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Article ; Online: Serious Mental Illness, Glycemic Control, and Neighborhood Factors within an Urban Diabetes Cohort.

Iturralde, Esti / Rubinsky, Anna D / Nguyen, Kim H / Anderson, Chelsie / Lyles, Courtney R / Mangurian, Christina

2023 Volume 50, Issue 3, Page(s) 653–662

Abstract: Background and hypothesis: Serious mental illness (SMI) may compromise diabetes self-management. This study assessed the association between SMI and glycemic control, and explored sociodemographic predictors and geographic clustering of this outcome ... ...

Abstract	Background and hypothesis: Serious mental illness (SMI) may compromise diabetes self-management. This study assessed the association between SMI and glycemic control, and explored sociodemographic predictors and geographic clustering of this outcome among patients with and without SMI. Study design: We used electronic health record data for adult primary care patients with diabetes from 2 San Francisco health care delivery systems. The primary outcome was poor glycemic control (hemoglobin A1c >9.0%), which was modeled on SMI diagnosis status and sociodemographics. Geospatial analyses examined hotspots of poor glycemic control and neighborhood characteristics. Study results: The study included 11 694 participants with diabetes, 21% with comorbid SMI, of whom 22% had a schizophrenia spectrum or bipolar disorder. Median age was 62 years; 52% were female and 79% were Asian, Black, or Hispanic. In adjusted models, having schizophrenia spectrum disorder or bipolar disorder was associated with greater risk for poor glycemic control (vs participants without SMI, adjusted relative risk [aRR] = 1.24; 95% confidence interval, 1.02, 1.49), but having broadly defined SMI was not. People with and without SMI had similar sociodemographic correlates of poor glycemic control including younger versus older age, Hispanic versus non-Hispanic White race/ethnicity, and English versus Chinese language preference. Hotspots for poor glycemic control were found in neighborhoods with more lower-income, Hispanic, and Black residents. Conclusions: Poor diabetes control was significantly related to having a schizophrenia spectrum or bipolar disorder, and to sociodemographic factors and neighborhood. Community-based mental health clinics in hotspots could be targets for implementation of diabetes management services.
MeSH term(s)	Humans ; Female ; Male ; Middle Aged ; Schizophrenia/epidemiology ; Aged ; Residence Characteristics/statistics & numerical data ; Urban Population/statistics & numerical data ; Glycemic Control/statistics & numerical data ; Adult ; San Francisco/epidemiology ; Bipolar Disorder/epidemiology ; Comorbidity ; Diabetes Mellitus/epidemiology ; Glycated Hemoglobin/metabolism ; Cohort Studies
Chemical Substances	Glycated Hemoglobin
Language	English
Publishing date	2023-08-15
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	439173-1
ISSN	1745-1701 ; 0586-7614
ISSN (online)	1745-1701
ISSN	0586-7614
DOI	10.1093/schbul/sbad122
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Article ; Online: Acceptability and Usability of a Wearable Device for Sleep Health Among English- and Spanish-Speaking Patients in a Safety Net Clinic: Qualitative Analysis.

Purnell, Larissa / Sierra, Maribel / Lisker, Sarah / Lim, Melissa S / Bailey, Emma / Sarkar, Urmimala / Lyles, Courtney R / Nguyen, Kim H

JMIR formative research

2023 Volume 7, Page(s) e43067

Abstract: Background: Sleep disorders are common and disproportionately affect marginalized populations. Technology, such as wearable devices, holds the potential to improve sleep quality and reduce sleep disparities, but most devices have not been designed or ... ...

Abstract	Background: Sleep disorders are common and disproportionately affect marginalized populations. Technology, such as wearable devices, holds the potential to improve sleep quality and reduce sleep disparities, but most devices have not been designed or tested with racially, ethnically, and socioeconomically diverse patients. Inclusion and engagement of diverse patients throughout digital health development and implementation are critical to achieving health equity. Objective: This study aims to evaluate the usability and acceptability of a wearable sleep monitoring device-SomnoRing-and its accompanying mobile app among patients treated in a safety net clinic. Methods: The study team recruited English- and Spanish-speaking patients from a mid-sized pulmonary and sleep medicine practice serving publicly insured patients. Eligibility criteria included initial evaluation of obstructed sleep apnea, which is most appropriate for limited cardiopulmonary testing. Patients with primary insomnia or other suspected sleep disorders were not included. Patients tested the SomnoRing over a 7-night period and participated in a 1-hour semistructured web-based qualitative interview covering perceptions of the device, motivators and barriers to use, and general experiences with digital health tools. The study team used inductive or deductive processes to code interview transcripts, guided by the Technology Acceptance Model. Results: A total of 21 individuals participated in the study. All participants owned a smartphone, almost all (19/21) felt comfortable using their phone, and few already owned a wearable (6/21). Almost all participants wore the SomnoRing for 7 nights and found it comfortable. The following four themes emerged from qualitative data: (1) the SomnoRing was easy to use compared to other wearable devices or traditional home sleep testing alternatives, such as the standard polysomnogram technology for sleep studies; (2) the patient's context and environment, such as family and peer influence, housing status, access to insurance, and device cost affected the overall acceptance of the SomnoRing; (3) clinical champions motivated use in supporting effective onboarding, interpretation of data, and, ongoing technical support; and (4) participants desired more assistance and information to best interpret their own sleep data summarized in the companion app. Conclusions: Racially, ethnically, and socioeconomically diverse patients with sleep disorders perceived a wearable as useful and acceptable for sleep health. Participants also uncovered external barriers related to the perceived usefulness of the technology, such as housing status, insurance coverage, and clinical support. Future studies should further examine how to best address these barriers so that wearables, such as the SomnoRing, can be successfully implemented in the safety net health setting.
Language	English
Publishing date	2023-06-05
Publishing country	Canada
Document type	Journal Article
ISSN	2561-326X
ISSN (online)	2561-326X
DOI	10.2196/43067
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Article ; Online: Transferring Racial/Ethnic Marketing Strategies From Tobacco to Food Corporations: Philip Morris and Kraft General Foods.

Nguyen, Kim H / Glantz, Stanton A / Palmer, Casey N / Schmidt, Laura A

American journal of public health

2020 Volume 110, Issue 3, Page(s) 329–336

Abstract: Objectives. ...

Abstract	Objectives.
MeSH term(s)	Ethnic Groups ; Food Industry/history ; Food Industry/methods ; Food Industry/organization & administration ; History, 20th Century ; History, 21st Century ; Humans ; Marketing/economics ; Marketing/history ; Marketing/methods ; Mass Media ; Minority Groups ; Tobacco Industry/history ; Tobacco Industry/methods ; Tobacco Industry/organization & administration ; United States
Language	English
Publishing date	2020-01-16
Publishing country	United States
Document type	Historical Article ; Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	121100-6
ISSN	1541-0048 ; 0090-0036 ; 0002-9572
ISSN (online)	1541-0048
ISSN	0090-0036 ; 0002-9572
DOI	10.2105/AJPH.2019.305482
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Article ; Online: Barriers and Facilitators to the Implementation of Virtual Reality as a Pain Management Modality in Academic, Community, and Safety-Net Settings: Qualitative Analysis.

Sarkar, Urmimala / Lee, Jane E / Nguyen, Kim H / Lisker, Sarah / Lyles, Courtney R

Journal of medical Internet research

2021 Volume 23, Issue 9, Page(s) e26623

Abstract: Background: Prior studies have shown that virtual reality (VR) is an efficacious treatment modality for opioid-sparing pain management. However, the majority of these studies were conducted among primarily White, relatively advantaged populations and in ...

Abstract	Background: Prior studies have shown that virtual reality (VR) is an efficacious treatment modality for opioid-sparing pain management. However, the majority of these studies were conducted among primarily White, relatively advantaged populations and in well-resourced settings. Objective: We conducted a qualitative, theory-informed implementation science study to assess the readiness for VR in safety-net settings. Methods: Using the theoretical lens of the Consolidated Framework for Implementation Research (CFIR) framework, we conducted semistructured interviews with current VR users and nonusers based in safety-net health systems (n=15). We investigated barriers and facilitators to a commercially available, previously validated VR technology platform AppliedVR (Los Angeles, CA, USA). We used deductive qualitative analysis using the overarching domains of the CFIR framework and performed open, inductive coding to identify specific themes within each domain. Results: Interviewees deemed the VR intervention to be useful, scalable, and an appealing alternative to existing pain management approaches. Both users and nonusers identified a lack of reimbursement for VR as a significant challenge for adoption. Current users cited positive patient feedback, but safety-net stakeholders voiced concern that existing VR content may not be relevant or appealing to diverse patients. All respondents acknowledged the challenge of integrating and maintaining VR in current pain management workflows across a range of clinical settings, and this adoption challenge was particularly acute, given resource and staffing constraints in safety-net settings. Conclusions: VR for pain management holds interest for frontline pain management clinicians and leadership in safety-net health settings but will require significant tailoring and adaption to address the needs of diverse populations. Integration into complex workflows for pain management is a significant barrier to adoption, and participants cited structural cost and reimbursement concerns as impediments to initial implementation and scaling of VR use.
MeSH term(s)	Analgesics, Opioid ; Humans ; Implementation Science ; Pain Management ; Virtual Reality
Chemical Substances	Analgesics, Opioid
Language	English
Publishing date	2021-09-22
Publishing country	Canada
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, U.S. Gov't, Non-P.H.S.
ZDB-ID	2028830-X
ISSN	1438-8871 ; 1439-4456
ISSN (online)	1438-8871
ISSN	1439-4456
DOI	10.2196/26623
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Article ; Online: COVID salivary diagnostics: A comparative technical study.

Nguyen-Kim, Hanh / Beckmann, Christiane / Redondo, Maurice / Ziliox, Jérémy / Vallet, Virginie / Berger-Sturm, Karin / Overbeck, Jan Von / Alberi Auber, Lavinia

Journal of medical virology

2022 Volume 94, Issue 9, Page(s) 4277–4286

Abstract: Since the beginning of the coronavirus disease 2019 (COVID-19) pandemic, molecular diagnostics of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) have taken center stage in the detection of infected individuals for isolation purposes but ... ...

Abstract	Since the beginning of the coronavirus disease 2019 (COVID-19) pandemic, molecular diagnostics of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) have taken center stage in the detection of infected individuals for isolation purposes but also in the mass surveillance as a preventive strategy to contain the virus spread. While nasopharyngeal swabs (NPS) have remained the golden standard substrate, salivary diagnostic for SARS-CoV-2 has been proposed as an alternative and noninvasive measure in vulnerable individuals. Nevertheless, there is a widespread assumption that salivary reverse-transcription polymerase chain reaction (RT-PCR) does not match the quality of testing using NPS and particular care should be taken in respect to food or beverage intake, when sampling saliva. Our study indicates that without any precaution in the selection of 190 patients, nor restriction over the time window of sampling, there is 99% match in the COVID-19 positivity between NPS and saliva when using RT-PCR, with a reported Delta in thermal cycles (Cts) values for the viral genes Envelope (E) and Open reading frame 1ab (Orf1ab) between 0 and 2, a 98.7% sensitivity and 100% specificity. This high accuracy is maintained in pooling configurations that can be used for mass-testing purposes in professional and educational settings. The further advantage to using crude saliva as compared to NPS or mouthwash is that direct methods yield robust results. Overall, our study validates and promotes the use of salivary diagnostic for COVID-19 eliminating the need of a medical practitioner for the sampling, resolving the unpleasantness of the NPS intervention and empowering the patient to do self-testing in times of need.
MeSH term(s)	COVID-19/diagnosis ; COVID-19 Testing ; Humans ; Nasopharynx ; Pandemics ; RNA, Viral/genetics ; SARS-CoV-2/genetics ; Saliva ; Specimen Handling/methods
Chemical Substances	RNA, Viral
Language	English
Publishing date	2022-06-02
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	752392-0
ISSN	1096-9071 ; 0146-6615
ISSN (online)	1096-9071
ISSN	0146-6615
DOI	10.1002/jmv.27883
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Article ; Online: Tobacco industry involvement in children's sugary drinks market.

Nguyen, Kim H / Glantz, Stanton A / Palmer, Casey N / Schmidt, Laura A

BMJ (Clinical research ed.)

2019 Volume 364, Page(s) l736

MeSH term(s)	Beverages/analysis ; Beverages/history ; Child ; Dietary Sucrose/administration & dosage ; Food Industry/history ; History, 20th Century ; History, 21st Century ; Humans ; Marketing/history ; Marketing/methods ; Public Health/history ; Tobacco Industry/history ; United States
Chemical Substances	Dietary Sucrose
Language	English
Publishing date	2019-03-14
Publishing country	England
Document type	Historical Article ; Journal Article
ZDB-ID	1362901-3
ISSN	1756-1833 ; 0959-8154 ; 0959-8146 ; 0959-8138 ; 0959-535X ; 1759-2151
ISSN (online)	1756-1833
ISSN	0959-8154 ; 0959-8146 ; 0959-8138 ; 0959-535X ; 1759-2151
DOI	10.1136/bmj.l736
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Article: Assessing Alignment of Patient and Clinician Perspectives on Community Health Resources for Chronic Disease Management.

Potharaju, Kameswari A / Fields, Jessica D / Cemballi, Anupama G / Pantell, Matthew S / Desai, Riya / Akom, Antwi / Shah, Aekta / Cruz, Tessa / Nguyen, Kim H / Lyles, Courtney R

Healthcare (Basel, Switzerland)

2022 Volume 10, Issue 10

Abstract: Addressing social determinants of health (SDoH) is associated with improved clinical outcomes for patients with chronic diseases in safety-net settings. This qualitative study supplemented by descriptive quantitative analysis investigates the degree of ... ...

Abstract	Addressing social determinants of health (SDoH) is associated with improved clinical outcomes for patients with chronic diseases in safety-net settings. This qualitative study supplemented by descriptive quantitative analysis investigates the degree of alignment between patient and clinicians’ perceptions of SDoH resources and referrals in clinics within the public healthcare delivery system in San Francisco. We conducted a qualitative analysis of in-depth interviews, patient-led neighborhood tours, and in-person clinic visit observations with 10 patients and 7 primary care clinicians. Using a convergent parallel mixed methodology, we also completed a descriptive quantitative analysis comparing the categories of neighborhood health resources mentioned by patients or community leaders to the resources integrated into the electronic health record. We found that patients held a wealth of knowledge about neighborhood resources relevant to SDoH that were highly localized and specific to their communities. In addition, multiple stakeholders were involved in conducting SDoH screenings and referrals, including clinicians, system navigators such as case workers, and community-based organizations. Yet, the information flow between these stakeholders and patients lacked systematization, and the prioritization of social needs by patients and clinicians was misaligned, as represented by qualitative themes as well as quantitative differences in resource category distribution analysis (p < 0.001). Our results shed light upon opportunities for strengthening social care delivery in safety-net healthcare settings by improving patient engagement, clinic workflow, EHR engagement, and resource dissemination.
Language	English
Publishing date	2022-10-12
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2721009-1
ISSN	2227-9032
ISSN	2227-9032
DOI	10.3390/healthcare10102006
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Article ; Online: The Cell Wall PAC (Proline-Rich, Arabinogalactan Proteins, Conserved Cysteines) Domain-Proteins Are Conserved in the Green Lineage.

Nguyen-Kim, Huan / San Clemente, Hélène / Laimer, Josef / Lackner, Peter / Gadermaier, Gabriele / Dunand, Christophe / Jamet, Elisabeth

International journal of molecular sciences

2020 Volume 21, Issue 7

Abstract: Plant cell wall proteins play major roles during plant development and in response to environmental cues. A bioinformatic search for functional domains has allowed identifying the PAC domain (Proline-rich, Arabinogalactan proteins, conserved Cysteines) ... ...

Abstract	Plant cell wall proteins play major roles during plant development and in response to environmental cues. A bioinformatic search for functional domains has allowed identifying the PAC domain (Proline-rich, Arabinogalactan proteins, conserved Cysteines) in several proteins (PDPs) identified in cell wall proteomes. This domain is assumed to interact with pectic polysaccharides and
MeSH term(s)	Cell Wall/metabolism ; Computational Biology/methods ; Conserved Sequence ; Cysteine/metabolism ; Databases, Protein ; Evolution, Molecular ; Models, Molecular ; Mucoproteins/metabolism ; Phylogeny ; Plant Proteins/chemistry ; Plant Proteins/metabolism ; Plants/metabolism ; Proline/metabolism ; Protein Domains ; Protein Folding ; Protein Structure, Secondary
Chemical Substances	Mucoproteins ; Plant Proteins ; arabinogalactan proteins ; Proline (9DLQ4CIU6V) ; Cysteine (K848JZ4886)
Language	English
Publishing date	2020-04-03
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms21072488
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Article ; Online: Impact of a cancer education seminar on knowledge and screening intent among Chinese Americans: Results from a randomized, controlled, community-based trial.

Fung, Lei-Chun / Nguyen, Kim H / Stewart, Susan L / Chen, Moon S / Tong, Elisa K

Cancer

2018 Volume 124 Suppl 7, Page(s) 1622–1630

Abstract: Background: Cancer is the leading cause of death for Asian Americans. The authors evaluated the status of cancer prevention for Chinese Americans in San Francisco, which has had years of cancer prevention efforts.: Methods: Through a community-based ... ...

Abstract	Background: Cancer is the leading cause of death for Asian Americans. The authors evaluated the status of cancer prevention for Chinese Americans in San Francisco, which has had years of cancer prevention efforts. Methods: Through a community-based clinic serving Chinese Americans, a randomized, controlled trial (n = 395) was conducted among participants who attended either a cancer prevention seminar or biospecimen education seminar. Changes in knowledge, attitudes, and screening completion/intent were measured across and between seminar groups. Results: Participants were mostly women who had low acculturation and education levels. Over two-thirds to almost all participants knew about modifiable risk factors for cancer and that screening tests were available, including for lung cancer. The majority of women had already completed mammography and Papanicolaou (Pap) tests. Approximately one-half reported having completed colorectal cancer screening, prostate screening, or hepatitis B screening. Most were nonsmokers, but about one-half "strongly agreed" that they would want a test for tobacco smoke exposure. After the cancer prevention seminar, significant increases within group were noted for knowledge (eating healthy foods, from 93.1% to 97.7% [P = .0002]; secondhand smoke causes cancer, from 66.3% to 74.8% [P = .04]) and for screening completion/intent (colorectal cancer, from 58.1% to 64.5% [P = .002] cervical cancer, from 72.9% to 75.5% [P = .04]) and there was a trend toward an increase for prostate cancer (from 50.0% to 61.1%; P = .10). There was a significant change between groups for eating healthy foods (P = .004). Conclusions: The current reports documents the gains in cancer prevention among Cantonese-speaking Chinese Americans, fostered by academic, community, and public health efforts. A community-based seminar demonstrated improvement in some cancer knowledge or screening intent and opportunities for continued efforts. Cancer 2018;124:1622-30. © 2018 American Cancer Society.
MeSH term(s)	Aged ; Asian Americans/psychology ; Asian Americans/statistics & numerical data ; Community-Based Participatory Research ; Early Detection of Cancer/psychology ; Early Detection of Cancer/statistics & numerical data ; Female ; Health Education ; Health Knowledge, Attitudes, Practice ; Humans ; Male ; Neoplasms/diagnosis ; Neoplasms/prevention & control ; Neoplasms/psychology ; Pilot Projects ; Prognosis ; San Francisco
Language	English
Publishing date	2018-03-26
Publishing country	United States
Document type	Journal Article ; Randomized Controlled Trial ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	1429-1
ISSN	1097-0142 ; 0008-543X ; 1934-662X
ISSN (online)	1097-0142
ISSN	0008-543X ; 1934-662X
DOI	10.1002/cncr.31111
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Article: Antibiotic use in Vietnamese fish and lobster sea cage farms; implications for coral reefs and human health

Hedberg, N / Stenson, I / Nitz Pettersson, M / Warshan, D / Nguyen-Kim, H / Tedengren, M / Kautsky, N

Aquaculture. 2018 Oct. 01, v. 495

2018

Abstract: Several papers have reported on the development of antibiotic resistance and implications for human medicine but fewer deal with environmental impacts of antibiotic use. Marine sea cage aquaculture in SE Asia is often established close to coral reef ... ...

Abstract	Several papers have reported on the development of antibiotic resistance and implications for human medicine but fewer deal with environmental impacts of antibiotic use. Marine sea cage aquaculture in SE Asia is often established close to coral reef ecosystems. Large amounts of antibiotics are used in the cultivation of fish and lobster and hence released directly into the environment.This study investigates the antibiotic practices in sea cage farms producing fish and spiny lobster in Vietnam, mainly for the domestic market. There are approximately 3500 sea cage farms in Vietnam and we performed semi-structured interviews with 109 sea cage farmers asking them if they use antibiotics and if so; what sort/when/how often/how much.We found that the Vietnamese cage farmers are using antibiotics in an unstructured way, which seems to have little or no effect on the survival of the stock, or profit of the farm. The fact that the farmers live at their farm and use the sea next to the cages both for fishing and collecting filter-feeding bivalves for direct consumption, as well as a toilet, poses an additional risk for the spreading of human antibiotic resistant pathogens. Thirteen different antibiotics were found in the study. Eighty-two percentage of the lobster farmers and 28% of the fishfarmers used antibiotics. The average amounts used were over 5 kg per produced ton of lobster and about 0.6 kg per ton of fish, which is much higher than in other studies. Several antibiotic substances listed as “critical” and “highly important” for human medicine by WHO were used prophylactically and routinely with little control and enforcement of regulations.We tested and detected antibiotic resistance to Tetracycline, Vancomycin and Rifampicin in the coral associated bacteria Bacillus niabensis as far as 660 m from fish farms with resistance decreasing with distance from the cage farms. The antibiotics are likely to have negative effects on the coral-symbiont relationship adding further risks to an already stressed environment.
Keywords	Bivalvia ; World Health Organization ; antibiotic resistance ; cage culture ; cages ; coral reefs ; corals ; domestic markets ; ecosystems ; environmental impact ; farmers ; farms ; fish ; human health ; humans ; interviews ; lobsters ; medicine ; pathogens ; rifampicin ; risk ; vancomycin ; Vietnam
Language	English
Dates of publication	2018-1001
Size	p. 366-375.
Publishing place	Elsevier B.V.
Document type	Article
ZDB-ID	185380-6
ISSN	0044-8486 ; 0044-8516
ISSN	0044-8486 ; 0044-8516
DOI	10.1016/j.aquaculture.2018.06.005
Database	NAL-Catalogue (AGRICOLA)

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