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  1. Article: On the application of Home Energy Management Systems for power grid support

    Nizami, M.S.H / Haque, A.N.M.M / Hossain, M.J / Nguyen, P.H

    Energy. 2019 Sept. 08,

    2019  

    Abstract: Home Energy Management Systems (HEMSs) are being implemented for residential energy management in various parts of the world. Conventionally, a HEMS is developed from the consumer's perspective, with the principal aim of cost-saving while maintaining ... ...

    Abstract Home Energy Management Systems (HEMSs) are being implemented for residential energy management in various parts of the world. Conventionally, a HEMS is developed from the consumer's perspective, with the principal aim of cost-saving while maintaining optimal consumers' comfort. In recent years, various Demand Response programs are being incorporated into HEMSs to address the power grid constraints. In this paper, the functionality of grid support through the HEMSs is presented. The developed scheme utilizes an agent-based coordination mechanism in an active distribution network and manages the household appliances to comply with thermal and voltage constraints of the grid. The proposed mechanism is evaluated through simulation of a typical Dutch low-voltage (LV) residential feeder. A hardware prototype has also been developed and tested in the laboratory environment. The proposed methodologies show promising perspectives for local voltage-violation support and direct load control for congestion management of the grid.
    Keywords consumer attitudes ; cost effectiveness ; electric potential difference ; household equipment ; management systems ; prototypes
    Language English
    Dates of publication 2019-0908
    Publishing place Elsevier Ltd
    Document type Article
    Note Pre-press version
    ZDB-ID 2019804-8
    ISSN 0360-5442 ; 0360-5442
    ISSN (online) 0360-5442
    ISSN 0360-5442
    DOI 10.1016/j.energy.2019.116104
    Database NAL-Catalogue (AGRICOLA)

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  2. Article ; Online: The effects of anthracycline drugs on the conformational distribution of mouse P-glycoprotein explains their transport rate differences.

    Nguyen, P H / Sigdel, K P / Schaefer, K G / Mensah, G A K / King, G M / Roberts, A G

    Biochemical pharmacology

    2020  Volume 174, Page(s) 113813

    Abstract: P-glycoprotein (Pgp) is an ATP-dependent efflux transporter and plays a major role in anti-cancer drug resistance by pumping a chemically diverse range of cytotoxic drugs from cancerous tumors. Despite numerous studies with the transporter, the molecular ...

    Abstract P-glycoprotein (Pgp) is an ATP-dependent efflux transporter and plays a major role in anti-cancer drug resistance by pumping a chemically diverse range of cytotoxic drugs from cancerous tumors. Despite numerous studies with the transporter, the molecular features that drive anti-cancer drug efflux are not well understood. Even subtle differences in the anti-cancer drug molecular structure can lead to dramatic differences in their transport rates. To unmask these structural differences, this study focused on two closely-related anthracycline drugs, daunorubicin (DNR), and doxorubicin (DOX), with mouse Pgp. While only differing by a single hydroxyl functional group, DNR has a 4 to 5-fold higher transport rate than DOX. They both non-competitively inhibited Pgp-mediated ATP hydrolysis below basal levels. The K
    MeSH term(s) ATP Binding Cassette Transporter, Subfamily B, Member 1/chemistry ; ATP Binding Cassette Transporter, Subfamily B, Member 1/metabolism ; Animals ; Anthracyclines/pharmacology ; Antibiotics, Antineoplastic/pharmacology ; Daunorubicin/pharmacology ; Dose-Response Relationship, Drug ; Doxorubicin/pharmacology ; Mice ; Protein Conformation/drug effects ; Protein Transport/drug effects ; Protein Transport/physiology
    Chemical Substances ATP Binding Cassette Transporter, Subfamily B, Member 1 ; Anthracyclines ; Antibiotics, Antineoplastic ; Doxorubicin (80168379AG) ; Daunorubicin (ZS7284E0ZP)
    Language English
    Publishing date 2020-01-16
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S.
    ZDB-ID 208787-x
    ISSN 1873-2968 ; 0006-2952
    ISSN (online) 1873-2968
    ISSN 0006-2952
    DOI 10.1016/j.bcp.2020.113813
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Book ; Online: Bihar - HINDI

    Singh, N. / Nguyen, P. H. / Jangid, M. / Singh, S. K. / Sarwal, R. / Bhatia, N. / Johnston, R. / Joe, W. / Menon, P. / Singh, Nishmeet / Nguyen, Phuong Hong / Menon, Purnima

    2022  

    Abstract: Non-PR ... IFPRI1; POSHAN; 2 Promoting Healthy Diets and Nutrition for all ... PHND; ... ...

    Abstract Non-PR

    IFPRI1; POSHAN; 2 Promoting Healthy Diets and Nutrition for all

    PHND; SAR
    Keywords INDIA ; SOUTH ASIA ; ASIA ; nutrition ; health ; malnutrition ; child nutrition ; food security ; households ; maternal and child health
    Language Hindi
    Publisher IFPRI
    Publishing country us
    Document type Book ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Book ; Article ; Online: Determining key research areas for healthier diets and sustainable food systems in Viet Nam

    Raneri, Jessica E. / Kennedy, G. / Nguyen, T. / Wertheim-Heck, Sigrid C.O. / Do, H. / Nguyen, P.H.

    2020  

    Abstract: Vietnamese food systems are undergoing rapid transformation, with important implications for human and environmental health and economic development. Poverty has decreased, and diet quality and undernutrition have improved significantly since the end of ... ...

    Abstract Vietnamese food systems are undergoing rapid transformation, with important implications for human and environmental health and economic development. Poverty has decreased, and diet quality and undernutrition have improved significantly since the end of the Doi Moi reform period (1986-1993) as a result of Viet Nam opening its economy and increasing its regional and global trade. Yet poor diet quality is still contributing the triple burden of malnutrition, with 25 percent stunting among children under age 5, 26 percent and 29 percent of women and children, respectively, anemic, and 21 percent of adults overweight. Agricultural production systems have shifted from predominantly diverse smallholder systems to larger more commercialized and specialized systems, especially for crops, while the ‘meatification’ of the Vietnamese diet is generating serious trade-offs between improved nutrition and sustainability of the Vietnamese food systems. The food processing industry has developed rapidly, together with food imports, resulting in new and processed food products penetrating the food retail outlets, trending towards an increase in the Westernized consumption patterns that are shifting nutrition-related problems towards overweight and obesity and, with it, an increase of non-communicable disease-related health risks. While regulatory policies exist across the food system, these are not systematically implemented, making food safety a major concern for consumers and policy makers alike. Where data exists, it is not easy to aggregate with data from across food system dimensions, making it difficult for Viet Nam to make an informed analysis of current and potential food system trade-offs. In our research, we reviewed existing literature and data, and applied a food systems framework to develop an initial food systems profile for Viet Nam and to identify a comprehensive set a of research questions to fill current data gaps identified through the review. Insights on these would provide the comprehensive evidence needed to ...
    Keywords nutrition ; food systems ; agriculture ; diet
    Language English
    Publishing date 2020-01-30T12:28:34Z
    Publisher International Food Policy Research Institute
    Publishing country fr
    Document type Book ; Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Article ; Online: RAMPVIS: Answering the challenges of building visualisation capabilities for large-scale emergency responses.

    Chen, M / Abdul-Rahman, A / Archambault, D / Dykes, J / Ritsos, P D / Slingsby, A / Torsney-Weir, T / Turkay, C / Bach, B / Borgo, R / Brett, A / Fang, H / Jianu, R / Khan, S / Laramee, R S / Matthews, L / Nguyen, P H / Reeve, R / Roberts, J C /
    Vidal, F P / Wang, Q / Wood, J / Xu, K

    Epidemics

    2022  Volume 39, Page(s) 100569

    Abstract: The effort for combating the COVID-19 pandemic around the world has resulted in a huge amount of data, e.g., from testing, contact tracing, modelling, treatment, vaccine trials, and more. In addition to numerous challenges in epidemiology, healthcare, ... ...

    Abstract The effort for combating the COVID-19 pandemic around the world has resulted in a huge amount of data, e.g., from testing, contact tracing, modelling, treatment, vaccine trials, and more. In addition to numerous challenges in epidemiology, healthcare, biosciences, and social sciences, there has been an urgent need to develop and provide visualisation and visual analytics (VIS) capacities to support emergency responses under difficult operational conditions. In this paper, we report the experience of a group of VIS volunteers who have been working in a large research and development consortium and providing VIS support to various observational, analytical, model-developmental, and disseminative tasks. In particular, we describe our approaches to the challenges that we have encountered in requirements analysis, data acquisition, visual design, software design, system development, team organisation, and resource planning. By reflecting on our experience, we propose a set of recommendations as the first step towards a methodology for developing and providing rapid VIS capacities to support emergency responses.
    MeSH term(s) COVID-19/epidemiology ; Contact Tracing ; Humans ; Pandemics
    Language English
    Publishing date 2022-04-28
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 2467993-8
    ISSN 1878-0067 ; 1755-4365
    ISSN (online) 1878-0067
    ISSN 1755-4365
    DOI 10.1016/j.epidem.2022.100569
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Superiority of a Novel Mp1p Antigen Detection Enzyme Immunoassay Compared to Standard BACTEC Blood Culture in the Diagnosis of Talaromycosis.

    Thu, Nguyen T M / Chan, Jasper F W / Ly, Vo Trieu / Ngo, Hoa T / Hien, Ha T A / Lan, Nguyen P H / Chau, Nguyen V V / Cai, Jian-Piao / Woo, Patrick C Y / Day, Jeremy N / van Doorn, Rogier / Thwaites, Guy / Perfect, John / Yuen, Kwok / Le, Thuy

    Clinical infectious diseases : an official publication of the Infectious Diseases Society of America

    2020  Volume 73, Issue 2, Page(s) e330–e336

    Abstract: Background: Talaromycosis is an invasive mycosis endemic in Southeast Asia and causes substantial morbidity and mortality in individuals with advanced human immunodeficiency virus (HIV) disease. Current diagnosis relies on isolating Talaromyces ... ...

    Abstract Background: Talaromycosis is an invasive mycosis endemic in Southeast Asia and causes substantial morbidity and mortality in individuals with advanced human immunodeficiency virus (HIV) disease. Current diagnosis relies on isolating Talaromyces marneffei in cultures, which takes up to 14 days and is detectable only during late-stage infection, leading to high mortality.
    Methods: In this retrospective case-control study, we assessed the accuracy of a novel Mp1p antigen-detecting enzyme immunoassay (EIA) in stored plasma samples of 372 patients who had culture-proven talaromycosis from blood or sterile body fluids (reference standard) and 517 individuals without talaromycosis (338 healthy volunteers; 179 with other infections). All participants were recruited between 2011 and 2017 in Vietnam.
    Results: Of cases and controls, 66.1% and 75.4%, respectively, were male; the median age was 33 and 37, respectively. All cases were HIV infected; median CD4 count was 10 cells/μL. At an optical density cutoff of 0.5, the specificity was 98.1% (95% CI, 96.3%-99.0%); the sensitivity was superior to blood culture (86.3% [95% CI, 82.3%-89.5%] vs 72.8% [95% CI, 68.0%-77.2%]) (P < .001, McNemar test). The time to diagnosis was 6 hours vs 6.6 ± 3.0 days for blood culture. Paired plasma and urine testing in the same patients (n = 269) significantly increased sensitivity compared to testing plasma alone or testing urine alone (P < .001 and P = .02, respectively, McNemar test).
    Conclusions: The Mp1p EIA is highly specific and is superior in sensitivity and time to diagnosis compared to blood culture for the diagnosis of talaromycosis. Paired plasma and urine testing further increases sensitivity, introducing a new tool for rapid diagnosis, enabling early treatment and potentially reducing mortality.
    MeSH term(s) Adult ; Asia, Southeastern ; Blood Culture ; Case-Control Studies ; Humans ; Immunoenzyme Techniques ; Male ; Mycoses ; Retrospective Studies ; Talaromyces ; Vietnam
    Language English
    Publishing date 2020-06-18
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 1099781-7
    ISSN 1537-6591 ; 1058-4838
    ISSN (online) 1537-6591
    ISSN 1058-4838
    DOI 10.1093/cid/ciaa826
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: Knowledge, Attitude, and Practices Regarding COVID-19 Among Chronic Illness Patients at Outpatient Departments in Ho Chi Minh City, Vietnam

    Huynh, G. / Nguyen, M. Q. / Tran, T. T. / Nguyen, V. T. / Nguyen, T. V. / Do, T. H. T. / Nguyen, P. H. N. / Phan, T. H. Y. / Vu, T. T. / Nguyen, T. N. H.

    Risk Manag Healthc Policy

    Abstract: BACKGROUND: The novel coronavirus disease (COVID-19) has become a major threat to human life around the world This study aims to assess the knowledge, attitude, and practices regarding COVID-19 among people with chronic diseases at the outpatient ... ...

    Abstract BACKGROUND: The novel coronavirus disease (COVID-19) has become a major threat to human life around the world This study aims to assess the knowledge, attitude, and practices regarding COVID-19 among people with chronic diseases at the outpatient departments in Ho Chi Minh City METHODS: A cross-sectional study was carried out between February and March 2020 using a convenience sampling strategy in three hospitals in Ho Chi Minh City (HCMC) via the use of a structured self-administered questionnaire Factors relating to practices, prevalence ratio (PR), and 95% confidence interval were estimated by using the Poisson regression with robust options P-value <0 05 was considered as statistically different RESULTS: A total of 522 participants had a mean age of 51 5 ± 10 6 years Most of them reported seeing information regarding the COVID-19 pandemic (93 7%) via television and social media (72 8% and 62 1%, respectively) Just over two-thirds of the participants (68 4%) answered with sufficient knowledge of COVID-19 Most respondents had a positive attitude toward COVID-19 (90 8%), although some misconceptions existed Almost over three-fourths of them (77 2%) maintained good practices for prevention The rate of good practices in those who had sufficient knowledge was 1 24 times greater than that among those who had insufficient knowledge (PR 1 24, 95% CI: 1 10-1 41, P<0 05) Also, the rate of good practices in males was lower than that of females (PR: 0 91, 95% CI: 0 83-0 99, P<0 05) CONCLUSION: There still exists an amount of insufficient knowledge and negative attitude regarding COVID-19, which may be barriers to good prevention practices among chronic illness patients Education programs need to continue via television and social media and emphasize that people with chronic diseases are more likely to experience severe symptoms, including death from COVID-19 Additionally, management authorities should prolong specific policies to protect the more vulnerable in our community
    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #801669
    Database COVID19

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  8. Article: Anaerobic digestion of municipal solid waste as a treatment prior to landfill.

    Nguyen, P H L / Kuruparan, P / Visvanathan, C

    Bioresource technology

    2007  Volume 98, Issue 2, Page(s) 380–387

    Abstract: Anaerobic digestion of organic fraction of municipal solid waste was conducted in pilot-scale reactor based on high-solid combined anaerobic digestion process. This study was performed in two runs. In Run 1 and Run 2, pre-stage flushing and micro- ... ...

    Abstract Anaerobic digestion of organic fraction of municipal solid waste was conducted in pilot-scale reactor based on high-solid combined anaerobic digestion process. This study was performed in two runs. In Run 1 and Run 2, pre-stage flushing and micro-aeration were conducted to determine their effect in terms of enhancing hydrolysis and acidification in ambient condition. In Run 2, after pre-stage, the methane phase (methanogenesis) was started-up after pH adjustment and inoculum addition in mesophilic condition. Acidified leachate produced in pre-stage was used for percolation during active methane phase. At the end of methane phase, air flushing was conducted before unloading the digesters. Hydrolysis and acidification yield of 140 g C/kg TS and 180 g VFA/kg TS were achieved, respectively in pre-stage. Micro-aeration exhibited an equivocal result in terms of enhancing hydrolysis/acidification; however it showed a positive effect in methane phase performance and this needed further investigation. Leachate percolation during methane phase showed an enhanced methanization when compared to the reactors without leachate percolation. After 60 days, 260 l CH(4)/kg VS was obtained. Based on the waste methane potential, 75% biogas conversion and 61% VS degradation were achieved.
    MeSH term(s) Anaerobiosis ; Bioreactors ; Pilot Projects ; Refuse Disposal/methods ; Time Factors
    Language English
    Publishing date 2007-01
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1065195-0
    ISSN 1873-2976 ; 0960-8524
    ISSN (online) 1873-2976
    ISSN 0960-8524
    DOI 10.1016/j.biortech.2005.12.018
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: A User Study on Curved Edges in Graph Visualization.

    Xu, Kai / Rooney, C / Passmore, P / Ham, Dong-Han / Nguyen, P H

    IEEE transactions on visualization and computer graphics

    2012  Volume 18, Issue 12, Page(s) 2449–2456

    Abstract: Recently there has been increasing research interest in displaying graphs with curved edges to produce more readable visualizations. While there are several automatic techniques, little has been done to evaluate their effectiveness empirically. In this ... ...

    Abstract Recently there has been increasing research interest in displaying graphs with curved edges to produce more readable visualizations. While there are several automatic techniques, little has been done to evaluate their effectiveness empirically. In this paper we present two experiments studying the impact of edge curvature on graph readability. The goal is to understand the advantages and disadvantages of using curved edges for common graph tasks compared to straight line segments, which are the conventional choice for showing edges in node-link diagrams. We included several edge variations: straight edges, edges with different curvature levels, and mixed straight and curved edges. During the experiments, participants were asked to complete network tasks including determination of connectivity, shortest path, node degree, and common neighbors. We also asked the participants to provide subjective ratings of the aesthetics of different edge types. The results show significant performance differences between the straight and curved edges and clear distinctions between variations of curved edges.
    Language English
    Publishing date 2012-12
    Publishing country United States
    Document type Journal Article
    ISSN 1941-0506
    ISSN (online) 1941-0506
    DOI 10.1109/TVCG.2012.189
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Helicobacter pylori generates cells with cancer stem cell properties via epithelial-mesenchymal transition-like changes.

    Bessède, E / Staedel, C / Acuña Amador, L A / Nguyen, P H / Chambonnier, L / Hatakeyama, M / Belleannée, G / Mégraud, F / Varon, C

    Oncogene

    2014  Volume 33, Issue 32, Page(s) 4123–4131

    Abstract: Helicobacter pylori infection is the major risk factor for gastric adenocarcinoma. The link with gastric adenocarcinoma is partly due to the H. pylori CagA oncoprotein. CagA is responsible for a particular cell phenotype in vitro, the 'hummingbird' ... ...

    Abstract Helicobacter pylori infection is the major risk factor for gastric adenocarcinoma. The link with gastric adenocarcinoma is partly due to the H. pylori CagA oncoprotein. CagA is responsible for a particular cell phenotype in vitro, the 'hummingbird' phenotype, that corresponds to an elongation of the cells, mimicking an epithelial-mesenchymal transition (EMT). EMT participates in the carcinogenesis process, and is involved in the generation of cancer stem cells (CSCs). However, its involvement in gastric carcinogenesis has yet not been studied. Therefore, the aim of this study was to determine the role of H. pylori in EMT and in the emergence of gastric CSCs. For this purpose, gastric epithelial cells were cocultured with a cagA-positive H. pylori strain or its isogenic-deleted mutants or were transfected with CagA expression vectors. Study of the expression of epithelial and mesenchymal markers showed that H. pylori, via CagA, is responsible for an EMT phenotype associated with an increase in mesenchymal markers as well as CD44 expression, a known gastric CSC marker. Moreover, infection led to an increased ability to migrate, to invade and to form tumorspheres. Cell sorting experiments showed that only the CD44(high) cells induced by H. pylori infection displayed the mesenchymal phenotype and CSC properties in vitro, and had higher tumorigenic properties than CD44(low) cells in xenografted mice. Immunohistochemistry analyses on human and mouse gastric mucosa tissue samples confirmed a high expression of CD44 and mesenchymal markers in H. pylori-infected cases, and in gastric dysplasia and carcinoma. All of these data suggest that H. pylori, via CagA, unveils CSC-like properties by induction of EMT-like changes in gastric epithelial cells.
    MeSH term(s) Aged ; Aged, 80 and over ; Animals ; Antigens, Bacterial/physiology ; Bacterial Proteins/physiology ; Cell Line, Tumor ; Cell Movement ; Coculture Techniques ; Epithelial-Mesenchymal Transition ; Female ; Helicobacter pylori/physiology ; Humans ; Hyaluronan Receptors/metabolism ; Male ; Mice ; Mice, Inbred C57BL ; Mutation ; Neoplasm Transplantation ; Neoplastic Stem Cells/cytology ; Phenotype ; Stomach ; Stomach Neoplasms/microbiology ; Stomach Neoplasms/physiopathology
    Chemical Substances Antigens, Bacterial ; Bacterial Proteins ; CD44 protein, human ; Hyaluronan Receptors ; cagA protein, Helicobacter pylori
    Language English
    Publishing date 2014-08-07
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 639046-8
    ISSN 1476-5594 ; 0950-9232
    ISSN (online) 1476-5594
    ISSN 0950-9232
    DOI 10.1038/onc.2013.380
    Database MEDical Literature Analysis and Retrieval System OnLINE

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