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Article: Thyroid disease post-COVID-19 infection: Report of a case with new-onset autoimmune thyroid disease.

Trinh, Anh Ngoc / Nguyen, Kim Han / Nguyen, Dinh Van

2023 Volume 13, Issue 1, Page(s) 54–56

Abstract: We present hyperthyroidism with autoimmune thyroid disease, which developed a few weeks after the COVID-19 infection in a patient with no prior thyroid disease. Our case was described with clinical presentations, diagnostic tests, and subsequent patient ... ...

Abstract	We present hyperthyroidism with autoimmune thyroid disease, which developed a few weeks after the COVID-19 infection in a patient with no prior thyroid disease. Our case was described with clinical presentations, diagnostic tests, and subsequent patient management and compared to other similar reported cases. A 28-year-old female patient with no prior history of thyroid dysfunction developed hyperthyroidism 8 weeks after COVID-19 infection, confirmed by low thyroid stimulating hormone, high free thyroxine 4, and thyroid receptor antibody. She was treated and responded well to methimazole 20 mg in a few weeks. We searched the literature and found three other similar reported cases and compared those. The effects of COVID-19 infection on the immune system and the thyroid gland might explain the pathology of hyperthyroidism post-COVID-19 infection in this patient. This new-onset hyperthyroidism was found in a woman with mild symptoms and responded well to thiamazole and β-blockers.
Language	English
Publishing date	2023-04-28
Publishing country	Netherlands
Document type	Case Reports
ZDB-ID	2614800-6
ISSN	2233-8268 ; 2233-8276
ISSN (online)	2233-8268
ISSN	2233-8276
DOI	10.5415/apallergy.0000000000000023
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Article ; Online: Ultrastructural Features of Membranous Replication Organelles Induced by Positive-Stranded RNA Viruses.

Nguyen-Dinh, Van / Herker, Eva

Cells

2021 Volume 10, Issue 9

Abstract: All intracellular pathogens critically depend on host cell organelles and metabolites for successful infection and replication. One hallmark of positive-strand RNA viruses is to induce alterations of the (endo)membrane system in order to shield their ... ...

Abstract	All intracellular pathogens critically depend on host cell organelles and metabolites for successful infection and replication. One hallmark of positive-strand RNA viruses is to induce alterations of the (endo)membrane system in order to shield their double-stranded RNA replication intermediates from detection by the host cell's surveillance systems. This spatial seclusion also allows for accruing host and viral factors and building blocks required for efficient replication of the genome and prevents access of antiviral effectors. Even though the principle is iterated by almost all positive-strand RNA viruses infecting plants and animals, the specific structure and the organellar source of membranes differs. Here, we discuss the characteristic ultrastructural features of the virus-induced membranous replication organelles in plant and animal cells and the scientific progress gained by advanced microscopy methods.
MeSH term(s)	Animals ; Host-Pathogen Interactions ; Intracellular Membranes/metabolism ; Intracellular Membranes/ultrastructure ; Intracellular Membranes/virology ; Organelles/metabolism ; Organelles/ultrastructure ; Organelles/virology ; Plants ; Positive-Strand RNA Viruses/pathogenicity ; RNA Virus Infections/metabolism ; RNA Virus Infections/pathology ; RNA Virus Infections/virology ; RNA, Viral/genetics ; Virus Replication
Chemical Substances	RNA, Viral
Language	English
Publishing date	2021-09-13
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	2661518-6
ISSN	2073-4409 ; 2073-4409
ISSN (online)	2073-4409
ISSN	2073-4409
DOI	10.3390/cells10092407
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Article ; Online: Cost-effectiveness of

Duong, Khanh Nc / Nguyen, Dinh Van / Chaiyakunapruk, Nathorn / Nelson, Richard E / Malone, Daniel C

Pharmacogenomics

2023 Volume 24, Issue 13, Page(s) 713–724

Abstract: Background: ...

Abstract	Background:
Language	English
Publishing date	2023-09-14
Publishing country	England
Document type	Journal Article
ZDB-ID	2019513-8
ISSN	1744-8042 ; 1462-2416
ISSN (online)	1744-8042
ISSN	1462-2416
DOI	10.2217/pgs-2023-0095
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Article ; Online: Hepatitis C virus infection restricts human LINE-1 retrotransposition in hepatoma cells.

Schöbel, Anja / Nguyen-Dinh, Van / Schumann, Gerald G / Herker, Eva

PLoS pathogens

2021 Volume 17, Issue 4, Page(s) e1009496

Abstract: LINE-1 (L1) retrotransposons are autonomous transposable elements that can affect gene expression and genome integrity. Potential consequences of exogenous viral infections for L1 activity have not been studied to date. Here, we report that hepatitis C ... ...

Abstract	LINE-1 (L1) retrotransposons are autonomous transposable elements that can affect gene expression and genome integrity. Potential consequences of exogenous viral infections for L1 activity have not been studied to date. Here, we report that hepatitis C virus (HCV) infection causes a significant increase of endogenous L1-encoded ORF1 protein (L1ORF1p) levels and translocation of L1ORF1p to HCV assembly sites at lipid droplets. HCV replication interferes with retrotransposition of engineered L1 reporter elements, which correlates with HCV RNA-induced formation of stress granules and can be partially rescued by knockdown of the stress granule protein G3BP1. Upon HCV infection, L1ORF1p localizes to stress granules, associates with HCV core in an RNA-dependent manner and translocates to lipid droplets. While HCV infection has a negative effect on L1 mobilization, L1ORF1p neither restricts nor promotes HCV infection. In summary, our data demonstrate that HCV infection causes an increase of endogenous L1 protein levels and that the observed restriction of retrotransposition of engineered L1 reporter elements is caused by sequestration of L1ORF1p in HCV-induced stress granules.
MeSH term(s)	Carcinoma, Hepatocellular/virology ; Cell Line, Tumor ; Cytoplasmic Granules/virology ; DNA Helicases/genetics ; DNA Helicases/metabolism ; Hepacivirus/physiology ; Hepatitis C/virology ; Humans ; Lipid Droplets/virology ; Liver Neoplasms/virology ; Long Interspersed Nucleotide Elements/genetics ; Poly-ADP-Ribose Binding Proteins/genetics ; Poly-ADP-Ribose Binding Proteins/metabolism ; RNA Helicases/genetics ; RNA Helicases/metabolism ; RNA Recognition Motif Proteins/genetics ; RNA Recognition Motif Proteins/metabolism ; Ribonucleoproteins/genetics ; Ribonucleoproteins/metabolism
Chemical Substances	L1 ORF1 protein, human ; Poly-ADP-Ribose Binding Proteins ; RNA Recognition Motif Proteins ; Ribonucleoproteins ; DNA Helicases (EC 3.6.4.-) ; G3BP1 protein, human (EC 3.6.4.12) ; RNA Helicases (EC 3.6.4.13)
Language	English
Publishing date	2021-04-19
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2205412-1
ISSN	1553-7374 ; 1553-7366
ISSN (online)	1553-7374
ISSN	1553-7366
DOI	10.1371/journal.ppat.1009496
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Article: Stiff Person Syndrome: A Case Report with Sudden Onset and Coexistence of Sero-Positive Antibodies to Glutamic Acid Decarboxylase and Anti-SOX1 Antibodies.

Nguyen, Phuong Minh / Vu, Dung Duy / Vu, Kien Dung / Nguyen, Hai Thanh / Nguyen, Dinh Van

Case reports in neurology

2022 Volume 14, Issue 2, Page(s) 237–244

Abstract: Stiff Person Syndrome (SPS) is an extremely rare neurological condition characterized by muscle stiffness and painful muscle spasms. The symptoms often progress slowly and can cause disability. Antibodies to glutamic acid decarboxylase (anti-GAD) have ... ...

Abstract	Stiff Person Syndrome (SPS) is an extremely rare neurological condition characterized by muscle stiffness and painful muscle spasms. The symptoms often progress slowly and can cause disability. Antibodies to glutamic acid decarboxylase (anti-GAD) have been reported in up to 80% of the classic type of SPS. Paraneoplastic syndrome comprises 5% of SPS cases. These patients present with different malignancies including lung, thymus, breast, colon, and lymph nodes. In this paper, we report a case of a 25-year-old Vietnamese female patient with SPS presenting with unusual clinical manifestations of sudden onset, rapidly progressive spinal, abdominal, and lower limb rigidity accompanied by painful spasms, autonomic disorders, and severe, multiple bone fractures. Serologic tests detected high-titer anti-GAD, combined with anti-SOX1 antibodies, suggesting paraneoplastic SPS. Intravenous immunoglobulin has been employed as the main treatment therapy, and the patient has had a complete remission.
Language	English
Publishing date	2022-05-10
Publishing country	Switzerland
Document type	Case Reports
ZDB-ID	2505302-4
ISSN	1662-680X
ISSN	1662-680X
DOI	10.1159/000523988
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Article: Offshore wind resource in the context of global climate change over a tropical area

Vu Dinh, Quang / Doan, Quang-Van / Ngo-Duc, Thanh / Nguyen Dinh, Van / Dinh Duc, Nguyen

Applied energy. 2022 Feb. 15, v. 308

2022

Abstract: Understanding the future offshore wind energy is crucial for making an appropriate energy strategy. Yet how offshore wind energy will respond to the rapidly intensifying global warming remains inconclusive. Focusing on a tropical sea in Vietnam, this ... ...

Abstract	Understanding the future offshore wind energy is crucial for making an appropriate energy strategy. Yet how offshore wind energy will respond to the rapidly intensifying global warming remains inconclusive. Focusing on a tropical sea in Vietnam, this study assesses the climatic impact of global warming on the local offshore wind potential. Dynamically downscaled wind data obtained by an edge-cutting fine-resolution regional climate model with two greenhouse-gases Representative Concentration Pathway (RCP) scenarios 8.5 and 4.5 were biased-corrected with a quantile mapping method before using for assessment. Results revealed a changing trend of the annual-mean offshore wind speed and power potential in Vietnam under both scenarios. However, the change is seasonally asymmetric with decreases of about 2 – 10% in September-October-November and slight increases of about 2 – 4% in December-January-February. The turbine-based assessment showed that the cumulative annual energy obtained from the 12 MW and 8 MW turbines could reach the highest about 50.9 GWh and 30.7 GWh (2080–2099 average under scenario RCP8.5) but the difference in their capacity factor is much smaller, suggesting that turbine 8 MW should be considered in the sense of cost-effectiveness in some areas.
Keywords	climate models ; cost effectiveness ; energy ; greenhouse gases ; wind power ; wind speed ; Vietnam
Language	English
Dates of publication	2022-0215
Publishing place	Elsevier Ltd
Document type	Article
ZDB-ID	2000772-3
ISSN	0306-2619
ISSN	0306-2619
DOI	10.1016/j.apenergy.2021.118369
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Article ; Online: Proximity labeling of host factor ANXA3 in HCV infection reveals a novel LARP1 function in viral entry.

Bley, Hanna / Krisp, Christoph / Schöbel, Anja / Hehner, Julia / Schneider, Laura / Becker, Miriam / Stegmann, Cora / Heidenfels, Elisa / Nguyen-Dinh, Van / Schlüter, Hartmut / Gerold, Gisa / Herker, Eva

The Journal of biological chemistry

2024 Volume 300, Issue 5, Page(s) 107286

Abstract: Hepatitis C virus (HCV) infection is tightly connected to the lipid metabolism with lipid droplets (LDs) serving as assembly sites for progeny virions. A previous LD proteome analysis identified annexin A3 (ANXA3) as an important HCV host factor that is ... ...

Abstract	Hepatitis C virus (HCV) infection is tightly connected to the lipid metabolism with lipid droplets (LDs) serving as assembly sites for progeny virions. A previous LD proteome analysis identified annexin A3 (ANXA3) as an important HCV host factor that is enriched at LDs in infected cells and required for HCV morphogenesis. To further characterize ANXA3 function in HCV, we performed proximity labeling using ANXA3-BioID2 as bait in HCV-infected cells. Two of the top proteins identified proximal to ANXA3 during HCV infection were the La-related protein 1 (LARP1) and the ADP ribosylation factor-like protein 8B (ARL8B), both of which have been previously described to act in HCV particle production. In follow-up experiments, ARL8B functioned as a pro-viral HCV host factor without localizing to LDs and thus likely independent of ANXA3. In contrast, LARP1 interacts with HCV core protein in an RNA-dependent manner and is translocated to LDs by core protein. Knockdown of LARP1 decreased HCV spreading without altering HCV RNA replication or viral titers. Unexpectedly, entry of HCV particles and E1/E2-pseudotyped lentiviral particles was reduced by LARP1 depletion, whereas particle production was not altered. Using a recombinant vesicular stomatitis virus (VSV)ΔG entry assay, we showed that LARP1 depletion also decreased entry of VSV with VSV, MERS, and CHIKV glycoproteins. Therefore, our data expand the role of LARP1 as an HCV host factor that is most prominently involved in the early steps of infection, likely contributing to endocytosis of viral particles through the pleiotropic effect LARP1 has on the cellular translatome.
Language	English
Publishing date	2024-04-16
Publishing country	United States
Document type	Journal Article
ZDB-ID	2997-x
ISSN	1083-351X ; 0021-9258
ISSN (online)	1083-351X
ISSN	0021-9258
DOI	10.1016/j.jbc.2024.107286
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Article ; Online: Allopurinol-induced severe cutaneous adverse reactions in Vietnamese: the role of

Ha Pham, Tran Thu / Tran, Quang Binh / Chu, Chi Hieu / Nga Do, Thi Quynh / Nguyen, Hoang Anh / Nguyen, Dinh Van / Phung, Thanh Huong

Pharmacogenomics

2022 Volume 23, Issue 5, Page(s) 303–313

Abstract: Aim: ...

Abstract	Aim:
MeSH term(s)	Alleles ; Allopurinol/adverse effects ; Case-Control Studies ; Cicatrix/complications ; Cicatrix/drug therapy ; Cicatrix/genetics ; HLA-A Antigens/genetics ; HLA-B Antigens/genetics ; HLA-C Antigens/genetics ; Humans ; Risk Factors ; Stevens-Johnson Syndrome/etiology ; Vietnam/epidemiology
Chemical Substances	HLA-A Antigens ; HLA-B Antigens ; HLA-C Antigens ; Allopurinol (63CZ7GJN5I)
Language	English
Publishing date	2022-02-21
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2019513-8
ISSN	1744-8042 ; 1462-2416
ISSN (online)	1744-8042
ISSN	1462-2416
DOI	10.2217/pgs-2021-0156
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Article: Human leukocyte antigen-associated severe cutaneous adverse drug reactions: from bedside to bench and beyond.

Nguyen, Dinh Van / Vidal, Christopher / Chu, Hieu Chi / van Nunen, Sheryl

Asia Pacific allergy

2019 Volume 9, Issue 3, Page(s) e20

Abstract: Despite their being uncommon, severe cutaneous adverse drug reactions (SCARs) result in a very great burden of disease. These reactions not only carry with them a high mortality (10%-50%) and high morbidity (60%) with severe ocular complications, ... ...

Abstract	Despite their being uncommon, severe cutaneous adverse drug reactions (SCARs) result in a very great burden of disease. These reactions not only carry with them a high mortality (10%-50%) and high morbidity (60%) with severe ocular complications, alopecia, oral and dental complications and development of autoimmune diseases, but also create a substantial economic burden for patients' families and society. SCARs are, therefore, an important medical problem needing a solution in many countries, especially in Asia. The clinical spectrum of SCARs comprises Stevens-Johnson syndrome, toxic epidermal necrolysis, DRESS (drug rash with eosinophilia and systemic symptoms) (also known as drug hypersensitivity syndrome or drug-induced hypersensitivity syndrome) and acute generalised exanthematous pustulosis. Recent crucial advances in determining genetic susceptibility and understanding how T cells recognise certain medications or their metabolites via the major histocompatibility complex and the effects of cofactors, have led to the implementation of cost-effective screening programs enabling prevention in a number of countries, and to further understanding of the patho-mechanisms involved in SCARs and their significance. In this review, we document comprehensively the journey of SCARs from bedside to bench and outline future perspectives in SCARs research.
Language	English
Publishing date	2019-05-31
Publishing country	Netherlands
Document type	Journal Article ; Review
ZDB-ID	2614800-6
ISSN	2233-8268 ; 2233-8276
ISSN (online)	2233-8268
ISSN	2233-8276
DOI	10.5415/apallergy.2019.9.e20
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Article: Developing pharmacogenetic screening methods for an emergent country: Vietnam.

Nguyen, Dinh Van / Vidal, Christopher / Chu, Hieu Chi / van Nunen, Sheryl

The World Allergy Organization journal

2019 Volume 12, Issue 5, Page(s) 100037

Abstract: Background: The finding of strong associations between certain human leukocyte antigen (HLA) genotypes and the development of severe cutaneous adverse drug reactions (SCARs), [for example, HLA-B*57:01 and abacavir (ABC), HLA-B*15:02 and carbamazepine ( ... ...

Abstract	Background: The finding of strong associations between certain human leukocyte antigen (HLA) genotypes and the development of severe cutaneous adverse drug reactions (SCARs), [for example, HLA-B57:01 and abacavir (ABC), HLA-B15:02 and carbamazepine (CBZ) and HLA-B58:01 and allopurinol], has led to HLA screening being used to prevent SCARs. Screening has been shown to be of great benefit in a number of studies. Clinical translation from bench to bedside, however, depends upon the development of simple, rapid and cost-effective assays to detect these risk alleles. In highly populated developing countries such as Vietnam, where there is a high prevalence of HLA-B15:02 and HLA-B58:01 correlating with a high incidence of CBZ- and allopurinol-induced SCARs, the crucial factor in the implementation of comprehensive screening programs to detect these major risk HLA alleles is the availability of suitable assays. Body:* We have summarized the role and economic benefits of HLA screening, reviewed published HLA screening methods used currently in pharmacogenetic screening and examined the advantages and disadvantages of assays developed specifically for use in screening for risk alleles in the prevention of HLA-associated SCARs in Vietnam. Conclusion: The optimal approach we propose may serve as a template for the development of screening programs in other emergent countries.
Language	English
Publishing date	2019-06-06
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	2581968-9
ISSN	1939-4551
ISSN	1939-4551
DOI	10.1016/j.waojou.2019.100037
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