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  1. Article ; Online: Brockenbrough-Braunwald-Morrow sign and Valsalva manoeuvre: how to unmask dynamic left ventricular outflow tract obstruction.

    Mabalukwa, Junior / Nguyen, Damien / Briki, Rachid / Audiat, Charles / Unger, Philippe

    European heart journal. Cardiovascular Imaging

    2022  Volume 23, Issue 4, Page(s) e169

    MeSH term(s) Cardiomyopathy, Hypertrophic ; Heart Defects, Congenital ; Humans ; Valsalva Maneuver ; Ventricular Dysfunction, Left ; Ventricular Outflow Obstruction/diagnostic imaging ; Ventricular Outflow Obstruction/etiology
    Language English
    Publishing date 2022-01-20
    Publishing country England
    Document type Journal Article
    ZDB-ID 2638345-7
    ISSN 2047-2412 ; 2047-2404
    ISSN (online) 2047-2412
    ISSN 2047-2404
    DOI 10.1093/ehjci/jeac008
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  2. Article ; Online: "The flying thymus sign".

    Nguyen, Damien / Nguyen, Thomas / Castro Rodriguez, José

    Internal and emergency medicine

    2021  Volume 16, Issue 6, Page(s) 1701–1702

    MeSH term(s) Adolescent ; Chest Pain/etiology ; Humans ; Male ; Mediastinal Emphysema/diagnosis ; Mediastinal Emphysema/diagnostic imaging ; Radiography/methods ; Thymus Gland/abnormalities ; Thymus Gland/diagnostic imaging
    Language English
    Publishing date 2021-01-16
    Publishing country Italy
    Document type Case Reports ; Journal Article
    ZDB-ID 2454173-4
    ISSN 1970-9366 ; 1828-0447
    ISSN (online) 1970-9366
    ISSN 1828-0447
    DOI 10.1007/s11739-020-02626-3
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  3. Article ; Online: A case of Takotsubo cardiomyopathy with COVID 19.

    Nguyen, Damien / Nguyen, Thomas / De Bels, David / Castro Rodriguez, José

    European heart journal cardiovascular Imaging

    2020  Volume 21, Issue 9, Page(s) 1052

    MeSH term(s) Aged ; Angioplasty, Balloon, Coronary/methods ; COVID-19 ; COVID-19 Testing ; Clinical Laboratory Techniques/methods ; Computed Tomography Angiography/methods ; Coronary Angiography/methods ; Coronary Stenosis/complications ; Coronary Stenosis/diagnostic imaging ; Coronary Stenosis/therapy ; Coronavirus Infections/complications ; Coronavirus Infections/diagnosis ; Drug-Eluting Stents ; Female ; Follow-Up Studies ; Humans ; Pandemics ; Pneumonia, Viral/complications ; Pneumonia, Viral/diagnosis ; Radiography, Thoracic/methods ; Risk Assessment ; Takotsubo Cardiomyopathy/complications ; Takotsubo Cardiomyopathy/diagnostic imaging ; Takotsubo Cardiomyopathy/therapy ; Treatment Outcome
    Keywords covid19
    Language English
    Publishing date 2020-05-12
    Publishing country England
    Document type Case Reports ; Journal Article
    ZDB-ID 2638345-7
    ISSN 2047-2412 ; 2047-2404
    ISSN (online) 2047-2412
    ISSN 2047-2404
    DOI 10.1093/ehjci/jeaa152
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  4. Article ; Online: Right ventricular lead perforation revealed by diaphragmatic stimulation.

    Nguyen, Damien / Nguyen, Thomas / Almorad, Alexandre / De Keyzer, Eva

    Internal and emergency medicine

    2020  Volume 16, Issue 3, Page(s) 783–784

    Abstract: Pacemaker implantation can be complicated by ventricular perforation. We present a case of diaphragmatic stimulation induced by right ventricular pacemaker lead perforation. ...

    Abstract Pacemaker implantation can be complicated by ventricular perforation. We present a case of diaphragmatic stimulation induced by right ventricular pacemaker lead perforation.
    MeSH term(s) Aged, 80 and over ; Device Removal ; Echocardiography ; Electrocardiography ; Electrodes, Implanted/adverse effects ; Female ; Heart Injuries/diagnostic imaging ; Heart Injuries/etiology ; Heart Ventricles/diagnostic imaging ; Heart Ventricles/injuries ; Humans ; Pacemaker, Artificial/adverse effects ; Tomography, X-Ray Computed
    Language English
    Publishing date 2020-09-16
    Publishing country Italy
    Document type Case Reports ; Journal Article
    ZDB-ID 2454173-4
    ISSN 1970-9366 ; 1828-0447
    ISSN (online) 1970-9366
    ISSN 1828-0447
    DOI 10.1007/s11739-020-02490-1
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  5. Article ; Online: Motion-insensitive rapid configuration relaxometry.

    Nguyen, Damien / Bieri, Oliver

    Magnetic resonance in medicine

    2016  Volume 78, Issue 2, Page(s) 518–526

    Abstract: Purpose: Triple echo steady state (TESS) uses the lowest steady state configuration modes for rapid relaxometry. Due to its unbalanced gradient scheme, however, TESS is inherently motion-sensitive. The purpose of this work is to merge TESS with a ... ...

    Abstract Purpose: Triple echo steady state (TESS) uses the lowest steady state configuration modes for rapid relaxometry. Due to its unbalanced gradient scheme, however, TESS is inherently motion-sensitive. The purpose of this work is to merge TESS with a balanced acquisition scheme for motion-insensitive rapid configuration relaxometry, termed MIRACLE.
    Methods: The lowest order steady state free precession (SSFP) configurations are retrieved by Fourier transformation of the frequency response of N frequency-shifted balanced SSFP (bSSFP) scans and subsequently processed for relaxometry, as proposed with TESS. Accuracy of MIRACLE is evaluated from simulations, phantom studies as well as in vivo brain and cartilage imaging at 3T.
    Results: Simulations and phantom results revealed no conceptual flaw, and artifact-free configuration imaging was achieved in vivo. Overall, relaxometry results were accurate in phantoms and in good agreement for cartilage and for T2 in the brain, but apparent low T1 values were observed for brain white matter; reflecting asymmetries in the bSSFP profile.
    Conclusion: Rapid T1 and T2 mapping with MIRACLE offers analogous properties as TESS while successfully mitigating its motion-sensitivity. As a result of the Fourier transformation, relaxometry becomes sensitive to the voxel frequency distribution, which may contain useful physiologic information, such as structural brain integrity. © 2016 International Society for Magnetic Resonance in Medicine. Magn Reson Med 78:518-526, 2017. © 2016 International Society for Magnetic Resonance in Medicine.
    MeSH term(s) Algorithms ; Brain/diagnostic imaging ; Humans ; Image Processing, Computer-Assisted/methods ; Magnetic Resonance Imaging/methods ; Movement/physiology ; Phantoms, Imaging
    Language English
    Publishing date 2016-09-08
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 605774-3
    ISSN 1522-2594 ; 0740-3194
    ISSN (online) 1522-2594
    ISSN 0740-3194
    DOI 10.1002/mrm.26384
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  7. Article ; Online: A case of Takotsubo cardiomyopathy with COVID 19

    Nguyen, Damien / Nguyen, Thomas / De Bels, David / Castro Rodriguez, José

    European Heart Journal - Cardiovascular Imaging

    2020  Volume 21, Issue 9, Page(s) 1052–1052

    Keywords Radiology Nuclear Medicine and imaging ; Cardiology and Cardiovascular Medicine ; General Medicine ; covid19
    Language English
    Publisher Oxford University Press (OUP)
    Publishing country uk
    Document type Article ; Online
    ZDB-ID 2638345-7
    ISSN 2047-2412 ; 2047-2404
    ISSN (online) 2047-2412
    ISSN 2047-2404
    DOI 10.1093/ehjci/jeaa152
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  8. Article ; Online: Liver-ultrasound-guided lung tumour tracking for scanned proton therapy: a feasibility study.

    Krieger, Miriam / Giger, Alina / Jud, Christoph / Duetschler, Alisha / Salomir, Rares / Bieri, Oliver / Bauman, Grzegorz / Nguyen, Damien / Cattin, Philippe C / Weber, Damien C / Lomax, Antony J / Zhang, Ye

    Physics in medicine and biology

    2021  Volume 66, Issue 3, Page(s) 35011

    Abstract: Pencil beam scanned (PBS) proton therapy of lung tumours is hampered by respiratory motion and the motion-induced density changes along the beam path. In this simulation study, we aim to investigate the effectiveness of proton beam tracking for lung ... ...

    Abstract Pencil beam scanned (PBS) proton therapy of lung tumours is hampered by respiratory motion and the motion-induced density changes along the beam path. In this simulation study, we aim to investigate the effectiveness of proton beam tracking for lung tumours both under ideal conditions and in conjunction with a respiratory motion model guided by real-time ultrasound imaging of the liver. Multiple-breathing-cycle 4DMRIs of the thorax and abdominal 2D ultrasound images were acquired simultaneously for five volunteers. Deformation vector fields extracted from the 4DMRI, referred to as ground truth motion, were used to generate 4DCT(MRI) data sets of two lung cancer patients, resulting in 10 data sets with variable motion patterns. Given the 4DCT(MRI) and the corresponding ultrasound images as surrogate data, a patient-specific motion model was built. The model consists of an autoregressive model and Gaussian process regression for the temporal and spatial prediction, respectively. Two-field PBS plans were optimised on the reference CTs, and 4D dose calculations (4DDC) were used to simulate dose delivery for (a) unmitigated motion, (b) ideal 2D and 3D tracking (both beam adaption and 4DDC based on ground truth motion), and (c) realistic 2D and 3D tracking (beam adaption based on motion predictions, 4DDC on ground truth motion). Model-guided tracking retrieved clinically acceptable target dose homogeneity, as seen in a substantial reduction of the D5%-D95% compared to the non-mitigated simulation. Tracking in 2D and 3D resulted in a similar improvement of the dose homogeneity, as did ideal and realistic tracking simulations. In some cases, however, the tracked deliveries resulted in a shift towards higher or lower dose levels, leading to unacceptable target over- or under-coverage. The presented motion modelling framework was shown to be an accurate motion prediction tool for the use in proton beam tracking. Tracking alone, however, may not always effectively mitigate motion effects, making it necessary to combine it with other techniques such as rescanning.
    MeSH term(s) Feasibility Studies ; Four-Dimensional Computed Tomography ; Humans ; Lung Neoplasms/diagnostic imaging ; Lung Neoplasms/physiopathology ; Lung Neoplasms/radiotherapy ; Magnetic Resonance Imaging ; Proton Therapy/methods ; Radiotherapy, Image-Guided/methods ; Respiration ; Ultrasonography
    Language English
    Publishing date 2021-01-26
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 208857-5
    ISSN 1361-6560 ; 0031-9155
    ISSN (online) 1361-6560
    ISSN 0031-9155
    DOI 10.1088/1361-6560/abcde6
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    Zs.A 199: Show issues Location:
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  9. Article ; Online: True constructive interference in the steady state (trueCISS).

    Hilbert, Tom / Nguyen, Damien / Thiran, Jean-Philippe / Krueger, Gunnar / Kober, Tobias / Bieri, Oliver

    Magnetic resonance in medicine

    2017  Volume 79, Issue 4, Page(s) 1901–1910

    Abstract: Purpose: To introduce a novel time-efficient method, termed true constructive interference in the steady state (trueCISS), that not only solves the problem of banding artifacts for balanced steady-state free precession (bSSFP) but also provides its ... ...

    Abstract Purpose: To introduce a novel time-efficient method, termed true constructive interference in the steady state (trueCISS), that not only solves the problem of banding artifacts for balanced steady-state free precession (bSSFP) but also provides its genuine, that is, true, on-resonant signal.
    Methods: After a compressed sensing reconstruction from a set of highly undersampled phase-cycled bSSFP scans, the local off-resonance, relaxation time ratio, and equilibrium magnetization are voxel-wise estimated using a dictionary-based fitting routine. Subsequently, on-resonant bSSFP images are generated using the previously estimated parameters. Due to the high undersampling factors used, the acquisition time is not prolonged with respect to a standard CISS acquisition.
    Results: From a set of 16 phase-cycled SSFP scans in combination with an eightfold undersampling, both phantom and in vivo whole-brain experiments demonstrate that banding successfully can be removed. Additionally, trueCISS allows the derivation of synthetic bSSFP images with arbitrary flip angles, which enables image contrasts that may not be possible to acquire in practice due to safety constraints.
    Conclusion: TrueCISS offers banding-free bSSFP images with on-resonant signal intensity and without requiring additional acquisition time compared to conventional methods. Magn Reson Med 79:1901-1910, 2018. © 2017 International Society for Magnetic Resonance in Medicine.
    MeSH term(s) Algorithms ; Artifacts ; Brain/diagnostic imaging ; Computer Simulation ; Contrast Media ; Data Compression ; Fourier Analysis ; Humans ; Image Interpretation, Computer-Assisted ; Image Processing, Computer-Assisted/methods ; Magnetic Resonance Imaging ; Models, Theoretical ; Neuroimaging/methods ; Phantoms, Imaging ; Radio Waves ; Reproducibility of Results ; Signal-To-Noise Ratio
    Chemical Substances Contrast Media
    Language English
    Publishing date 2017-07-24
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 605774-3
    ISSN 1522-2594 ; 0740-3194
    ISSN (online) 1522-2594
    ISSN 0740-3194
    DOI 10.1002/mrm.26836
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  10. Article ; Online: Synthetic 4DCT(MRI) lung phantom generation for 4D radiotherapy and image guidance investigations.

    Duetschler, Alisha / Bauman, Grzegorz / Bieri, Oliver / Cattin, Philippe C / Ehrbar, Stefanie / Engin-Deniz, Georg / Giger, Alina / Josipovic, Mirjana / Jud, Christoph / Krieger, Miriam / Nguyen, Damien / Persson, Gitte F / Salomir, Rares / Weber, Damien C / Lomax, Antony J / Zhang, Ye

    Medical physics

    2022  Volume 49, Issue 5, Page(s) 2890–2903

    Abstract: Purpose: Respiratory motion is one of the major challenges in radiotherapy. In this work, a comprehensive and clinically plausible set of 4D numerical phantoms, together with their corresponding "ground truths," have been developed and validated for 4D ... ...

    Abstract Purpose: Respiratory motion is one of the major challenges in radiotherapy. In this work, a comprehensive and clinically plausible set of 4D numerical phantoms, together with their corresponding "ground truths," have been developed and validated for 4D radiotherapy applications.
    Methods: The phantoms are based on CTs providing density information and motion from multi-breathing-cycle 4D Magnetic Resonance imagings (MRIs). Deformable image registration (DIR) has been utilized to extract motion fields from 4DMRIs and to establish inter-subject correspondence by registering binary lung masks between Computer Tomography (CT) and MRI. The established correspondence is then used to warp the CT according to the 4DMRI motion. The resulting synthetic 4DCTs are called 4DCT(MRI)s. Validation of the 4DCT(MRI) workflow was conducted by directly comparing conventional 4DCTs to derived synthetic 4D images using the motion of the 4DCTs themselves (referred to as 4DCT(CT)s). Digitally reconstructed radiographs (DRRs) as well as 4D pencil beam scanned (PBS) proton dose calculations were used for validation.
    Results: Based on the CT image appearance of 13 lung cancer patients and deformable motion of five volunteer 4DMRIs, synthetic 4DCT(MRI)s with a total of 871 different breathing cycles have been generated. The 4DCT(MRI)s exhibit an average superior-inferior tumor motion amplitude of 7 ± 5 mm (min: 0.5 mm, max: 22.7 mm). The relative change of the DRR image intensities of the conventional 4DCTs and the corresponding synthetic 4DCT(CT)s inside the body is smaller than 5% for at least 81% of the pixels for all studied cases. Comparison of 4D dose distributions calculated on 4DCTs and the synthetic 4DCT(CT)s using the same motion achieved similar dose distributions with an average 2%/2 mm gamma pass rate of 90.8% (min: 77.8%, max: 97.2%).
    Conclusion: We developed a series of numerical 4D lung phantoms based on real imaging and motion data, which give realistic representations of both anatomy and motion scenarios and the accessible "ground truth" deformation vector fields of each 4DCT(MRI). The open-source code and motion data allow foreseen users to generate further 4D data by themselves. These numeric 4D phantoms can be used for the development of new 4D treatment strategies, 4D dose calculations, DIR algorithm validations, as well as simulations of motion mitigation and different online image guidance techniques for both proton and photon radiation therapy.
    MeSH term(s) Four-Dimensional Computed Tomography/methods ; Humans ; Lung/diagnostic imaging ; Lung Neoplasms/diagnostic imaging ; Lung Neoplasms/radiotherapy ; Magnetic Resonance Imaging/methods ; Phantoms, Imaging ; Protons ; Respiration ; Tomography, X-Ray Computed
    Chemical Substances Protons
    Language English
    Publishing date 2022-03-17
    Publishing country United States
    Document type Journal Article
    ZDB-ID 188780-4
    ISSN 2473-4209 ; 0094-2405
    ISSN (online) 2473-4209
    ISSN 0094-2405
    DOI 10.1002/mp.15591
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