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  1. Article: 2020

    Nguyen, Nam-Trung

    Micromachines

    2021  Volume 12, Issue 1

    Abstract: After an extensive voting period, we are proud to present the winner of ... ...

    Abstract After an extensive voting period, we are proud to present the winner of the
    Language English
    Publishing date 2021-01-02
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2620864-7
    ISSN 2072-666X
    ISSN 2072-666X
    DOI 10.3390/mi12010048
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Micromachines

    Nguyen, Nam-Trung

    Micromachines

    2021  Volume 12, Issue 12

    Abstract: ... ...

    Abstract Micromachines
    Language English
    Publishing date 2021-12-17
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2620864-7
    ISSN 2072-666X
    ISSN 2072-666X
    DOI 10.3390/mi12121573
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Microfluidic solutions for biofluids handling in on-skin wearable systems.

    Kashaninejad, Navid / Nguyen, Nam-Trung

    Lab on a chip

    2023  Volume 23, Issue 5, Page(s) 913–937

    Abstract: On-skin wearable systems for biofluid sampling and biomarker sensing can revolutionize the current practices in healthcare monitoring and personalized medicine. However, there is still a long path toward complete market adoption and acceptance of this ... ...

    Abstract On-skin wearable systems for biofluid sampling and biomarker sensing can revolutionize the current practices in healthcare monitoring and personalized medicine. However, there is still a long path toward complete market adoption and acceptance of this fascinating technology. Accordingly, microfluidic science and technology can provide excellent solutions for bridging the gap between basic research and clinical research. The research gap has led to the emerging field of epidermal microfluidics. Moreover, recent advances in the fabrication of highly flexible and stretchable microfluidic systems have revived the concept of micro elastofluidics, which can provide viable solutions for on-skin wearable biofluid handling. In this context, this review highlights the current state-of-the-art platforms in this field and discusses the potential technologies that can be used for on-skin wearable devices. Toward this aim, we first compare various microfluidic platforms that could be used for on-skin wearable devices. These platforms include semiconductor-based, polymer-based, liquid metal-based, paper-based, and textile-based microfluidics. Next, we discuss how these platforms can enhance the stretchability of on-skin wearable biosensors at the device level. Next, potential microfluidic solutions for collecting, transporting, and controlling the biofluids are discussed. The application of finger-powered micropumps as a viable solution for precise and on-demand biofluid pumping is highlighted. Finally, we present the future directions of this field by emphasizing the applications of droplet-based microfluidics, stretchable continuous-flow micro elastofluidics, stretchable superhydrophobic surfaces, liquid beads as a form of digital micro elastofluidics, and topological liquid diodes that received less attention but have enormous potential to be integrated into on-skin wearable devices.
    MeSH term(s) Microfluidics ; Wearable Electronic Devices ; Biosensing Techniques ; Skin
    Language English
    Publishing date 2023-03-01
    Publishing country England
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 2056646-3
    ISSN 1473-0189 ; 1473-0197
    ISSN (online) 1473-0189
    ISSN 1473-0197
    DOI 10.1039/d2lc00993e
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Recent developments and future perspectives of microfluidics and smart technologies in wearable devices.

    Apoorva, Sasikala / Nguyen, Nam-Trung / Sreejith, Kamalalayam Rajan

    Lab on a chip

    2024  Volume 24, Issue 7, Page(s) 1833–1866

    Abstract: Wearable devices are gaining popularity in the fields of health monitoring, diagnosis, and drug delivery. Recent advances in wearable technology have enabled real-time analysis of biofluids such as sweat, interstitial fluid, tears, saliva, wound fluid, ... ...

    Abstract Wearable devices are gaining popularity in the fields of health monitoring, diagnosis, and drug delivery. Recent advances in wearable technology have enabled real-time analysis of biofluids such as sweat, interstitial fluid, tears, saliva, wound fluid, and urine. The integration of microfluidics and emerging smart technologies, such as artificial intelligence (AI), machine learning (ML), and Internet of Things (IoT), into wearable devices offers great potential for accurate and non-invasive monitoring and diagnosis. This paper provides an overview of current trends and developments in microfluidics and smart technologies in wearable devices for analyzing body fluids. The paper discusses common microfluidic technologies in wearable devices and the challenges associated with analyzing each type of biofluid. The paper emphasizes the importance of combining smart technologies with microfluidics in wearable devices, and how they can aid diagnosis and therapy. Finally, the paper covers recent applications, trends, and future developments in the context of intelligent microfluidic wearable devices.
    MeSH term(s) Artificial Intelligence ; Microfluidics ; Body Fluids ; Drug Delivery Systems ; Wearable Electronic Devices
    Language English
    Publishing date 2024-03-26
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2056646-3
    ISSN 1473-0189 ; 1473-0197
    ISSN (online) 1473-0189
    ISSN 1473-0197
    DOI 10.1039/d4lc00089g
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Micro Elastofluidics: Elasticity and Flexibility for Efficient Microscale Liquid Handling.

    Nguyen, Nam-Trung

    Micromachines

    2020  Volume 11, Issue 11

    Abstract: Microfluidics is the science and technology around the behaviour of fluid and fluid flow at the microscale [ ... ]. ...

    Abstract Microfluidics is the science and technology around the behaviour of fluid and fluid flow at the microscale [...].
    Language English
    Publishing date 2020-11-14
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2620864-7
    ISSN 2072-666X
    ISSN 2072-666X
    DOI 10.3390/mi11111004
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Magnetophoresis-Enhanced Elasto-Inertial Migration of Microparticles and Cells in Microfluidics.

    Yan, Sheng / Liu, Yong / Nguyen, Nam-Trung / Zhang, Jun

    Analytical chemistry

    2024  Volume 96, Issue 9, Page(s) 3925–3932

    Abstract: Microfluidic particle and cell manipulation techniques possess many potentials for biomedicine and healthcare. Many techniques have been developed based on active (e.g., electrical, magnetic, acoustic, and thermal) force fields and passive hydrodynamic ... ...

    Abstract Microfluidic particle and cell manipulation techniques possess many potentials for biomedicine and healthcare. Many techniques have been developed based on active (e.g., electrical, magnetic, acoustic, and thermal) force fields and passive hydrodynamic forces (e.g., inertial and elastic lift forces). However, techniques based on a single active or passive manipulating physics cannot always meet the demands, and combining multiple physics becomes a promising strategy to promote technique flexibility and versatility. In this work, we explored the physical coupling of magnetophoresis with the elastic and inertial (i.e., elasto-inertial) lift forces for the manipulation of microparticles. Particle lateral migration was studied in a coflowing configuration of viscoelastic ferrofluid/water (sample/sheath). The particles were suspended in the viscoelastic ferrofluid and confined near the channel sidewall by a sheath flow. The coordination of magnetophoresis and elasto-inertial lift forces promoted the cross-stream migration of particles. Besides, we investigated the effect of the flow rate ratio and total flow rate on the migration of particles. Furthermore, we also investigated the effects of fluid elasticity in sample and sheath flows on particle migration using different combinations of sample and sheath flows, including Newtonian ferrofluid/water, Newtonian ferrofluid/viscoelastic fluid, and viscoelastic ferrofluid/viscoelastic coflows. Experimental results demonstrated and ascertained the promoted particle lateral migration in the PEO-based ferrofluid/water coflow. Finally, we demonstrate the proof-of-concept application of the physical coupling strategy for cell cross-stream migration and solution exchange. We envisage that this novel multiphysical coupling scheme has great potential for the flexible and versatile manipulation of microparticles and cells.
    Language English
    Publishing date 2024-02-12
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1508-8
    ISSN 1520-6882 ; 0003-2700
    ISSN (online) 1520-6882
    ISSN 0003-2700
    DOI 10.1021/acs.analchem.3c05803
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4033: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  7. Article ; Online: Unravelling Surface Modification Strategies for Preventing Medical Device-Induced Thrombosis.

    Luu, Cuong Hung / Nguyen, Nam-Trung / Ta, Hang Thu

    Advanced healthcare materials

    2023  Volume 13, Issue 1, Page(s) e2301039

    Abstract: The use of biomaterials in implanted medical devices remains hampered by platelet adhesion and blood coagulation. Thrombus formation is a prevalent cause of failure of these blood-contacting devices. Although systemic anticoagulant can be used to support ...

    Abstract The use of biomaterials in implanted medical devices remains hampered by platelet adhesion and blood coagulation. Thrombus formation is a prevalent cause of failure of these blood-contacting devices. Although systemic anticoagulant can be used to support materials and devices with poor blood compatibility, its negative effects such as an increased chance of bleeding, make materials with superior hemocompatibility extremely attractive, especially for long-term applications. This review examines blood-surface interactions, the pathogenesis of clotting on blood-contacting medical devices, popular surface modification techniques, mechanisms of action of anticoagulant coatings, and discusses future directions in biomaterial research for preventing thrombosis. In addition, this paper comprehensively reviews several novel methods that either entirely prevent interaction between material surfaces and blood components or regulate the reaction of the coagulation cascade, thrombocytes, and leukocytes.
    MeSH term(s) Humans ; Blood Coagulation ; Thrombosis/prevention & control ; Anticoagulants/pharmacology ; Biocompatible Materials/pharmacology ; Blood Platelets ; Surface Properties
    Chemical Substances Anticoagulants ; Biocompatible Materials
    Language English
    Publishing date 2023-10-05
    Publishing country Germany
    Document type Journal Article ; Review
    ZDB-ID 2649576-4
    ISSN 2192-2659 ; 2192-2640
    ISSN (online) 2192-2659
    ISSN 2192-2640
    DOI 10.1002/adhm.202301039
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6966: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  8. Article ; Online: Evaluating thrombosis risk and patient-specific treatment strategy using an atherothrombosis-on-chip model.

    Akther, Fahima / Fallahi, Hedieh / Zhang, Jun / Nguyen, Nam-Trung / Ta, Hang Thu

    Lab on a chip

    2024  

    Abstract: Platelets play an essential role in thrombotic processes. Recent studies suggest a direct link between increased plasma glucose, lipids, and inflammatory cytokines with platelet activation and aggregation, resulting in an increased risk of ... ...

    Abstract Platelets play an essential role in thrombotic processes. Recent studies suggest a direct link between increased plasma glucose, lipids, and inflammatory cytokines with platelet activation and aggregation, resulting in an increased risk of atherothrombotic events in cardiovascular patients. Antiplatelet therapies are commonly used for the primary prevention of atherosclerosis. Transitioning from a population-based strategy to patient-specific care requires a better understanding of the risks and advantages of antiplatelet therapy for individuals. This proof-of-concept study evaluates the potential to assess an individual's risk of forming atherothrombosis using a dual-channel microfluidic model emulating multiple atherogenic factors
    Language English
    Publishing date 2024-04-09
    Publishing country England
    Document type Journal Article
    ZDB-ID 2056646-3
    ISSN 1473-0189 ; 1473-0197
    ISSN (online) 1473-0189
    ISSN 1473-0197
    DOI 10.1039/d4lc00131a
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: Instant

    Clack, Kimberley / Sallam, Mohamed / Muyldermans, Serge / Sambasivam, Prabhakaran / Nguyen, Cong Minh / Nguyen, Nam-Trung

    Micromachines

    2024  Volume 15, Issue 2

    Abstract: Fungal pathogens such ... ...

    Abstract Fungal pathogens such as
    Language English
    Publishing date 2024-01-31
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2620864-7
    ISSN 2072-666X
    ISSN 2072-666X
    DOI 10.3390/mi15020216
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Actuation for flexible and stretchable microdevices.

    Roshan, Uditha / Mudugamuwa, Amith / Cha, Haotian / Hettiarachchi, Samith / Zhang, Jun / Nguyen, Nam-Trung

    Lab on a chip

    2024  Volume 24, Issue 8, Page(s) 2146–2175

    Abstract: Flexible and stretchable microdevices incorporate highly deformable structures, facilitating precise functionality at the micro- and millimetre scale. Flexible microdevices have showcased extensive utility in the fields of biomedicine, microfluidics, and ...

    Abstract Flexible and stretchable microdevices incorporate highly deformable structures, facilitating precise functionality at the micro- and millimetre scale. Flexible microdevices have showcased extensive utility in the fields of biomedicine, microfluidics, and soft robotics. Actuation plays a critical role in transforming energy between different forms, ensuring the effective operation of devices. However, when it comes to actuating flexible microdevices at the small millimetre or even microscale, translating actuation mechanisms from conventional rigid large-scale devices is not straightforward. The recent development of actuation mechanisms leverages the benefits of device flexibility, particularly in transforming conventional actuation concepts into more efficient approaches for flexible devices. Despite many reviews on soft robotics, flexible electronics, and flexible microfluidics, a specific and systematic review of the actuation mechanisms for flexible and stretchable microdevices is still lacking. Therefore, the present review aims to address this gap by providing a comprehensive overview of state-of-the-art actuation mechanisms for flexible and stretchable microdevices. We elaborate on the different actuation mechanisms based on fluid pressure, electric, magnetic, mechanical, and chemical sources, thoroughly examining and comparing the structure designs, characteristics, performance, advantages, and drawbacks of these diverse actuation mechanisms. Furthermore, the review explores the pivotal role of materials and fabrication techniques in the development of flexible and stretchable microdevices. Finally, we summarise the applications of these devices in biomedicine and soft robotics and provide perspectives on current and future research.
    Language English
    Publishing date 2024-04-16
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2056646-3
    ISSN 1473-0189 ; 1473-0197
    ISSN (online) 1473-0189
    ISSN 1473-0197
    DOI 10.1039/d3lc01086d
    Database MEDical Literature Analysis and Retrieval System OnLINE

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