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  1. Article ; Online: Integration of Interbull's multiple across-country evaluation approach breeding values into the multiple-trait single-step random regression test-day genetic evaluation for yield traits of Australian Red breeds.

    Boerner, Vinzent / Nguyen, Thuy T T / Nieuwhof, Gert J

    Journal of dairy science

    2022  Volume 106, Issue 2, Page(s) 1159–1167

    Abstract: Interbull's multiple across-country evaluaftion provides national breeding organizations with breeding values for internationally used bulls, which integrate performance data obtained in different breeding populations, environments, and production ... ...

    Abstract Interbull's multiple across-country evaluaftion provides national breeding organizations with breeding values for internationally used bulls, which integrate performance data obtained in different breeding populations, environments, and production systems. However, breeding value-based selection decisions on domestic individuals born to foreign sires can only benefit from Interbull breeding values if they are integrated such that their information can contribute to the breeding values of all related domestic animals. For that purpose, several methods have been proposed which either model Interbull breeding values as prior information in a Bayesian approach, as additional pseudo data points, or as correlated traits, where these methods also differ in their software and parameterization requirements. Further, the complexity of integration also depends on the traits and genetic evaluation models. Especially random regression models require attention because of the dimensionality discrepancy between the number of Interbull breeding values and the number of modeled genetic effects. This paper presents the results from integrating 16,063 Interbull breeding values into the domestic single-step random regression test-day model for milk, fat, and protein yield for Australian Red dairy cattle breeds. Interbull breeding values were modeled as pseudo data points with data point-specific residual variances derived within animal across traits, ignoring relationships between integrated animals. Results suggest that the integration was successful with regard to alignment of Interbull breeding values with their domestic equivalent as well as with regard to the individual and population-wide increase in reliabilities. Depending on the relationship structure between integration candidates, further work is required to account for those relationships in a computationally feasible manner. Other traits with separate parity effects nationally could use a similar approach, even if not modeled with a test-day model.
    MeSH term(s) Animals ; Cattle/genetics ; Male ; Female ; Bayes Theorem ; Australia ; Phenotype ; Milk/chemistry ; Lactation/genetics ; Models, Genetic
    Language English
    Publishing date 2022-11-29
    Publishing country United States
    Document type Journal Article
    ZDB-ID 242499-x
    ISSN 1525-3198 ; 0022-0302
    ISSN (online) 1525-3198
    ISSN 0022-0302
    DOI 10.3168/jds.2022-21816
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Population-Based Pharmacokinetics and Dose Optimization of Imipenem in Vietnamese Critically-Ill Patients.

    Dinh, Thanh D / Nguyen, Hung N / Le, Ba Hai / Nguyen, Thuy T T / Nguyen, Huong T L

    Infection and drug resistance

    2022  Volume 15, Page(s) 4575–4583

    Abstract: Purpose: The purpose of this study was to characterize the population-based pharmacokinetic (POP-PK) profile of imipenem in Vietnamese adult patients and to assess the probability of target attainment (PTA) of the pharmacokinetic/pharmacodynamic (PK/PD) ...

    Abstract Purpose: The purpose of this study was to characterize the population-based pharmacokinetic (POP-PK) profile of imipenem in Vietnamese adult patients and to assess the probability of target attainment (PTA) of the pharmacokinetic/pharmacodynamic (PK/PD) parameter to determine the optimal dose.
    Patients and methods: A POP-PK model of imipenem was developed in patients with severe infection from a 1500-bed general hospital in Vietnam, using MONOLIX 2019. After the initial dose infusion, 6 blood samples per patient were collected to measure plasma imipenem levels. Eight covariates (eg, age, weight) were investigated to ascertain their influence on imipenem's PK. Monte Carlo simulations were performed to determine the PTA for the time in which the total steady-state imipenem concentrations remained above the MIC (T>MIC) for 40% and 100% of the dosing interval.
    Results: The best fit to the PK data was a two-compartment model with inter-individual variability (IIV) in clearance (CL), central volume of distribution (Vc), intercompartmental clearance (Q), and peripheral volume of distribution (Vp). Only creatinine clearance was retained as a covariate on CL in the final model. The typical value of CL and Vc were estimated to be 4.79 L/h and 11.1 L, respectively. The between-subject variability in this population was noted to be high (>38%, especially for IIV on Q at 110%). Prolonged or continuous infusion demonstrated efficacy (40%
    Conclusion: A population pharmacokinetic model of imipenem was developed for Vietnamese adult patients with severe illness. By using Monte Carlo simulation, the appropriate dose has been suggested based on the bacterial MIC value and the targeted PK/PD goal.
    Language English
    Publishing date 2022-08-17
    Publishing country New Zealand
    Document type Journal Article
    ZDB-ID 2494856-1
    ISSN 1178-6973
    ISSN 1178-6973
    DOI 10.2147/IDR.S373348
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Arbovirus research in the Asia-Pacific needs more women in leadership.

    Frentiu, Francesca D / Belvis, Ann Florence V / Dupont-Rouzeyrol, Myrielle / Edillo, Frances E / Harishchandra, Jeevanie / Mariasua, Joanne / Nguyen, Thuy T T / O'Connor, Olivia / Santoso, Marsha Sinditia / Tran, Ninh T H / Yudhaputri, Frilasita Aisyah

    The Lancet. Infectious diseases

    2024  Volume 24, Issue 3, Page(s) 231–232

    MeSH term(s) Female ; Humans ; Arboviruses ; Leadership ; Asia/epidemiology ; Pacific Islands/epidemiology
    Language English
    Publishing date 2024-01-15
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2061641-7
    ISSN 1474-4457 ; 1473-3099
    ISSN (online) 1474-4457
    ISSN 1473-3099
    DOI 10.1016/S1473-3099(23)00817-4
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: A unique genetic variation with respect to blast (

    Nguyen, Ngoc B / Nguyen, Nguyet T M / Nguyen, Nhai T / Le, Linh H / La, Nghia T / Nguyen, Thuy T T / Yanoria, Mary Jeany / Hayashi, Nagao / Saito, Hiroki / Obara, Mitsuhiro / Sato, Tadashi / Fukuta, Yoshimichi

    Breeding science

    2023  Volume 73, Issue 2, Page(s) 193–203

    Abstract: A unique genetic variation with respect to blast resistance was clarified in 201 rice accessions from Vietnam. These accessions were classified into three clusters-A, B1, and B2-based on their reactions to 26 standard differential blast isolates selected ...

    Abstract A unique genetic variation with respect to blast resistance was clarified in 201 rice accessions from Vietnam. These accessions were classified into three clusters-A, B1, and B2-based on their reactions to 26 standard differential blast isolates selected in Vietnam. Cluster A was the dominant cultivar group in Vietnam and the most susceptible of the three clusters. Cluster B1 was the smallest group and the most resistant. Cluster B2 was the second-most dominant group and of intermediate resistance between clusters A and B1. The percentages of accessions comprising each cluster varied by region and area. Accessions in cluster A were distributed widely throughout Vietnam and had the highest frequencies in both the Central and North regions. Accessions in cluster B2 were found with highest frequencies in the mountainous and intermediate areas of the North region. Accessions in cluster B1 were found with highest frequencies in the Central region and Red River Delta area (North region). These results suggest that rice accessions in Vietnam were basically susceptible (cluster A) or of intermediate resistance (cluster B2), and that high-resistance cultivars were mainly distributed in the low altitude areas, such as the Red River Delta area and Central region.
    Language English
    Publishing date 2023-04-25
    Publishing country Japan
    Document type Journal Article
    ZDB-ID 1190370-3
    ISSN 1344-7610 ; 0536-3683
    ISSN 1344-7610 ; 0536-3683
    DOI 10.1270/jsbbs.22073
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: A descriptive case report of telesupervision and online case-based learning for speech and language therapy students in Vietnam during the COVID-19 pandemic.

    McAllister, Lindy L / Atherton, Marie / Winkworth, Alison / Wells, Stephanie / Le, Dien K / Sandweg, Karina / Nguyen, Thuy T T / Henderson-Faranda, Natalia / Broadmore, Sharon

    The South African journal of communication disorders = Die Suid-Afrikaanse tydskrif vir Kommunikasieafwykings

    2022  Volume 69, Issue 2, Page(s) e1–e6

    Abstract: Background:  Vietnam's first speech and language therapy (SLT) degrees commenced in 2019 utilising international educators. Continuity of the degrees was impacted by travel restrictions during the coronavirus disease 2019 (COVID-19) pandemic.: ... ...

    Abstract Background:  Vietnam's first speech and language therapy (SLT) degrees commenced in 2019 utilising international educators. Continuity of the degrees was impacted by travel restrictions during the coronavirus disease 2019 (COVID-19) pandemic.
    Objectives:  This article presents a descriptive case report exploring the viability of online learning to continue clinical education (CE) of SLT students in Vietnam during the pandemic.
    Method:  Students were scheduled for face to face placements throughout 2021. International SLT educators were to travel to Vietnam and work with interpreters and locally trained certificate level therapists to provide placement supervision. When travel became impossible, tele-supervision by international therapists working remotely and in partnership with local therapists and interpreters was arranged. The second wave of Covid-19 excluded students from healthcare settings early in their placements. To conclude these placements, tele-supervisors led online case-based discussions with students. For subsequent placements, Vietnamese and international therapists facilitated two to three weeks of online case-based group discussions for students, using cases with videos or avatars.
    Results:  Learning outcomes for students, as evidenced in written and oral assessments demonstrated attainment of many of the learning objectives of the placements. Satisfaction for all participants (students, tele-supervisors, online group facilitators) was high. Students will undertake face to face placements in the future; however they will commence these placements with heightened clinical reasoning and planning skills.
    Conclusion:  Online CE is possible in LMIC and, as part of a program which includes face to face placements, can support essential CE outcomes and enhance preparation for subsequent direct experiences with patients.
    MeSH term(s) COVID-19 ; Education, Distance ; Humans ; Language Therapy ; Pandemics ; Speech ; Vietnam
    Language English
    Publishing date 2022-08-15
    Publishing country South Africa
    Document type Case Reports ; Journal Article
    ZDB-ID 424442-4
    ISSN 2225-4765 ; 0379-8046
    ISSN (online) 2225-4765
    ISSN 0379-8046
    DOI 10.4102/sajcd.v69i2.897
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: A practical future-scenarios selection tool to breed for heat tolerance in Australian dairy cattle

    Nguyen, Thuy T. T / Ben J. Hayes / Jennie E. Pryce

    Animal production science. 2017, v. 57, no. 7

    2017  

    Abstract: Climate change will have an impact on dairy cow performance. When heat stressed, animals consume less feed, followed by a decline in milk yield. Previously, we have found that there is genetic variation in this decline. Selection for increased milk ... ...

    Abstract Climate change will have an impact on dairy cow performance. When heat stressed, animals consume less feed, followed by a decline in milk yield. Previously, we have found that there is genetic variation in this decline. Selection for increased milk production, a major breeding objective, is expected to reduce heat tolerance (HT), as these traits are genetically unfavourably correlated. We aimed to develop a future-scenarios selection tool to assist farmers in making selection decisions, that combines the current national dairy selection index, known as the balanced performance index (BPI), with a proposed HT genomic estimated breeding value (GEBV). Heat-tolerance GEBV was estimated for 12062 genotyped cows and 10981 bulls, using an established genomic-prediction equation. Publicly available future daily average temperature and humidity data were used to estimate mean daily temperature–humidity index for each dairy herd. An economic estimate of an individual cow’s heat-tolerance breeding value (BV_HT) was calculated by multiplying head-tolerance GEBVs for milk, fat and protein by their respective economic values that are already used in the BPI. This was scaled for each region by multiplying BV_HT by the heat load, which is the temperature–humidity index units exceeding the threshold per year at a particular location. BV_HT were incorporated into the BPI as: BPI_HT = BPI + BV_HT; where BPI_HT is the ‘augmented BPI’ breeding value including HT. A web-based application was developed enabling farmers to predict the future heat load of a herd and take steps to aim at genetic improvement in future generations by selecting bulls and cows that rank high for the ‘augmented BPI’.
    Keywords Internet ; breeding value ; bulls ; climate change ; dairy cows ; dairy herds ; economic valuation ; equations ; farmers ; genetic improvement ; genetic variation ; genotyping ; heat ; heat tolerance ; humidity ; milk ; milk yield ; selection index ; temperature
    Language English
    Size p. 1488-1493.
    Publishing place CSIRO Publishing
    Document type Article
    ZDB-ID 2472524-9
    ISSN 1836-5787 ; 1836-0939
    ISSN (online) 1836-5787
    ISSN 1836-0939
    DOI 10.1071/AN16449
    Database NAL-Catalogue (AGRICOLA)

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  7. Article: Population structure in the highly fragmented range of Tor douronensis (Cyprinidae) in Sarawak, Malaysia revealed by microsatellite DNA markers

    NGUYEN, THUY T.T

    Freshwater biology. 2008 May, v. 53, no. 5

    2008  

    Abstract: 1. Understanding the structure of threatened populations, particularly those that exist in degraded or fragmented habitats is crucial for their effective management and conservation. Recently developed methods of individual-based analysis of genetic data ...

    Abstract 1. Understanding the structure of threatened populations, particularly those that exist in degraded or fragmented habitats is crucial for their effective management and conservation. Recently developed methods of individual-based analysis of genetic data provide an unprecedented opportunity to understand the relationships amongst fragmented populations. 2. In the present study, population structure of an important cyprinid species (Tor douronensis), which is indigenous to Sarawak, Malaysia, is investigated as part of an ongoing conservation effort to restore threatened wild populations of the species. The population structure inferred using data from seven autosomal microsatellite loci was generally consistent with geography and habitat fragmentation. 3. The results indicate that there are two well-defined clusters of T. douronensis in Sarawak, namely the 'northeastern' and the 'southwestern' clusters. In addition, a further subdivision was observed in each of the clusters distributed between river systems. Low levels of gene flow were also observed and migrants between habitat fragments were identified, possibly resulting from human-mediated translocations. 4. Implications of the findings for management and conservation of T. douronensis are discussed.
    Keywords microsatellite repeats ; population structure ; administrative management
    Language English
    Dates of publication 2008-05
    Size p. 924-934.
    Publisher Blackwell Publishing Ltd
    Publishing place Oxford, UK
    Document type Article
    ZDB-ID 121180-8
    ISSN 0046-5070
    ISSN 0046-5070
    DOI 10.1111/j.1365-2427.2007.01948.x
    Database NAL-Catalogue (AGRICOLA)

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  8. Article ; Online: Genomic selection for tolerance to heat stress in Australian dairy cattle.

    Nguyen, Thuy T T / Bowman, Phil J / Haile-Mariam, Mekonnen / Pryce, Jennie E / Hayes, Benjamin J

    Journal of dairy science

    2016  Volume 99, Issue 4, Page(s) 2849–2862

    Abstract: Temperature and humidity levels above a certain threshold decrease milk production in dairy cattle, and genetic variation is associated with the amount of lost production. To enable selection for improved heat tolerance, the aim of this study was to ... ...

    Abstract Temperature and humidity levels above a certain threshold decrease milk production in dairy cattle, and genetic variation is associated with the amount of lost production. To enable selection for improved heat tolerance, the aim of this study was to develop genomic estimated breeding values (GEBV) for heat tolerance in dairy cattle. Heat tolerance was defined as the rate of decline in production under heat stress. We combined herd test-day recording data from 366,835 Holstein and 76,852 Jersey cows with daily temperature and humidity measurements from weather stations closest to the tested herds for test days between 2003 and 2013. We used daily mean values of temperature-humidity index averaged for the day of test and the 4 previous days as the measure of heat stress. Tolerance to heat stress was estimated for each cow using a random regression model with a common threshold of temperature-humidity index=60 for all cows. The slope solutions for cows from this model were used to define the daughter trait deviations of their sires. Genomic best linear unbiased prediction was used to calculate GEBV for heat tolerance for milk, fat, and protein yield. Two reference populations were used, the first consisted of genotyped sires only (2,300 Holstein and 575 Jersey sires), and the other included genotyped sires and cows (2,189 Holstein and 1,188 Jersey cows). The remainder of the genotyped sires were used as a validation set. All animals had genotypes for 632,003 single nucleotide polymorphisms. When using only genotyped sires in the reference set and only the first parity data, the accuracy of GEBV for heat tolerance in relation to changes in milk, fat, and protein yield were 0.48, 0.50, and 0.49 in the Holstein validation sires and 0.44, 0.61, and 0.53 in the Jersey validation sires, respectively. Some slight improvement in the accuracy of prediction was achieved when cows were included in the reference population for Holsteins. No clear improvements in the accuracy of genomic prediction were observed when data from the second and third parities were included. Correlations of GEBV for heat tolerance with Australian Breeding Values for other traits suggested heat tolerance had a favorable genetic correlation with fertility (0.29-0.39 in Holsteins and 0.15-0.27 in Jerseys), but unfavorable correlations for some production traits. Options to improve heat tolerance with genomic selection in Australian dairy cattle are discussed.
    MeSH term(s) Animals ; Australia ; Breeding ; Cattle/genetics ; Cattle/physiology ; Cattle Diseases/genetics ; Female ; Fertility/genetics ; Genetic Variation ; Genotype ; Hot Temperature ; Humidity ; Lactation/genetics ; Male ; Milk/chemistry ; Milk/secretion ; Parity/genetics ; Polymorphism, Single Nucleotide/genetics ; Pregnancy ; Selection, Genetic ; Stress, Physiological/genetics
    Language English
    Publishing date 2016-04
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 242499-x
    ISSN 1525-3198 ; 0022-0302
    ISSN (online) 1525-3198
    ISSN 0022-0302
    DOI 10.3168/jds.2015-9685
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: Genomic selection for tolerance to heat stress in Australian dairy cattle

    Nguyen, Thuy T.T / Benjamin J. Hayes / Jennie E. Pryce / Mekonnen Haile-Mariam / Phil J. Bowman

    American Dairy Science Association Journal of dairy science. 2016 Apr., v. 99, no. 4

    2016  

    Abstract: Temperature and humidity levels above a certain threshold decrease milk production in dairy cattle, and genetic variation is associated with the amount of lost production. To enable selection for improved heat tolerance, the aim of this study was to ... ...

    Abstract Temperature and humidity levels above a certain threshold decrease milk production in dairy cattle, and genetic variation is associated with the amount of lost production. To enable selection for improved heat tolerance, the aim of this study was to develop genomic estimated breeding values (GEBV) for heat tolerance in dairy cattle. Heat tolerance was defined as the rate of decline in production under heat stress. We combined herd test-day recording data from 366,835 Holstein and 76,852 Jersey cows with daily temperature and humidity measurements from weather stations closest to the tested herds for test days between 2003 and 2013. We used daily mean values of temperature-humidity index averaged for the day of test and the 4 previous days as the measure of heat stress. Tolerance to heat stress was estimated for each cow using a random regression model with a common threshold of temperature-humidity index=60 for all cows. The slope solutions for cows from this model were used to define the daughter trait deviations of their sires. Genomic best linear unbiased prediction was used to calculate GEBV for heat tolerance for milk, fat, and protein yield. Two reference populations were used, the first consisted of genotyped sires only (2,300 Holstein and 575 Jersey sires), and the other included genotyped sires and cows (2,189 Holstein and 1,188 Jersey cows). The remainder of the genotyped sires were used as a validation set. All animals had genotypes for 632,003 single nucleotide polymorphisms. When using only genotyped sires in the reference set and only the first parity data, the accuracy of GEBV for heat tolerance in relation to changes in milk, fat, and protein yield were 0.48, 0.50, and 0.49 in the Holstein validation sires and 0.44, 0.61, and 0.53 in the Jersey validation sires, respectively. Some slight improvement in the accuracy of prediction was achieved when cows were included in the reference population for Holsteins. No clear improvements in the accuracy of genomic prediction were observed when data from the second and third parities were included. Correlations of GEBV for heat tolerance with Australian Breeding Values for other traits suggested heat tolerance had a favorable genetic correlation with fertility (0.29–0.39 in Holsteins and 0.15–0.27 in Jerseys), but unfavorable correlations for some production traits. Options to improve heat tolerance with genomic selection in Australian dairy cattle are discussed.
    Keywords breeding value ; cows ; dairy cattle ; genetic correlation ; genetic variation ; genotype ; genotyping ; heat stress ; heat tolerance ; herds ; Holstein ; humidity ; Jersey ; marker-assisted selection ; milk ; milk production ; models ; prediction ; regression analysis ; single nucleotide polymorphism ; sires ; temperature ; weather stations
    Language English
    Dates of publication 2016-04
    Size p. 2849-2862.
    Publishing place Elsevier Inc.
    Document type Article
    ZDB-ID 242499-x
    ISSN 1525-3198 ; 0022-0302
    ISSN (online) 1525-3198
    ISSN 0022-0302
    DOI 10.3168/jds.2015-9685
    Database NAL-Catalogue (AGRICOLA)

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  10. Article: Genetic parameters and response to selection in blue mussel (Mytilus galloprovincialis) using a SNP-based pedigree

    Nguyen, Thuy T.T / Ben J. Hayes / Brett A. Ingram

    Aquaculture. 2014 Jan. 15, v. 420-421

    2014  

    Abstract: In this study, we estimated genetic parameters and realised response to selection in the second generation of a breeding programme of the blue mussel (Mytilus galloprovincialis). A total of 77 full-sib families were produced and reared communally after ... ...

    Abstract In this study, we estimated genetic parameters and realised response to selection in the second generation of a breeding programme of the blue mussel (Mytilus galloprovincialis). A total of 77 full-sib families were produced and reared communally after the fertilisation stage. To assist the reconstruction of a pedigree from these families, a panel of single nucleotide polymorphisms (SNPs) was developed de novo from genomic sequences. A total of 227 out of 432 SNPs were validated. We used only SNPs with polymorphic information content greater than or equal to 0.10 (i.e. 179 SNPs) for family identification. The Bayesian approach using Cervus-type model could assign 92.5% of offspring to the intended parent pairs, which is a significant improvement compared to previously used microsatellites. Likely as a result of both improved parentage assignment and greater depth of pedigree, estimates of heritability of economic traits increased compared to that reported in the first generation. In the second generation, estimates for heritability of total weight (TW), shape (SH), meat yield as ratio between meat weight and total weight (MY1), and meat yield as ratio between meat weight and the sum of meat weight and shell weight (MY2) were 0.35±0.09, 0.64±0.10, 0.23±0.08 and 0.46±0.10, respectively. Realised selection response (compared to wild–wild matings) from the selection decisions in the first generation of the breeding programme were positive and up to 10%, indicating that further genetic gains can be achieved through this family-based breeding programme.
    Keywords Bayesian theory ; breeding ; genetic improvement ; heritability ; meat ; microsatellite repeats ; models ; Mytilus edulis ; Mytilus galloprovincialis ; parentage ; pedigree ; progeny ; rearing ; selection response ; single nucleotide polymorphism
    Language English
    Dates of publication 2014-0115
    Size p. 295-301.
    Publishing place Elsevier B.V.
    Document type Article
    ZDB-ID 185380-6
    ISSN 0044-8486 ; 0044-8516
    ISSN 0044-8486 ; 0044-8516
    DOI 10.1016/j.aquaculture.2013.11.021
    Database NAL-Catalogue (AGRICOLA)

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