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  1. Article ; Online: Two new antidiabetic xanthones from the twigs of Garcinia oblongifolia

    Bui, Dzung N. / Nguyen, Ly T. T. / Nguyen, Le-Thu T. / Ngo, Ngoc T. N. / Tran, Phuong T. / Nguyen, Hieu T. / Dang, Linh T. N. / Nguyen, Lien-Hoa D. / Trinh, Binh T. D.

    Natural Product Research. 2023 Aug. 3, v. 37, no. 15 p.2541-2550

    2023  

    Abstract: Two new xanthones, oblongixanthones I (1) and J (2), and seven known compounds (3–9), were isolated from an EtOAc extract of the twigs of Garcinia oblongifolia. Their structures were elucidated using spectroscopic methods, mainly 1 D and 2 D NMR. The ... ...

    Abstract Two new xanthones, oblongixanthones I (1) and J (2), and seven known compounds (3–9), were isolated from an EtOAc extract of the twigs of Garcinia oblongifolia. Their structures were elucidated using spectroscopic methods, mainly 1 D and 2 D NMR. The antidiabetic effects of the two new compounds were evaluated using α-glucosidase and PTP1B inhibition assays. Both compounds displayed strong inhibition towards α-glucosidase with IC₅₀ values of 258.7 ± 49.3 and 187.1 ± 27.5 μM, respectively (compared with acarbose, IC₅₀ = 900.0 ± 3.0 μM) and moderate effects against PTP1B with IC₅₀ values of 93.9 ± 12.3 and 64.1 ± 5.8 μM, respectively (compared with RK682, IC₅₀ = 4.4 ± 0.3 l μM).
    Keywords Garcinia ; acarbose ; ethyl acetate ; research ; spectroscopy ; xanthones ; Type 2 diabetes ; α-glucosidase ; PTP1B ; Garcinia oblongifolia
    Language English
    Dates of publication 2023-0803
    Size p. 2541-2550.
    Publishing place Taylor & Francis
    Document type Article ; Online
    ZDB-ID 2185747-7
    ISSN 1478-6427 ; 1478-6419
    ISSN (online) 1478-6427
    ISSN 1478-6419
    DOI 10.1080/14786419.2022.2055016
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  2. Article ; Online: Triterpenoids from the bark of Entandrophragma angolense

    Trinh, Binh T. D. / Bui, Dzung N. / Nguyen, Ly T. T. / Nguyen, Hieu T. / Nguyen, Chi N. / Nguyen, Lien-Hoa D. / Huynh, Tuyen N. M. / Cao, Tien T. C. / Nguyen, Le-Thu T.

    Natural Product Research. 2023 Jan. 17, v. 37, no. 2 p.240-247

    2023  

    Abstract: Two new triterpenoids, entanolide (1) and methyl 3,4-secotirucalla-23-oxo-4(28),7,24-trien-21-al-3-oate (2), together with nine known compounds (3-11), were isolated from the bark of Entandrophragma angolense. Their structures were elucidated based on ... ...

    Abstract Two new triterpenoids, entanolide (1) and methyl 3,4-secotirucalla-23-oxo-4(28),7,24-trien-21-al-3-oate (2), together with nine known compounds (3-11), were isolated from the bark of Entandrophragma angolense. Their structures were elucidated based on spectroscopic analyses, mainly 1 D and 2 D NMR spectral data. Compounds 1-6 and 8 were evaluated for their cytotoxicity against HepG2 cells, and compounds 2-5 exhibited weak activities.
    Keywords Entandrophragma angolense ; bark ; cytotoxicity ; research ; spectral analysis ; spectroscopy ; triterpenoids ; Meliaceae
    Language English
    Dates of publication 2023-0117
    Size p. 240-247.
    Publishing place Taylor & Francis
    Document type Article ; Online
    ZDB-ID 2185747-7
    ISSN 1478-6427 ; 1478-6419
    ISSN (online) 1478-6427
    ISSN 1478-6419
    DOI 10.1080/14786419.2021.1961253
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  3. Article ; Online: In vitro and in silico antioxidant and α-glucosidase inhibitory potential of compounds isolated from

    Nguyen, Le-Thu T / Dinh, Chau-Phi / Nguyen, Phuong T D / To, Huong T / Nguyen, Dieu K A / Trinh, Duong H / Ngo, Ngoc T N / Nguyen, Ly T T / Nguyen, Thanh-Nhan / Nguyen, Lien-Hoa D / Trinh, Binh T D

    Natural product research

    2022  Volume 37, Issue 5, Page(s) 750–758

    Abstract: Nine compounds including a new one, garcichaudiic acid ( ...

    Abstract Nine compounds including a new one, garcichaudiic acid (
    MeSH term(s) Antioxidants/chemistry ; alpha-Glucosidases/metabolism ; Glycoside Hydrolase Inhibitors/chemistry ; Molecular Docking Simulation ; Garcinia/chemistry
    Chemical Substances Antioxidants ; alpha-Glucosidases (EC 3.2.1.20) ; Glycoside Hydrolase Inhibitors
    Language English
    Publishing date 2022-06-21
    Publishing country England
    Document type Journal Article
    ZDB-ID 2185747-7
    ISSN 1478-6427 ; 1478-6419
    ISSN (online) 1478-6427
    ISSN 1478-6419
    DOI 10.1080/14786419.2022.2089985
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Two new antidiabetic xanthones from the twigs of

    Bui, Dzung N / Nguyen, Ly T T / Nguyen, Le-Thu T / Ngo, Ngoc T N / Tran, Phuong T / Nguyen, Hieu T / Dang, Linh T N / Nguyen, Lien-Hoa D / Trinh, Binh T D

    Natural product research

    2022  Volume 37, Issue 15, Page(s) 2541–2550

    Abstract: Two new xanthones, oblongixanthones I ( ...

    Abstract Two new xanthones, oblongixanthones I (
    MeSH term(s) Xanthones/chemistry ; Xanthones/pharmacology ; Hypoglycemic Agents/chemistry ; Hypoglycemic Agents/pharmacology ; Molecular Structure ; Garcinia/chemistry ; alpha-Glucosidases/metabolism
    Chemical Substances Xanthones ; Hypoglycemic Agents ; alpha-Glucosidases (EC 3.2.1.20)
    Language English
    Publishing date 2022-03-25
    Publishing country England
    Document type Journal Article
    ZDB-ID 2185747-7
    ISSN 1478-6427 ; 1478-6419
    ISSN (online) 1478-6427
    ISSN 1478-6419
    DOI 10.1080/14786419.2022.2055016
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: In vitro and in silico antioxidant and α-glucosidase inhibitory potential of compounds isolated from Garcinia gaudichaudii

    Nguyen, Le-Thu T. / Dinh, Chau-Phi / Nguyen, Phuong T. D. / To, Huong T. / Nguyen, Dieu K. A. / Trinh, Duong H. / Ngo, Ngoc T. N. / Nguyen, Ly T. T. / Nguyễn, Thanh Nhân / Nguyen, Lien-Hoa D. / Trinh, Binh T. D.

    Natural Product Research. 2023 Mar. 4, v. 37, no. 5 p.750-758

    2023  

    Abstract: Nine compounds including a new one, garcichaudiic acid (1), were isolated from the bark of G. gaudichaudii and their structures were characterized mainly by 1 D and 2 D NMR experiments. The antioxidant capacity of the isolated compounds was determined ... ...

    Abstract Nine compounds including a new one, garcichaudiic acid (1), were isolated from the bark of G. gaudichaudii and their structures were characterized mainly by 1 D and 2 D NMR experiments. The antioxidant capacity of the isolated compounds was determined using DPPH radical scavenging assay and the anti-hyperglycemic activity was assessed by measuring the inhibitory effect against α-glucosidase. Among them, compound 4 showed higher antioxidant activity than the positive control, ascorbic acid, while both compounds 1 and 7 exhibited more significant α-glucosidase inhibitory activity than the reference drug acarbose. Molecular docking analysis of the bioactive compounds was also performed to examine the binding modes and key interactions with the catalytic site.
    Keywords Garcinia ; acarbose ; active sites ; antioxidant activity ; antioxidants ; ascorbic acid ; bark ; computer simulation ; drugs ; glycemic effect ; research ; Diabetes ; antioxidant ; α-glucosidase ; garcichaudiic acid ; Garcinia gaudichaudii
    Language English
    Dates of publication 2023-0304
    Size p. 750-758.
    Publishing place Taylor & Francis
    Document type Article ; Online
    ZDB-ID 2185747-7
    ISSN 1478-6427 ; 1478-6419
    ISSN (online) 1478-6427
    ISSN 1478-6419
    DOI 10.1080/14786419.2022.2089985
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  6. Article: Antioxidant and Antimicrobial Activities of the Extracts from Different

    Nguyen, Nguyen Hoai / Nguyen, Minh Tan / Nguyen, Hiep Dinh / Pham, Phuoc Dien / Thach, Ut Dong / Trinh, Binh T D / Nguyen, Ly T T / Dang, Son V / Do, Anh Thu / Do, Bich Hang

    Evidence-based complementary and alternative medicine : eCAM

    2021  Volume 2021, Page(s) 5542938

    Abstract: Background: Garcinia: Aim: To determine the antioxidant and antimicrobial capabilities of the extracts from different : Results: Many : Conclusion: Several extracts ... ...

    Abstract Background: Garcinia
    Aim: To determine the antioxidant and antimicrobial capabilities of the extracts from different
    Results: Many
    Conclusion: Several extracts of
    Language English
    Publishing date 2021-06-18
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2171158-6
    ISSN 1741-4288 ; 1741-427X
    ISSN (online) 1741-4288
    ISSN 1741-427X
    DOI 10.1155/2021/5542938
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5995: Show issues Location:
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  7. Article ; Online: Triterpenoids from the bark of

    Trinh, Binh T D / Bui, Dzung N / Nguyen, Ly T T / Nguyen, Hieu T / Nguyen, Chi N / Nguyen, Lien-Hoa D / Huynh, Tuyen N M / Cao, Tien T C / Nguyen, Le-Thu T

    Natural product research

    2021  , Page(s) 1–8

    Abstract: Two new triterpenoids, entanolide ( ...

    Abstract Two new triterpenoids, entanolide (
    Language English
    Publishing date 2021-08-05
    Publishing country England
    Document type Journal Article
    ZDB-ID 2185747-7
    ISSN 1478-6427 ; 1478-6419
    ISSN (online) 1478-6427
    ISSN 1478-6419
    DOI 10.1080/14786419.2021.1961253
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: Three labdane diterpenoids from the aerial parts of Leonurus japonicus

    Nguyen, Ly T.T / Tran, Phuong T / Bui, Dzung N / Nguyen, Hieu T / Trinh, Binh T.D / Ngo, Ngoc T.N / Nguyen, Le-Thu T / Nguyen, Lien-Hoa D

    Phytochemical Society of Europe Phytochemistry letters. 2021 Aug., v. 44

    2021  

    Abstract: Three undescribed labdane diterpenoids, 15,16-epoxy-13,15-dihydroxylabd-8-ene-7-one (1), 15,16-epoxy-13-hydroxy-15-methoxylabd-8-ene-7-one (2) and 15-hydroxyleoheteronin B (3), along with eight known compounds, were isolated from an ethyl acetate extract ...

    Abstract Three undescribed labdane diterpenoids, 15,16-epoxy-13,15-dihydroxylabd-8-ene-7-one (1), 15,16-epoxy-13-hydroxy-15-methoxylabd-8-ene-7-one (2) and 15-hydroxyleoheteronin B (3), along with eight known compounds, were isolated from an ethyl acetate extract of Leonurus japonicus. Their structures were elucidated using spectroscopic methods, mainly 1-D and 2-D NMR. Compound 1 showed the strongest cytotoxic activity against MCF-7 cells with IC₅₀ values of 26.8 μM, using the sulforhodamine B assay.
    Keywords Leonurus japonicus ; cytotoxicity ; ethyl acetate ; labdane ; plant biochemistry
    Language English
    Dates of publication 2021-08
    Size p. 82-86.
    Publishing place Elsevier Ltd
    Document type Article
    ISSN 1874-3900
    DOI 10.1016/j.phytol.2021.06.003
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  9. Article: Labdane and norlabdane diterpenoids from the aerial parts of Leonurus japonicus

    Nguyen, Ly T.T / Huong K.T. Vo / Le-Thu T. Nguyen / Lien-Hoa D. Nguyen / Ly D. Ha / Son V. Dang / Tho H. Le

    Phytochemical Society of Europe Phytochemistry letters. 2017 Dec., v. 22

    2017  

    Abstract: A new labdane diterpenoid, leojaponicin (1), a novel norlabdane, methyl 15,16-dinor-7-oxolabda-8-ene-14-oate (2), along with four known labdanes, hispanone (3), leoheteronins A (4) and B (5), 15-methoxyleoheteronin B (6), and three norlabdanes, 14,15,16- ... ...

    Abstract A new labdane diterpenoid, leojaponicin (1), a novel norlabdane, methyl 15,16-dinor-7-oxolabda-8-ene-14-oate (2), along with four known labdanes, hispanone (3), leoheteronins A (4) and B (5), 15-methoxyleoheteronin B (6), and three norlabdanes, 14,15,16-trinor-7-oxolabda-8-ene-13-oic acid (7), methyl 14,15,16-trinor-7-oxolabda-8-ene-13-oate (8), 14,15-dinor-8-labdene-7,13-dione (9), and a steroid, stigmast-4-ene-3-one (10), were isolated from a hexane extract of Leonurus japonicus. Their structures were determined using spectroscopic methods, mainly 1-D and 2-D NMR. Compounds 7 and 8 were previously semisynthesized but are reported here for the first time as naturally occurring compounds. In addition, α-glucosidase inhibitory activity of the isolated compounds was evaluated and compound 6 exhibited the strongest effect with IC50 value of 26.7μM (compared with the positive control acarbose, IC50=214.5μM).
    Keywords acarbose ; aerial parts ; alpha-glucosidase ; hexane ; inhibitory concentration 50 ; labdane ; Leonurus japonicus ; nuclear magnetic resonance spectroscopy
    Language English
    Dates of publication 2017-12
    Size p. 174-178.
    Publishing place Elsevier Ltd
    Document type Article
    ISSN 1874-3900
    DOI 10.1016/j.phytol.2017.09.023
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  10. Article ; Online: Cytotoxic limonoids from the bark of Walsura cochinchinensis.

    Trinh, Binh T D / Nguyen, Hiep D / Nguyen, Hieu T / Pham, Phuoc D / Ngo, Ngoc T N / Nguyen, Le-Thu T / Nguyen, Ly T T / Bui, Dzung N / Dang, Son V / Nguyen, Lien-Hoa D

    Fitoterapia

    2018  Volume 133, Page(s) 75–79

    Abstract: Three new limonoids, walsucochinones A-C (1-3), along with eight known compounds, were isolated from an ethyl acetate extract of the bark of Walsura cochinchinensis. Their structures were determined using spectroscopic techniques, mainly 1-D and 2-D NMR. ...

    Abstract Three new limonoids, walsucochinones A-C (1-3), along with eight known compounds, were isolated from an ethyl acetate extract of the bark of Walsura cochinchinensis. Their structures were determined using spectroscopic techniques, mainly 1-D and 2-D NMR. The ethyl acetate extract showed cytotoxic activity against MCF-7 human breast cancer cells and cytotoxicity of the isolated compounds were evaluated in vitro using the SRB assay. Walsucochinone C (3) exhibited the most active effect with IC
    MeSH term(s) Antineoplastic Agents, Phytogenic/isolation & purification ; Antineoplastic Agents, Phytogenic/pharmacology ; Humans ; Inhibitory Concentration 50 ; Limonins/isolation & purification ; Limonins/pharmacology ; MCF-7 Cells ; Meliaceae/chemistry ; Molecular Structure ; Phytochemicals/isolation & purification ; Phytochemicals/pharmacology ; Plant Bark/chemistry ; Vietnam
    Chemical Substances Antineoplastic Agents, Phytogenic ; Limonins ; Phytochemicals
    Language English
    Publishing date 2018-12-19
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 412385-2
    ISSN 1873-6971 ; 0367-326X
    ISSN (online) 1873-6971
    ISSN 0367-326X
    DOI 10.1016/j.fitote.2018.11.008
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.B 1873: Show issues Location:
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