    Methods: This multicenter retrospective cohort study included consecutive patients with anterior circulation large-vessel occlusion ischemic stroke who underwent EVT. Repeated time-stamped blood pressure data were recorded for the first 72 hours after thrombectomy. Latent variable mixture modeling was used to separate subjects into five groups with distinct postprocedural systolic blood pressure (SBP) trajectories. The primary outcome was functional status, measured on the modified Rankin Scale 90 days after stroke. Secondary outcomes included hemorrhagic transformation, symptomatic intracranial hemorrhage, and death.
    Results: Two thousand two hundred sixty-eight patients (mean age [±SD] 69±15, mean National Institutes of Health Stroke Scale 15±7) were included in the analysis. Five distinct SBP trajectories were observed: low (18%), moderate (37%), moderate-to-high (20%), high-to-moderate (18%), and high (6%). SBP trajectory group was independently associated with functional outcome at 90 days (
    Conclusions: Patients with acute ischemic stroke demonstrate distinct SBP trajectories during the first 72 hours after EVT that have differing associations with functional outcome. These findings may help identify potential candidates for future blood pressure modulation trials.
    MeSH term(s) Aged ; Aged, 80 and over ; Blood Pressure/physiology ; Brain Ischemia/complications ; Brain Ischemia/diagnostic imaging ; Brain Ischemia/surgery ; Endovascular Procedures/adverse effects ; Humans ; Ischemic Stroke ; Middle Aged ; Retrospective Studies ; Stroke/etiology ; Thrombectomy/adverse effects ; Treatment Outcome
    Language English
    Publishing date 2021-11-16
    Publishing country United States
    Document type Journal Article ; Multicenter Study
    ZDB-ID 80381-9
    ISSN 1524-4628 ; 0039-2499 ; 0749-7954
    ISSN (online) 1524-4628
    ISSN 0039-2499 ; 0749-7954
    DOI 10.1161/STROKEAHA.121.034408
    Database MEDical Literature Analysis and Retrieval System OnLINE

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