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  1. Article ; Online: Culturally relevant mentoring is important.

    Nguyen, Thuy-Vy T

    Nature human behaviour

    2024  

    Language English
    Publishing date 2024-05-09
    Publishing country England
    Document type Journal Article
    ISSN 2397-3374
    ISSN (online) 2397-3374
    DOI 10.1038/s41562-024-01880-1
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  2. Article ; Online: Investigating solitude as a tool for downregulation of daily arousal using ecological momentary assessments.

    Nguyen, Thuy-Vy T / Konu, Delali / Forbes, Samuel

    Journal of personality

    2024  

    Abstract: Objective: This research explored arousal levels as a motivating factor for solitude-seeking. We hypothesized that solitude becomes more desirable when high-arousal emotions were heightened and individual differences in extraversion and neuroticism ... ...

    Abstract Objective: This research explored arousal levels as a motivating factor for solitude-seeking. We hypothesized that solitude becomes more desirable when high-arousal emotions were heightened and individual differences in extraversion and neuroticism would moderate this pattern.
    Method: We tracked individuals' hourly experiences throughout a day. We assessed their high-arousal positive (e.g., excitement) and negative emotions (e.g., tension), whether they were alone or with others, and their preferred situation at the time of the signal. We gathered 4338 surveys from 362 participants, with 103 participants completing all hourly surveys.
    Results: Preference for and incidence of solitude changed throughout the day. Contrary to our hypotheses, lagged analyses did not indicate high-arousal emotions predicting reports of being alone an hour later. However, individuals were more likely to express a preference for solitude while experiencing high-arousal negative emotions, and less so while experiencing positive emotions. Younger individuals display stronger preference for solitude during experiences of high-arousal negative emotions. Extraversion and neuroticism did not moderate these patterns.
    Conclusions: The results highlight the distinctive appeal of solitude as a space for young adults to deal with negative emotions. We discussed how these findings are connected to existing literature and implications for future research.
    Language English
    Publishing date 2024-05-17
    Publishing country United States
    Document type Journal Article
    ZDB-ID 420745-2
    ISSN 1467-6494 ; 0022-3506
    ISSN (online) 1467-6494
    ISSN 0022-3506
    DOI 10.1111/jopy.12939
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1363: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (1.OG)
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  3. Article ; Online: Prenatal diagnosis of non-typical Chiari malformation type I associated with de novo Nuclear Factor I A gene mutation: a case report.

    Tomai, Xuan-Hong / Nguyen, Huu-Trung / Nguyen Thi, Thanh-Truc / Nguyen, Tuan-Anh / Nguyen, Thuy-Vy

    Journal of medical case reports

    2024  Volume 18, Issue 1, Page(s) 90

    Abstract: Background: Chiari malformation is one of the most common Central nervous system (CNS) abnormalities that can be detected in routine fetal scanning. Chiari malformation type I (CMI) is a congenital defect characterized by a displacement of the ... ...

    Abstract Background: Chiari malformation is one of the most common Central nervous system (CNS) abnormalities that can be detected in routine fetal scanning. Chiari malformation type I (CMI) is a congenital defect characterized by a displacement of the cerebellar tonsils through the foramen magnum. The etiology of CMI has not been well established and suggested having multifactorial contributions, especially genetic deletion. Clinical characteristics of this anomaly may express in different symptoms from neurological dysfunction and/or skeletal abnormalities in the later age, but it is rarely reported in pregnancy.
    Case presentation: We present a case in which the Chiari malformation type I was diagnosed with comorbidities of facial anomalies (flatting forehead and micrognathia) and muscular-skeletal dysmorphologies (clenched hands and clubfeet) at the 24
    Conclusion: CMI may only represent with facial abnormalities and muscle-skeletal malformations at the early stage of pregnancy, which may also alert an adverse outcome. A novel heterozygous NFIA gene mutation identified after birth helps to confirm prenatal diagnosis of CMI and to provide an appropriate consultation.
    MeSH term(s) Male ; Pregnancy ; Female ; Infant, Newborn ; Humans ; Adult ; Arnold-Chiari Malformation/diagnosis ; Arnold-Chiari Malformation/genetics ; NFI Transcription Factors/genetics ; Prenatal Diagnosis ; Amniocentesis ; Mutation ; Magnetic Resonance Imaging
    Chemical Substances NFI Transcription Factors
    Language English
    Publishing date 2024-02-13
    Publishing country England
    Document type Case Reports ; Journal Article
    ZDB-ID 2269805-X
    ISSN 1752-1947 ; 1752-1947
    ISSN (online) 1752-1947
    ISSN 1752-1947
    DOI 10.1186/s13256-024-04361-1
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Balance between solitude and socializing: everyday solitude time both benefits and harms well-being.

    Weinstein, Netta / Vuorre, Matti / Adams, Mark / Nguyen, Thuy-Vy

    Scientific reports

    2023  Volume 13, Issue 1, Page(s) 21160

    Abstract: Two literatures argue that time alone is harmful (i.e., isolation) and valuable (i.e., positive solitude). We explored whether people benefit from a balance between their daily solitude and social time, such that having 'right' quantities of both ... ...

    Abstract Two literatures argue that time alone is harmful (i.e., isolation) and valuable (i.e., positive solitude). We explored whether people benefit from a balance between their daily solitude and social time, such that having 'right' quantities of both maximizes well-being. Participants (n = 178) completed a 21-day diary study, which quantified solitude time in hours through reconstructing daily events. This procedure minimized retrospective bias and tested natural variations across time. There was no evidence for a one-size-fits-all 'optimal balance' between solitude and social time. Linear effects suggested that people were lonelier and less satisfied on days in which they spent more hours in solitude. These detrimental relations were nullified or reduced when daily solitude was autonomous (choiceful) and did not accumulate across days; those who were generally alone more were not, on the whole, lonelier. On days in which people spent more time alone they felt less stress and greater autonomy satisfaction (volitional, authentic, and free from pressure). These benefits were cumulative; those who spent more time alone across the span of the study were less stressed and more autonomy satisfied overall. Solitude time risks lowering well-being on some metrics but may hold key advantages to other aspects of well-being. PROTOCOL REGISTRATION: The stage 1 protocol for this Registered Report was accepted in principle on June 1, 2022. The protocol, as accepted by the journal, can be found at: https://doi.org/10.17605/OSF.IO/5KXQ3 .
    MeSH term(s) Humans ; Retrospective Studies ; Social Behavior ; Loneliness ; Emotions ; Personal Satisfaction
    Language English
    Publishing date 2023-12-05
    Publishing country England
    Document type Journal Article
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-023-44507-7
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Effect of Helicobacter pylori on non-homologous end joining-mediated repair of proximal DNA double-strand breaks in GCV6 cells.

    Vo-Ho, My-Phuc / Pham-Thi, Hong-Dao / Nguyen, Thuy-Vy

    Microbial pathogenesis

    2023  Volume 180, Page(s) 106154

    Abstract: Infection with Helicobacter pylori is the strongest known risk factor for gastric cancer, which is one of the leading causes of cancer-related mortality worldwide. H. pylori can contribute to carcinogenesis by inducing the genomic instability of infected ...

    Abstract Infection with Helicobacter pylori is the strongest known risk factor for gastric cancer, which is one of the leading causes of cancer-related mortality worldwide. H. pylori can contribute to carcinogenesis by inducing the genomic instability of infected cells through increasing accumulation of DNA double-stranded breaks (DSBs) and deregulating DSB repair systems. However, the mechanism of this phenomenon is still being elucidated. This study aims to investigate the impact of H. pylori on the efficacy of non-homologous end joining (NHEJ)-mediated repair of DSB. In this study, we used a human fibroblast cell line bearing a single copy of an NHEJ-reporter substrate stably inserted into the genome, which provides a quantitative measurement of NHEJ. Our results indicated the potential abilities of H. pylori strains to alter the NHEJ-mediated repair of proximal DSB in infected cells. In addition, we found an association between the alteration in the NHEJ efficiency, and the inflammation responses of infected cells caused by H. pylori.
    MeSH term(s) Humans ; DNA Breaks, Double-Stranded ; Helicobacter pylori/genetics ; DNA End-Joining Repair ; Cell Line ; DNA ; DNA Repair
    Chemical Substances DNA (9007-49-2)
    Language English
    Publishing date 2023-05-11
    Publishing country England
    Document type Journal Article
    ZDB-ID 632772-2
    ISSN 1096-1208 ; 0882-4010
    ISSN (online) 1096-1208
    ISSN 0882-4010
    DOI 10.1016/j.micpath.2023.106154
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2136: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  6. Article ; Online: Definitions of Solitude in Everyday Life.

    Weinstein, Netta / Hansen, Heather / Nguyen, Thuy-Vy

    Personality & social psychology bulletin

    2022  Volume 49, Issue 12, Page(s) 1663–1678

    Abstract: What does it mean to be in solitude? Researchers building this nascent field are learning much about the potential affordances of solitude, but lack an agreed-upon definition or set of definitions. Arriving at that meaning is crucial to forming a solid ... ...

    Abstract What does it mean to be in solitude? Researchers building this nascent field are learning much about the potential affordances of solitude, but lack an agreed-upon definition or set of definitions. Arriving at that meaning is crucial to forming a solid foundation for studies that use both naturalistic and laboratory designs to explore outcomes of solitude. This study identified themes from semi-structured interviews with adults aged 19 to 80 from diverse backgrounds. We concluded that solitude is a state in which the dominant relationship is with the self. If not physically alone, people in solitude are mentally distanced from others and away from active technology-mediated interactions. Complete solitude involves both physical separation and inner focus, but solitude is best defined through a taxonomy that recognizes physical separation and internal focus as independent, sufficient characteristics. An internal focus benefits from (but is not defined by) balancing solitude with social time, quiet, and choice.
    MeSH term(s) Adult ; Humans ; Young Adult ; Middle Aged ; Aged ; Aged, 80 and over ; Psychological Distance
    Language English
    Publishing date 2022-09-03
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2047603-6
    ISSN 1552-7433 ; 0146-1672
    ISSN (online) 1552-7433
    ISSN 0146-1672
    DOI 10.1177/01461672221115941
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  7. Article ; Online: Who enjoys solitude? autonomous functioning (but not introversion) predicts self-determined motivation (but not preference) for solitude.

    Nguyen, Thuy-Vy T / Weinstein, Netta / Ryan, Richard M

    PloS one

    2022  Volume 17, Issue 5, Page(s) e0267185

    Abstract: Within the solitude literature, two discrete constructs reflect different perspectives on how time spent alone is motivated. Self-determined motivation for solitude reflects wanting time alone to find enjoyment and gain meaningful benefits from it, ... ...

    Abstract Within the solitude literature, two discrete constructs reflect different perspectives on how time spent alone is motivated. Self-determined motivation for solitude reflects wanting time alone to find enjoyment and gain meaningful benefits from it, whereas preference for solitude concerns wanting time for oneself over others' company regardless of reasons for why time alone is wanted. We investigated two personality characteristics: introversion from Big-Five personality theory and dispositional autonomy from self-determination theory. In two diary studies university students completed personality measures and reported about their experiences with time spent alone over a period of seven days. Across both studies, contrary to popular belief that introverts spend time alone because they enjoy it, results showed no evidence that introversion is predictive of either preference or motivation for solitude. Dispositional autonomy-the tendency to regulate from a place of self-congruence, interest, and lack of pressure-consistently predicted self-determined motivation for solitude but was unrelated to preference for solitude. These findings provided evidence supporting the link between valuing time spent alone with individual differences in the capacity to self-regulate in choiceful and authentic way.
    MeSH term(s) Humans ; Introversion, Psychological ; Motivation ; Personal Autonomy ; Personality ; Pleasure
    Language English
    Publishing date 2022-05-25
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2267670-3
    ISSN 1932-6203 ; 1932-6203
    ISSN (online) 1932-6203
    ISSN 1932-6203
    DOI 10.1371/journal.pone.0267185
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: Motivation and preference in isolation: a test of their different influences on responses to self-isolation during the COVID-19 outbreak.

    Weinstein, Netta / Nguyen, Thuy-Vy

    Royal Society open science

    2020  Volume 7, Issue 5, Page(s) 200458

    Abstract: This multi-wave study examined the extent that both preference and motivation for time alone shapes ill-being during self-isolation. Individuals in the USA and the UK are self-isolating in response to the COVID-19 outbreak. Different motivations may ... ...

    Abstract This multi-wave study examined the extent that both preference and motivation for time alone shapes ill-being during self-isolation. Individuals in the USA and the UK are self-isolating in response to the COVID-19 outbreak. Different motivations may drive their self-isolation: some might see value in it (understood as the identified form of autonomous motivation), while others might feel forced into it by authorities or close others (family, friends, neighbourhoods, doctors; the external form of controlled motivation). People who typically prefer company will find themselves spending more time alone, and may experience ill-being uniformly, or as a function of their identified or external motivations for self-isolation. Self-isolation, therefore, offers a unique opportunity to distinguish two constructs coming from disparate literatures. This project examined preference and motivation (identified and external) for solitude, and tested their independent and interacting contributions to ill-being (loneliness, depression and anxiety during the time spent alone) across two weeks. Confirmatory hypotheses regarding preference and motivation were not supported by the data. A statistically significant effect of controlled motivation on change in ill-being was observed one week later, and preference predicted ill-being across two weeks. However, effect sizes for both were below our minimum threshold of interest.
    Keywords covid19
    Language English
    Publishing date 2020-05-13
    Publishing country England
    Document type Journal Article
    ZDB-ID 2787755-3
    ISSN 2054-5703
    ISSN 2054-5703
    DOI 10.1098/rsos.200458
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: Solitude profiles and psychological adjustment in Chinese late adolescence: a person-centered research.

    Zhou, Tong / Liao, Longyue / Nguyen, Thuy-Vy T / Li, Dan / Liu, Junsheng

    Frontiers in psychiatry

    2023  Volume 14, Page(s) 1173441

    Abstract: Objectives: From the perspective of person-centered research, the present study aimed to identify the potential profiles of solitude among late adolescents based on their solitary behavior, motivation, attitude, and time alone. In addition, to echo the ... ...

    Abstract Objectives: From the perspective of person-centered research, the present study aimed to identify the potential profiles of solitude among late adolescents based on their solitary behavior, motivation, attitude, and time alone. In addition, to echo the paradox of solitude, we further explored the links between solitude profiles and adjustment outcomes.
    Methods: The participants of the study were 355 late adolescents (56.34% female,
    Results: Latent profile analysis revealed four distinct groups: absence of the aloneness group (21.13%), the positive motivational solitude group (29.01%), the negative motivational solitude group (38.03%), and the activity-oriented solitude group (11.83%). Differences emerged among these four groups in terms of loneliness, depressive symptoms, and basic needs satisfaction, with adolescents in the negative motivational solitude group facing the most risk of psychological maladjustment.
    Conclusion: Findings revealed the possible heterogeneous nature of solitude among Chinese late adolescents and provided a theoretical basis for further understanding of adolescents' solitary state.
    Language English
    Publishing date 2023-07-06
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2564218-2
    ISSN 1664-0640
    ISSN 1664-0640
    DOI 10.3389/fpsyt.2023.1173441
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: What Time Alone Offers: Narratives of Solitude From Adolescence to Older Adulthood.

    Weinstein, Netta / Nguyen, Thuy-Vy / Hansen, Heather

    Frontiers in psychology

    2021  Volume 12, Page(s) 714518

    Abstract: Solitude - the state of being alone and not physically with another - can be rewarding. The present research explored the potential benefits of solitude from a pragmatist approach: a ground-up, top-down perspective that is receptive to new knowledge but ... ...

    Abstract Solitude - the state of being alone and not physically with another - can be rewarding. The present research explored the potential benefits of solitude from a pragmatist approach: a ground-up, top-down perspective that is receptive to new knowledge but informed by theory. Participant recruitment was stratified by age and gender, and the sample involved 2,035 individuals including adolescents (13-16 years), adults (35-55 years), or older adults (65+ years). Data were analyzed with a mixed-methods approach. Coded themes from brief narratives about solitude were extracted, and their frequencies (i.e.,
    Language English
    Publishing date 2021-11-01
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2563826-9
    ISSN 1664-1078
    ISSN 1664-1078
    DOI 10.3389/fpsyg.2021.714518
    Database MEDical Literature Analysis and Retrieval System OnLINE

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