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Article: Prevalence of Thyroid Nodules and Associated Clinical Characteristics: Findings from a Large Sample of People Undergoing Health Checkups at a University Hospital in Vietnam.

Tran, Nam Quang / Le, Bao Hoang / Hoang, Chi Khanh / Nguyen, Huu-Thinh / Thai, Truc Thanh

2023 Volume 16, Page(s) 899–907

Abstract: Background: Thyroid nodule is a common disorder normally detected by ultrasound. However, little is known about the population prevalence of thyroid nodules in a Vietnamese population. This study aimed to estimate the prevalence of thyroid nodules, its ... ...

Abstract	Background: Thyroid nodule is a common disorder normally detected by ultrasound. However, little is known about the population prevalence of thyroid nodules in a Vietnamese population. This study aimed to estimate the prevalence of thyroid nodules, its characteristics, and associated factors in a large number of people undergoing annual health checkups. Methods: A retrospective, cross-sectional descriptive study was conducted, based on electronic medical records of people undergoing health checkups at the Health Checkup Department, University Medical Center at Ho Chi Minh City. All of the participants underwent thyroid ultrasonography, anthropometric measurements, and serum examinations. Results: A total of 16,784 participants (mean age: 40.4 ± 12.7 years, 45.1% female) were included in this study. The overall prevalence of thyroid nodules was 48.4%. The mean diameter of nodules was 7.2 ± 5.8 mm. The prevalence of nodules with malignant characteristics was 36.9%. Women had a significantly higher prevalence of thyroid nodules than men (55.2% vs 42.9%, p<0.001). Advanced age, hypertension, and hyperglycemia were significantly associated with thyroid nodules in both genders. In men, significant factors also included increased body mass index. In women, these included increased total cholesterol and LDLc, hypertriglyceridemia, and hyperuricemia. Conclusion: This study showed a high prevalence of TNs in Vietnamese people undergoing general health checkups. Importantly, the proportion of TNs with malignant risk was quite high. Therefore, screening for TNs should be added to annual health checkups to improve early detection of TNs, targeting those who have a high-risk profile based on factors identified in this study.
Language	English
Publishing date	2023-05-17
Publishing country	England
Document type	Journal Article
ZDB-ID	2495128-6
ISSN	1179-1594
ISSN	1179-1594
DOI	10.2147/RMHP.S410964
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Article ; Online: Prevalence and genetic spectrum associated with hereditary colorectal cancer syndromes, the need to improve cancer risk awareness, and family cascade testing in Vietnam.

Nguyen, Huu-Thinh / Lu, Y-Thanh / Tran, Duc-Huy / Tieu, Ba-Linh / Le, Kien-Trung / Pham, Truong-Vinh Ngoc / Do, Thanh-Thuy Thi / Truong, Dinh-Kiet / Giang, Hoa / Tang, Hung-Sang

Familial cancer

2023 Volume 22, Issue 4, Page(s) 449–458

Abstract: In Vietnam, colorectal cancer is one of the top diagnosed cancers, with 5-10% originating from inherited mutations. This study aims to define the mutation spectrum associated with hereditary colorectal cancer syndromes (HCCS) in Vietnam, evaluate the ... ...

Abstract	In Vietnam, colorectal cancer is one of the top diagnosed cancers, with 5-10% originating from inherited mutations. This study aims to define the mutation spectrum associated with hereditary colorectal cancer syndromes (HCCS) in Vietnam, evaluate the influence of genetic testing on carriers' awareness, and also investigate the barriers in familial testing. Genetic test reports were collected to identify HCCS cases, then cases underwent a survey investigating self-risk and familial-risk awareness, proactive cancer screening, and familial testing barriers. Participant characteristics, mutation prevalence, and results from the survey were descriptively analyzed and reported. Of all genetic test results, 3% (49/1632) were identified with mutations related to HCCS. Over 77% of them belonged to Lynch syndrome. PMS2 appeared to be the gene with the highest mutation frequency, while MLH1 was the lowest. 44% of cases further undertook cancer screening tests, and 48% of cases' families had uptake genetic testing. The biggest barrier of familial members for not taking genetic test was psychological reasons (fear, not being interested, or not feeling necessary). This study provided new evidence for HCCS mutation spectrum in Vietnamese population and the success in promoting cascade test in high-risk family members through financial and technical support. Also, study has suggested the needs of an innovative genetic testing process focusing on the quality of pre-and post-test consultancy, an increase in follow-ups, and the change in policy for permission of contacting relatives directly to improve the rate of cascade testing and proactive cancer screening.
MeSH term(s)	Humans ; Genetic Predisposition to Disease ; Vietnam/epidemiology ; Prevalence ; Genetic Testing ; Neoplastic Syndromes, Hereditary/genetics ; Colorectal Neoplasms, Hereditary Nonpolyposis/diagnosis ; Colorectal Neoplasms, Hereditary Nonpolyposis/epidemiology ; Colorectal Neoplasms, Hereditary Nonpolyposis/genetics
Language	English
Publishing date	2023-07-30
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	1502496-9
ISSN	1573-7292 ; 1389-9600
ISSN (online)	1573-7292
ISSN	1389-9600
DOI	10.1007/s10689-023-00344-1
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Article ; Online: Improvement in neoantigen prediction via integration of RNA sequencing data for variant calling.

Nguyen, Bui Que Tran / Tran, Thi Phuong Diem / Nguyen, Huu Thinh / Nguyen, Thanh Nhan / Pham, Thi Mong Quynh / Nguyen, Hoang Thien Phuc / Tran, Duc Huy / Nguyen, Vy / Tran, Thanh Sang / Pham, Truong-Vinh Ngoc / Le, Minh-Triet / Phan, Minh-Duy / Giang, Hoa / Nguyen, Hoai-Nghia / Tran, Le Son

Frontiers in immunology

2023 Volume 14, Page(s) 1251603

Abstract: Introduction: Neoantigen-based immunotherapy has emerged as a promising strategy for improving the life expectancy of cancer patients. This therapeutic approach heavily relies on accurate identification of cancer mutations using DNA sequencing (DNAseq) ... ...

Abstract	Introduction: Neoantigen-based immunotherapy has emerged as a promising strategy for improving the life expectancy of cancer patients. This therapeutic approach heavily relies on accurate identification of cancer mutations using DNA sequencing (DNAseq) data. However, current workflows tend to provide a large number of neoantigen candidates, of which only a limited number elicit efficient and immunogenic T-cell responses suitable for downstream clinical evaluation. To overcome this limitation and increase the number of high-quality immunogenic neoantigens, we propose integrating RNA sequencing (RNAseq) data into the mutation identification step in the neoantigen prediction workflow. Methods: In this study, we characterize the mutation profiles identified from DNAseq and/or RNAseq data in tumor tissues of 25 patients with colorectal cancer (CRC). Immunogenicity was then validated by ELISpot assay using long synthesis peptides (sLP). Results: We detected only 22.4% of variants shared between the two methods. In contrast, RNAseq-derived variants displayed unique features of affinity and immunogenicity. We further established that neoantigen candidates identified by RNAseq data significantly increased the number of highly immunogenic neoantigens (confirmed by ELISpot) that would otherwise be overlooked if relying solely on DNAseq data. Discussion: This integrative approach holds great potential for improving the selection of neoantigens for personalized cancer immunotherapy, ultimately leading to enhanced treatment outcomes and improved survival rates for cancer patients.
MeSH term(s)	Humans ; Base Sequence ; Biological Assay ; Enzyme-Linked Immunospot Assay ; Immunotherapy ; Mutation ; RNA
Chemical Substances	RNA (63231-63-0)
Language	English
Publishing date	2023-09-04
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2606827-8
ISSN	1664-3224 ; 1664-3224
ISSN (online)	1664-3224
ISSN	1664-3224
DOI	10.3389/fimmu.2023.1251603
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Article ; Online: Post-traumatic stress disorder, anxiety, depression and related factors among COVID-19 patients during the fourth wave of the pandemic in Vietnam.

Nguyen, Hoang Bac / Nguyen, Thi Hong Minh / Vo, Thi Hong Nhan / Vo, Thi Cam Nhung / Nguyen, Duc Nguyet Quynh / Nguyen, Huu-Thinh / Tang, Tuan-Ngan / Nguyen, Thi-Hiep / Do, Van Trang / Truong, Quang Binh

International health

2022 Volume 15, Issue 4, Page(s) 365–375

Abstract: Background: This study investigated post-traumatic stress disorder (PTSD), anxiety, depression and their related factors among coronavirus disease 2019 (COVID-19) patients during the fourth wave of the pandemic in Vietnam.: Methods: Vietnamese-fluent ...

Abstract	Background: This study investigated post-traumatic stress disorder (PTSD), anxiety, depression and their related factors among coronavirus disease 2019 (COVID-19) patients during the fourth wave of the pandemic in Vietnam. Methods: Vietnamese-fluent confirmed COVID-19 patients for at least 3 d were recruited in this online cross-sectional study to answer a three-part questionnaire including participants' sociodemographic characteristics, PTSD (Impact of Event Scale-Revised) and anxiety and depression (Hospital Anxiety and Depression Scale). Associated factors were determined using multivariable binary logistic regression models. Results: Of 1544 responses, the majority were female (53.0%), ages 18-39 y (74.8%) and were isolated and treated at field hospitals (72.2%). Family or friends were the greatest sources of mental support (68.2%), followed by healthcare providers (51.1%). The overall prevalence rates of PTSD, anxiety and depression among COVID-19 patients were 22.9%, 11.2% and 17.4%, respectively. Risk factors included older age, higher education, getting infected from the public, knowing someone who died from COVID-19 and high perception of life threat. Meanwhile, mental assistance from family or friends, a greater number of supporters, living with someone not vulnerable and higher salaries were significantly protective factors. Conclusions: The psychological responses associated with some sociodemographic details. Family or friends should be the first line of mental interventions for COVID-19 patients.
MeSH term(s)	Humans ; Female ; Male ; COVID-19/epidemiology ; Stress Disorders, Post-Traumatic/epidemiology ; Depression/epidemiology ; Depression/psychology ; Pandemics ; Cross-Sectional Studies ; Vietnam/epidemiology ; SARS-CoV-2 ; Anxiety/epidemiology ; Anxiety/psychology
Language	English
Publishing date	2022-05-19
Publishing country	England
Document type	Journal Article
ZDB-ID	2526175-7
ISSN	1876-3405 ; 1876-3413
ISSN (online)	1876-3405
ISSN	1876-3413
DOI	10.1093/inthealth/ihac040
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Article: Examination of entry portal and pathogenesis of Edwardsiella ictaluri infection in striped catfish, Pangasianodon hypophthalmus

Pirarat, Nopadon / Ei Lin Ooi / Kim D. Thompson / Masashi Maita / Nguyen Huu Thinh / Takayuki Katagiri

Aquaculture. 2016 Nov. 01, v. 464

2016

Abstract: The host-bacterium interaction between striped pangasius catfish (Pangasianodon hypophthalmus) and Edwardsiella ictaluri was examined during experimentally induced bacillary necrosis of pangasius (BNP). After infection by immersion challenge, fish ... ...

Abstract	The host-bacterium interaction between striped pangasius catfish (Pangasianodon hypophthalmus) and Edwardsiella ictaluri was examined during experimentally induced bacillary necrosis of pangasius (BNP). After infection by immersion challenge, fish samples were taken over the course of the infection. Necrotic dermatitis, associated with vasculitis-perivasculitis changes, was the most notable gross and histopathological change observed, similar to that described during channel catfish enteric septicemia. Typical histopathological change associated with BNP were initially observed by 96h post-infection (hpi) and these lasted until 14days post infection (dpi) with no granulomatous formation evident. The presence of the bacterium was observed in various organs using immunohistochemistry (IHC), except for the brain, with positive staining observed within differing cell types, including phagocytic cells, myocardia, gill epithelia and capillary endothelia. No extracellular deposition of bacterial antigen was observed. Bacterial antigen persisted up to 1month in the independent phagocytic cells, necrotic-associated phagocytic cells and melano-macrophage centers, confirming the intracellular nature of E. ictaluri disseminated in the tissues during septicemia. The bacterium was evident in the gills early in the infection (6–12 hpi) and in necrotic skin at 72hpi. With the histopathological changes observed, this suggests that skin is another possible natural route for disseminating E. ictaluri in pangasius catfish during infection.This information will improve our understanding of the pathogenesis of BNP, and establish more effective methods of control for this important disease, including methods for quantifying sub-lethal infections and assessing response against the invading pathogen.
Keywords	bacteria ; bacterial antigens ; brain ; catfish ; control methods ; dermatitis ; Edwardsiella ictaluri ; epithelium ; gills ; histopathology ; Ictalurus punctatus ; immunohistochemistry ; necrosis ; Pangasianodon hypophthalmus ; pathogenesis ; pathogens ; phagocytes ; septicemia ; staining
Language	English
Dates of publication	2016-1101
Size	p. 279-285.
Publishing place	Elsevier B.V.
Document type	Article
ZDB-ID	185380-6
ISSN	0044-8486 ; 0044-8516
ISSN	0044-8486 ; 0044-8516
DOI	10.1016/j.aquaculture.2016.06.043
Database	NAL-Catalogue (AGRICOLA)

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Article: A Natural Forest of Commercial Timber Species: Logging or Not Logging

Van Do, Tran / Osamu Kozan / Mamoru Yamamoto / Vo Dai Hai / Phung Dinh Trung / Nguyen Toan Thang / Hoang Van Thang / Tran Duc Manh / Vu Tien Lam / Nguyen Huu Thinh

Small-scale forestry. 2018 Dec., v. 17, no. 4

2018

Abstract: Most tropical forests outside protected areas have been or will be selectively logged because the timber industry is a main income-generating resource for many developing countries. Therefore, understanding the composition of commercial timber species ... ...

Abstract	Most tropical forests outside protected areas have been or will be selectively logged because the timber industry is a main income-generating resource for many developing countries. Therefore, understanding the composition of commercial timber species and logging types is key for sustainable forest management in countries like Vietnam as they move toward fulfilling Reducing Emissions from Deforestation and Forest Degradation (REDD+) agreements. Seven 1-ha plots were surveyed in the Central Highland of Vietnam, and 18 commercial tree species from these plots, whose timber is widely used by local people for housing and furniture making and timber is easily sold at local markets for high prices, were analyzed. In total, 151 tree species with a diameter at breast height (DBH) of ≥ 10 cm were recorded. The 18 commercially valuable species assessed in this study accounted for 33.2% of all stems (total of 524 stems ha⁻¹ for all species), 47.1% of basal area (total of 34.35 m² ha⁻¹ for all species), and 50.8% of aboveground biomass/AGB (total of 262.68 Mg ha⁻¹ for all species). Practicing diameter-limit harvesting of all commercially valuable species with DBH of ≥ 40 cm, which is widely performed in Vietnam, will reduce the number of stems by 7%, basal area by 31.6%, and AGB by 38.2%. Because such harvesting practices cause severe ecological impacts on the remaining forest, logged forests may require > 40 years to recover the structure status of a pre-logged forest. In addition, the recovery of the 18 commercially valuable species may require a much longer time because they comprised 33.2% of stems. Permission for logging natural forests should be given in Vietnam to sustain lives of local communities, where logging has been prohibited. However, alternative harvesting systems, such as reduced-impact logging systems, should be considered. The systems selected must simultaneously generate economic returns for local people and respect the REDD+ agreements with regard to protecting biodiversity and reducing carbon emissions.
Keywords	aboveground biomass ; basal area ; biodiversity ; carbon ; conservation areas ; costs and returns ; deforestation ; developing countries ; emissions ; environmental impact ; furniture making ; harvesting ; logging ; markets ; prices ; stems ; sustainable forestry ; tree and stand measurements ; trees ; tropical forests ; wood industry ; Vietnam
Language	English
Dates of publication	2018-12
Size	p. 555-568.
Publishing place	Springer Netherlands
Document type	Article
ZDB-ID	2365256-1
ISSN	1873-7854 ; 1873-7617
ISSN (online)	1873-7854
ISSN	1873-7617
DOI	10.1007/s11842-018-9403-8
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Article: Pathogenic Variant Profile of Hereditary Cancer Syndromes in a Vietnamese Cohort.

Tran, Van Thuan / Nguyen, Sao Trung / Pham, Xuan Dung / Phan, Thanh Hai / Nguyen, Van Chu / Nguyen, Huu Thinh / Nguyen, Huu Phuc / Doan, Phuong Thao Thi / Le, Tuan Anh / Nguyen, Bao Toan / Jasmine, Thanh Xuan / Nguyen, Duy Sinh / Nguyen, Hong-Dang Luu / Nguyen, Ngoc Mai / Do, Duy Xuan / Tran, Vu Uyen / Nguyen, Hue Hanh Thi / Le, Minh Phong / Nguyen, Yen Nhi /

Do, Thanh Thuy Thi / Truong, Dinh Kiet / Tang, Hung Sang / Phan, Minh-Duy / Nguyen, Hoai-Nghia / Giang, Hoa / Tu, Lan N

Frontiers in oncology

2022 Volume 11, Page(s) 789659

Abstract: Background: Hereditary cancer syndromes (HCS) are responsible for 5-10% of cancer cases. Genetic testing to identify pathogenic variants associated with cancer predisposition has not been routinely available in Vietnam. Consequently, the prevalence and ... ...

Abstract	Background: Hereditary cancer syndromes (HCS) are responsible for 5-10% of cancer cases. Genetic testing to identify pathogenic variants associated with cancer predisposition has not been routinely available in Vietnam. Consequently, the prevalence and genetic landscape of HCS remain unknown. Methods: 1165 Vietnamese individuals enrolled in genetic testing at our laboratory in 2020. We performed analysis of germline mutations in 17 high- and moderate- penetrance genes associated with HCS by next generation sequencing. Results: A total of 41 pathogenic variants in 11 genes were detected in 3.2% individuals. The carrier frequency was 4.2% in people with family or personal history of cancer and 2.6% in those without history. The percentage of mutation carriers for hereditary colorectal cancer syndromes was 1.3% and for hereditary breast and ovarian cancer syndrome was 1.6%. Conclusion: This is the first largest analysis of carrier frequency and mutation spectrum of HCS in Vietnam. The findings demonstrate the clinical significance of multigene panel testing to identify carriers and their at-risk relatives for better cancer surveillance and management strategies.
Language	English
Publishing date	2022-01-05
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2649216-7
ISSN	2234-943X
ISSN	2234-943X
DOI	10.3389/fonc.2021.789659
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Article ; Online: Monitoring fine root growth to identify optimal fertilization timing in a forest plantation

Tran Van Do / Nguyen Toan Thang / Vu Tien Lam / Dang Van Thuyet / Phung Dinh Trung / Tran Hoang Quy / Nguyen Thi Thu Phuong / Ly Thi Thanh Huyen / Nguyen Huu Thinh / Nguyen Van Tuan / Dao Trung Duc / Dang Thi Hai Ha / Duong Quang Trung / Ho Trung Luong / Nguyen Thi Hoai Anh / Patrick Nykiel

PLoS ONE, Vol 14, Iss 11, p e

A case study in Northeast Vietnam.

2019 Volume 0225567

Abstract: Fertilizer is applied widely to improve the productivity of plantations. Traditionally, fertilization is conducted in spring and/or in the early rainy season, and it is believed to support the growth of planted trees in the growing season. Little ... ...

Abstract	Fertilizer is applied widely to improve the productivity of plantations. Traditionally, fertilization is conducted in spring and/or in the early rainy season, and it is believed to support the growth of planted trees in the growing season. Little attention to date has been paid on identification of the optimal timing of fertilization and fertilizer dose. In this study, application of the fine root monitoring technique in identifying optimal fertilization timing for an Acacia plantation in Vietnam is described. The study used two fertilizer doses (100 and 200 g NPK/tree) and three fertilization timings (in spring; in the early rainy season; and based on the fine root monitoring technique to identify when the fine roots reach their growth peak). As expected fertilization timings significantly affected growth and above-ground biomass (AGB) of the plantation. Fertilization based on the fine root monitoring technique resulted in the highest growths and AGB, followed by fertilization in the early rainy season and then in spring. Applying fertilizer at 200 g NPK/tree based on the fine root monitoring technique increased diameter at breast height (DBH) by 16%, stem height by 8%, crown diameter (Dc) by 16%, and AGB by 40% as compared to early rainy season fertilization. Increases of 32% DBH, 23% stem height, 44% Dc, and 87% AGB were found in fertilization based on fine root monitoring technique compared to spring fertilization. This study concluded that forest growers should use the fine root monitoring technique to identify optimal fertilization timing for higher productivity.
Keywords	Medicine ; R ; Science ; Q
Subject code	333
Language	English
Publishing date	2019-01-01T00:00:00Z
Publisher	Public Library of Science (PLoS)
Document type	Article ; Online
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Article ; Online: Molecular characterization of antibiotic resistance in Pseudomonas and Aeromonas isolates from catfish of the Mekong Delta, Vietnam.

Nguyen, Hoang Nam Kha / Van, Thi Thu Hao / Nguyen, Huu Thinh / Smooker, Peter M / Shimeta, Jeff / Coloe, Peter J

Veterinary microbiology

2014 Volume 171, Issue 3-4, Page(s) 397–405

Abstract: A collection of 116 motile Pseudomonas spp. and 92 Aeromonas spp. isolated from 15 Vietnamese intensive catfish farms was analyzed to examine the molecular antibiotic resistance characteristics and the transferability of resistance markers within and ... ...

Abstract	A collection of 116 motile Pseudomonas spp. and 92 Aeromonas spp. isolated from 15 Vietnamese intensive catfish farms was analyzed to examine the molecular antibiotic resistance characteristics and the transferability of resistance markers within and between species. High levels of resistance to ampicillin, trimethoprim/sulfamethoxazole, nalidixic acid, chloramphenicol, and nitrofurantoin were observed. The percentage of multiple drug resistance of Pseudomonas spp. and Aeromonas spp. isolates was 96.6% and 61.9%, respectively. The multiple antibiotic resistance (MAR) index mean values of 0.457 and 0.293 of Pseudomonas and Aeromonas isolates, respectively, indicated that these isolates were exposed to high risk sources of contamination where antibiotics were commonly used. Approximately 33% of Pseudomonas spp. and 28% of Aeromonas spp. isolates from catfish contained class 1 integrons, but no class 2 integrons were detected. Several common resistance genes including aadA, dfrA and catB were harbored in class 1 integrons. Large plasmids (>55 kb) were frequently detected in 50% and 71.4% of the plasmids extracted from Pseudomonas and Aeromonas isolates, respectively. Conjugation and transformation experiments demonstrated the successful transfer of all or part of the resistance phenotypes of catfish isolates to the recipient strains, including laboratory strains and strains isolated from this study. These results highlight the likely role of catfish bacteria as a reservoir of antibiotic resistant, Gram-negative bacteria harboring a pool of mobile genetic elements that can readily be transferred intra- and interspecies. To our knowledge, this is the first report on molecular characterization of antibiotic resistance of bacteria isolated from catfish in Vietnam.
MeSH term(s)	Aeromonas/drug effects ; Aeromonas/genetics ; Animals ; Anti-Bacterial Agents/pharmacology ; Aquaculture ; Catfishes/microbiology ; Drug Resistance, Multiple, Bacterial/genetics ; Gene Transfer, Horizontal/genetics ; Integrons/genetics ; Microbial Sensitivity Tests ; Plasmids/genetics ; Pseudomonas/drug effects ; Pseudomonas/genetics ; Species Specificity ; Vietnam
Chemical Substances	Anti-Bacterial Agents
Language	English
Publishing date	2014-07-16
Publishing country	Netherlands
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	753154-0
ISSN	1873-2542 ; 0378-1135
ISSN (online)	1873-2542
ISSN	0378-1135
DOI	10.1016/j.vetmic.2014.01.028
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Article ; Online: Ultra-Deep Sequencing of Plasma-Circulating DNA for the Detection of Tumor- Derived Mutations in Patients with Nonmetastatic Colorectal Cancer.

Nguyen, Huu-Thinh / Luong, Bac An / Tran, Duc-Huy / Nguyen, Trong-Hieu / Ngo, Quoc Dat / Le, Linh Gia Hoang / Ho, Quoc Chuong / Nguyen, Hue-Hanh Thi / Nguyen, Cao Minh / Tran, Vu Uyen / Pham, Truong Vinh Ngoc / Le, Minh Triet / Le, Ngoc An Trinh / Le, Trung Kien / Nguyen, Thanh Luan / Pham, Hong-Anh Thi / Le, Hong Thuy / Duong, Hong Diep Thi / Hoang, Anh Vu /

Nguyen, Hoang Bac / Truong Dinh, Kiet / Phan, Minh-Duy / Nguyen, Hoai-Nghia / Do, Thanh-Thuy Thi / Giang, Hoa / Tran, Le Son / Tran, Diep Tuan

Cancer investigation

2021 Volume 40, Issue 4, Page(s) 354–365

Abstract: Identification of tumor-derived mutation (TDM) in liquid biopsies (LB), especially in early-stage patients, faces several challenges, including low variant-allele frequencies, interference by white blood cell (WBC)-derived mutations (WDM), benign somatic ...

Abstract	Identification of tumor-derived mutation (TDM) in liquid biopsies (LB), especially in early-stage patients, faces several challenges, including low variant-allele frequencies, interference by white blood cell (WBC)-derived mutations (WDM), benign somatic mutations and tumor heterogeneity. Here, we addressed the above-mentioned challenges in a cohort of 50 nonmetastatic colorectal cancer patients, via a workflow involving parallel sequencing of paired WBC- and tumor-gDNA. After excluding potential false positive mutations, we detected at least one TDM in LB of 56% (28/50) of patients, with the majority showing low-patient coverage, except for one TDM mapped to
MeSH term(s)	Cell-Free Nucleic Acids/genetics ; Circulating Tumor DNA/genetics ; Colorectal Neoplasms/genetics ; High-Throughput Nucleotide Sequencing ; Humans ; Mutation
Chemical Substances	Cell-Free Nucleic Acids ; Circulating Tumor DNA
Language	English
Publishing date	2021-12-22
Publishing country	England
Document type	Journal Article
ZDB-ID	604942-4
ISSN	1532-4192 ; 0735-7907
ISSN (online)	1532-4192
ISSN	0735-7907
DOI	10.1080/07357907.2021.2017951
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