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Article ; Online: Scientometric Review of Research Trends on Public Private Partnership (PPP) for Infrastructure Projects From 2000 to 2020

Nguyen Van Tam

CSID Journal of Infrastructure Development, Vol 4, Iss 1, Pp 32-

2021 Volume 49

Abstract: In the construction industry, public-private partnership (PPP) has been becoming increasingly common. While real-world PPP for infrastructure projects have been reported in many journals, published work on systematically summarizing what they have ... ...

Abstract	In the construction industry, public-private partnership (PPP) has been becoming increasingly common. While real-world PPP for infrastructure projects have been reported in many journals, published work on systematically summarizing what they have already provided remains limited. Based on the 1749 publications on PPP for infrastructure collected from the Scopus database for the period of 2000-2020, this study conducted a scientometric analysis in terms of annual publications, regional distribution, active contributors, published journals, co-occurrence keywords, and main research themes of previous studies. This paper found that there was a significant increase in the number of publications on PPP for infrastructure since 2008. Researchers from the USA, China, and Australia have been the main contributors to this research area. In addition, four main themes of research on PPP for infrastructure are explored, and several research gaps and research directions in this area are established for further studies.
Keywords	ppp ; infrastructure project ; scientometric ; analysis ; network ; General Works ; A ; Social Sciences ; H ; Technology ; T
Subject code	690
Language	English
Publishing date	2021-05-01T00:00:00Z
Publisher	center for sustainable infrastructure development
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Molnupiravir for SARS-CoV-2 infection: Public health and policy implications.

Gray, Edward J / Nguyen-Van-Tam, Jonathan S

The Journal of infection

2022 Volume 86, Issue 2, Page(s) 121–122

MeSH term(s)	Humans ; Public Health ; COVID-19 ; SARS-CoV-2 ; Hydroxylamines ; Antiviral Agents
Chemical Substances	molnupiravir (YA84KI1VEW) ; Hydroxylamines ; Antiviral Agents
Language	English
Publishing date	2022-12-23
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	424417-5
ISSN	1532-2742 ; 0163-4453
ISSN (online)	1532-2742
ISSN	0163-4453
DOI	10.1016/j.jinf.2022.10.040
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Article ; Online: Uptake and safety of pneumococcal vaccination in adults with immune mediated inflammatory diseases: a UK wide observational study.

Nakafero, Georgina / Grainge, Matthew J / Card, Tim / Mallen, Christian D / Nguyen Van-Tam, Jonathan S / Abhishek, Abhishek

Rheumatology (Oxford, England)

2024

Abstract: Objective: The uptake and safety of pneumococcal vaccination in people with immune mediated inflammatory diseases (IMIDs) is poorly understood. We investigated the UK wide pneumococcal vaccine uptake in adults with IMIDs and explored the association ... ...

Abstract	Objective: The uptake and safety of pneumococcal vaccination in people with immune mediated inflammatory diseases (IMIDs) is poorly understood. We investigated the UK wide pneumococcal vaccine uptake in adults with IMIDs and explored the association between vaccination and IMID flare. Methods: Adults with IMIDs diagnosed on or before 01/09/2018, prescribed steroid-sparing drugs within the last 12 months and contributing data to the Clinical Practice Research Datalink Gold were included. Vaccine uptake was assessed using a cross-sectional study design. Self-controlled case series (SCCS) analysis investigated the association between pneumococcal vaccination and IMID flare. The SCCS observation period was up-to six-month before and after pneumococcal vaccination. This was partitioned into a 14-day pre-vaccination induction, 90-days post-vaccination exposed, and the remaining unexposed periods. Results: We included 32 277 patients, 14 151 with RA, 13 631 with IBD, 3,804 with axial spondyloarthritis and 691 with SLE. Overall, 57% were vaccinated against pneumococcus. Vaccine uptake was lower in those younger than 45 years (32%), with IBD (42%), and without additional indication(s) for vaccination (46%). In the vaccine-safety study, data for 1,067, 935, and 451vaccinated patients with primary-care consultations for joint pain, AIRD flare and IBD flare respectively were included. Vaccination against pneumococcal pneumonia was not associated with primary-care consultations for joint pain, AIRD flare and IBD flare in the exposed period with incidence rate ratios (95% Confidence Interval) 0.95 (0.83-1.09), 1.05 (0.92-1.19), and 0.83 (0.65-1.06) respectively. Conclusion: Uptake of pneumococcal vaccination in UK patients with IMIDs was suboptimal. Vaccination against pneumococcal disease was not associated with IMID flare.
Language	English
Publishing date	2024-03-13
Publishing country	England
Document type	Journal Article
ZDB-ID	1464822-2
ISSN	1462-0332 ; 1462-0324
ISSN (online)	1462-0332
ISSN	1462-0324
DOI	10.1093/rheumatology/keae160
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Article ; Online: Lessons learned from 2 years of influenza vaccinations in the UK and USA during the COVID-19 pandemic as respiratory viruses return.

Tan, Litjen J / Ahmed, Syed / Rothholz, Mitchel C / Kassianos, George / Nguyen-Van-Tam, Jonathan S

Human vaccines & immunotherapeutics

2022 Volume 18, Issue 6, Page(s) 2125754

Abstract: During the COVID-19 pandemic, immunization programs for other respiratory infections, notably influenza continued worldwide but attracted less public or political attention than COVID-19 vaccinations. Due to non-pharmaceutical intervention measures the ... ...

Abstract	During the COVID-19 pandemic, immunization programs for other respiratory infections, notably influenza continued worldwide but attracted less public or political attention than COVID-19 vaccinations. Due to non-pharmaceutical intervention measures the global influenza burden decreased substantially; but with lifting of restrictions a rebound in other respiratory virus pathogens is both plausible and likely. This article discusses lessons identified from the UK and USA, and provides recommendations for future influenza vaccination programs in light of emerging data from the southern hemisphere and the need for harmonization with COVID-19 vaccination, focusing on operational delivery and messaging to practitioners and the public.
Language	English
Publishing date	2022-09-26
Publishing country	United States
Document type	Journal Article
ZDB-ID	2664176-8
ISSN	2164-554X ; 2164-5515
ISSN (online)	2164-554X
ISSN	2164-5515
DOI	10.1080/21645515.2022.2125754
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Article ; Online: Is vaccination against COVID-19 associated with autoimmune rheumatic disease flare? A self-controlled case series analysis.

Nakafero, Georgina / Grainge, Matthew J / Card, Tim / Mallen, Christian D / Nguyen Van-Tam, Jonathan S / Williams, Hywel C / Abhishek, Abhishek

Rheumatology (Oxford, England)

2023 Volume 62, Issue 4, Page(s) 1445–1450

Abstract: Objectives: To investigate the association between vaccination against coronavirus disease 2019 (COVID-19) and autoimmune rheumatic disease (AIRD) flare.: Material and methods: Patients with AIRDs vaccinated against COVID-19 who consulted for disease ...

Abstract	Objectives: To investigate the association between vaccination against coronavirus disease 2019 (COVID-19) and autoimmune rheumatic disease (AIRD) flare. Material and methods: Patients with AIRDs vaccinated against COVID-19 who consulted for disease flare between 1 December 2020 and 31 December 2021 were ascertained in Clinical Practice Research Datalink (Aurum). AIRD flare was defined as consultation for AIRD with CS prescription on the same day or the next day. Vaccination was defined using date of vaccination and product code. The observation period was partitioned into vaccine-exposed (21 days after vaccination), pre-vaccination (7 days before vaccination) and remaining vaccine-unexposed periods. Participants contributed data with multiple vaccinations and outcomes. Season adjusted incidence rate ratios (aIRR) and 95% CI were calculated using self-controlled case series analysis. Results: Data for 3554 AIRD cases, 72% female, mean age 65 years and 68.3% with RA, were included. COVID-19 vaccination was associated with significantly fewer AIRD flares in the 21-day vaccine-exposed period when all vaccinations were considered [aIRR (95% CI) 0.89 (0.80, 0.98)]. Using dose-stratified analyses there was a statistically significant negative association in the 21 days after first COVID-19 vaccination but no association after the second or third COVID-19 vaccinations [aIRR (95% CI) 0.76 (0.66, 0.89), 0.94 (0.79, 1.11) and 1.01 (0.85, 1.20), respectively]. On AIRD-type stratified analyses, vaccination was not associated with disease flares. Vaccination without or after severe acute respiratory syndrome coronavirus 2 infection, and with vectored DNA or mRNA vaccines, associated with comparable reduced risk of AIRD flares in the vaccine-exposed period after first COVID-19 vaccination. Conclusions: Vaccination against COVID-19 was not associated with increased AIRD flares regardless of prior COVID-19, AIRD type, and whether mRNA or DNA vaccination technology were used.
MeSH term(s)	Aged ; Female ; Humans ; Male ; Autoimmune Diseases ; COVID-19/complications ; COVID-19/prevention & control ; COVID-19 Vaccines/adverse effects ; Rheumatic Diseases/complications ; Vaccines
Chemical Substances	COVID-19 Vaccines ; Vaccines
Language	English
Publishing date	2023-02-17
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1464822-2
ISSN	1462-0332 ; 1462-0324
ISSN (online)	1462-0332
ISSN	1462-0324
DOI	10.1093/rheumatology/keac484
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Article ; Online: Real world evidence for public health decision-making on vaccination policies: perspectives from an expert roundtable.

de Waure, Chiara / Gärtner, Barbara C / Lopalco, Pier Luigi / Puig-Barbera, Joan / Nguyen-Van-Tam, Jonathan S

Expert review of vaccines

2023 Volume 23, Issue 1, Page(s) 27–38

Abstract: Introduction: Influenza causes significant morbidity and mortality, but influenza vaccine uptake remains below most countries' targets. Vaccine policy recommendations vary, as do procedures for reviewing and appraising the evidence.: Areas covered: ... ...

Abstract	Introduction: Influenza causes significant morbidity and mortality, but influenza vaccine uptake remains below most countries' targets. Vaccine policy recommendations vary, as do procedures for reviewing and appraising the evidence. Areas covered: During a series of roundtable discussions, we reviewed procedures and methodologies used by health ministries in four European countries to inform vaccine recommendations. We review the type of evidence currently recommended by each health ministry and the range of approaches toward considering randomized controlled trials (RCTs) and real-world evidence (RWE) studies when setting influenza vaccine recommendations. Expert opinion: Influenza vaccine recommendations should be based on data from both RCTs and RWE studies of efficacy, effectiveness, and safety. Such data should be considered alongside health-economic, cost-effectiveness, and budgetary factors. Although RCT data are more robust and less prone to bias, well-designed RWE studies permit timely evaluation of vaccine benefits, effectiveness comparisons over multiple seasons in large populations, and detection of rare adverse events, under real-world conditions. Given the variability of vaccine effectiveness due to influenza virus mutations and increasing diversification of influenza vaccines, we argue that consideration of both RWE and RCT evidence is the best approach to more nuanced and timely updates of influenza vaccine recommendations.
MeSH term(s)	Humans ; Influenza Vaccines/adverse effects ; Public Health ; Influenza, Human/prevention & control ; Vaccination/adverse effects ; Policy
Chemical Substances	Influenza Vaccines
Language	English
Publishing date	2023-12-12
Publishing country	England
Document type	Review ; Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2181284-6
ISSN	1744-8395 ; 1476-0584
ISSN (online)	1744-8395
ISSN	1476-0584
DOI	10.1080/14760584.2023.2290194
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Article ; Online: Risk prediction of covid-19 related death or hospital admission in adults testing positive for SARS-CoV-2 infection during the omicron wave in England (QCOVID4): cohort study.

Hippisley-Cox, Julia / Khunti, Kamlesh / Sheikh, Aziz / Nguyen-Van-Tam, Jonathan S / Coupland, Carol A C

BMJ (Clinical research ed.)

2023 Volume 381, Page(s) e072976

Abstract: Objectives: To derive and validate risk prediction algorithms (QCOVID4) to estimate the risk of covid-19 related death and hospital admission in people with a positive SARS-CoV-2 test result during the period when the omicron variant of the virus was ... ...

Abstract	Objectives: To derive and validate risk prediction algorithms (QCOVID4) to estimate the risk of covid-19 related death and hospital admission in people with a positive SARS-CoV-2 test result during the period when the omicron variant of the virus was predominant in England, and to evaluate performance compared with a high risk cohort from NHS Digital. Design: Cohort study. Setting: QResearch database linked to English national data on covid-19 vaccinations, SARS-CoV-2 test results, hospital admissions, and cancer and mortality data, 11 December 2021 to 31 March 2022, with follow-up to 30 June 2022. Participants: 1.3 million adults in the derivation cohort and 0.15 million adults in the validation cohort, aged 18-100 years, with a positive test result for SARS-CoV-2 infection. Main outcome measures: Primary outcome was covid-19 related death and secondary outcome was hospital admission for covid-19. Risk equations with predictor variables were derived from models fitted in the derivation cohort. Performance was evaluated in a separate validation cohort. Results: Of 1 297 922 people with a positive test result for SARS-CoV-2 infection in the derivation cohort, 18 756 (1.5%) had a covid-19 related hospital admission and 3878 (0.3%) had a covid-19 related death during follow-up. The final QCOVID4 models included age, deprivation score and a range of health and sociodemographic factors, number of covid-19 vaccinations, and previous SARS-CoV-2 infection. The risk of death related to covid-19 was lower among those who had received a covid-19 vaccine, with evidence of a dose-response relation (42% risk reduction associated with one vaccine dose and 92% reduction with four or more doses in men). Previous SARS-CoV-2 infection was associated with a reduction in the risk of covid-19 related death (49% reduction in men). The QCOVID4 algorithm for covid-19 explained 76.0% (95% confidence interval 73.9% to 78.2%) of the variation in time to covid-19 related death in men with a D statistic of 3.65 (3.43 to 3.86) and Harrell's C statistic of 0.970 (0.962 to 0.979). Results were similar for women. QCOVID4 was well calibrated. QCOVID4 was substantially more efficient than the NHS Digital algorithm for correctly identifying patients at high risk of covid-19 related death. Of the 461 covid-19 related deaths in the validation cohort, 333 (72.2%) were in the QCOVID4 high risk group and 95 (20.6%) in the NHS Digital high risk group. Conclusion: The QCOVID4 risk algorithm, modelled from data during the period when the omicron variant of the SARS-CoV-2 virus was predominant in England, now includes vaccination dose and previous SARS-CoV-2 infection, and predicted covid-19 related death among people with a positive test result. QCOVID4 more accurately identified individuals at the highest levels of absolute risk for targeted interventions than the approach adopted by NHS Digital. QCOVID4 performed well and could be used for targeting treatments for covid-19 disease.
MeSH term(s)	Male ; Humans ; Adult ; Female ; COVID-19/epidemiology ; SARS-CoV-2 ; COVID-19 Vaccines ; Cohort Studies ; England/epidemiology ; Hospitals
Chemical Substances	COVID-19 Vaccines
Language	English
Publishing date	2023-06-21
Publishing country	England
Document type	Journal Article
ZDB-ID	1362901-3
ISSN	1756-1833 ; 0959-8154 ; 0959-8146 ; 0959-8138 ; 0959-535X ; 1759-2151
ISSN (online)	1756-1833
ISSN	0959-8154 ; 0959-8146 ; 0959-8138 ; 0959-535X ; 1759-2151
DOI	10.1136/bmj-2022-072976
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Article ; Online: Real world evidence for public health decision-making on vaccination policies

Chiara de Waure / Barbara C. Gärtner / Pier Luigi Lopalco / Joan Puig-Barbera / Jonathan S. Nguyen-Van-Tam

Expert Review of Vaccines, Vol 23, Iss 1, Pp 27-

perspectives from an expert roundtable

2024 Volume 38

Abstract: ABSTRACTIntroduction Influenza causes significant morbidity and mortality, but influenza vaccine uptake remains below most countries’ targets. Vaccine policy recommendations vary, as do procedures for reviewing and appraising the evidence.Areas Covered ... ...

Abstract	ABSTRACTIntroduction Influenza causes significant morbidity and mortality, but influenza vaccine uptake remains below most countries’ targets. Vaccine policy recommendations vary, as do procedures for reviewing and appraising the evidence.Areas Covered During a series of roundtable discussions, we reviewed procedures and methodologies used by health ministries in four European countries to inform vaccine recommendations. We review the type of evidence currently recommended by each health ministry and the range of approaches toward considering randomized controlled trials (RCTs) and real-world evidence (RWE) studies when setting influenza vaccine recommendations.Expert Opinion Influenza vaccine recommendations should be based on data from both RCTs and RWE studies of efficacy, effectiveness, and safety. Such data should be considered alongside health-economic, cost-effectiveness, and budgetary factors. Although RCT data are more robust and less prone to bias, well-designed RWE studies permit timely evaluation of vaccine benefits, effectiveness comparisons over multiple seasons in large populations, and detection of rare adverse events, under real-world conditions. Given the variability of vaccine effectiveness due to influenza virus mutations and increasing diversification of influenza vaccines, we argue that consideration of both RWE and RCT evidence is the best approach to more nuanced and timely updates of influenza vaccine recommendations.
Keywords	Influenza ; influenza vaccination ; vaccine effectiveness ; vaccination recommendations ; evidence base ; evaluation methodology ; Internal medicine ; RC31-1245
Subject code	306
Language	English
Publishing date	2024-12-01T00:00:00Z
Publisher	Taylor & Francis Group
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: A 40 MHz 11-Bit ENOB Delta Sigma ADC for Communication and Acquisition Systems.

Fakhoury, Hussein / Jabbour, Chadi / Nguyen, Van-Tam

Sensors (Basel, Switzerland)

2022 Volume 23, Issue 1

Abstract: This paper describes a Delta Sigma ADC IC that embeds a 5th-order Continuous-Time Delta Sigma modulator with 40 MHz signal bandwidth, a low ripple 20 to 80 MS/s variable-rate digital decimation filter, a bandgap voltage reference, and high-speed CML ... ...

Abstract	This paper describes a Delta Sigma ADC IC that embeds a 5th-order Continuous-Time Delta Sigma modulator with 40 MHz signal bandwidth, a low ripple 20 to 80 MS/s variable-rate digital decimation filter, a bandgap voltage reference, and high-speed CML buffers on a single die. The ADC also integrates on-chip calibrations for RC time-constant variation and quantizer offset. The chip was fabricated in a 1P7M 65 nm CMOS process. Clocked at 640 MHz, the Continuous-Time Delta Sigma modulator achieves 11-bit ENOB and 76.5 dBc THD up to 40 MHz of signal bandwidth while consuming 82.3 mW.
MeSH term(s)	CLOCK Proteins ; Communication
Chemical Substances	CLOCK Proteins (EC 2.3.1.48)
Language	English
Publishing date	2022-12-20
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2052857-7
ISSN	1424-8220 ; 1424-8220
ISSN (online)	1424-8220
ISSN	1424-8220
DOI	10.3390/s23010036
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Book ; Online ; Thesis: Improving the representation of hydrological connectivity in conceptual models

Nguyen, Van Tam [Verfasser]

2020

Author's details	Van Tam Nguyen
Keywords	Geowissenschaften ; Earth Sciences
Subject code	sg550
Language	English
Publisher	Gottfried Wilhelm Leibniz Universität Hannover
Publishing place	Hannover
Document type	Book ; Online ; Thesis
Database	Digital theses on the web

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