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  1. Book ; Online: Language Models are Bounded Pragmatic Speakers

    Nguyen, Khanh

    Understanding RLHF from a Bayesian Cognitive Modeling Perspective

    2023  

    Abstract: How do language models "think"? This paper formulates a probabilistic cognitive model called the bounded pragmatic speaker, which can characterize the operation of different variations of language models. Specifically, we demonstrate that large language ... ...

    Abstract How do language models "think"? This paper formulates a probabilistic cognitive model called the bounded pragmatic speaker, which can characterize the operation of different variations of language models. Specifically, we demonstrate that large language models fine-tuned with reinforcement learning from human feedback (Ouyang et al., 2022) embody a model of thought that conceptually resembles a fast-and-slow model (Kahneman, 2011), which psychologists have attributed to humans. We discuss the limitations of reinforcement learning from human feedback as a fast-and-slow model of thought and propose avenues for expanding this framework. In essence, our research highlights the value of adopting a cognitive probabilistic modeling approach to gain insights into the comprehension, evaluation, and advancement of language models.

    Comment: Proceedings of the First Workshop on Theory of Mind in Communicating Agents at (TOM @ ICML 2023)
    Keywords Computer Science - Computation and Language ; Computer Science - Machine Learning
    Subject code 401
    Publishing date 2023-05-28
    Publishing country us
    Document type Book ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  2. Article ; Online: The sounds of silencing: dynamic epigenetic control of HIV latency.

    Nguyen, Kien / Karn, Jonathan

    Current opinion in HIV and AIDS

    2024  Volume 19, Issue 3, Page(s) 102–109

    Abstract: Purpose of review: This review highlights advances in understanding the epigenetic control mechanisms that regulate HIV-1 latency mechanisms in T-cells and microglial cells and describes the potential of current therapeutic approaches targeting the ... ...

    Abstract Purpose of review: This review highlights advances in understanding the epigenetic control mechanisms that regulate HIV-1 latency mechanisms in T-cells and microglial cells and describes the potential of current therapeutic approaches targeting the epigenetic machinery to eliminate or block the HIV-1 latent reservoir.
    Recent findings: Large-scale unbiased CRISPR-Cas9 library-based screenings, coupled with biochemical studies, have comprehensively identified the epigenetic factors pivotal in regulating HIV-1 latency, paving the way for potential novel targets in therapeutic development. These studies also highlight how the bivalency observed at the HIV-1 5'LTR primes latent proviruses for rapid reactivation.
    Summary: The HIV-1 latent is established very early during infection, and its persistence is the major obstacle to achieving an HIV-1 cure. Here, we present a succinct summary of the latest research findings, shedding light on the pivotal roles played by host epigenetic machinery in the control of HIV-1 latency. Newly uncovered mechanisms permitting rapid reversal of epigenetic restrictions upon viral reactivation highlight the formidable challenges of achieving enduring and irreversible epigenetic silencing of HIV-1.
    MeSH term(s) Humans ; Virus Latency/genetics ; HIV Infections/genetics ; HIV-1/genetics ; T-Lymphocytes ; Epigenesis, Genetic ; CD4-Positive T-Lymphocytes
    Language English
    Publishing date 2024-03-12
    Publishing country United States
    Document type Review ; Journal Article
    ZDB-ID 2502511-9
    ISSN 1746-6318 ; 1746-630X
    ISSN (online) 1746-6318
    ISSN 1746-630X
    DOI 10.1097/COH.0000000000000850
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Ophthalmic Sequelae of Late-Stage Primary Hyperoxaluria Type 1.

    Nguyen, Kimberly / Sun, Lynn

    Ophthalmology

    2023  

    Language English
    Publishing date 2023-12-15
    Publishing country United States
    Document type Journal Article
    ZDB-ID 392083-5
    ISSN 1549-4713 ; 0161-6420
    ISSN (online) 1549-4713
    ISSN 0161-6420
    DOI 10.1016/j.ophtha.2023.11.012
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Urogenital presentation of a male patient with focal dermal hypoplasia.

    Nguyen, Khoa / Sosa, Valentina

    Pediatric dermatology

    2023  Volume 40, Issue 3, Page(s) 580–581

    Abstract: Focal dermal hypoplasia (FDH) is a rare X-linked dominant syndrome characterized by streaky cutaneous atrophy in a blaschkoid distribution, skeletal dysplasias, and ocular abnormalities. Here, we report hypospadias and chordee identified in a male ... ...

    Abstract Focal dermal hypoplasia (FDH) is a rare X-linked dominant syndrome characterized by streaky cutaneous atrophy in a blaschkoid distribution, skeletal dysplasias, and ocular abnormalities. Here, we report hypospadias and chordee identified in a male patient with molecularly confirmed FDH. This report highlights a new clinical manifestation of male patients with FDH.
    MeSH term(s) Humans ; Male ; Focal Dermal Hypoplasia/complications ; Focal Dermal Hypoplasia/diagnosis ; Focal Dermal Hypoplasia/genetics ; Atrophy
    Language English
    Publishing date 2023-02-15
    Publishing country United States
    Document type Journal Article
    ZDB-ID 605539-4
    ISSN 1525-1470 ; 0736-8046
    ISSN (online) 1525-1470
    ISSN 0736-8046
    DOI 10.1111/pde.15256
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Book ; Online: Influence of plant traits on water cycle processes in the Amazon Basin

    Nguyen, Kien / Santos, Maria J.

    eISSN:

    2024  

    Abstract: Plants play a key role in the soil-plant-atmosphere-climate hydrological continuum. Plants depend on the water cycle and, in return, several hydrological processes could be impacted via vegetation-induced mechanisms. Changes in plant composition are ... ...

    Abstract Plants play a key role in the soil-plant-atmosphere-climate hydrological continuum. Plants depend on the water cycle and, in return, several hydrological processes could be impacted via vegetation-induced mechanisms. Changes in plant composition are known to affect this relationship, however, detailed understanding on how plant characteristics, i.e., their traits, are seldom included in observational and modeling studies. Here we examine the effect of plant traits on water cycle processes in the Amazon Basin. We used remotely-sensed estimates of four plant traits, namely Specific Leaf Area (SLA), Leaf Dry Matter Content (LDMC), Leaf Phosphorus Content (LPC), Leaf Nitrogen Content (LNC), and two vegetation indices, the Normalised Difference Vegetation Index (NDVI), and Leaf Area Index (LAI), for 10 years between 2001 and 2010. We examined the relationship between plant traits and six parameters relevant for water cycle processes, namely Evapotranspiration (ET), Potential Evapotranspiration (PET), Vapour Pressure Deficit (VPD), Land Surface Temperature (LST) Day/Night and Soil Moisture (SM). We used multivariate and quantile regressions to analyse how plant traits explain the average and standard deviation in water cycle process parameters. We find that SLA, NDVI, and LAI exert the strongest effects across the whole of Amazon basin and the sub-basins, most important for the regulation of atmospheric water content and of land surface temperature, but little effect on the regulation of soil moisture content. These effects are exacerbated at extreme values of water process parameters, where plant traits exert an even stronger effect at low values of ET and PET and high values of VPD and LST. Leaf gas exchange traits are most important in comparison to the other traits, and these results also highlight that if water cycle process parameters achieve extreme values, plant traits are key to the persistence of hydrological processes fundamental to the resilience of the Amazon.
    Subject code 580
    Language English
    Publishing date 2024-01-29
    Publishing country de
    Document type Book ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  6. Article ; Online: Advancing Data Collection of Sexual Orientation and Gender Identity in Cardiology.

    Tran, Nguyen K / Rosendale, Nicole / Lunn, Mitchell R

    JAMA cardiology

    2024  Volume 9, Issue 3, Page(s) 206–208

    MeSH term(s) Female ; Humans ; Male ; Gender Identity ; Sexual Behavior ; Data Collection ; Cardiology ; Cardiovascular System
    Language English
    Publishing date 2024-01-24
    Publishing country United States
    Document type Journal Article
    ISSN 2380-6591
    ISSN (online) 2380-6591
    DOI 10.1001/jamacardio.2023.5264
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: Ichthyosis Skin Changes in a Patient With Hereditary Hemochromatosis.

    Arora, Neha / Nguyen, Kaycee / Hudson, Andrew / Bicknell, Lindsay

    Cureus

    2024  Volume 16, Issue 1, Page(s) e52823

    Abstract: Hereditary hemochromatosis (HH) is characterized by elevated iron absorption in the body, leading to iron accumulation with subsequent dysfunction and end-organ damage. While the progression of the disease can result in arthralgias, hepatomegaly, ... ...

    Abstract Hereditary hemochromatosis (HH) is characterized by elevated iron absorption in the body, leading to iron accumulation with subsequent dysfunction and end-organ damage. While the progression of the disease can result in arthralgias, hepatomegaly, cardiomyopathies, and diabetes, over a third of HH patients present with cutaneous manifestations. We present the case of a 56-year-old male with HH who presented to dermatology with a rash and diffuse scaling. The patient exhibited brown plate-like scales clinically consistent with diffuse ichthyosis vulgaris. While ichthyosis has been seen in patients with idiopathic hemochromatosis, its association with HH is not well reported. Due to the high prevalence of cutaneous involvement in hereditary hemochromatosis, physicians should familiarize themselves with ichthyosis and the other dermatologic manifestations of this disease.
    Language English
    Publishing date 2024-01-23
    Publishing country United States
    Document type Case Reports
    ZDB-ID 2747273-5
    ISSN 2168-8184
    ISSN 2168-8184
    DOI 10.7759/cureus.52823
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Hypertensive Emergency Team-Based Learning.

    Nguyen, Khoa / Shin, Jordan Gawon / Andrusaitis, Jessica

    Journal of education & teaching in emergency medicine

    2024  Volume 9, Issue 2, Page(s) T1–T39

    Abstract: Audience: The target audiences for this team-based learning (TBL) activity are resident physicians and medical students.: Introduction: According to the Centers for Disease Control and Prevention (CDC), nearly half of the adults in the United States ... ...

    Abstract Audience: The target audiences for this team-based learning (TBL) activity are resident physicians and medical students.
    Introduction: According to the Centers for Disease Control and Prevention (CDC), nearly half of the adults in the United States have hypertension,1 which is a leading cause of cardiovascular disease and premature death.2 In extreme cases, patients may present in hypertensive emergencies, defined as an acute, marked elevation of systolic blood pressure >180mmHg or diastolic blood pressure >120mmHg with evidence of organ dysfunction.3,4 Patients presenting to the emergency department (ED) with symptoms of hypertensive emergencies must be promptly diagnosed and treated to prevent further morbidity and mortality. This TBL utilizes four clinical cases to educate resident physicians and medical students not only on the recognition of hypertensive emergencies, but also on the workup, management, and disposition of patients who present to the ED with hypertension.
    Educational objectives: By the end of this TBL session, learners should be able to: 1) define features of asymptomatic hypertension versus hypertensive emergency, 2) discuss which patients with elevated blood pressure may require further diagnostic workup and intervention, 3) identify a differential diagnosis for patients presenting with elevated blood pressures, 4) recognize the features of different types of end-organ damage, 5) review an algorithm for the pharmacologic management of hypertensive emergencies, 6) indicate dosing and routes of various anti-hypertensive medications, 7) choose the appropriate treatment for a patient who is hypertensive and presenting with flash pulmonary edema, 8) identify an aortic dissection on computed tomography (CT), 9) choose the appropriate treatment for a patient who is hypertensive and presenting with an aortic dissection, 10) identify intracranial hemorrhage on CT, 11) choose the appropriate treatment for a patient who is hypertensive and presenting with an intracranial hemorrhage, and 12) describe the intervention for warfarin reversal.
    Educational methods: This is a classic TBL that includes an individual readiness assessment test (iRAT), a multiple-choice group readiness assessment test (gRAT), and a group application exercise (GAE).
    Research methods: Learners and instructors were given the opportunity to provide verbal feedback after completion of the TBL. Learners included senior medical students and first-, second-, and third-year emergency-medicine residents. Learners were specifically asked if they felt the cases were educational, relevant, and useful to their training.
    Results: Six resident physicians and three medical students volunteered their verbal feedback, and agreed when they were specifically asked if the cases were educational, relevant, and useful to their training. The same learners also agreed when asked if they felt the TBL was a more enjoyable activity than a direct lecture to refresh their knowledge and skills. One instructor observed that interns and medical students were generally able to reach a correct diagnosis; however, they seemed to struggle more with describing appropriate pharmacologic interventions when compared to more senior learners.
    Discussion: Hypertension is a common complaint and incidental finding in patients presenting to the ED. Given its non-specific value, it can be a difficult topic for the novice healthcare provider to master. The differential diagnosis for a patient presenting with hypertension is vast, ranging from benign to emergent, and can sometimes necessitate minimal to substantial workups. Thus, this TBL is a useful, relevant, and effective exercise for residents-in-training to review and understand the management of hypertension.
    Topics: Hypertension, hypertensive emergency, asymptomatic hypertension, flash pulmonary edema, aortic dissection, intracranial hemorrhage, warfarin reversal, team-based learning.
    Language English
    Publishing date 2024-04-30
    Publishing country United States
    Document type Journal Article
    ISSN 2474-1949
    ISSN (online) 2474-1949
    DOI 10.21980/J8BP90
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: Eye movements reveal age differences in how arousal modulates saliency priority but not attention processing speed.

    Kim, Andy Jeesu / Nguyen, Kristine / Mather, Mara

    bioRxiv : the preprint server for biology

    2024  

    Abstract: The arousal-biased competition theory posits that inducing arousal increases attentional priority of salient stimuli while reducing priority of non-pertinent stimuli. However, unlike in young adults, older adults rarely exhibit shifts in priority under ... ...

    Abstract The arousal-biased competition theory posits that inducing arousal increases attentional priority of salient stimuli while reducing priority of non-pertinent stimuli. However, unlike in young adults, older adults rarely exhibit shifts in priority under increased arousal, and prior studies have proposed different neural mechanisms to explain how arousal differentially modulates selective attention in older adults. Therefore, we investigated how the threat of unpredictable shock differentially modulates attentional control mechanisms in young and older adults by observing eye movements. Participants completed two oculomotor search tasks in which the salient distractor was typically captured by attention (singleton search) or proactively suppressed (feature search). We found that arousal did not modulate attentional priority for any stimulus among older adults nor affect the speed of attention processing in either age group. Furthermore, we observed that arousal modulated pupil sizes and found a correlation between evoked pupil responses and oculomotor function. Our findings suggest age differences in how the locus coeruleus-noradrenaline system interacts with neural networks of attention and oculomotor function.
    Language English
    Publishing date 2024-05-08
    Publishing country United States
    Document type Preprint
    DOI 10.1101/2024.05.06.592619
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: Pathophysiologie des Hustens

    Nguyen, K. / Dinh, C.P. / Dinh, Q.T.

    Atemwegs- und Lungenkrankheiten

    2023  Volume 49, Issue 6, Page(s) 244

    Language German
    Document type Article
    ZDB-ID 534006-8
    ISSN 0341-3055
    Database Current Contents Medicine

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