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  1. Article ; Online: Complete mitochondrial genome of

    Xuan, Bo / Li, Mingyue / Ni, Xiaomin / Fu, Cuizhang

    Mitochondrial DNA. Part B, Resources

    2023  Volume 8, Issue 3, Page(s) 434–438

    Abstract: Belligobio ... ...

    Abstract Belligobio pengxianensis
    Language English
    Publishing date 2023-03-25
    Publishing country England
    Document type Journal Article
    ISSN 2380-2359
    ISSN (online) 2380-2359
    DOI 10.1080/23802359.2023.2192310
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  2. Article: The role of landscape evolution in the genetic diversification of a stream fish

    Li, Mingyue / Yang, Xishu / Ni, Xiaomin / Fu, Cuizhang

    Frontiers in genetics

    2023  Volume 13, Page(s) 1075617

    Abstract: Sarcocheilichthys ... ...

    Abstract Sarcocheilichthys parvus
    Language English
    Publishing date 2023-01-06
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2606823-0
    ISSN 1664-8021
    ISSN 1664-8021
    DOI 10.3389/fgene.2022.1075617
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  3. Article ; Online: Intention of Psychological Counseling, Attitude Toward Seeking Psychological Help, and Shame Among Vocational College Students: A Cross-Sectional Survey.

    Yin, Changchun / Gao, Ru / Ni, Xiaomin

    Alpha psychiatry

    2023  Volume 24, Issue 5, Page(s) 186–192

    Abstract: Objective: The aim of this study was to explore the psychological counseling intention of college students, the attitude of seeking psychological help, and the related factors of shame so as to promote the psychological health of college students.: ... ...

    Abstract Objective: The aim of this study was to explore the psychological counseling intention of college students, the attitude of seeking psychological help, and the related factors of shame so as to promote the psychological health of college students.
    Methods: In 4 comprehensive colleges with sound psychological counseling centers, students of different grades were selected and divided into an active help-seeking group (n = 216) and a help-refusal group (n = 270). Students' shame behaviors were evaluated using the Self-Stigma of Seeking Help (SSOSH) scale and Self-Stigma Scale (SSS). The intention of psychological counseling was measured by the General Help-Seeking Questionnaire. The Inventory of Attitudes Toward Seeking Mental Health Services was used to evaluate the psychological status. Data from the above scales were compared through the
    Results: The study found that the active help-seeking group scored lower on SSOSH scale compared to those in the help-refusal group (total score: 41.2 ± 9.1 vs. 37.9 ± 8.7,
    Conclusion: Our study findings suggest that shame has a negative impact on the intention of seeking psychological help and counseling among college students, highlighting the importance of addressing shame-related factors to promote psychological health and encourage the utilization of professional psychological counseling services.
    Language English
    Publishing date 2023-09-01
    Publishing country Turkey
    Document type Journal Article
    ISSN 2757-8038
    ISSN (online) 2757-8038
    DOI 10.5152/alphapsychiatry.2023.231235
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  4. Article ; Online: Pleistocene Landscape Dynamics Drives Lineage Divergence of a Temperate Freshwater Fish

    Ni, Xiaomin / Chen, Yun / Deng, Guangmin / Fu, Cuizhang

    Genes

    2023  Volume 14, Issue 12

    Abstract: Understanding historical processes underlying lineage distribution patterns is a primary goal of phylogeography. We ... ...

    Abstract Understanding historical processes underlying lineage distribution patterns is a primary goal of phylogeography. We selected
    MeSH term(s) Animals ; DNA, Mitochondrial/genetics ; Phylogeny ; Phylogeography ; Fresh Water ; Cypriniformes/genetics
    Chemical Substances DNA, Mitochondrial
    Language English
    Publishing date 2023-11-27
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2527218-4
    ISSN 2073-4425 ; 2073-4425
    ISSN (online) 2073-4425
    ISSN 2073-4425
    DOI 10.3390/genes14122146
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  5. Article ; Online: Transgenerational Effects of Hexavalent Chromium on Marine Medaka (

    Ni, Xiaomin / Shen, Yingjia

    Biomolecules

    2021  Volume 11, Issue 2

    Abstract: Hexavalent chromium [Cr(VI)] pollution is one of most serious heavy metal pollutants in the coastal area and posed serious threats to marine organisms and human beings. Many studies have been conducted on its toxicological effects on living organisms ... ...

    Abstract Hexavalent chromium [Cr(VI)] pollution is one of most serious heavy metal pollutants in the coastal area and posed serious threats to marine organisms and human beings. Many studies have been conducted on its toxicological effects on living organisms from morphological to physiological aspects. However, there are few studies about the transgenerational toxicological of Cr(VI). In this study, we exposed adult marine medaka fishes with Cr(VI) and their offspring with Cr(VI) to examine transgenerational effects of Cr(VI). We found that there were mechanisms such as changing reproduction modes in males to compensate for impacts on the reproduction. There were differences and similarities between the parental effect and the environmental effect, with the former one causing more serious adverse effects on the offspring of Cr(VI)-exposed fish. It was noteworthy that there was an interaction between the parental and offspring treatment which leads to the attenuation of the parental effects on offspring when the offspring also underwent the same treatment. In addition, physiological adaptation has also been observed in fish to improve their fitness. Overall, effects of Cr(VI) on fish and their offspring were studied to pave a way to study the of mechanisms of adaptation.
    MeSH term(s) Adaptation, Physiological ; Animals ; Chromium/chemistry ; DNA/chemistry ; Female ; Fertilization/drug effects ; Hot Temperature ; Male ; Oryzias/physiology ; Reproduction/drug effects ; Teratogens ; Water Pollutants, Chemical
    Chemical Substances Teratogens ; Water Pollutants, Chemical ; Chromium (0R0008Q3JB) ; chromium hexavalent ion (18540-29-9) ; DNA (9007-49-2)
    Language English
    Publishing date 2021-01-22
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2701262-1
    ISSN 2218-273X ; 2218-273X
    ISSN (online) 2218-273X
    ISSN 2218-273X
    DOI 10.3390/biom11020138
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  6. Article: The correlation between admission hyperglycemia and 30-day readmission after hip fracture surgery in geriatric patients: a propensity score-matched study.

    Tang, Wanyun / Ni, Xiaomin / Yao, Wei / Wang, Wei / Lv, Qiaomei / Ding, Wenbo / He, Renjian

    Frontiers in endocrinology

    2024  Volume 15, Page(s) 1340435

    Abstract: Purpose: This study aimed to investigate the association between admission hyperglycemia and 30-day readmission after hip fracture surgery in geriatric patients.: Methods: This retrospective study included 1253 geriatric hip fracture patients. ... ...

    Abstract Purpose: This study aimed to investigate the association between admission hyperglycemia and 30-day readmission after hip fracture surgery in geriatric patients.
    Methods: This retrospective study included 1253 geriatric hip fracture patients. Patients were categorized into normoglycemia(<6.10 mmol/L) and hyperglycemia groups(≥6.10 mmol/L) based on admission blood glucose. We performed multivariable logistic regression analyses and propensity score matching (PSM) to estimate adjusted odds ratios and 95% confidence intervals for 30-day readmission, controlling for potential confounding factors. An analysis of the dose-dependent association between admission blood glucose and the probability of 30-day readmission was performed. Additional subgroup analysis was conducted to examine the impact of other factors on the relationship between admission blood glucose and 30-day readmission.
    Results: Patients with hyperglycemia had higher 30-day readmission rates than normoglycemic patients before (19.1% vs 9.7%, p<0.001) and after PSM (18.1% vs 12.3%, p=0.035). Admission hyperglycemia was an independent predictor of increased 30-day readmission risk, with an adjusted odds ratio of 1.57 (95% CI 1.08-2.29, p=0.019) after multivariable regression and 1.57 (95% CI 1.03-2.39, p=0.036) after PSM. A dose-response relationship was observed between higher glucose levels and increased readmission risk.
    Conclusion: Admission hyperglycemia is an independent risk factor for 30-day readmission after hip fracture surgery in the elderly. Routine glucose testing upon admission and perioperative glycemic control may help reduce short-term readmissions in this vulnerable population.
    MeSH term(s) Aged ; Humans ; Patient Readmission ; Propensity Score ; Blood Glucose ; Retrospective Studies ; Hip Fractures/surgery ; Hyperglycemia/epidemiology
    Chemical Substances Blood Glucose
    Language English
    Publishing date 2024-02-21
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2592084-4
    ISSN 1664-2392
    ISSN 1664-2392
    DOI 10.3389/fendo.2024.1340435
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  7. Article ; Online: Association between admission albumin levels and 30-day readmission after hip fracture surgery in geriatric patients: a propensity score-matched study.

    Tang, Wanyun / Yao, Wei / Wang, Wei / Ding, Wenbo / Ni, Xiaomin / He, RenJian

    BMC musculoskeletal disorders

    2024  Volume 25, Issue 1, Page(s) 234

    Abstract: Purpose: This study aimed to evaluate the correlation admission albumin levels and 30-day readmission after hip fracture surgery in geriatric patients.: Methods: In this retrospective cohort study, 1270 geriatric patients admitted for hip fractures ... ...

    Abstract Purpose: This study aimed to evaluate the correlation admission albumin levels and 30-day readmission after hip fracture surgery in geriatric patients.
    Methods: In this retrospective cohort study, 1270 geriatric patients admitted for hip fractures to a level I trauma center were included. Patients were stratified by clinical thresholds and albumin level quartiles. The association between admission albumin levels and 30-day readmission risk was assessed using multivariate logistic regression and propensity score-matched analyses. The predictive accuracy of albumin levels for readmission was evaluated by ROC curves. The dose-response relationship between albumin levels and readmission risk was examined.
    Results: The incidence of 30-day readmission was significantly higher among hypoalbuminemia patients than those with normal albumin levels (OR = 2.090, 95%CI:1.296-3.370, p = 0.003). Furthermore, propensity score-matched analyses demonstrated that patients in the Q2(35.0-37.9 g/L) (OR 0.621, 95%CI 0.370-1.041, p = 0.070), Q3(38.0-40.9 g/L) (OR 0.378, 95%CI 0.199-0.717, p < 0.001) and Q4 (≥ 41 g/L) (OR 0.465, 95%CI 0.211-0.859, p = 0.047) quartiles had a significantly lower risk of 30-day readmission compared to those in the Q1(< 35 g/L) quartile. These associations remained significant after propensity score matching (PSM) and subgroup analyses. Dose-response relationships between albumin levels and 30-day readmission were observed.
    Conclusions: Lower admission albumin levels were independently associated with higher 30-day readmission rates in elderly hip fracture patients. Our findings indicate that serum albumin may assist perioperative risk assessment, and prompt correction of hypoalbuminemia and malnutrition could reduce short-term readmissions after hip fracture surgery in this high-risk population.
    MeSH term(s) Aged ; Humans ; Hip Fractures/surgery ; Hip Fractures/complications ; Hypoalbuminemia/epidemiology ; Hypoalbuminemia/complications ; Patient Readmission ; Postoperative Complications/diagnosis ; Postoperative Complications/epidemiology ; Propensity Score ; Retrospective Studies ; Risk Factors ; Serum Albumin, Human/analysis ; Serum Albumin, Human/chemistry
    Chemical Substances Serum Albumin, Human (ZIF514RVZR)
    Language English
    Publishing date 2024-03-25
    Publishing country England
    Document type Journal Article
    ZDB-ID 2041355-5
    ISSN 1471-2474 ; 1471-2474
    ISSN (online) 1471-2474
    ISSN 1471-2474
    DOI 10.1186/s12891-024-07336-x
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  8. Article ; Online: Structural insights into a regulatory mechanism of FIR RRM1-FUSE interaction.

    Ni, Xiaomin / Joerger, Andreas C / Chaikuad, Apirat / Knapp, Stefan

    Open biology

    2023  Volume 13, Issue 5, Page(s) 230031

    Abstract: FUBP-interacting repressor (FIR) is a suppressor of transcription of the proto-oncogene MYC. FIR binds to the far upstream element (FUSE) of the MYC promoter. Competition of FIR with FUSE-binding protein 1 (FUBP1) is a key mechanism of MYC ... ...

    Abstract FUBP-interacting repressor (FIR) is a suppressor of transcription of the proto-oncogene MYC. FIR binds to the far upstream element (FUSE) of the MYC promoter. Competition of FIR with FUSE-binding protein 1 (FUBP1) is a key mechanism of MYC transcriptional regulation. To gain insights into the structural mechanisms regulating FIR DNA interaction, we determined the crystal structure of two FIR RRM domains (RRM1-2) with single-stranded FUSE DNA sequences. These structures revealed an ability of the RRM domain to recognize diverse FUSE regions through distinct intermolecular interactions and binding modes. Comparative structural analyses against available RRM-ssDNA/RNA complexes showed that the nucleotide configurations in FIR were similar to those in other RRMs that harbour a tyrosine at the conserved aromatic position in the RNP2 motif (Y-type RRM), but not those with a phenylalanine (F-type RRM). Site-directed mutagenesis experiments demonstrated that a single substitution, Y115F, altered the binding affinities of oligonucleotides to FIR RRM, suggesting an important role of this conserved aromatic residue in ssDNA/RNA interactions. Our study provides the structural basis for further mechanistic studies on this important protein-DNA interaction.
    MeSH term(s) RNA Splicing Factors ; Repressor Proteins/metabolism ; Protein Binding ; RNA/metabolism ; DNA/metabolism
    Chemical Substances RNA Splicing Factors ; Repressor Proteins ; RNA (63231-63-0) ; DNA (9007-49-2)
    Language English
    Publishing date 2023-05-31
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2630944-0
    ISSN 2046-2441 ; 2046-2441
    ISSN (online) 2046-2441
    ISSN 2046-2441
    DOI 10.1098/rsob.230031
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  9. Article ; Online: The complete mitochondrial genome of

    Tian, Wei / Ni, Xiaomin / Fu, Cuizhang

    Mitochondrial DNA. Part B, Resources

    2022  Volume 7, Issue 10, Page(s) 1810–1813

    Abstract: ... ...

    Abstract Although
    Language English
    Publishing date 2022-10-19
    Publishing country England
    Document type Journal Article
    ISSN 2380-2359
    ISSN (online) 2380-2359
    DOI 10.1080/23802359.2022.2131370
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  10. Article: Phylogeographical Analysis of the Freshwater Gudgeon

    Yang, Xishu / Ni, Xiaomin / Fu, Cuizhang

    Life (Basel, Switzerland)

    2022  Volume 12, Issue 7

    Abstract: The freshwater ... ...

    Abstract The freshwater gudgeon
    Language English
    Publishing date 2022-07-09
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662250-6
    ISSN 2075-1729
    ISSN 2075-1729
    DOI 10.3390/life12071024
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