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  1. Article: PIPDeploy: Development and implementation of a gamified table top simulation exercise to strengthen national pandemic vaccine preparedness and readiness

    Ghiga, Ioana / Richardson, Sol / Álvarez, Alba Maria Ropero / Kato, Masaya / Naidoo, Dhamari / Otsu, Satoko / Nguyen, Phuc Thi / Nguyen, Phuong Nam / Nguyen, Tim

    Vaccine. 2021 Jan. 08, v. 39, no. 2

    2021  

    Abstract: Successful emergency vaccination campaigns rely on effective deployment and vaccination plans. This applies to localised outbreaks as well as for pandemics. In the wake of the 2009 H1N1 influenza pandemic, analysis of the global Vaccine Deployment ... ...

    Abstract Successful emergency vaccination campaigns rely on effective deployment and vaccination plans. This applies to localised outbreaks as well as for pandemics. In the wake of the 2009 H1N1 influenza pandemic, analysis of the global Vaccine Deployment Initiative, through which the World Health Organization (WHO) donated pandemic influenza vaccines to countries in need, revealed that an absence of vaccine deployment plans in many countries significantly hindered vaccine deployment. Through the Pandemic Influenza Preparedness Framework adopted by the World Health Assembly in 2011, WHO is engaging in several capacity building activities to improve pandemic influenza preparedness and response and make provisions for access to vaccines and sharing of other benefits. The Framework calls for the development and exercise of operational plans for deployment of influenza vaccines to enhance pandemic preparedness. To this end, WHO has supported the development of PIPDeploy, an interactive, in-person table top simulation exercise to facilitate learning for emergency preparedness. It employs various game design elements including a game board, time pressure, leaderboards and teams to enhance participants’ motivation. PIPDeploy formed part of five WHO Pandemic Influenza Vaccine Deployment Workshops attended by national-level managers responsible for pandemic influenza vaccine response predominantly in non-producing countries. The purpose of this study was to describe the features and application of PIPDeploy, and present findings of the evaluation of participants’ experiences during the simulation involving a “hot wash” discussion and collection of quantitative data. The simulation’s instructional approach was widely accepted by participants, who reported that the format was novel and engaging. They reflected on its utility for identifying gaps in their own vaccine deployment plans and regulatory frameworks for importation of vaccine products. All participants found the simulation relevant to their professional objectives. A range of other potential applications were suggested, including PIPDeploy’s adaptation to sub-national contexts and to other epidemic diseases.
    Keywords World Health Organization ; disaster preparedness ; exercise ; influenza ; influenza vaccines ; motivation ; pandemic ; vaccination
    Language English
    Dates of publication 2021-0108
    Size p. 364-371.
    Publishing place Elsevier Ltd
    Document type Article
    Note NAL-AP-2-clean
    ZDB-ID 605674-x
    ISSN 1873-2518 ; 0264-410X
    ISSN (online) 1873-2518
    ISSN 0264-410X
    DOI 10.1016/j.vaccine.2020.11.047
    Database NAL-Catalogue (AGRICOLA)

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  2. Article ; Online: PIPDeploy: Development and implementation of a gamified table top simulation exercise to strengthen national pandemic vaccine preparedness and readiness.

    Ghiga, Ioana / Richardson, Sol / Álvarez, Alba Maria Ropero / Kato, Masaya / Naidoo, Dhamari / Otsu, Satoko / Nguyen, Phuc Thi / Nguyen, Phuong Nam / Nguyen, Tim

    Vaccine

    2020  Volume 39, Issue 2, Page(s) 364–371

    Abstract: Successful emergency vaccination campaigns rely on effective deployment and vaccination plans. This applies to localised outbreaks as well as for pandemics. In the wake of the 2009 H1N1 influenza pandemic, analysis of the global Vaccine Deployment ... ...

    Abstract Successful emergency vaccination campaigns rely on effective deployment and vaccination plans. This applies to localised outbreaks as well as for pandemics. In the wake of the 2009 H1N1 influenza pandemic, analysis of the global Vaccine Deployment Initiative, through which the World Health Organization (WHO) donated pandemic influenza vaccines to countries in need, revealed that an absence of vaccine deployment plans in many countries significantly hindered vaccine deployment. Through the Pandemic Influenza Preparedness Framework adopted by the World Health Assembly in 2011, WHO is engaging in several capacity building activities to improve pandemic influenza preparedness and response and make provisions for access to vaccines and sharing of other benefits. The Framework calls for the development and exercise of operational plans for deployment of influenza vaccines to enhance pandemic preparedness. To this end, WHO has supported the development of PIPDeploy, an interactive, in-person table top simulation exercise to facilitate learning for emergency preparedness. It employs various game design elements including a game board, time pressure, leaderboards and teams to enhance participants' motivation. PIPDeploy formed part of five WHO Pandemic Influenza Vaccine Deployment Workshops attended by national-level managers responsible for pandemic influenza vaccine response predominantly in non-producing countries. The purpose of this study was to describe the features and application of PIPDeploy, and present findings of the evaluation of participants' experiences during the simulation involving a "hot wash" discussion and collection of quantitative data. The simulation's instructional approach was widely accepted by participants, who reported that the format was novel and engaging. They reflected on its utility for identifying gaps in their own vaccine deployment plans and regulatory frameworks for importation of vaccine products. All participants found the simulation relevant to their professional objectives. A range of other potential applications were suggested, including PIPDeploy's adaptation to sub-national contexts and to other epidemic diseases.
    MeSH term(s) Humans ; Immunization Programs ; Influenza A Virus, H1N1 Subtype ; Influenza Vaccines ; Influenza, Human/epidemiology ; Influenza, Human/prevention & control ; Vaccination
    Chemical Substances Influenza Vaccines
    Language English
    Publishing date 2020-12-05
    Publishing country Netherlands
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 605674-x
    ISSN 1873-2518 ; 0264-410X
    ISSN (online) 1873-2518
    ISSN 0264-410X
    DOI 10.1016/j.vaccine.2020.11.047
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Correction to α-Glucosidase Inhibitory and Cytotoxic Taxane Diterpenoids from the Stem Bark of Taxus wallichiana.

    Dang, Phu Hoang / Nguyen, Hai Xuan / Duong, Truc Thanh Thi / Tran, Thao Kim Thi / Nguyen, Phuc Thi / Vu, Trang Kieu Thi / Vuong, Hung Chi / Phan, Nguyen Huu Trong / Nguyen, Mai Thanh Thi / Nguyen, Nhan Trung / Awale, Suresh

    Journal of natural products

    2017  Volume 80, Issue 7, Page(s) 2188

    Language English
    Publishing date 2017-06-21
    Publishing country United States
    Document type Journal Article ; Published Erratum
    ZDB-ID 304325-3
    ISSN 1520-6025 ; 0163-3864
    ISSN (online) 1520-6025
    ISSN 0163-3864
    DOI 10.1021/acs.jnatprod.7b00502
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: α-Glucosidase Inhibitory and Cytotoxic Taxane Diterpenoids from the Stem Bark of Taxus wallichiana.

    Dang, Phu Hoang / Nguyen, Hai Xuan / Duong, Truc Thanh Thi / Tran, Thao Kim Thi / Nguyen, Phuc Thi / Vu, Trang Kieu Thi / Vuong, Hung Chi / Phan, Nguyen Huu Trong / Nguyen, Mai Thanh Thi / Nguyen, Nhan Trung / Awale, Suresh

    Journal of natural products

    2017  Volume 80, Issue 4, Page(s) 1087–1095

    Abstract: ... From a ... ...

    Abstract From a CH
    MeSH term(s) Antineoplastic Agents, Phytogenic/chemistry ; Antineoplastic Agents, Phytogenic/isolation & purification ; Antineoplastic Agents, Phytogenic/pharmacology ; Bridged-Ring Compounds/chemistry ; Diterpenes/chemistry ; Diterpenes/isolation & purification ; Diterpenes/pharmacology ; Glycoside Hydrolase Inhibitors/chemistry ; Glycoside Hydrolase Inhibitors/isolation & purification ; Glycoside Hydrolase Inhibitors/pharmacology ; Humans ; Molecular Structure ; Paclitaxel/pharmacology ; Plant Bark/chemistry ; Taxoids/chemistry ; Taxoids/isolation & purification ; Taxoids/pharmacology ; Taxus/chemistry ; alpha-Glucosidases
    Chemical Substances Antineoplastic Agents, Phytogenic ; Bridged-Ring Compounds ; Diterpenes ; Glycoside Hydrolase Inhibitors ; Taxoids ; wallitaxane A ; taxane (1605-68-1) ; 10-deacetyltaxol (78432-77-6) ; alpha-Glucosidases (EC 3.2.1.20) ; Paclitaxel (P88XT4IS4D)
    Language English
    Publishing date 2017-02-27
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 304325-3
    ISSN 1520-6025 ; 0163-3864
    ISSN (online) 1520-6025
    ISSN 0163-3864
    DOI 10.1021/acs.jnatprod.7b00006
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: α-Glucosidase Inhibitory and Cytotoxic Taxane Diterpenoids from the Stem Bark of Taxus wallichiana

    Dang, Phu Hoang / Nguyen Hai Xuan / Duong Truc Thanh Thi / Tran Thao Kim Thi / Nguyen Phuc Thi / Vu Trang Kieu Thi / Vuong Hung Chi / Phan Nguyen Huu Trong / Nguyen Mai Thanh Thi / Nguyen Nhan Trung / Awale Suresh

    Journal of natural products. 2017 Apr. 28, v. 80, no. 4

    2017  

    Abstract: From a CH₂Cl₂ extract of the bark of Taxus wallichiana, six new taxoids, wallitaxanes A–F (1–6), were isolated, together with 29 known compounds. The structures of the new compounds were elucidated on the basis of spectroscopic data ... ...

    Abstract From a CH₂Cl₂ extract of the bark of Taxus wallichiana, six new taxoids, wallitaxanes A–F (1–6), were isolated, together with 29 known compounds. The structures of the new compounds were elucidated on the basis of spectroscopic data interpretation. Wallitaxane D (4) was identified as an opened oxetane-type taxoid having the first naturally occurring C(H)-20 acetal group, while wallitaxanes E (5) and F (6) are representative of the rare abeo-taxoid class. The isolated compounds were evaluated for their α-glucosidase inhibitory activity and for cytotoxicity against the HeLa human cervical cancer cell line. In the present work, taxanes were found to exhibit α-glucosidase inhibitory activity for the first time, and wallitaxane A (1) showed the most potent effect, with an IC₅₀ value of 3.6 μM. In turn, 7-epi-taxol (16) and 7-epi-10-deacetyltaxol (17) showed IC₅₀ values of 0.05 and 0.085 nM, respectively, against HeLa cells.
    Keywords Taxus wallichiana ; alpha-glucosidase ; bark ; cytotoxicity ; diterpenoids ; human cell lines ; inhibitory concentration 50 ; methylene chloride ; spectral analysis ; taxanes ; uterine cervical neoplasms
    Language English
    Dates of publication 2017-0428
    Size p. 1087-1095.
    Publishing place American Chemical Society and American Society of Pharmacognosy
    Document type Article
    ZDB-ID 304325-3
    ISSN 1520-6025 ; 0163-3864
    ISSN (online) 1520-6025
    ISSN 0163-3864
    DOI 10.1021%2Facs.jnatprod.7b00006
    Database NAL-Catalogue (AGRICOLA)

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