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  1. Article ; Online: Associations of childhood overweight and obesity with upper-extremity fracture characteristics.

    Nhan, Derek T / Leet, Arabella I / Lee, R Jay

    Medicine

    2021  Volume 100, Issue 18, Page(s) e25302

    Abstract: Abstract: Childhood obesity is a growing epidemic in the United States, and is associated with an increased risk of lower-extremity physeal fractures, and fractures requiring operative intervention. However, no study has assessed the risk upper ... ...

    Abstract Abstract: Childhood obesity is a growing epidemic in the United States, and is associated with an increased risk of lower-extremity physeal fractures, and fractures requiring operative intervention. However, no study has assessed the risk upper extremity physeal fractures among overweight children. Our purpose was to compare the following upper-extremity fracture characteristics in overweight and obese children with those of normal-weight/underweight children (herein, "normal weight"): mechanism of injury, anatomical location, fracture pattern, physeal involvement, and treatment types. We hypothesized that overweight and obese children would be higher risk for physeal and complete fractures with low-energy mechanisms and would therefore more frequently require operative intervention compared with normal-weight children.We performed a cross-sectional review of our database of 608 patients aged 2 to 16 years, and included patients who sustained isolated upper-extremity fractures at our level-1 pediatric tertiary care center from January 2014 to August 2017. Excluded were patients who sustained pathologic fractures and those without basic demographic or radiologic information. Using body mass index percentile for age and sex, we categorized patients as obese (≥95th percentile), overweight (85th to <95th percentile), normal weight (5th to <85th percentile), or underweight (<5th percentile). The obese and overweight groups were analyzed both separately and as a combined overweight/obese group. Demographic data included age, sex, height, and weight. Fractures were classified based on fracture location, fracture pattern (transverse, comminuted, buckle, greenstick, avulsion, or oblique), physeal involvement, and treatment type. Of the 608 patients, 58% were normal weight, 23% were overweight, and 19% were obese. There were no differences in the mean ages or sex distributions among the 3 groups.Among patients with low-energy mechanisms of injury, overweight/obese patients had significantly greater proportions of complete fractures compared with normal-weight children (complete: 65% vs 55%, P = .001; transverse: 43% vs 27%, P = .006). In addition, the overweight/obese group sustained significantly more upper-extremity physeal fractures (37%) than did the normal-weight group (23%) (P = .007).Compared with those in normal-weight children, upper-extremity fracture patterns differ in overweight and obese children, who have higher risk of physeal injuries and complete fractures caused by low-energy mechanisms.Level of Evidence: Level III, retrospective comparative study.
    MeSH term(s) Age Distribution ; Bones of Upper Extremity/injuries ; Child ; Child, Preschool ; Cross-Sectional Studies ; Female ; Fractures, Bone/epidemiology ; Hospitals, Pediatric/statistics & numerical data ; Humans ; Male ; Pediatric Obesity/epidemiology ; Retrospective Studies ; Risk Factors ; Sex Distribution ; Tertiary Care Centers/statistics & numerical data ; United States/epidemiology
    Language English
    Publishing date 2021-05-05
    Publishing country United States
    Document type Comparative Study ; Journal Article
    ZDB-ID 80184-7
    ISSN 1536-5964 ; 0025-7974
    ISSN (online) 1536-5964
    ISSN 0025-7974
    DOI 10.1097/MD.0000000000025302
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Bilateral Anterior Innominate Osteotomy for Bladder Exstrophy.

    Nhan, Derek T / Sponseller, Paul D

    JBJS essential surgical techniques

    2019  Volume 9, Issue 1, Page(s) e1

    Abstract: Background: Bladder exstrophy is a congenital condition that affects the genitourinary and musculoskeletal systems, and less commonly affects the intestinal system, with cloacal exstrophy. This condition results from abnormal migration of the mesenchyme, ...

    Abstract Background: Bladder exstrophy is a congenital condition that affects the genitourinary and musculoskeletal systems, and less commonly affects the intestinal system, with cloacal exstrophy. This condition results from abnormal migration of the mesenchyme, between the endoderm and ectoderm, leading to anterior rupture of the cloacal membrane. Numerous osseous morphologic changes are observed in bladder exstrophy. Rotational anomalies include external rotation of the posterior part of the pelvis and iliac wings, on average 12°, and acetabular retroversion
    Description: The steps of the procedure include (1) preoperative planning, (2) patient positioning, (3) incision, (4) identification of the lateral femoral cutaneous nerve, (5) subperiosteal dissection of the iliac wing, (6) guide pin placement and anterior osteotomy, (7) posterior hinge osteotomy (for cloacal exstrophy and for patients ≥2 years old), (8) external fixator pin placement, (9) anterior internal fixation of the pubic symphysis (for cloacal exstrophy and for patients ≥2 years old), and (10) resumption of the urologic procedure followed by wound closure and application of external fixator.
    Alternatives: Numerous previous techniques for osteotomies in bladder exstrophy have been developed, starting with Shultz in 1958, who recognized the importance of bringing the pubic bones together for gait correction in exstrophy repair
    Rationale: This procedure has several advantages over the prior conventional posterior approach. These include better approximation and improved mobility of the pubic rami at the time of closure, prevention of vertical migration of the hemipelvis, direct visual placement of an external fixator and adjustment postoperatively, and no requirement for turning the patient during the operation. In addition, this procedure allows for adjunctive posterior osteotomy from the anterior approach to provide adequate closure in those with cloacal exstrophy, prior failed closure, or extreme diastasis of >6 cm
    Language English
    Publishing date 2019-01-09
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2747088-X
    ISSN 2160-2204
    ISSN 2160-2204
    DOI 10.2106/JBJS.ST.18.00018
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Patient-Reported Outcomes in Axial Spondyloarthritis.

    Nhan, Derek T / Caplan, Liron

    Rheumatic diseases clinics of North America

    2016  Volume 42, Issue 2, Page(s) 285–299

    Abstract: Axial spondyloarthritis (axSpA), a subtype of spondyloarthritis, is a debilitating inflammatory condition involving the spinal and sacroiliac joints, contributing to a significant diminution in quality of life. Historically, characterization of patient ... ...

    Abstract Axial spondyloarthritis (axSpA), a subtype of spondyloarthritis, is a debilitating inflammatory condition involving the spinal and sacroiliac joints, contributing to a significant diminution in quality of life. Historically, characterization of patient outcomes in axSpA has been a challenge due to the lack of data from longitudinal epidemiologic studies and the nonspecific nature of inflammatory laboratory markers to monitor disease activity. In this review, measures developed to address these clinical domains are discussed and compared, of which 3 are commonly used in diagnosis and therapeutic planning. Provider data regarding utilization of these measures are also included to clarify current clinical practice trends.
    MeSH term(s) Activities of Daily Living ; Humans ; Patient Reported Outcome Measures ; Quality of Life ; Reproducibility of Results ; Severity of Illness Index ; Spondylarthropathies/physiopathology ; Spondylitis, Ankylosing/physiopathology ; Surveys and Questionnaires
    Language English
    Publishing date 2016-05
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 92118-x
    ISSN 1558-3163 ; 0889-857X
    ISSN (online) 1558-3163
    ISSN 0889-857X
    DOI 10.1016/j.rdc.2016.01.011
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Using the Remnant Anterior Cruciate Ligament to Improve Knee Stability: Biomechanical Analysis Using a Cadaveric Model.

    Nhan, Derek T / Belkoff, Stephen M / Singh, Prerna / Sullivan, Brian T / Klyce, Walter / Lee, R Jay

    Orthopaedic journal of sports medicine

    2021  Volume 9, Issue 4, Page(s) 2325967121996487

    Abstract: Background: Injured anterior cruciate ligament (ACL) tissue retains proprioceptive nerve fibers, vascularity, and biomechanical properties. For these reasons, remnant ACL tissue is often preserved during the treatment of ACL injuries.: Purpose: To ... ...

    Abstract Background: Injured anterior cruciate ligament (ACL) tissue retains proprioceptive nerve fibers, vascularity, and biomechanical properties. For these reasons, remnant ACL tissue is often preserved during the treatment of ACL injuries.
    Purpose: To assess through a cadaveric model whether reorienting and retensioning the residual ACL via an osteotomy improves knee stability after partial ACL tear, with substantial remnant tissue and intact femoral and tibial attachments.
    Study design: Controlled laboratory study.
    Methods: In 8 adult cadaveric knees, we measured anterior tibial translation and rotational laxity at 30° and 90° of flexion with the ACL in its native state and in 3 conditions: partial tear, retensioned, and ACL-deficient. The partial-tear state consisted of a sectioned anteromedial ACL bundle.
    Results: In the native state, the translation was 10 ± 2.7 mm (mean ± SD) at 30° of flexion and 8.4 ± 3.6 mm at 90° of flexion. Anterior translation of the knees in the partial-tear state (14 ± 2.7 mm at 30° and 12 ± 2.7 mm at 90°) was significantly greater than baseline (
    Conclusion: In a cadaveric model of an incomplete ACL tear, a reorienting and retensioning core osteotomy at the tibial insertion of the remnant ACL improved anteroposterior translation of the knee without compromising its rotational laxity.
    Clinical relevance: The findings of this study support the concept of ACL tissue reorienting and retensioning in the treatment of ACL laxity as an area for future investigation.
    Language English
    Publishing date 2021-04-06
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2706251-X
    ISSN 2325-9671
    ISSN 2325-9671
    DOI 10.1177/2325967121996487
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Bilateral Bicondylar Osteochondritis Dissecans in a Child with Spastic Diplegia and Crouch Gait: A Case Report.

    Nhan, Derek T / Garcia, Marcel Robles / Lee, R Jay

    JBJS case connector

    2018  Volume 8, Issue 2, Page(s) e41

    Abstract: Case: The cause of osteochondritis dissecans is unknown. Various hypotheses suggest mechanical, ischemic, and hereditary causes. We describe a 13-year-old girl with spastic diplegia, a form of cerebral palsy, who had an associated crouch gait and ... ...

    Abstract Case: The cause of osteochondritis dissecans is unknown. Various hypotheses suggest mechanical, ischemic, and hereditary causes. We describe a 13-year-old girl with spastic diplegia, a form of cerebral palsy, who had an associated crouch gait and presented with bilateral osteochondral defects of the medial and lateral femoral condyles.
    Conclusion: This case highlights the potential role of repetitive microtrauma, likely due to the poor biomechanical forces in a crouch gait, and provides support for a mechanical cause of osteochondritis dissecans.
    MeSH term(s) Adolescent ; Cerebral Palsy/complications ; Female ; Gait Disorders, Neurologic/complications ; Humans ; Knee Joint/diagnostic imaging ; Knee Joint/pathology ; Knee Joint/physiopathology ; Knee Joint/surgery ; Osteoarthritis, Knee ; Osteochondritis Dissecans
    Language English
    Publishing date 2018-06-27
    Publishing country United States
    Document type Case Reports ; Journal Article
    ISSN 2160-3251
    ISSN (online) 2160-3251
    DOI 10.2106/JBJS.CC.17.00271
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Epidemiological Patterns of Alternative Racquet-Sport Injuries in the United States, 1997-2016.

    Nhan, Derek T / Klyce, Walter / Lee, R Jay

    Orthopaedic journal of sports medicine

    2018  Volume 6, Issue 7, Page(s) 2325967118786237

    Abstract: Background: Racquet sports have increased in popularity over the past decade. Although research is available regarding the epidemiological characteristics of tennis injuries, little is known about the frequency and characteristics of injuries in other ... ...

    Abstract Background: Racquet sports have increased in popularity over the past decade. Although research is available regarding the epidemiological characteristics of tennis injuries, little is known about the frequency and characteristics of injuries in other racquet sports.
    Hypothesis: Given the increase in all racquet sport participation in the United States (US), it is hypothesized that injuries have accordingly become more frequent.
    Study design: Descriptive epidemiology study.
    Methods: Using the National Electronic Injury Surveillance System database, we reviewed the numbers of badminton and squash/racquetball injuries presenting to a representative sample of US emergency departments (EDs). We used weighted estimates to extrapolate the data to the US population. Incidence estimates were compared with national participation data and stratified.
    Results: A total of 4330 injuries were reported, representing an estimated 173,000 injuries presenting to US EDs from 1997 through 2016. Despite the increase in the number of players from 2006 through 2016, the annual injury rate for squash/racquetball declined significantly, including the rates for each body region assessed. No similar trend was found for badminton injuries. Within our extrapolated ED cohort, the lower extremities were the most common body region injured (37%). Strains/sprains were the most common injury type in the trunk (73%), lower extremities (65%), and upper extremities (32%), whereas lacerations were most common in the head/neck (49%). In badminton, the youngest players (age range, 5-18 years) sustained twice as many fractures (relative risk [RR], 1.96; 95% CI, 1.14-3.38) and almost 3 times as many lacerations as patients in any other age group. Similarly, the youngest squash/racquetball players were at highest risk for lacerations (RR, 1.45; 95% CI, 1.22-1.73) and head and neck injuries (RR, 1.52; 95% CI, 1.26-1.83).
    Conclusion: Although declines in rates of squash/racquetball injuries were observed, the increasing popularity of badminton, squash, and racquetball necessitates further preventive measures to improve player safety, with an emphasis on the youngest players.
    Language English
    Publishing date 2018-07-23
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2706251-X
    ISSN 2325-9671
    ISSN 2325-9671
    DOI 10.1177/2325967118786237
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Culturing explants for Cutibacterium at revision shoulder arthroplasty: an analysis of explant and tissue samples at corresponding anatomic sites.

    Nhan, Derek T / Gong, Davin C / Khoo, Kevin J / Whitson, Anastasia J / Matsen, Frederick A / Hsu, Jason E

    Journal of shoulder and elbow surgery

    2022  Volume 31, Issue 10, Page(s) 2017–2022

    Abstract: Background: Culturing of deep tissues obtained at revision arthroplasty for Cutibacterium is a key component of diagnosing a periprosthetic infection. The value of culturing explanted components has not been well described. This study sought to answer ... ...

    Abstract Background: Culturing of deep tissues obtained at revision arthroplasty for Cutibacterium is a key component of diagnosing a periprosthetic infection. The value of culturing explanted components has not been well described. This study sought to answer the following questions: (1) How does the culture positivity of explant cultures compare with that of deep tissue cultures? (2) How often are explant cultures positive when tissue cultures are not, and vice versa? (3) How does the bacterial density in explant cultures compare with that in tissue cultures?
    Methods: A total of 106 anatomic arthroplasties revised over a 7-year period were included. Explant (humeral head, humeral stem, and glenoid) and tissue (collar membrane, humeral canal tissue, and periglenoid tissue) specimens were sent for semiquantitative Cutibacterium culture. We compared culture positivity and bacterial density when cultures of an explant and tissue adjacent to the implant were both available.
    Results: Explants had positive cultures at a higher rate than adjacent tissue specimens for most anatomic sites. Of the shoulders that had Cutibacterium growth, a higher proportion of explants were culture positive when tissue samples were negative (23%-43%) than vice versa (0%-21%). The Cutibacterium density was higher in explants than in tissues. Considering only the results of tissue samples, 16% of the shoulders met our threshold for infection treatment (≥2 positive cultures); however, with the inclusion of the results for explant cultures, additional 14% of cases-a total of 30%-met the criteria for infection treatment.
    Conclusions: In this group of patients, culturing explants in addition to tissue cultures increased the sensitivity for detecting Cutibacterium in revision shoulder arthroplasty.
    MeSH term(s) Arthroplasty ; Arthroplasty, Replacement, Shoulder/adverse effects ; Humans ; Propionibacteriaceae ; Prosthesis-Related Infections/diagnosis ; Prosthesis-Related Infections/microbiology ; Prosthesis-Related Infections/surgery ; Reoperation ; Retrospective Studies ; Shoulder Joint/microbiology ; Shoulder Joint/surgery
    Language English
    Publishing date 2022-04-18
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1170782-3
    ISSN 1532-6500 ; 1058-2746
    ISSN (online) 1532-6500
    ISSN 1058-2746
    DOI 10.1016/j.jse.2022.03.004
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Efficacy of Home Prophylactic Benzoyl Peroxide and Chlorhexidine in Shoulder Surgery: A Systematic Review and Meta-Analysis.

    Nhan, Derek T / Woodhead, Benjamin M / Gilotra, Mohit N / Matsen, Frederick A / Hsu, Jason E

    JBJS reviews

    2020  Volume 8, Issue 8, Page(s) e2000023

    Abstract: Two predominant prophylactic home skin-disinfection regimens exist in shoulder surgery, benzoyl peroxide and chlorhexidine. Of these 2 regimens, benzoyl peroxide gel is more effective than chlorhexidine in reducing the rate of positive Cutibacterium ... ...

    Abstract Two predominant prophylactic home skin-disinfection regimens exist in shoulder surgery, benzoyl peroxide and chlorhexidine. Of these 2 regimens, benzoyl peroxide gel is more effective than chlorhexidine in reducing the rate of positive Cutibacterium cultures on the skin surface. At present, there are no studies that assess the impact of these home prophylactic measures on clinical infection rates.
    MeSH term(s) Anti-Infective Agents, Local/therapeutic use ; Benzoyl Peroxide/therapeutic use ; Chlorhexidine/therapeutic use ; Humans ; Shoulder/microbiology ; Shoulder/surgery ; Surgical Wound Infection/prevention & control
    Chemical Substances Anti-Infective Agents, Local ; Chlorhexidine (R4KO0DY52L) ; Benzoyl Peroxide (W9WZN9A0GM)
    Language English
    Publishing date 2020-08-12
    Publishing country United States
    Document type Comparative Study ; Journal Article ; Meta-Analysis ; Systematic Review
    ISSN 2329-9185
    ISSN (online) 2329-9185
    DOI 10.2106/JBJS.RVW.20.00023
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Are We Spending Wisely? Impact of POSNA Grants on Scholarly Productivity and Future Funding Success.

    Nhan, Derek T / Schoenecker, Jonathan G / Larson, A Noelle / Sponseller, Paul D

    Journal of pediatric orthopedics

    2018  Volume 39, Issue 1, Page(s) e82–e86

    Abstract: Background: The Pediatric Orthopaedic Society of North America (POSNA) funds grants to improve pediatric musculoskeletal care and maximize new knowledge through publications, presentations, and further funding. We assessed the productivity of POSNA ... ...

    Abstract Background: The Pediatric Orthopaedic Society of North America (POSNA) funds grants to improve pediatric musculoskeletal care and maximize new knowledge through publications, presentations, and further funding. We assessed the productivity of POSNA grants by number and rate of grant-specific publications, citations, and extramural funding; determined whether project type or completion status was associated with extramural funding; and compared the success of POSNA-funded versus all other podium presentations by publication rate and POSNA awards.
    Methods: We reviewed final reports for all 85 POSNA grants from 2003 to 2014. To determine grant productivity, we assessed the publication, presentation, and extramural funding rates, and the percentage of grants that achieved at least 1 scholarly output (publication or presentation). Citation counts were determined within 3 years after publication.
    Results: Overall, each grant achieved ~1.53 publications and 15.4 citations. Thirty-three percent secured extramural funding. However, 25% of grants could not be tracked to a scholarly product. Projects that reached completion and were of the basic science type (compared with clinical) were more likely to receive extramural funding. Compared with all other podiums, a greater proportion of POSNA-funded presentations led to a publication (64% vs. 48%, respectively; P=0.02) and were more likely to receive a POSNA award. Approximately 52% of funded projects were not presented at POSNA meetings.
    Conclusions: Although most POSNA-funded projects led to scholarly output, 25% of them produced no publications or podium presentations. POSNA-funded projects were more likely to lead to a publication and to have a higher chance of winning a POSNA award compared with all other projects. The POSNA grant process is effective at identifying impactful research, but continued process improvement, such as a prospectively maintained database of grant recipient productivity and improved tracking of grant submission histories, are both in development as the first steps to improve accountability of grant recipients in translating their projects to scholarly products.
    MeSH term(s) Financing, Organized/statistics & numerical data ; Humans ; North America ; Orthopedics ; Publishing/statistics & numerical data ; Research Support as Topic/statistics & numerical data ; Societies, Medical
    Language English
    Publishing date 2018-09-27
    Publishing country United States
    Document type Journal Article
    ZDB-ID 604642-3
    ISSN 1539-2570 ; 0271-6798
    ISSN (online) 1539-2570
    ISSN 0271-6798
    DOI 10.1097/BPO.0000000000001261
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Patient-reported outcomes after operative versus nonoperative treatment of pediatric lateral humeral condyle fractures.

    Ikwuezunma, Ijezie A / Suresh, Krishna V / Nhan, Derek T / Bryant, Barry R / Kotian, Ronak N / Lee, R Jay

    Medicine

    2021  Volume 100, Issue 41, Page(s) e27440

    Abstract: Abstract: Lateral humeral condyle fractures in children are treated with several approaches, yet it is unclear which has the best treatment outcomes. We hypothesized that functional outcomes would be equivalent between treatment types, reduction ... ...

    Abstract Abstract: Lateral humeral condyle fractures in children are treated with several approaches, yet it is unclear which has the best treatment outcomes. We hypothesized that functional outcomes would be equivalent between treatment types, reduction approaches, and fixation types. Our purpose was to assess patient-reported outcomes and complications by treatment type (operative versus nonoperative), reduction approach (open versus percutaneous), and fixation type (cannulated screws versus Kirschner wires).We retrospectively reviewed data from acute lateral humeral condyle fractures treated at our level-1 pediatric trauma center from 2008 to 2017. Patients were included if they were 8 years or older and had completed clinical follow-up. Fractures were categorized by fracture severity as mild (<2-mm displacement), moderate (isolated, 2- to 5-mm displacement), or severe (isolated, >5-mm displacement or >2-mm displacement with concomitant elbow dislocation or other elbow fracture). We extracted data on patient age, sex, treatment type, reduction approach, fixation type, patient-reported outcomes (shortened Disabilities of the Arm, Shoulder, and Hand and Patient Reported Outcome Measurement Information System upper extremity), treatment complications, and follow-up duration. Patients in the operative versus nonoperative group and across fracture severity subgroups did not differ significantly by age, sex, or follow-up duration. Bivariate analysis was performed to determine whether outcomes differed by intervention. Alpha = 0.05.No differences were observed in patient-reported outcomes between operative versus nonoperative groups for the mild and severe fracture subgroups. No differences were observed between approach (open versus percutaneous) or instrumentation (cannulated screw versus Kirschner wire fixation) for any outcome measure within the operative group. Patients whose fractures were stabilized with screws versus wires had significantly higher rates of return to the operating room (94% versus 8.3%, P < .001). The overall complication rate for our cohort was low, with no differences by treatment type or fracture severity.In our cohort, patient-reported outcomes were similar across fracture severity categories, irrespective of treatment or fixation type. Patients who underwent internal fixation with cannulated screws experienced significantly higher rates of return to the operating room compared with those treated with Kirschner wires but otherwise had similar complication rates and patient-reported outcomes.Level of Evidence: 3.
    MeSH term(s) Bone Screws ; Bone Wires ; Child ; Child, Preschool ; Closed Fracture Reduction/methods ; Decision Making, Shared ; Female ; Humans ; Humeral Fractures/therapy ; Injury Severity Score ; Male ; Open Fracture Reduction/methods ; Patient Reported Outcome Measures ; Retrospective Studies
    Language English
    Publishing date 2021-11-03
    Publishing country United States
    Document type Journal Article ; Observational Study
    ZDB-ID 80184-7
    ISSN 1536-5964 ; 0025-7974
    ISSN (online) 1536-5964
    ISSN 0025-7974
    DOI 10.1097/MD.0000000000027440
    Database MEDical Literature Analysis and Retrieval System OnLINE

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