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Article ; Online: Alterations of biochemical indicators in military personnel with different endurance qualities before and after high altitude exposure

LI Song / YANG Lijun / NI Zhenhong

陆军军医大学学报, Vol 45, Iss 7, Pp 715-

2023 Volume 719

Abstract: Objective To explore the changes in biochemical indicators among soldiers with different endurance qualities after high altitude exposure and their adaptation to plateau environment. Methods A status survey was carried out on 253 young male soldiers who ... ...

Abstract	Objective To explore the changes in biochemical indicators among soldiers with different endurance qualities after high altitude exposure and their adaptation to plateau environment. Methods A status survey was carried out on 253 young male soldiers who were planned to station in Malone, Yunnan Province (2 100 m) for 4 weeks from July to August, 2018. The sampling method is cluster sampling. The endurance quality and biochemical indicators were assessed and measured before exposure and after 4 weeks' training. Their endurance quality was evaluated with grading 3-km armed cross-country. The included biochemical indicators were levels of creatine kinase, hemoglobin, average hemoglobin and cardiac troponin, and counts of blood red cells, lymphocytes and basophils. Results Based on the results of the 3-km armed cross-country, the participants were divided into excellent (12%), good (21%), passing (40%) and failing (27%) groups. Except for basophil counts, levels of creatine kinase, cardiac troponin, hemoglobin and average hemoglobin, and counts of red blood cells and lymphocyte changed significantly in all the 4 groups before and after high altitude exposure (P < 0.01). While, obvious changes were observed in cardiac troponin level and lymphocyte count among the 4 groups after they were stationed at high altitude (P < 0.01), and these changes were correlated with endurance quality (cardiac troponin: rs=-0.409, P < 0.01; lymphocytes: rs=0.205, P < 0.01). Conclusion There are some differences in blood biochemical indicators in soldiers with different endurance qualities at high altitude. Our results suggest that soldiers with higher endurance quality have a relatively lower risk of myocardial injury and stronger immune function after entering high altitude.
Keywords	high altitude ; endurance quality ; immune function ; myocardial injury ; Medicine (General) ; R5-920
Subject code	796
Language	Chinese
Publishing date	2023-04-01T00:00:00Z
Publisher	Editorial Office of Journal of Army Medical University
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: Editorial: Autophagy in diseases-From basic to clinic.

Yang, Jie / Ni, Zhenhong / Pi, Huifeng / Bohnert, Adam / Deng, Zhiqiang

Frontiers in physiology

2023 Volume 13, Page(s) 1115511

Language	English
Publishing date	2023-01-04
Publishing country	Switzerland
Document type	Editorial
ZDB-ID	2564217-0
ISSN	1664-042X
ISSN	1664-042X
DOI	10.3389/fphys.2022.1115511
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Effects and Mechanisms of Exogenous Electromagnetic Field on Bone Cells: A Review.

Zhang, Bin / Xie, Yangli / Ni, Zhenhong / Chen, Lin

Bioelectromagnetics

2020 Volume 41, Issue 4, Page(s) 263–278

Abstract: Osteoporosis, fractures, and other bone diseases or injuries represent serious health problems in modern society. A variety of treatments including drugs, surgeries, physical therapies, etc. have been used to prevent or delay the progression of these ... ...

Abstract	Osteoporosis, fractures, and other bone diseases or injuries represent serious health problems in modern society. A variety of treatments including drugs, surgeries, physical therapies, etc. have been used to prevent or delay the progression of these diseases/injuries with limited effects. Electromagnetic field (EMF) has been used to non-invasively treat bone diseases, such as fracture and osteoporosis, for many years. However, because a variety of cellular and molecular events can be affected by EMF with various parameters, the precise bioeffects and underlying mechanisms of specific EMF on bone cells are still obscure. Here, we summarize the common therapeutic parameters (frequency and intensity) of major types of EMF used to treat bone cells taken from 32 papers we selected from the PubMed database published in English from 1991 to 2018. Briefly, pulse EMF promotes the proliferation of osteoblasts when its frequency is 7.5-15 Hz or 50-75 Hz and the intensity is 0.40-1.55 mT or 3.8-4 mT. Sinusoidal EMF, with 0.9-4.8 mT and 45-60 Hz, and static magnetic field with 0.1-0.4 mT or 400 mT, can promote osteoblast differentiation and maturation. Finally, we summarize the latest advances on the molecular signaling pathways influenced by EMF in osteoblasts and osteoclasts. A variety of molecules such as adenosine receptors, calcium channels, BMP2, Notch, Wnt1, etc., can be influenced by EMF in osteoblasts. For osteoclasts, EMF affects RANK, NF-κB, MAPK, etc. We speculate that EMF with different frequencies and intensities exert distinct bioeffects on specific bone cells. More high-quality work is required to explore the detailed effects and underlying mechanisms of EMF on bone cells/skeleton to optimize the application of EMF on bone diseases/injuries. Bioelectromagnetics. 2020;41:263-278 © 2020 Bioelectromagnetics Society.
MeSH term(s)	Animals ; Bone and Bones/cytology ; Electromagnetic Fields ; Humans ; Magnetic Field Therapy/methods ; NF-kappa B/metabolism ; Osteoblasts/physiology ; Osteoclasts/physiology ; RANK Ligand/metabolism
Chemical Substances	NF-kappa B ; RANK Ligand
Language	English
Publishing date	2020-03-11
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	760683-7
ISSN	1521-186X ; 0197-8462
ISSN (online)	1521-186X
ISSN	0197-8462
DOI	10.1002/bem.22258
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Article: Correlation between the Signal Intensity Alteration of Infrapatellar Fat Pad and Knee Osteoarthritis: A Retrospective, Cross-Sectional Study.

Liu, Zheng / Wu, Jiangyi / Xiang, Wei / Wu, Jinhui / Huang, Shu / Zhou, Yizhao / Xia, Hui / Ni, Zhenhong / Liu, Baorong

Journal of clinical medicine

2023 Volume 12, Issue 4

Abstract: Infrapatellar fat pad (IPFP) inflammation is a common pathological manifestation in knee osteoarthritis (OA). However, the significance of IPFP signal intensity alteration for clinical diagnosis and treatment of knee OA needs further research. We ... ...

Abstract	Infrapatellar fat pad (IPFP) inflammation is a common pathological manifestation in knee osteoarthritis (OA). However, the significance of IPFP signal intensity alteration for clinical diagnosis and treatment of knee OA needs further research. We assessed IPFP signal intensity alteration (0-3), IPFP maximum cross-sectional area (CSA) and IPFP depth, meniscus injury, bone marrow edema, and cartilage injury from magnetic-resonance imaging (MRI) in 41 non-KOA patients (K-L grade 0 and grade I) and 68 KOA patients (K-L grade 2,3 and 4). We found that IPFP signaling was altered in all patients with KOA whose alteration was closely related to the K-L grading. We found that the IPFP signal intensity was increased in most OA patients, especially the ones in the late stage. There were significant differences in IPFP maximum CSA and IPFP depth between groups in KOA and non-KOA patients. Moreover, Spearman correlation analysis showed that IPFP signal intensity was moderately positively correlated with age, meniscal injury, cartilage injury, and bone marrow edema, and negatively correlated with height, while not correlated with visual analogue scale (VAS) scoring and body mass index (BMI). In addition, women have higher IPFP inflammation scores on MRI than men. In conclusion, IPFP signal intensity alteration is associated with joint damage in knee OA, which may have clinical significance for diagnosing and treating KOA.
Language	English
Publishing date	2023-02-07
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2662592-1
ISSN	2077-0383
ISSN	2077-0383
DOI	10.3390/jcm12041331
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Article: Natural products in osteoarthritis treatment: bridging basic research to clinical applications.

Fang, Shunzheng / Zhang, Bin / Xiang, Wei / Zheng, Liujie / Wang, Xiaodong / Li, Song / Zhang, Tongyi / Feng, Daibo / Gong, Yunquan / Wu, Jinhui / Yuan, Jing / Wu, Yaran / Zhu, Yizhen / Liu, Enli / Ni, Zhenhong

Chinese medicine

2024 Volume 19, Issue 1, Page(s) 25

Abstract: Osteoarthritis (OA) is the most prevalent degenerative musculoskeletal disease, severely impacting the function of patients and potentially leading to disability, especially among the elderly population. Natural products (NPs), obtained from components ... ...

Abstract	Osteoarthritis (OA) is the most prevalent degenerative musculoskeletal disease, severely impacting the function of patients and potentially leading to disability, especially among the elderly population. Natural products (NPs), obtained from components or metabolites of plants, animals, microorganisms etc., have gained significant attention as important conservative treatments for various diseases. Recently, NPs have been well studied in preclinical and clinical researches, showing promising potential in the treatment of OA. In this review, we summed up the main signaling pathways affected by NPs in OA treatment, including NF-κB, MAPKs, PI3K/AKT, SIRT1, and other pathways, which are related to inflammation, anabolism and catabolism, and cell death. In addition, we described the therapeutic effects of NPs in different OA animal models and the current clinical studies in OA patients. At last, we discussed the potential research directions including in-depth analysis of the mechanisms and new application strategies of NPs for the OA treatment, so as to promote the basic research and clinical transformation in the future. We hope that this review may allow us to get a better understanding about the potential bioeffects and mechanisms of NPs in OA therapy, and ultimately improve the effectiveness of NPs-based clinical conservative treatment for OA patients.
Language	English
Publishing date	2024-02-15
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	2260322-0
ISSN	1749-8546
ISSN	1749-8546
DOI	10.1186/s13020-024-00899-w
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Article ; Online: Lymphatic vessels: roles and potential therapeutic intervention in rheumatoid arthritis and osteoarthritis.

Zhou, Siru / Zhao, Guangyu / Chen, Ran / Li, Yang / Huang, Junlan / Kuang, Liang / Zhang, Dali / Li, Zhijun / Xu, Haofeng / Xiang, Wei / Xie, Yangli / Chen, Lin / Ni, Zhenhong

Theranostics

2024 Volume 14, Issue 1, Page(s) 265–282

Abstract: Lymphatic vessel networks are a main part of the vertebrate cardiovascular system, which participate in various physiological and pathological processes via regulation of fluid transport and immunosurveillance. Targeting lymphatic vessels has become a ... ...

Abstract	Lymphatic vessel networks are a main part of the vertebrate cardiovascular system, which participate in various physiological and pathological processes via regulation of fluid transport and immunosurveillance. Targeting lymphatic vessels has become a potent strategy for treating various human diseases. The presence of varying degrees of inflammation in joints of rheumatoid arthritis (RA) and osteoarthritis (OA), characterized by heightened infiltration of inflammatory cells, increased levels of inflammatory factors, and activation of inflammatory signaling pathways, significantly contributes to the disruption of cartilage and bone homeostasis in arthritic conditions. Increasing evidence has demonstrated the pivotal role of lymphatic vessels in maintaining joint homeostasis, with their pathological alterations closely associated with the initiation and progression of inflammatory joint diseases. In this review, we provide a comprehensive overview of the evolving knowledge regarding the structural and functional aspects of lymphatic vessels in the pathogenesis of RA and OA. In addition, we summarized the potential regulatory mechanisms underlying the modulation of lymphatic function in maintaining joint homeostasis during inflammatory conditions, and further discuss the distinctions between RA and OA. Moreover, we describe therapeutic strategies for inflammatory arthritis based on lymphatic vessels, including the promotion of lymphangiogenesis, restoration of proper lymphatic vessel function through anti-inflammatory approaches, enhancement of lymphatic contractility and drainage, and alleviation of congestion within the lymphatic system through the elimination of inflammatory cells. At last, we envisage potential research perspectives and strategies to target lymphatic vessels in treating these inflammatory joint diseases.
MeSH term(s)	Humans ; Arthritis, Rheumatoid/pathology ; Osteoarthritis/metabolism ; Lymphatic Vessels/metabolism ; Inflammation/metabolism ; Lymphangiogenesis
Language	English
Publishing date	2024-01-01
Publishing country	Australia
Document type	Journal Article ; Review
ZDB-ID	2592097-2
ISSN	1838-7640 ; 1838-7640
ISSN (online)	1838-7640
ISSN	1838-7640
DOI	10.7150/thno.90940
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Article: Total body water percentage and 3rd space water are novel risk factors for training-related lower extremity muscle injuries in young males.

Chen, Liang / Jin, Ke-Xing / Yang, Jing / Ouyang, Jun-Jie / Chen, Han-Gang / Zhou, Si-Ru / Luo, Xiao-Qing / Liu, Mi / Kuang, Liang / Xie, Yang-Li / Hu, Yan / Chen, Lin / Ni, Zhen-Hong / Du, Xiao-Lan

Chinese journal of traumatology = Zhonghua chuang shang za zhi

2024

Abstract: Purpose: To identify the risk factors for training-related lower extremity muscle injuries in young males by a non-invasive method of body composition analysis.: Methods: A total of 282 healthy young male volunteers aged 18 - 20 years participated in ...

Abstract	Purpose: To identify the risk factors for training-related lower extremity muscle injuries in young males by a non-invasive method of body composition analysis. Methods: A total of 282 healthy young male volunteers aged 18 - 20 years participated in this cohort study. Injury location, degree, and injury rate were adjusted by a questionnaire based on the overuse injury assessment methods used in epidemiological studies of sports injuries. The occurrence of training injuries is monitored and diagnosed by physicians and treated accordingly. The body composition was measured using the BodyStat QuadScan 4000 multifrequency Bio-impedance system at 5, 50, 100 and 200 kHz to obtain 4 impedance values. The Shapiro-Wilk test was used to check whether the data conforms to a normal distribution. Data of normal distribution were shown as mean ± SD and analyzed by t-test, while those of non-normal distribution were shown as median (Q Results: Among the 282 subjects, 78 (27.7%) developed training injuries. Lower extremity training injuries revealed the highest incidence, accounting for 23.4 % (66 cases). These patients showed higher percentages of lean body mass (p = 0.001), total body water (TBW, p = 0.006), extracellular water (p = 0.020) and intracellular water (p = 0.010) as well as a larger ratio of basal metabolic rate/total weight (p = 0.006), compared with those without lower extremity muscle injuries. On the contrary, the percentage of body fat (p = 0.001) and body fat mass index (p = 0.002) was lower. Logistic regression analysis showed that TBW percentage > 65.35% (p = 0.050, OR = 3.114) and 3rd space water > 0.95% (p = 0.045, OR = 2.342) were independent risk factors for lower extremity muscle injuries. Conclusion: TBW percentage and 3rd space water measured with bio-impedance method are potential risk factors for predicting the incidence of lower extremity muscle injuries in young males following training.
Language	English
Publishing date	2024-01-04
Publishing country	China
Document type	Journal Article
ZDB-ID	2276839-7
ISSN	1008-1275
ISSN	1008-1275
DOI	10.1016/j.cjtee.2024.01.001
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Article ; Online: Low-intensity pulsed ultrasound suppresses synovitis by modulating polarization of synovial macrophages in mice with osteoarthritis

ZHANG Bin / NI Zhenhong / YANG Peng / KUANG Liang / OUYANG Junjie

Di-san junyi daxue xuebao, Vol 41, Iss 8, Pp 747-

2019 Volume 756

Abstract: Objective To investigate the therapeutic effect of low-intensity pulsed ultrasound (LIPUS) on synovitis in a mouse model of osteoarthritis and explore the possible mechanism. Methods We assessed the therapeutic effect of LIPUS on synovitis in a mouse ... ...

Abstract	Objective To investigate the therapeutic effect of low-intensity pulsed ultrasound (LIPUS) on synovitis in a mouse model of osteoarthritis and explore the possible mechanism. Methods We assessed the therapeutic effect of LIPUS on synovitis in a mouse model of destabilization of medial meniscus (DMM). The histopathology of the synovium of the knee joint was examined in 7 mice with DMM (model group), 7 normal mice (control group) and 7 mice with DMM treated with LIPUS. The proportion of iNOS- and CD206-positive cells in F4/80-positive macrophages in the synovium was detected. Cultured THP-1 macrophages were divided into control group, LIPUS group, lipopolysaccharide (LPS) group and LPS+LIPUS group, and Raw 264.7 cells were divided into LPS group and LPS+LIPUS group with corresponding treatments. The mRNA levels of polarization-related indexes (IL-1β, TNF-α, IL-10 and Arg1) were detected using real-time quantitative PCR after the treatments, and the protein levels of p-JNK and p-NF-κB p65 were detected using Western blotting. Confocal laser scanning microscopy was used to observe the nuclear translocation of nuclear factor-κB (NF-κB) in THP-1 cells after LPS or LPS+LIPUS treatment. Results In the mouse models of DMM, treatment with LIPUS significantly reduced the thicknesses of the synovium (P < 0.05), decreased the proportion of M1 macrophages and upregulated the proportion of M2 macrophages in the synovium (P < 0.05). In THP-1 and Raw 264.7 macrophages stimulated with LPS, LIPUS treatment significantly lowered IL-1β and TNF-α levels but increased IL-10 and Arg1 levels (P < 0.05). LIPUS also decreased the protein levels of p-JNK and p-NF-κB p65 in LPS-stimulated macrophages (P < 0.05) and suppressed LPS-induced nuclear translocation of NF-κB (P < 0.05). Conclusion LIPUS produces anti-inflammatory effects on the synovium in the mouse model of osteoarthritis possibly by modulating the polarization of synovial macrophages through the JNK and NF-κB signaling pathways.
Keywords	low-intensity pulsed ultrasound ; osteoarthritis ; macrophages ; polarization ; Medicine (General) ; R5-920
Subject code	630
Language	Chinese
Publishing date	2019-04-01T00:00:00Z
Publisher	Editorial Office of Journal of Third Military Medical University
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Cir-DNA Sequencing Revealed the Landscape of Extrachromosomal Circular DNA in Articular Cartilage and the Potential Roles in Osteoarthritis.

Xiang, Wei / Zhang, Tongyi / Li, Song / Gong, Yunquan / Luo, Xiaoqing / Yuan, Jing / Wu, Yaran / Yan, Xiaojing / Xiong, Yan / Lian, Jiqin / Zhao, Guangyu / Gao, Changyue / Kuang, Liang / Ni, Zhenhong

Cartilage

2023 , Page(s) 19476035231205690

Abstract: Objective: Extrachromosomal circular DNA (eccDNA) has been shown to be involved in several physiological and pathological processes including immunity, inflammation, aging, and tumor. However, the expression of eccDNA in cartilage has not been reported ... ...

Abstract	Objective: Extrachromosomal circular DNA (eccDNA) has been shown to be involved in several physiological and pathological processes including immunity, inflammation, aging, and tumor. However, the expression of eccDNA in cartilage has not been reported until now. In this study, we aimed to investigate the landscape of eccDNA in articular cartilage and analyze the potential roles in osteoarthritis (OA). Methods: The samples of articular cartilage were obtained from total knee arthroplasty (TKA) donors with OA. The mitochondrial DNA (mtDNAs) and the linear DNAs from chondrocytes of articular cartilage were removed. Then the eccDNAs were enriched for cir-DNA sequencing. After quality control evaluation, we systematically revealed the identified eccDNA data including size distribution, the size range, and sequence pattern. Moreover, we explored and discussed the potential roles of eccDNA in OA via motif analysis and Gene Ontology (GO)/Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analysis. Results: The chondrocytes from OA cartilage contained an abundance of eccDNAs, which was termed as OC-eccDNAs (OA cartilage-derived eccDNA). The characteristics of OC-eccDNAs were tissue-specific, including the distribution, the size range, and sequence pattern. Moreover, the functional analysis indicated that eccDNA may be involved in the homeostasis maintenance of chondrocytes and participated in the process of OA. Conclusions: Our data first showed the landscape of eccDNA in articular cartilage and preliminarily indicated the potential roles of eccDNA in OA.
Language	English
Publishing date	2023-10-16
Publishing country	United States
Document type	Journal Article
ZDB-ID	2515870-3
ISSN	1947-6043 ; 1947-6035
ISSN (online)	1947-6043
ISSN	1947-6035
DOI	10.1177/19476035231205690
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Article: Autophagy in the pathogenesis and therapeutic potential of post-traumatic osteoarthritis.

Gong, Yunquan / Li, Song / Wu, Jinghui / Zhang, Tongyi / Fang, Shunzheng / Feng, Daibo / Luo, Xiaoqing / Yuan, Jing / Wu, Yaran / Yan, Xiaojing / Zhang, Yan / Zhu, Jun / Wu, Jiangyi / Lian, Jiqin / Xiang, Wei / Ni, Zhenhong

Burns & trauma

2023 Volume 11, Page(s) tkac060

Abstract: Autophagy, as a fundamental mechanism for cellular homeostasis, is generally involved in the occurrence and progression of various diseases. Osteoarthritis (OA) is the most common musculoskeletal disease that often leads to pain, disability and economic ... ...

Abstract	Autophagy, as a fundamental mechanism for cellular homeostasis, is generally involved in the occurrence and progression of various diseases. Osteoarthritis (OA) is the most common musculoskeletal disease that often leads to pain, disability and economic loss in patients. Post-traumatic OA (PTOA) is a subtype of OA, accounting for >12% of the overall burden of OA. PTOA is often caused by joint injuries including anterior cruciate ligament rupture, meniscus tear and intra-articular fracture. Although a variety of methods have been developed to treat acute joint injury, the current measures have limited success in effectively reducing the incidence and delaying the progression of PTOA. Therefore, the pathogenesis and intervention strategy of PTOA need further study. In the past decade, the roles and mechanisms of autophagy in PTOA have aroused great interest in the field. It was revealed that autophagy could maintain the homeostasis of chondrocytes, reduce joint inflammatory level, prevent chondrocyte death and matrix degradation, which accordingly improved joint symptoms and delayed the progression of PTOA. Moreover, many strategies that target PTOA have been revealed to promote autophagy. In this review, we summarize the roles and mechanisms of autophagy in PTOA and the current strategies for PTOA treatment that depend on autophagy regulation, which may be beneficial for PTOA patients in the future.
Language	English
Publishing date	2023-01-31
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	2775996-9
ISSN	2321-3876 ; 2321-3868
ISSN (online)	2321-3876
ISSN	2321-3868
DOI	10.1093/burnst/tkac060
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