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Article ; Online: NOxBOXi fluctuations delivering inhaled nitric oxide via high-frequency oscillator: A conundrum and a hypothesis.

Singh, Ajay Pratap / Chao, Howard / Nguyen, Richard / Evey, Lee / Iniguez, Suzanne / Fernandes, Caraciolo J

2024

Language	English
Publishing date	2024-05-02
Publishing country	United States
Document type	Journal Article
ZDB-ID	632784-9
ISSN	1099-0496 ; 8755-6863
ISSN (online)	1099-0496
ISSN	8755-6863
DOI	10.1002/ppul.27020
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Article: Diagnostic yield of dental radiography and digital tomosynthesis for the identification of anatomic structures in cats.

Soltero-Rivera, Maria M / Nguyen, Richard / Goldschmidt, Stephanie Lynne / Hatcher, David C / Arzi, Boaz

Frontiers in veterinary science

2024 Volume 11, Page(s) 1408807

Abstract: Introduction: Digital tomosynthesis (DT) has emerged as a potential imaging modality for evaluating anatomic structures in veterinary medicine. This study aims to validate the diagnostic yield of DT in identifying predefined anatomic structures in ... ...

Abstract	Introduction: Digital tomosynthesis (DT) has emerged as a potential imaging modality for evaluating anatomic structures in veterinary medicine. This study aims to validate the diagnostic yield of DT in identifying predefined anatomic structures in feline cadaver heads, comparing it with conventional intraoral dental radiography (DR). Methods: A total of 16 feline cadaver heads were utilized to evaluate 19 predefined clinically relevant anatomic structures using both DR and DT. A semi-quantitative scoring system was employed to characterize the ability of each imaging method to identify these structures. Results: DT demonstrated a significantly higher diagnostic yield compared to DR for all evaluated anatomic structures. Orthogonal DT imaging identified 13 additional anatomic landmarks compared to a standard 10-view feline set obtained via DR. Moreover, DT achieved statistically significant higher scores for each of these landmarks, indicating improved visualization over DR. Discussion: These findings validate the utility of DT technology in reliably identifying clinically relevant anatomic structures in the cat skull. This validation serves as a foundation for further exploration of DT imaging in detecting dentoalveolar and other maxillofacial bony lesions and pathologies in cats.
Language	English
Publishing date	2024-05-02
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2834243-4
ISSN	2297-1769
ISSN	2297-1769
DOI	10.3389/fvets.2024.1408807
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Article: A rare presentation of delayed traumatic lumbar hernia after motor vehicle collision.

Nguyen, Richard B / Trivedi, Aakash A / Yang, James Y / Anand, Aakash A / Zuberi, Jamshed / Rebein, Benjamin

Journal of surgical case reports

2022 Volume 2022, Issue 5, Page(s) rjac188

Abstract: Traumatic abdominal wall hernia is defined as protrusion of bowel or an abdominal organ through a disruption of musculature and fascia following a severe blunt trauma. We report a case of a patient who had a delayed presentation of a traumatic, ... ...

Abstract	Traumatic abdominal wall hernia is defined as protrusion of bowel or an abdominal organ through a disruption of musculature and fascia following a severe blunt trauma. We report a case of a patient who had a delayed presentation of a traumatic, superiorly located paralumbar hernia months after the initial admission.
Language	English
Publishing date	2022-05-31
Publishing country	England
Document type	Case Reports
ZDB-ID	2580919-2
ISSN	2042-8812
ISSN	2042-8812
DOI	10.1093/jscr/rjac188
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Article ; Online: Beyond the Traditional Classroom: Increased Course Structure and Cooperative Learning Remove Differences in Achievement between Students in an In-Person versus Hybrid Microbiology Course.

Foster-Hartnett, Dawn / Mwakalundwa, Gwantwa / Bofenkamp, Lisa / Patton, Liz / Nguyen, Richard / Goodman-Mamula, Patricia

CBE life sciences education

2022 Volume 21, Issue 2, Page(s) ar33

Abstract: The increase in online learning brought on by the COVID-19 pandemic will likely result in a greater availability of online and hybrid course offerings. In this study, students enrolled in parallel sections of a microbiology lab course with in-person labs ...

Abstract	The increase in online learning brought on by the COVID-19 pandemic will likely result in a greater availability of online and hybrid course offerings. In this study, students enrolled in parallel sections of a microbiology lab course with in-person labs and either face-to-face (F2F) or all-online lectures (hybrid, H). Course material and method of assessment in the two sections were identical; student demographics were similar. In the first year, F2F students scored significantly higher on two out of four exams. In the second year, two interventions were introduced: team-building activities (in both sections) and online group discussions (H only). Students in both the F2F and H sections reported similar positive teamwork reviews based on Comprehensive Assessment of Team Member Effectiveness (catme.org) and survey data. Although the COVID-19 pandemic eventually forced all learning online, exam scores from the two sections in the first half of the semester were similar, suggesting that the interventions were effective. In both sections, exam scores were positively correlated with entering grade point averages. This study adds to the body of literature supporting the effectiveness of hybrid learning.
MeSH term(s)	Achievement ; COVID-19 ; Humans ; Learning ; Pandemics ; Students
Language	English
Publishing date	2022-04-22
Publishing country	United States
Document type	Journal Article
ZDB-ID	2465176-X
ISSN	1931-7913 ; 1931-7913
ISSN (online)	1931-7913
ISSN	1931-7913
DOI	10.1187/cbe.21-01-0007
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Article ; Online: Testing positive pressure delivered from commercial and WHO-style pediatric bubble CPAP devices.

Ettinger, Nicholas A / Serazin, Nathan / Nguyen, Richard / Werdenberg, Jennifer / Huibers, Minke / Torrey, Susan

BMC pediatrics

2021 Volume 21, Issue 1, Page(s) 524

Abstract: Background/aim: Low-cost commercial bCPAP devices have been deployed in resource-limited settings to treat neonatal respiratory failure. The use of these devices has increased access to pediatric respiratory support for infants. However, constrained ... ...

Abstract	Background/aim: Low-cost commercial bCPAP devices have been deployed in resource-limited settings to treat neonatal respiratory failure. The use of these devices has increased access to pediatric respiratory support for infants. However, constrained resources may result in substitution of recommended consumables and/or use in older age groups. We hypothesized that commercially available bCPAP devices, the standard WHO-style device and various improvised adaptations would all generate effective, safe positive pressure at the patient interface. Methods: Performance of 2 commercially available bCPAP devices was tested against the standard WHO-style bCPAP device, as well as several improvised modifications of these devices, by measuring positive pressure delivered at the patient interface. Variables tested included different flow rates, patient interfaces and respiratory circuit tubing. Results: Both commercial devices utilized according to manufacturer recommendations generated the expected positive pressure at the patient interface. When testing the recommended WHO-style bCPAP device with recommended materials as well as other improvised modifications, we found variable and potentially unpredictable generation of positive pressure at the patient interface. Conclusions: Modified or improvised bCPAP devices should be used with extreme caution as the support provided may be more or less than expected depending on respiratory tubing and flow rates employed. Our data support the effectiveness of bCPAP in newborns and young infants. But, to our knowledge, there are no bCPAP patient interfaces for older children effective with low liter flow devices. Therefore, based on these results, we recommend against using WHO-style bCPAP devices for non-infant patients with respiratory failure and instead recommend using standard oxygen therapy with nasal cannulae or face-masks, as well as early consideration of transfer to a higher level of care.
MeSH term(s)	Adolescent ; Aged ; Child ; Continuous Positive Airway Pressure ; Humans ; Infant ; Infant, Newborn ; Oxygen Inhalation Therapy ; Respiratory Distress Syndrome, Newborn/therapy ; World Health Organization
Language	English
Publishing date	2021-11-27
Publishing country	England
Document type	Journal Article
ZDB-ID	2041342-7
ISSN	1471-2431 ; 1471-2431
ISSN (online)	1471-2431
ISSN	1471-2431
DOI	10.1186/s12887-021-03006-2
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Article: Incidental discovery of goblet cell carcinoid, a rare appendiceal malignancy case report.

Barbash, Daniel / Trivedi, Aakash A / Yang, James Y / Nguyen, Richard B / Huribal, John C / Zuberi, Jamshed / Elsawy, Osama / Wessner, Scott

Journal of surgical case reports

2022 Volume 2022, Issue 7, Page(s) rjac356

Abstract: Goblet cell carcinoid (GCC) tumor is a rare appendiceal carcinoma that has had several names throughout its history. Often found incidentally on pathology following an appendectomy, treatment includes a right hemicolectomy and possible adjuvant ... ...

Abstract	Goblet cell carcinoid (GCC) tumor is a rare appendiceal carcinoma that has had several names throughout its history. Often found incidentally on pathology following an appendectomy, treatment includes a right hemicolectomy and possible adjuvant chemotherapy. Survival rate has been shown to be correlated with the histological features. Here, we report a 45-year-old African American male who presented with signs and symptoms consistent with acute appendicitis, but was ultimately diagnosed with GCC. After undergoing a right hemicolectomy, he continues to undergo long-term surveillance with his oncologist. Due to the rarity of this tumor, we describe the history of GCC and our recommendations for surgical and long-term management.
Language	English
Publishing date	2022-07-31
Publishing country	England
Document type	Case Reports
ZDB-ID	2580919-2
ISSN	2042-8812
ISSN	2042-8812
DOI	10.1093/jscr/rjac356
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Book ; Online: Feature Construction and Selection for PV Solar Power Modeling

Yang, Yu / Mao, Jia / Nguyen, Richard / Tohmeh, Annas / Yeh, Hen-Geul

2022

Abstract: Using solar power in the process industry can reduce greenhouse gas emissions and make the production process more sustainable. However, the intermittent nature of solar power renders its usage challenging. Building a model to predict photovoltaic (PV) ... ...

Abstract	Using solar power in the process industry can reduce greenhouse gas emissions and make the production process more sustainable. However, the intermittent nature of solar power renders its usage challenging. Building a model to predict photovoltaic (PV) power generation allows decision-makers to hedge energy shortages and further design proper operations. The solar power output is time-series data dependent on many factors, such as irradiance and weather. A machine learning framework for 1-hour ahead solar power prediction is developed in this paper based on the historical data. Our method extends the input dataset into higher dimensional Chebyshev polynomial space. Then, a feature selection scheme is developed with constrained linear regression to construct the predictor for different weather types. Several tests show that the proposed approach yields lower mean squared error than classical machine learning methods, such as support vector machine (SVM), random forest (RF), and gradient boosting decision tree (GBDT). Comment: 6 pages, 8 figures
Keywords	Electrical Engineering and Systems Science - Systems and Control ; Computer Science - Machine Learning
Subject code	670
Publishing date	2022-02-13
Publishing country	us
Document type	Book ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: The c-Abl inhibitor IkT-148009 suppresses neurodegeneration in mouse models of heritable and sporadic Parkinson's disease.

Karuppagounder, Senthilkumar S / Wang, Hu / Kelly, Terence / Rush, Roger / Nguyen, Richard / Bisen, Shivani / Yamashita, Yoko / Sloan, Nicholas / Dang, Brianna / Sigmon, Alexander / Lee, Hyeun Woo / Marino Lee, Shirley / Watkins, Leslie / Kim, Erica / Brahmachari, Saurav / Kumar, Manoj / Werner, Milton H / Dawson, Ted M / Dawson, Valina L

Science translational medicine

2023 Volume 15, Issue 679, Page(s) eabp9352

Abstract: Parkinson's disease (PD) is the second most prevalent neurodegenerative disease of the central nervous system, with an estimated 5,000,000 cases worldwide. PD pathology is characterized by the accumulation of misfolded α-synuclein, which is thought to ... ...

Abstract	Parkinson's disease (PD) is the second most prevalent neurodegenerative disease of the central nervous system, with an estimated 5,000,000 cases worldwide. PD pathology is characterized by the accumulation of misfolded α-synuclein, which is thought to play a critical role in the pathogenesis of the disease. Animal models of PD suggest that activation of Abelson tyrosine kinase (c-Abl) plays an essential role in the initiation and progression of α-synuclein pathology and initiates processes leading to degeneration of dopaminergic and nondopaminergic neurons. Given the potential role of c-Abl in PD, a c-Abl inhibitor library was developed to identify orally bioavailable c-Abl inhibitors capable of crossing the blood-brain barrier based on predefined characteristics, leading to the discovery of IkT-148009. IkT-148009, a brain-penetrant c-Abl inhibitor with a favorable toxicology profile, was analyzed for therapeutic potential in animal models of slowly progressive, α-synuclein-dependent PD. In mouse models of both inherited and sporadic PD, IkT-148009 suppressed c-Abl activation to baseline and substantially protected dopaminergic neurons from degeneration when administered therapeutically by once daily oral gavage beginning 4 weeks after disease initiation. Recovery of motor function in PD mice occurred within 8 weeks of initiating treatment concomitantly with a reduction in α-synuclein pathology in the mouse brain. These findings suggest that IkT-148009 may have potential as a disease-modifying therapy in PD.
MeSH term(s)	Mice ; Animals ; alpha-Synuclein/metabolism ; Parkinson Disease/drug therapy ; Parkinson Disease/pathology ; Neurodegenerative Diseases/pathology ; Proto-Oncogene Proteins c-abl/metabolism ; Brain/metabolism ; Disease Models, Animal ; Synucleinopathies ; Dopaminergic Neurons/metabolism
Chemical Substances	alpha-Synuclein ; Proto-Oncogene Proteins c-abl (EC 2.7.10.2)
Language	English
Publishing date	2023-01-18
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	2518854-9
ISSN	1946-6242 ; 1946-6234
ISSN (online)	1946-6242
ISSN	1946-6234
DOI	10.1126/scitranslmed.abp9352
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Article: Bridge Helix of Cas9 Modulates Target DNA Cleavage and Mismatch Tolerance

Babu, Kesavan / Amrani, Nadia / Jiang, Wei / Yogesha, S.D / Nguyen, Richard / Qin, Peter Z / Rajan, Rakhi

Biochemistry. 2019 Mar. 27, v. 58, no. 14

2019

Abstract: CRISPR-Cas systems are RNA-guided nucleases that provide adaptive immune protection for bacteria and archaea against intruding genomic materials. The programmable nature of CRISPR-targeting mechanisms has enabled their adaptation as powerful genome ... ...

Abstract	CRISPR-Cas systems are RNA-guided nucleases that provide adaptive immune protection for bacteria and archaea against intruding genomic materials. The programmable nature of CRISPR-targeting mechanisms has enabled their adaptation as powerful genome engineering tools. Cas9, a type II CRISPR effector protein, has been widely used for gene-editing applications owing to the fact that a single-guide RNA can direct Cas9 to cleave desired genomic targets. An understanding of the role of different domains of the protein and guide RNA-induced conformational changes of Cas9 in selecting target DNA has been and continues to enable development of Cas9 variants with reduced off-targeting effects. It has been previously established that an arginine-rich bridge helix (BH) present in Cas9 is critical for its activity. In the present study, we show that two proline substitutions within a loop region of the BH of Streptococcus pyogenes Cas9 impair the DNA cleavage activity by accumulating nicked products and reducing target DNA linearization. This in turn imparts a higher selectivity in DNA targeting. We discuss the probable mechanisms by which the BH-loop contributes to target DNA recognition.
Keywords	Archaea ; DNA ; DNA damage ; RNA ; Streptococcus pyogenes ; bacteria ; gene editing ; genomics ; nucleases ; proline
Language	English
Dates of publication	2019-0327
Size	p. 1905-1917.
Publishing place	American Chemical Society
Document type	Article
ZDB-ID	1108-3
ISSN	1520-4995 ; 0006-2960
ISSN (online)	1520-4995
ISSN	0006-2960
DOI	10.1021/acs.biochem.8b01241
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Intracellular Delivery of DNA and Protein by a Novel Cell-Permeable Peptide Derived from DOT1L.

Geng, Jingping / Guo, Xiangli / Wang, Lidan / Nguyen, Richard Q / Wang, Fengqin / Liu, Changbai / Wang, Hu

Biomolecules

2020 Volume 10, Issue 2

Abstract: Cellular uptake and intracellular release efficiency of biomacromolecules is low because of hurdles in the cell membrane that result in limited access to intra-cellular targets with few functional effects. Cell-penetrating peptides (CPPs) act as cargo ... ...

Abstract	Cellular uptake and intracellular release efficiency of biomacromolecules is low because of hurdles in the cell membrane that result in limited access to intra-cellular targets with few functional effects. Cell-penetrating peptides (CPPs) act as cargo delivery vehicles to promote therapeutic molecule translocation. Here, we describe the novel CPP-Dot1l that not only penetrates by itself, but also mediates cargo translocation in cultured cells, as confirmed by fluorescence microscopy and fluorescence spectrophotometry. We conducted cytotoxicity assays and safety evaluations, and determined peptide-membrane interactions to understand the possible pathway for cargo translocation. Additional nucleic acid and covalently conjugated green fluorescence protein (GFP) studies mediated by CPP-Dot1l were conducted to show functional delivery potential. Results indicate that CPP-Dot1l is a novel and effective CPP due to its good penetrating properties in different cell lines and its ability to enter cells in a concentration-dependent manner. Its penetration efficiency can be prompted by DMSO pretreatment. In addition, not only can it mediate plasmid delivery, but CPP-Dot1l can also deliver GFP protein into cytosol. In conclusion, the findings of this study showed CPP-Dot1l is an attractive pharmaceutical and biochemical tool for future drug, regenerative medicine, cell therapy, gene therapy, and gene editing-based therapy development.
MeSH term(s)	Cell-Penetrating Peptides/chemistry ; Computational Biology ; Cytosol/chemistry ; DNA/chemistry ; Drug Delivery Systems ; Erythrocytes/chemistry ; Green Fluorescent Proteins/chemistry ; Hemolysis ; Histone-Lysine N-Methyltransferase/chemistry ; Humans ; MCF-7 Cells ; Microscopy, Fluorescence ; Nucleic Acids/chemistry ; Particle Size ; Plasmids/chemistry ; Protein Binding ; Protein Transport
Chemical Substances	Cell-Penetrating Peptides ; Nucleic Acids ; Green Fluorescent Proteins (147336-22-9) ; DNA (9007-49-2) ; DOT1L protein, human (EC 2.1.1.-) ; Histone-Lysine N-Methyltransferase (EC 2.1.1.43)
Language	English
Publishing date	2020-02-02
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2701262-1
ISSN	2218-273X ; 2218-273X
ISSN (online)	2218-273X
ISSN	2218-273X
DOI	10.3390/biom10020217
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