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  1. Article ; Online: Comparaison des systèmes de déclaration d’incidents en radiothérapie en France et à l’étranger.

    Nguyen, M-N / Chambrelant, I / Meyer, P / Tripard, L / Antoni, D / Noël, G

    Cancer radiotherapie : journal de la Societe francaise de radiotherapie oncologique

    2023  Volume 27, Issue 3, Page(s) 249–258

    Abstract: Reporting and learning are key components of quality and safety in radiotherapy. Each event must be reported to national authorities if considered significant according to national criteria. Lessons learnt from analysis of causal factors are primordial ... ...

    Title translation Comparison of incident reporting and learning systems for radiation oncology in France and abroad.
    Abstract Reporting and learning are key components of quality and safety in radiotherapy. Each event must be reported to national authorities if considered significant according to national criteria. Lessons learnt from analysis of causal factors are primordial to decrease the risk of reoccurrence or the severity of further events. Thanks to national or international, mandatory or voluntary incidents reporting systems, and experience feedbacks, various sources of learning are available to improve risk management. This article aims to compare the regulations about mandatory declarations of significant events and describe national or international incident reporting and learning systems available.
    MeSH term(s) Humans ; Radiation Oncology ; Risk Management ; Feedback ; France ; Patient Safety
    Language French
    Publishing date 2023-02-10
    Publishing country France
    Document type English Abstract ; Journal Article ; Review
    ZDB-ID 1397169-4
    ISSN 1769-6658 ; 1278-3218
    ISSN (online) 1769-6658
    ISSN 1278-3218
    DOI 10.1016/j.canrad.2022.09.002
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  2. Article ; Online: La réirradiation des métastases cérébrales : revue des cinq dernières années.

    Nguyen, M-N / Noel, G / Antoni, D

    Cancer radiotherapie : journal de la Societe francaise de radiotherapie oncologique

    2019  Volume 23, Issue 6-7, Page(s) 531–540

    Abstract: No recommandations have been established for reirradiation of brain metastases yet. The purpose of this review is to analyse the data of the five last years about the feasibility, efficacy and tolerance of reirradiation of brain metastases. Reirradiation ...

    Title translation Reirradiation of brain metastasis: Review of the last five years.
    Abstract No recommandations have been established for reirradiation of brain metastases yet. The purpose of this review is to analyse the data of the five last years about the feasibility, efficacy and tolerance of reirradiation of brain metastases. Reirradiation can be 3D conformal or stereotactic. Whole brain irradiation seems appropriate for multiple brain metastases in order to obtain symptomatic relief, with or without supportive care. Stereotactic reirradiation has shown satisfying results in terms of overall survival, local control, without significant toxicity. Prospective trials are necessary in order to validate consensual recommandations.
    MeSH term(s) Brain Neoplasms/prevention & control ; Brain Neoplasms/radiotherapy ; Brain Neoplasms/secondary ; Cranial Irradiation/methods ; Feasibility Studies ; Humans ; Karnofsky Performance Status ; Radiation Tolerance ; Radiosurgery/statistics & numerical data ; Radiotherapy, Conformal ; Re-Irradiation/methods ; Retrospective Studies ; Time Factors
    Language French
    Publishing date 2019-08-22
    Publishing country France
    Document type Journal Article ; Review
    ZDB-ID 1397169-4
    ISSN 1769-6658 ; 1278-3218
    ISSN (online) 1769-6658
    ISSN 1278-3218
    DOI 10.1016/j.canrad.2019.07.144
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  3. Article ; Online: Fuzzy CMAC With incremental Bayesian Ying-Yang learning and dynamic rule construction.

    Nguyen, M N

    IEEE transactions on systems, man, and cybernetics. Part B, Cybernetics : a publication of the IEEE Systems, Man, and Cybernetics Society

    2010  Volume 40, Issue 2, Page(s) 548–552

    Abstract: Inspired by the philosophy of ancient Chinese Taoism, Xu's Bayesian ying-yang (BYY) learning technique performs clustering by harmonizing the training data (yang) with the solution (ying). In our previous work, the BYY learning technique was applied to a ...

    Abstract Inspired by the philosophy of ancient Chinese Taoism, Xu's Bayesian ying-yang (BYY) learning technique performs clustering by harmonizing the training data (yang) with the solution (ying). In our previous work, the BYY learning technique was applied to a fuzzy cerebellar model articulation controller (FCMAC) to find the optimal fuzzy sets; however, this is not suitable for time series data analysis. To address this problem, we propose an incremental BYY learning technique in this paper, with the idea of sliding window and rule structure dynamic algorithms. Three contributions are made as a result of this research. First, an online expectation-maximization algorithm incorporated with the sliding window is proposed for the fuzzification phase. Second, the memory requirement is greatly reduced since the entire data set no longer needs to be obtained during the prediction process. Third, the rule structure dynamic algorithm with dynamically initializing, recruiting, and pruning rules relieves the "curse of dimensionality" problem that is inherent in the FCMAC. Because of these features, the experimental results of the benchmark data sets of currency exchange rates and Mackey-Glass show that the proposed model is more suitable for real-time streaming data analysis.
    MeSH term(s) Algorithms ; Bayes Theorem ; Cluster Analysis ; Fuzzy Logic ; Humans ; Models, Genetic ; Models, Neurological ; Neural Networks (Computer)
    Language English
    Publishing date 2010-04
    Publishing country United States
    Document type Letter
    ISSN 1941-0492
    ISSN (online) 1941-0492
    DOI 10.1109/TSMCB.2009.2030333
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  4. Article ; Online: HPLC-UV assay of tramadol and O-desmethyltramadol in human plasma containing other drugs potentially co-administered to participants in a paediatric population pharmacokinetic study.

    Yoo, O / Tang, E K Y / Nguyen, M N / Salman, S / Hua, A J / von Ungern Sternberg, B S / Lim, L Y

    Journal of chromatography. B, Analytical technologies in the biomedical and life sciences

    2021  Volume 1184, Page(s) 122971

    Abstract: Multimodal analgesia is employed in paediatric pain management to maximise analgesia and minimise side effects. Tramadol is dosed at 1-1.5 mg/kg to treat severe pain in children but the assay for tramadol in plasma samples for pharmacokinetic and ... ...

    Abstract Multimodal analgesia is employed in paediatric pain management to maximise analgesia and minimise side effects. Tramadol is dosed at 1-1.5 mg/kg to treat severe pain in children but the assay for tramadol in plasma samples for pharmacokinetic and toxicology studies does not often consider concurrently administered medications. In this study we developed and validated an HPLC-UV method to quantify tramadol and its main metabolite (O-desmethyltramadol) in human plasma in the presence of seven potentially interfering drugs. Sample preparation method was developed by combining liquid-liquid extraction and protein precipitation. Chromatographic separation was achieved on a BDS-Hypersil-C18 column (5 µm, 250 × 4.6 mm) using a double gradient method. The limit of quantification was 6.7 ng/ml for both tramadol and ODT. The precision and accuracy were in compliance with ICH guidelines. This method was successfully employed to analyse the blood samples of 137 paediatric participants in a tramadol pharmacokinetic trial.
    MeSH term(s) Adult ; Child ; Chromatography, High Pressure Liquid/methods ; Humans ; Limit of Detection ; Linear Models ; Reproducibility of Results ; Spectrophotometry, Ultraviolet ; Tramadol/analogs & derivatives ; Tramadol/blood ; Tramadol/chemistry ; Tramadol/pharmacokinetics
    Chemical Substances O-demethyltramadol (2WA8F50C3F) ; Tramadol (39J1LGJ30J)
    Language English
    Publishing date 2021-10-07
    Publishing country Netherlands
    Document type Journal Article ; Review
    ZDB-ID 1180823-8
    ISSN 1873-376X ; 0378-4347 ; 1570-0232 ; 1387-2273
    ISSN (online) 1873-376X
    ISSN 0378-4347 ; 1570-0232 ; 1387-2273
    DOI 10.1016/j.jchromb.2021.122971
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  5. Article ; Online: Deubiquitylating enzyme, USP9X, regulates proliferation of cells of head and neck cancer lines.

    Nanayakkara, D M / Nguyen, M N / Wood, S A

    Cell proliferation

    2016  Volume 49, Issue 4, Page(s) 494–502

    Abstract: Objectives: Truncating mutations in USP9X have been identified in oral squamous cell carcinoma patients. The aim of this study was to determine USP9X's functional role, if any, in head and neck cancer cells.: Materials and methods: USP9X was depleted/ ...

    Abstract Objectives: Truncating mutations in USP9X have been identified in oral squamous cell carcinoma patients. The aim of this study was to determine USP9X's functional role, if any, in head and neck cancer cells.
    Materials and methods: USP9X was depleted/overexpressed in head and neck cancer cell line: SCC15 (tongue), CAL27 (tongue), FaDu (pharynx) and Detroit 562 (pharynx). Cell proliferation was monitored using the CyQUANT assay, and cell cycle distribution was determined by flow cytometry. Immunoblot assays were conducted to assess protein levels. RT-qPCR was performed to determine Notch and Wnt pathway target gene expression.
    Results: Our data showed a direct correlation between USP9X protein levels and proliferation, as well as Notch pathway activity in head and neck cancer cells. However, at least in FaDu, USP9X did not appear to regulate proliferation through the Notch pathway. Immunoblotting revealed a dramatic reduction in downstream targets of mTOR complex 1, namely total ribosomal protein (S6) and its phosphorylated form (pS6), when USP9X was depleted in FaDu cells. In contrast, in immortalized but non-tumorigenic HaCaT keratinocytes, USP9X depletion led to increase in cell proliferation, maintaining direct regulation of Notch activity.
    Conclusions: The functional role of USP9X was found to be context dependent. USP9X possibly promotes head and neck cancer cell proliferation through the mTOR pathway.
    MeSH term(s) Cell Line ; Cell Line, Tumor ; Cell Proliferation ; Gene Expression Regulation, Neoplastic ; Head and Neck Neoplasms/genetics ; Head and Neck Neoplasms/metabolism ; Head and Neck Neoplasms/pathology ; Humans ; Receptors, Notch/metabolism ; Signal Transduction ; TOR Serine-Threonine Kinases/metabolism ; Ubiquitin Thiolesterase/genetics ; Ubiquitin Thiolesterase/metabolism
    Chemical Substances Receptors, Notch ; USP9X protein, human ; TOR Serine-Threonine Kinases (EC 2.7.1.1) ; Ubiquitin Thiolesterase (EC 3.4.19.12)
    Language English
    Publishing date 2016-07-04
    Publishing country England
    Document type Journal Article
    ZDB-ID 1064202-x
    ISSN 1365-2184 ; 0008-8730 ; 0960-7722
    ISSN (online) 1365-2184
    ISSN 0008-8730 ; 0960-7722
    DOI 10.1111/cpr.12273
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  6. Article: HPLC-UV assay of tramadol and O-desmethyltramadol in human plasma containing other drugs potentially co-administered to participants in a paediatric population pharmacokinetic study

    Yoo, O. / Tang, E.K.Y. / Nguyen, M.N. / Salman, S. / Hua, A.J. / von Ungern Sternberg, B.S. / Lim, L.Y.

    Journal of chromatography. 2021 Nov. 01, v. 1184

    2021  

    Abstract: Multimodal analgesia is employed in paediatric pain management to maximise analgesia and minimise side effects. Tramadol is dosed at 1–1.5 mg/kg to treat severe pain in children but the assay for tramadol in plasma samples for pharmacokinetic and ... ...

    Abstract Multimodal analgesia is employed in paediatric pain management to maximise analgesia and minimise side effects. Tramadol is dosed at 1–1.5 mg/kg to treat severe pain in children but the assay for tramadol in plasma samples for pharmacokinetic and toxicology studies does not often consider concurrently administered medications. In this study we developed and validated an HPLC–UV method to quantify tramadol and its main metabolite (O-desmethyltramadol) in human plasma in the presence of seven potentially interfering drugs. Sample preparation method was developed by combining liquid–liquid extraction and protein precipitation. Chromatographic separation was achieved on a BDS-Hypersil-C18 column (5 µm, 250 × 4.6 mm) using a double gradient method. The limit of quantification was 6.7 ng/ml for both tramadol and ODT. The precision and accuracy were in compliance with ICH guidelines. This method was successfully employed to analyse the blood samples of 137 paediatric participants in a tramadol pharmacokinetic trial.
    Keywords analgesia ; compliance ; humans ; liquid-liquid extraction ; metabolites ; pain ; pharmacokinetics ; toxicology
    Language English
    Dates of publication 2021-1101
    Publishing place Elsevier B.V.
    Document type Article
    ISSN 1570-0232
    DOI 10.1016/j.jchromb.2021.122971
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  7. Article ; Online: A randomised controlled trial of a novel tramadol chewable tablet: pharmacokinetics and tolerability in children.

    Yoo, O / Tang, E K Y / Salman, S / Nguyen, M N / Sommerfield, D / Sommerfield, A / Khan, N / von Ungern Sternberg, B S / Lim, L Y

    Anaesthesia

    2022  Volume 77, Issue 4, Page(s) 438–448

    Abstract: Tramadol is a bitter atypical opioid analgesic drug and is prescribed to treat postoperative pain in children. However, in many countries there is no licensed paediatric tramadol formulation available. We have formulated a novel chewable chocolate-based ... ...

    Abstract Tramadol is a bitter atypical opioid analgesic drug and is prescribed to treat postoperative pain in children. However, in many countries there is no licensed paediatric tramadol formulation available. We have formulated a novel chewable chocolate-based drug delivery system for the administration of tramadol to children. This pilot, single-centre, open-label, randomised clinical study assessed the taste tolerability and comparative population pharmacokinetics of the novel tramadol chewable tablet against a compounded tramadol hydrochloride oral liquid, at a dose of 1 mg.kg
    MeSH term(s) Administration, Oral ; Adolescent ; Analgesics, Opioid ; Child ; Child, Preschool ; Chocolate ; Humans ; Tablets ; Tramadol/pharmacokinetics
    Chemical Substances Analgesics, Opioid ; Tablets ; Tramadol (39J1LGJ30J)
    Language English
    Publishing date 2022-01-27
    Publishing country England
    Document type Journal Article ; Randomized Controlled Trial
    ZDB-ID 80033-8
    ISSN 1365-2044 ; 0003-2409
    ISSN (online) 1365-2044
    ISSN 0003-2409
    DOI 10.1111/anae.15650
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  8. Article: Effect of silicic acid on the aggregation properties of goethite

    Nguyen, M. N / F. Picardal / S. Dultz / L. Nguyen‐Thanh / T. T. N. Dam / K. M. Nguyen

    European journal of soil science. 2017 Sept., v. 68, no. 5

    2017  

    Abstract: Aggregation properties of iron oxide particles have received much attention because of their environmental importance in soil and aquatic environments. The effects of silicic acid on the pH‐dependent surface charges that govern the aggregation of ... ...

    Abstract Aggregation properties of iron oxide particles have received much attention because of their environmental importance in soil and aquatic environments. The effects of silicic acid on the pH‐dependent surface charges that govern the aggregation of goethite have received little attention. In this study we determined the effect of silicic acid as a function of pH and ionic strength (IS) on the aggregation of a synthetic goethite by a combination of particle‐size analysis using dynamic light scattering and test tube experiments to quantify particles in suspension. We investigated silicic acid adsorption on goethite quantitatively by batch adsorption isotherms, and the changes in surface charge on the adsorption of silicic acid were identified by the zeta potential (ζ). Our results revealed that silicic acid can lead to a significant decrease in ζ. A change in the pHᵢₑₚ (iep: isoelectric point) from 8.5 to lower pH values, typically pH 4–5.5, in the presence of silicic acid suggests enhanced aggregation of goethite in the acidic pH range. At alkaline pH, both goethite and silicic acid were negatively charged because of strong deprotonation, and silicic acid adsorption promoted goethite dispersion. Ionic strength affected the aggregation of goethite by shifting ζ towards the iep and it can also obscure the role of silicic acid. HIGHLIGHTS: Effect of silicic acid on surface charge and aggregation of goethite was investigated. Adsorption of silicic acid reduces ζ and allows goethite to aggregate at lower pH. Ionic strength can also affect aggregation of goethite by shifting ζ towards the isoelectric point. Silicic acid in soil might maintain goethite particles in an aggregated state.
    Keywords adsorption ; aquatic environment ; goethite ; ionic strength ; iron oxides ; isoelectric point ; light scattering ; pH ; particle size ; silicic acid ; soil ; sorption isotherms ; zeta potential
    Language English
    Dates of publication 2017-09
    Size p. 650-657.
    Publishing place Blackwell Publishing Ltd
    Document type Article
    Note JOURNAL ARTICLE
    ZDB-ID 1191614-x
    ISSN 1365-2389 ; 1351-0754
    ISSN (online) 1365-2389
    ISSN 1351-0754
    DOI 10.1111/ejss.12453
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  9. Article ; Online: The enhanced recovery after surgery (ERAS) Greenie Board: a Navy-inspired quality improvement tool.

    Smirk, A J / Nicholson, J J / Console, Y L / Hunt, N J / Herschtal, A / Nguyen, M N H H / Riedel, B

    Anaesthesia

    2018  Volume 73, Issue 6, Page(s) 692–702

    Abstract: The United States Navy uses a visual feedback system for pilots, named 'the Greenie Board', to improve flight manoeuvres on aircraft carriers. Given that increased compliance with enhanced recovery after surgery protocols reduces postoperative ... ...

    Abstract The United States Navy uses a visual feedback system for pilots, named 'the Greenie Board', to improve flight manoeuvres on aircraft carriers. Given that increased compliance with enhanced recovery after surgery protocols reduces postoperative complications, we decided to apply a similar feedback system to our institutional enhanced recovery programme. We undertook a prospective 12-month audit of 194 patients assigned to our enhanced recovery programme and evaluated adherence to the anaesthesia-related components of our protocol, before and after implementing a Greenie Board. A compliance score was calculated by summing points for adherence to: intra-operative antibiotic prophylaxis; temperature management; goal-directed intravenous fluid therapy; postoperative nausea and vomiting prophylaxis; and postoperative fluid restriction. The score for each patient was then colour-coded and anonymously displayed for each anaesthetist on a Greenie Board within the operating theatre suite. Protocol adherence improved significantly following introduction, with 'Green' scores (acceptable compliance) increasing from 33% to 72% of patients (p < 0.0001). The greatest improvement was seen with anti-emetic prophylaxis (49% to 70%, p = 0.004) with a consequent reduction in postoperative nausea and vomiting (OR 0.42, 95% CI 0.19-0.88, p = 0.021). We did not observe a decrease in other postoperative complications nor hospital length of stay. We conclude that this US Navy-inspired feedback system is an easily implemented, low-cost quality improvement tool that significantly improved adherence to intra-operative components of our enhanced recovery protocol. The system lends itself to global scaling to drive quality improvement in healthcare delivery and would be suited to institutions without electronic medical records, including low-resource countries.
    MeSH term(s) Anesthesia Recovery Period ; Anesthesiology/methods ; Antiemetics/therapeutic use ; Aviation/methods ; Feedback, Sensory ; Fluid Therapy/standards ; Guideline Adherence ; Humans ; Length of Stay ; Operating Rooms/organization & administration ; Operating Rooms/standards ; Perioperative Care/methods ; Perioperative Care/standards ; Postoperative Care/methods ; Postoperative Nausea and Vomiting/epidemiology ; Prospective Studies ; Quality Improvement
    Chemical Substances Antiemetics
    Language English
    Publishing date 2018-03-26
    Publishing country England
    Document type Journal Article
    ZDB-ID 80033-8
    ISSN 1365-2044 ; 0003-2409
    ISSN (online) 1365-2044
    ISSN 0003-2409
    DOI 10.1111/anae.14157
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  10. Article ; Online: CLICK--topology-independent comparison of biomolecular 3D structures.

    Nguyen, M N / Tan, K P / Madhusudhan, M S

    Nucleic acids research

    2011  Volume 39, Issue Web Server issue, Page(s) W24–8

    Abstract: Our server, CLICK: http://mspc.bii.a-star.edu.sg/click, is capable of superimposing the 3D structures of any pair of biomolecules (proteins, DNA, RNA, etc.). The server makes use of the Cartesian coordinates of the molecules with the option of using ... ...

    Abstract Our server, CLICK: http://mspc.bii.a-star.edu.sg/click, is capable of superimposing the 3D structures of any pair of biomolecules (proteins, DNA, RNA, etc.). The server makes use of the Cartesian coordinates of the molecules with the option of using other structural features such as secondary structure, solvent accessible surface area and residue depth to guide the alignment. CLICK first looks for cliques of points (3-7 residues) that are structurally similar in the pair of structures to be aligned. Using these local similarities, a one-to-one equivalence is charted between the residues of the two structures. A least square fit then superimposes the two structures. Our method is especially powerful in establishing protein relationships by detecting similarities in structural subdomains, domains and topological variants. CLICK has been extensively benchmarked and compared with other popular methods for protein and RNA structural alignments. In most cases, CLICK alignments were statistically significantly better in terms of structure overlap. The method also recognizes conformational changes that may have occurred in structural domains or subdomains in one structure with respect to the other. For this purpose, the server produces complementary alignments to maximize the extent of detectable similarity. Various examples showcase the utility of our web server.
    MeSH term(s) Algorithms ; Models, Molecular ; Molecular Conformation ; Nucleic Acid Conformation ; Protein Conformation ; RNA/chemistry ; Software
    Chemical Substances RNA (63231-63-0)
    Language English
    Publishing date 2011-05-20
    Publishing country England
    Document type Journal Article
    ZDB-ID 186809-3
    ISSN 1362-4962 ; 1362-4954 ; 0301-5610 ; 0305-1048
    ISSN (online) 1362-4962 ; 1362-4954
    ISSN 0301-5610 ; 0305-1048
    DOI 10.1093/nar/gkr393
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