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  1. Article ; Online: Genomic islands of speciation harbor genes underlying coloration differences in a pair of Neotropical seedeaters.

    Nguyen, Tram N / Repenning, Márcio / Suertegaray Fontana, Carla / Campagna, Leonardo

    Evolution; international journal of organic evolution

    2024  

    Abstract: Incomplete speciation can be leveraged to associate phenotypes with genotypes, thus providing insights into the traits relevant to the reproductive isolation of diverging taxa. We investigate the genetic underpinnings of the phenotypic differences ... ...

    Abstract Incomplete speciation can be leveraged to associate phenotypes with genotypes, thus providing insights into the traits relevant to the reproductive isolation of diverging taxa. We investigate the genetic underpinnings of the phenotypic differences between Sporophila plumbea and S. beltoni. S. beltoni has only recently been described based, most notably, on differences in bill coloration (yellow vs. black in S. plumbea). Both species are indistinguishable through mtDNA or reduced-representation genomic data, and even whole-genome sequencing revealed low genetic differentiation. Demographic reconstructions attribute this genetic homogeneity to gene flow, despite divergence in the order of millions of generations. We found a narrow hybrid zone in southern Brazil where genetically, yet not phenotypically, admixed individuals appear to be prevalent. Despite the overall low genetic differentiation, we identified three narrow peaks along the genome with highly differentiated SNPs. These regions harbor six genes, one of which is involved in pigmentation (EDN3) and is a candidate for controlling bill color. Within the outlier peaks we found signatures of resistance to gene flow, as expected for islands of speciation. Our study shows how genes related to coloration traits are likely involved in generating prezygotic isolation and establishing species boundaries early in speciation.
    Language English
    Publishing date 2024-03-26
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2036375-8
    ISSN 1558-5646 ; 0014-3820
    ISSN (online) 1558-5646
    ISSN 0014-3820
    DOI 10.1093/evolut/qpae051
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Dynamics of reduced genetic diversity in increasingly fragmented populations of Florida scrub jays,

    Nguyen, Tram N / Chen, Nancy / Cosgrove, Elissa J / Bowman, Reed / Fitzpatrick, John W / Clark, Andrew G

    Evolutionary applications

    2022  Volume 15, Issue 6, Page(s) 1018–1027

    Abstract: Understanding the genomic consequences of population decline is important for predicting species' vulnerability to intensifying global change. Empirical information about genomic changes in populations in the early stages of decline, especially for those ...

    Abstract Understanding the genomic consequences of population decline is important for predicting species' vulnerability to intensifying global change. Empirical information about genomic changes in populations in the early stages of decline, especially for those still experiencing immigration, remains scarce. We used 7834 autosomal SNPs and demographic data for 288 Florida scrub jays (
    Language English
    Publishing date 2022-06-01
    Publishing country England
    Document type Journal Article
    ZDB-ID 2405496-3
    ISSN 1752-4563 ; 1752-4571
    ISSN (online) 1752-4563
    ISSN 1752-4571
    DOI 10.1111/eva.13421
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  3. Article ; Online: Influence of the heating rate on the thermodegradation during the mild pyrolysis of the wood

    Pétrissans, Anelie / Lin, Yuying / Nguyen, Tram N. / Colin, Baptiste / Quirino, Rafael L. / Rios-Teixeira, Priscila / Chen, Wei-Hsin / Pétrissans, Mathieu

    Wood Material Science & Engineering. 2023 Mar. 04, v. 18, no. 2 p.412-421

    2023  

    Abstract: Wood constitutes a renewable and sustainable material, which raw utilization is limited because of the weak durability and dimensional instability. To improve shortcomings, a mild pyrolysis in the temperature range 200–300°C in oxygen-free atmosphere has ...

    Abstract Wood constitutes a renewable and sustainable material, which raw utilization is limited because of the weak durability and dimensional instability. To improve shortcomings, a mild pyrolysis in the temperature range 200–300°C in oxygen-free atmosphere has been used for years. However, a significant lack of knowledge persists in the initial stage of the process. The purpose of this study is to investigate the influence of the heating rate on the wood thermodegradation pathway and the impact of this parameter on the conferred properties. The heating rate influences the total duration of the process and is strongly related to the power capacity of the heater. Experiments of thermal degradation were carried out at two different scales. Thermogravimetric analysis on wood powder allows to better understand the degradation scheme of biomass polymers. Experiments in a semi-industrial pilot-scale system on wood boards allow to transpose the process towards real conditions. Similar to industry practices, the heating rate has been varied between 0.2 and 1.0°C min⁻¹. The results reveal noticeable differences in the degradation kinetics. A numerical tool has been tested to predict the advancement of the thermo-modification process. The observations are of interest for industrial applications.
    Keywords biomass ; durability ; industry ; materials science ; pyrolysis ; temperature ; thermogravimetry ; wood ; Heating rate ; heat treatment ; mass loss ; mild pyrolysis
    Language English
    Dates of publication 2023-0304
    Size p. 412-421.
    Publishing place Taylor & Francis
    Document type Article ; Online
    ISSN 1748-0280
    DOI 10.1080/17480272.2022.2039289
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  4. Article ; Online: Screening for Depression in Pregnancy-There's an App for That!

    Ricketts, Sarah / Nguyen, Tram N B / Narasimhan, Varsha

    Annals of family medicine

    2019  Volume 17, Issue 3, Page(s) 275

    Language English
    Publishing date 2019-07-25
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2171425-3
    ISSN 1544-1717 ; 1544-1709
    ISSN (online) 1544-1717
    ISSN 1544-1709
    DOI 10.1370/afm.2388
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  5. Article: Multimodal Investigations of Reward Circuitry and Anhedonia in Adolescent Depression.

    Ely, Benjamin A / Nguyen, Tram N B / Tobe, Russell H / Walker, Audrey M / Gabbay, Vilma

    Frontiers in psychiatry

    2021  Volume 12, Page(s) 678709

    Abstract: Depression is a highly prevalent condition with devastating personal and public health consequences that often first manifests during adolescence. Though extensively studied, the pathogenesis of depression remains poorly understood, and efforts to ... ...

    Abstract Depression is a highly prevalent condition with devastating personal and public health consequences that often first manifests during adolescence. Though extensively studied, the pathogenesis of depression remains poorly understood, and efforts to stratify risks and identify optimal interventions have proceeded slowly. A major impediment has been the reliance on an all-or-nothing categorical diagnostic scheme based solely on whether a patient endorses an arbitrary number of common symptoms for a sufficiently long period. This approach masks the well-documented heterogeneity of depression, a disorder that is highly variable in presentation, severity, and course between individuals and is frequently comorbid with other psychiatric conditions. In this targeted review, we outline the limitations of traditional diagnosis-based research and instead advocate an alternative approach centered around symptoms as unique dimensions of clinical dysfunction that span across disorders and more closely reflect underlying neurobiological abnormalities. In particular, we highlight anhedonia-the reduced ability to anticipate and experience pleasure-as a specific, quantifiable index of reward dysfunction and an ideal candidate for dimensional investigation. Anhedonia is a core symptom of depression but also a salient feature of numerous other conditions, and its severity varies widely within clinical and even healthy populations. Similarly, reward dysfunction is a hallmark of depression but is evident across many psychiatric conditions. Reward function is especially relevant in adolescence, a period characterized by exaggerated reward-seeking behaviors and rapid maturation of neural reward circuitry. We detail extensive work by our research group and others to investigate the neural and systemic factors contributing to reward dysfunction in youth, including our cumulative findings using multiple neuroimaging and immunological measures to study depressed adolescents but also trans-diagnostic cohorts with diverse psychiatric symptoms. We describe convergent evidence that reward dysfunction: (a) predicts worse clinical outcomes, (b) is associated with functional and chemical abnormalities within and beyond the neural reward circuitry, (c) is linked to elevated peripheral levels of inflammatory biomarkers, and (d) manifests early in the course of illness. Emphasis is placed on high-resolution neuroimaging techniques, comprehensive immunological assays, and data-driven analyses to fully capture and characterize the complex, interconnected nature of these systems and their contributions to adolescent reward dysfunction.
    Language English
    Publishing date 2021-07-23
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2564218-2
    ISSN 1664-0640
    ISSN 1664-0640
    DOI 10.3389/fpsyt.2021.678709
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  6. Article: Assessing possible hybridization among managed Nubian ibex in North America

    Putnam, Andrea S / Nguyen, Tram N / Mott, Alison / Korody, Marisa L / Ryder, Oliver A

    Zoo biology. 2020 Mar., v. 39, no. 2

    2020  

    Abstract: Hybridization among closely related species is a concern in zoo and aquarium populations where unpedigreed animals are frequently exchanged with the private sector. In this study, we examine possible hybridization in a group of Nubian ibex (Capra nubiana) ...

    Abstract Hybridization among closely related species is a concern in zoo and aquarium populations where unpedigreed animals are frequently exchanged with the private sector. In this study, we examine possible hybridization in a group of Nubian ibex (Capra nubiana) imported into the Association of Zoos and Aquariums’ (AZA) Species Survival Program (SSP) from a private institution. These individuals appeared smaller in stature than adult SSP Nubian ibex and were excluded from breeding recommendations over the concern that they were hybrids. Twenty‐six microsatellites were used to rule out recent hybridization with domestic goats, Siberian ibex (Capra sibirica), and Alpine ibex (Capra ibex). We argue that natural phenotypic variation across the large geographic range of Nubian ibex may account for the small stature of the imported ibex, as private institutions may have historically acquired individuals from locations that differed from the SSP founders. However, the imported Nubian ibex appeared genetically differentiated from the SSP Nubian ibex and may represent a source of genetic variation for the managed population.
    Keywords Capra ibex ; Capra sibirica ; adults ; captive animals ; genetic variation ; geographical distribution ; goats ; hybridization ; hybrids ; microsatellite repeats ; phenotypic variation ; private sector ; zoos ; North America
    Language English
    Dates of publication 2020-03
    Size p. 121-128.
    Publishing place John Wiley & Sons, Ltd
    Document type Article
    Note JOURNAL ARTICLE
    ZDB-ID 1499116-0
    ISSN 1098-2361 ; 0733-3188
    ISSN (online) 1098-2361
    ISSN 0733-3188
    DOI 10.1002/zoo.21527
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  7. Article ; Online: Clenbuterol attenuates immune reaction to lipopolysaccharide and its relationship to anhedonia in adolescents.

    Nguyen, Tram N B / Ely, Benjamin A / Pick, Danielle / Patel, Manishkumar / Xie, Hui / Kim-Schulze, Seunghee / Gabbay, Vilma

    Brain, behavior, and immunity

    2022  Volume 106, Page(s) 89–99

    Abstract: While inflammation has been implicated in psychopathology, relationships between immune-suppressing processes and psychiatric constructs remain elusive. This study sought to assess whether ... ...

    Abstract While inflammation has been implicated in psychopathology, relationships between immune-suppressing processes and psychiatric constructs remain elusive. This study sought to assess whether β
    MeSH term(s) Anhedonia ; Biomarkers ; Chemokine CCL3 ; Chemokine CCL4 ; Chemokine CXCL10 ; Clenbuterol/pharmacology ; Cytokines/metabolism ; Epidermal Growth Factor ; Humans ; Interleukin 1 Receptor Antagonist Protein ; Interleukin-6 ; Lipopolysaccharides/pharmacology ; Transforming Growth Factor alpha ; Tumor Necrosis Factor-alpha
    Chemical Substances Biomarkers ; Chemokine CCL3 ; Chemokine CCL4 ; Chemokine CXCL10 ; Cytokines ; Interleukin 1 Receptor Antagonist Protein ; Interleukin-6 ; Lipopolysaccharides ; Transforming Growth Factor alpha ; Tumor Necrosis Factor-alpha ; Epidermal Growth Factor (62229-50-9) ; Clenbuterol (XTZ6AXU7KN)
    Language English
    Publishing date 2022-07-29
    Publishing country Netherlands
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 639219-2
    ISSN 1090-2139 ; 0889-1591
    ISSN (online) 1090-2139
    ISSN 0889-1591
    DOI 10.1016/j.bbi.2022.07.163
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2276: Show issues Location:
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  8. Article ; Online: Aspirin-induced postoperative bleeding.

    Nguyen, Tram N

    Nursing

    2009  Volume 39, Issue 5, Page(s) 64

    MeSH term(s) Aspirin/adverse effects ; Emergencies/nursing ; Humans ; Male ; Middle Aged ; Nursing Assessment/methods ; Platelet Aggregation Inhibitors/adverse effects ; Postoperative Care/methods ; Postoperative Care/nursing ; Postoperative Hemorrhage/chemically induced ; Postoperative Hemorrhage/diagnosis ; Postoperative Hemorrhage/prevention & control ; Urinary Bladder Neoplasms/surgery
    Chemical Substances Platelet Aggregation Inhibitors ; Aspirin (R16CO5Y76E)
    Language English
    Publishing date 2009-05
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 197895-0
    ISSN 1538-8689 ; 0360-4039
    ISSN (online) 1538-8689
    ISSN 0360-4039
    DOI 10.1097/01.NURSE.0000350767.47290.3f
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    In stock of ZB MED Cologne/Königswinter

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  9. Article ; Online: Assessing possible hybridization among managed Nubian ibex in North America.

    Putnam, Andrea S / Nguyen, Tram N / Mott, Alison / Korody, Marisa L / Ryder, Oliver A

    Zoo biology

    2019  Volume 39, Issue 2, Page(s) 121–128

    Abstract: Hybridization among closely related species is a concern in zoo and aquarium populations where unpedigreed animals are frequently exchanged with the private sector. In this study, we examine possible hybridization in a group of Nubian ibex (Capra nubiana) ...

    Abstract Hybridization among closely related species is a concern in zoo and aquarium populations where unpedigreed animals are frequently exchanged with the private sector. In this study, we examine possible hybridization in a group of Nubian ibex (Capra nubiana) imported into the Association of Zoos and Aquariums' (AZA) Species Survival Program (SSP) from a private institution. These individuals appeared smaller in stature than adult SSP Nubian ibex and were excluded from breeding recommendations over the concern that they were hybrids. Twenty-six microsatellites were used to rule out recent hybridization with domestic goats, Siberian ibex (Capra sibirica), and Alpine ibex (Capra ibex). We argue that natural phenotypic variation across the large geographic range of Nubian ibex may account for the small stature of the imported ibex, as private institutions may have historically acquired individuals from locations that differed from the SSP founders. However, the imported Nubian ibex appeared genetically differentiated from the SSP Nubian ibex and may represent a source of genetic variation for the managed population.
    MeSH term(s) Animals ; Animals, Zoo/genetics ; Body Size ; Breeding ; Female ; Goats/classification ; Goats/genetics ; Hybridization, Genetic ; Male ; Microsatellite Repeats/genetics ; Phenotype
    Language English
    Publishing date 2019-12-13
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1499116-0
    ISSN 1098-2361 ; 0733-3188
    ISSN (online) 1098-2361
    ISSN 0733-3188
    DOI 10.1002/zoo.21527
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  10. Article: Clozapine-associated cardiac dysfunction during a gastroenteritis outbreak.

    Szema, Anthony M / Marboe, Charles / Fritz, Paul / Nguyen, Tram N B

    Journal of community hospital internal medicine perspectives

    2016  Volume 6, Issue 6, Page(s) 32683

    Abstract: We report that two young adult patients who were initiated with clozapine for severe psychosis during a hospital-wide gastroenteritis outbreak went into severe shock. Neither patient had troponin elevation. Each required left ventricular assist device ... ...

    Abstract We report that two young adult patients who were initiated with clozapine for severe psychosis during a hospital-wide gastroenteritis outbreak went into severe shock. Neither patient had troponin elevation. Each required left ventricular assist device support for myocarditis. Endomyocardial biopsy revealed lymphocytic myocarditis in one patient and eosinophilic myocarditis in the other. The former patient expired. Polymerase chain reaction testing was negative for Coxsackie virus. These two patients illustrate that myocarditis can occur at usual incipient doses and that there may be an epidemiologic risk associated with gastroenteritis. Although the white blood cell (WBC) count is expected to decrease with clozapine, these patients had persistently elevated WBC counts. In conclusion, physicians should exercise caution when prescribing clozapine, especially for those with diarrhea.
    Language English
    Publishing date 2016-12-15
    Publishing country United States
    Document type Case Reports
    ZDB-ID 2616884-4
    ISSN 2000-9666
    ISSN 2000-9666
    DOI 10.3402/jchimp.v6.32683
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