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Article ; Online: Preeclampsia, Natural History, Genes, and miRNAs Associated with the Syndrome.

Parada-Niño, Laura / Castillo-León, Luisa Fernanda / Morel, Adrien

2022 Volume 2022, Page(s) 3851225

Abstract: Preeclampsia (PE) is a hypertensive disease that affects pregnant women after 20 weeks of gestation. This disease is associated with an important risk of maternal and fetal mortality. PE is described as a placental pathology because, after delivery, most ...

Abstract	Preeclampsia (PE) is a hypertensive disease that affects pregnant women after 20 weeks of gestation. This disease is associated with an important risk of maternal and fetal mortality. PE is described as a placental pathology because, after delivery, most women recover normal arterial pressure. Poor invasion of the spiral arteries is a phenomenon well described in PE; this leads to a hypoxic uterine bed and imbalance of antiangiogenic and proangiogenic factors in the uteroplacental region, which in turn triggers the disease phenotype. The causes of the pathology are unclear; nevertheless, numerous approaches, including next-generation sequencing, association, and case control and miRNA studies, have shed light on the genetic/molecular basis of PE. These studies help us better understand the disease to advance new treatment strategies.
MeSH term(s)	Female ; Humans ; Hypertension ; MicroRNAs/genetics ; Placenta ; Placenta Growth Factor ; Pre-Eclampsia/genetics ; Pregnancy
Chemical Substances	MicroRNAs ; Placenta Growth Factor (144589-93-5)
Language	English
Publishing date	2022-02-14
Publishing country	Egypt
Document type	Journal Article ; Review
ZDB-ID	2595413-1
ISSN	2090-2735 ; 2090-2735
ISSN (online)	2090-2735
ISSN	2090-2735
DOI	10.1155/2022/3851225
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Article ; Online: Mixed Matrix Membranes Using Porous Organic Polymers (POPs)-Influence of Textural Properties on CO

Matesanz-Niño, Laura / Moranchel-Pérez, Jorge / Álvarez, Cristina / Lozano, Ángel E / Casado-Coterillo, Clara

Polymers

2023 Volume 15, Issue 20

Abstract: Mixed matrix membranes (MMMs) provide the opportunity to test new porous materials in challenging applications. A series of low-cost porous organic polymer (POPs) networks, possessing tunable porosity and high ... ...

Abstract	Mixed matrix membranes (MMMs) provide the opportunity to test new porous materials in challenging applications. A series of low-cost porous organic polymer (POPs) networks, possessing tunable porosity and high CO
Language	English
Publishing date	2023-10-18
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2527146-5
ISSN	2073-4360 ; 2073-4360
ISSN (online)	2073-4360
ISSN	2073-4360
DOI	10.3390/polym15204135
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Article ; Online: Hyperthyroidism in children and adolescents: Experience in a university hospital in Colombia

García, Judith Sofía / Sarmiento, María Paula / Bello, Jesús David / Zuluaga, Nora Alejandra / Forero, Adriana Carolina / Niño, Laura Fernanda

Biomedica : revista del Instituto Nacional de Salud

2022 Volume 42, Issue 2, Page(s) 342–354

Title translation	Hipertiroidismo en niños y adolescentes: experiencia en un hospital universitario en Colombia
MeSH term(s)	Colombia ; Hospitals ; Retrospective Studies
Language	Spanish
Publishing date	2022-06-01
Publishing country	Colombia
Document type	Journal Article
ZDB-ID	2059952-3
ISSN	2590-7379 ; 2590-7379
ISSN (online)	2590-7379
ISSN	2590-7379
DOI	10.7705/biomedica.6244
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Article ; Online: Morbimortality assessment in abdominal surgery: are we predicting or overreacting?

Valenzuela, Sebastian / Niño, Laura / Conde, Danny / Girón, Felipe / Rodríguez, Lina / Venegas, David / Rey, Carlos / Nassar, Ricardo / Vanegas, Marco / Jiménez, Daniel

BMC surgery

2022 Volume 22, Issue 1, Page(s) 19

Abstract: Background: High-risk surgical procedures represent a fundamental part of general surgery practice due to its significant rates of morbidity and mortality. Different predictive tools have been created in order to quantify perioperative morbidity and ... ...

Abstract	Background: High-risk surgical procedures represent a fundamental part of general surgery practice due to its significant rates of morbidity and mortality. Different predictive tools have been created in order to quantify perioperative morbidity and mortality risk. POSSUM (Physiological and Operative Severity Score for the enumeration of Mortality and morbidity) is one of the most widely validated predictive scores considering physiological and operative variables to precisely define morbimortality risk. Nevertheless, seeking greater accuracy in predictions P-POSSUM was proposed. We aimed to compare POSSUM and P-POSSUM for patients undergoing abdominal surgery. Methods: A retrospective observational study with a prospective database was conducted. Patients over 18 years old who complied with inclusion criteria between 2015 and 2016 were included. Variables included in the POSSUM and P-POSSUM Scores were analyzed. Descriptive statistics of all study parameters were provided. The analysis included socio-demographic data, laboratory values , and imaging. Bivariate analysis was performed. Results: 350 Patients were included in the analysis, 55.1% were female. The mean age was 55.9 ± 20.4 years old. POSSUM revealed a moderated index score in 61.7% of the patients, mean score of 12.85 points ± 5.61. 89.1% of patients had no neoplastic diagnosis associated. Overall morbidity and mortality rate was 14.2% and 7.1%. P-POSSUM could predict more precisely mortality (p < 0.00). Conclusions: The POSSUM score is likely to overestimate the risk of morbidity and mortality in patients with high/moderate risk, while the P-POSSUM score seems to be a more accurate predictor of mortality risk. Further studies are needed to confirm our results.
MeSH term(s)	Adolescent ; Adult ; Aged ; Female ; Humans ; Middle Aged ; Morbidity ; Postoperative Complications/epidemiology ; Retrospective Studies ; Risk Assessment ; Severity of Illness Index
Language	English
Publishing date	2022-01-18
Publishing country	England
Document type	Journal Article ; Observational Study
ZDB-ID	2050442-1
ISSN	1471-2482 ; 1471-2482
ISSN (online)	1471-2482
ISSN	1471-2482
DOI	10.1186/s12893-021-01455-1
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Article ; Online: Pharmacogenetics of ABCB1, CDA, DCK, GSTT1, GSTM1 and outcomes in a cohort of pediatric acute myeloid leukemia patients from Colombia.

Yunis, Luz K / Linares-Ballesteros, Adriana / Aponte, Nelson / Barros, Gisela / García, Johnny / Niño, Laura / Uribe, Gloria / Quintero, Edna / Yunis, Juan J

Cancer reports (Hoboken, N.J.)

2022 Volume 6, Issue 3, Page(s) e1744

Abstract: Background and aim: Different studies have shown pharmacogenetic variants related to drug toxicity in acute myeloid leukemia (AML) patients. Our aim was to identify the association between ABCB1, CDA, DCK, GSTT1, and GSTM1 variants with clinical ... ...

Abstract	Background and aim: Different studies have shown pharmacogenetic variants related to drug toxicity in acute myeloid leukemia (AML) patients. Our aim was to identify the association between ABCB1, CDA, DCK, GSTT1, and GSTM1 variants with clinical outcomes and toxicity in pediatric patients with AML. Methods: Fifty-one confirmed de novo AML pediatric patients were included. A SNaPshot™ assay and conventional PCR were used to evaluate ABCB1, CDA, DCK, GSTT1, and GSTM1 variants. Clinical outcomes and toxicity associations were evaluated using odds ratios and Chi-square analysis. Results: Patients carrying ABCB1 (1236C > T, rs1128503) GG genotype in had a 6.8 OR (CI 95% 1.08-42.73, p = .044) for cardiotoxicity as compared to patients carrying either AA or GA genotypes 0.14 OR (CI 95% 0.023-0.92, p = .044). For ABCB1 (1236G > A rs1128503/2677C > A/T rs2032582/3435G > A rs1045642) AA/AA/AA combined genotypes had a strong association with death after HSTC OR 13.73 (CI 95% 1.94-97.17, p = .009). Combined genotypes GG/CC/GG with CDA (79A > C, rs2072671) CA genotype or CDA (-451G > A, rs532545) CT genotype, had a 4.11 OR (CI 95% 2.32-725, p = .007) and 3.8 OR (CI 95% 2.23-6.47, p = .027) with MRD >0.1% after first chemotherapy cycle, respectively. Conclusion: Our results highlight the importance of pharmacogenetic analysis in pediatric AML, particularly in populations with a high degree of admixture, and might be useful as a future tool for patient stratification for treatment.
MeSH term(s)	Humans ; Child ; Pharmacogenetics ; Colombia/epidemiology ; Leukemia, Myeloid, Acute/drug therapy ; Leukemia, Myeloid, Acute/genetics ; Genotype ; ATP Binding Cassette Transporter, Subfamily B/genetics ; ATP Binding Cassette Transporter, Subfamily B/therapeutic use
Chemical Substances	ABCB1 protein, human ; ATP Binding Cassette Transporter, Subfamily B
Language	English
Publishing date	2022-10-31
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ISSN	2573-8348
ISSN (online)	2573-8348
DOI	10.1002/cnr2.1744
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Article: Intermediate risk of choledocholithiasis: are we on the right path?

Girón, Felipe / Rodríguez, Lina M / Conde, Danny / Rey Chaves, Carlos E / Vanegas, Marco / Venegas, David / Gutiérrez, Fernando / Nassar, Ricardo / Hernández, Juan D / Jiménez, Daniel / Núñez-Rocha, Ricardo E / Niño, Laura / Rojas, Susana

Annals of medicine and surgery (2012)

2023 Volume 85, Issue 4, Page(s) 659–664

Abstract: The risk of choledocholithiasis should be assessed in every patient undergoing cholecystectomy to define the next step. The American Society for Gastrointestinal Endoscopy proposed a stratified predictor scale of choledocholithiasis. Therefore, we aimed ... ...

Abstract	The risk of choledocholithiasis should be assessed in every patient undergoing cholecystectomy to define the next step. The American Society for Gastrointestinal Endoscopy proposed a stratified predictor scale of choledocholithiasis. Therefore, we aimed to describe our experience managing patients with an intermediate risk of choledocholithiasis according to the American Society for Gastrointestinal Endoscopy guidelines and the actual presence of bile duct stones in magnetic resonance cholangiopancreatography. Methods: A retrospective observational study with a prospective database was conducted. The analysis included sociodemographic data, laboratory values, and imaging. Bivariate, multivariate, and receiver operating characteristic analysis were performed. Results: Three hundred twenty-seven patients had an intermediate risk for choledocholithiasis. Half the patients were at least 65 years old. 24.77% were diagnosed with choledocholithiasis. Bile duct dilation was documented in only 3.06% of cases. Diagnosis of choledocholithiasis is associated with an age odds ratio (OR): 1.87 ( Conclusions: High variability in the accuracy of imaging techniques results in a large number of patients classified as intermediate risk without choledocholithiasis in cholangioresonance. Therefore, enhancing the criteria to define intermediate risk for patients in order to optimize resources is of paramount importance.
Language	English
Publishing date	2023-03-27
Publishing country	England
Document type	Journal Article
ZDB-ID	2745440-X
ISSN	2049-0801
ISSN	2049-0801
DOI	10.1097/MS9.0000000000000124
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Article ; Online: Isomeric Aromatic Polyimides Containing Biphenyl Moieties for Gas Separation Applications.

Matesanz-Niño, Laura / Cuellas, David / Aguilar-Lugo, Carla / Palacio, Laura / González-Ortega, Alfonso / de la Campa, José G / Álvarez, Cristina / Lozano, Ángel E

Polymers

2023 Volume 15, Issue 6

Abstract: An optimized synthesis of the monomer 2,2'3,3'-biphenyltetracarboxylic dianhydride, iBPDA, was performed to obtain high molecular weight polymers. This monomer has a contorted structure that produces a non-linear shape, hindering the packing of the ... ...

Abstract	An optimized synthesis of the monomer 2,2'3,3'-biphenyltetracarboxylic dianhydride, iBPDA, was performed to obtain high molecular weight polymers. This monomer has a contorted structure that produces a non-linear shape, hindering the packing of the polymer chain. Aromatic polyimides of high molecular weight were obtained by reaction with the commercial diamine 2,2-bis(4-aminophenyl) hexafluoropropane, 6FpDA, which is a very common monomer in gas separation applications. This diamine has hexafluoroisopropylidine groups which introduce rigidity in the chains, hindering efficient packing. The thermal treatment of the polymers processed as dense membranes had two targets: on the one hand, to achieve the complete elimination of the solvent used, which could remain occluded in the polymeric matrix, and on the other hand to ensure the complete cycloimidization of the polymer. A thermal treatment exceeding the glass transition temperature was performed to ensure the maximum degree of imidization at 350 °C. The good mechanical properties of these materials allow for their use in high-pressure gas purification applications. Moreover, models of the polymers exhibited an Arrhenius-like behavior characteristic of secondary relaxations, normally associated with local motions of the molecular chain. The gas productivity of these membranes was high.
Language	English
Publishing date	2023-03-07
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2527146-5
ISSN	2073-4360 ; 2073-4360
ISSN (online)	2073-4360
ISSN	2073-4360
DOI	10.3390/polym15061333
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Article ; Online: Genomic alterations in a cohort of pediatric acute myeloid leukemia patients at two cancer centers in Colombia.

Yunis, Luz K / Linares-Ballesteros, Adriana / Barros, Gisela / Garcia, Johnny / Aponte, Nelson / Niño, Laura / Uribe, Gloria / Quintero, Edna / Perez, Jaime / Martinez, Leila / Yunis, Juan J

International journal of hematology

2022 Volume 117, Issue 2, Page(s) 269–277

Abstract: Few studies identifying genomic aspects in pediatric acute myeloid leukemia patients in Latin American countries have been reported. The aim of this study was to identify genomic alterations, clinical characteristics and outcomes in a cohort of pediatric ...

Abstract	Few studies identifying genomic aspects in pediatric acute myeloid leukemia patients in Latin American countries have been reported. The aim of this study was to identify genomic alterations, clinical characteristics and outcomes in a cohort of pediatric AML patients. This descriptive observational cohort study included patients with confirmed de novo acute myeloid leukemia up to 18 years of age. Cytogenetics and conventional FISH analysis, next-generation sequencing and PCR testing were performed. The correlation of genomic data with treatment response and outcomes were analyzed. Of the 51 patients analyzed, 67.4% had a cytogenetic abnormality and 74.5% had a genetic variant. FLT3 variants (ITD or TKD D835) were found in 27.4%, followed by NRAS (21.6%), KRAS (13.7%) and WT1 and KIT (11.8%). Patients were stratified by risk (66.6% high-risk) after the end of induction. FLT3-ITD was associated with relapse (OR 11.25; CI 1.89-66.72, p 0.006) and NRAS with death during induction (OR 16.71; CI 1.51-184.59, p 0.022). Our study highlights the importance of rapid incorporation of genetic testing in pediatric AML in Colombia, as it directly affects treatment decisions and outcomes. Incorporation of targeted therapies with conventional chemotherapy is an increasingly urgent need in pediatric patients.
MeSH term(s)	Humans ; Colombia/epidemiology ; Leukemia, Myeloid, Acute/genetics ; Leukemia, Myeloid, Acute/drug therapy ; Chromosome Aberrations ; Recurrence ; Genomics ; Mutation ; Prognosis ; fms-Like Tyrosine Kinase 3/genetics
Chemical Substances	fms-Like Tyrosine Kinase 3 (EC 2.7.10.1)
Language	English
Publishing date	2022-10-24
Publishing country	Japan
Document type	Observational Study ; Journal Article
ZDB-ID	1076875-0
ISSN	1865-3774 ; 0917-1258 ; 0925-5710
ISSN (online)	1865-3774
ISSN	0917-1258 ; 0925-5710
DOI	10.1007/s12185-022-03475-w
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Article ; Online: Analysis of Linguistically and Culturally Tailored Initiatives in Websites of Kidney Transplant Programs in the United States Between 2013-2018.

Caicedo, Juan Carlos / Carbunaru, Samuel / Brooks, Joseph Tyler / Ortiz, Christopher Chiodo / Ortiz, Alejandro Chiodo / Benavides, Xiomara / Niño, Laura / Ortiz, Jorge / Locke, Jayme E

Progress in transplantation (Aliso Viejo, Calif.)

2020 Volume 31, Issue 1, Page(s) 13–18

Abstract: Introduction: Minority patients constitute the majority of the kidney transplant waiting list, yet they suffer greater difficulties in listing and longer wait times to transplantation. There is a lack of information regarding targeted efforts by ... ...

Abstract	Introduction: Minority patients constitute the majority of the kidney transplant waiting list, yet they suffer greater difficulties in listing and longer wait times to transplantation. There is a lack of information regarding targeted efforts by transplant centers to improve transplant care for minority populations. Research question: Our aim was to analyze all kidney transplant websites in the United States to identify changes over a 5-year period in the number of multilingual websites, reported culturally targeted initiatives, and center and provider diversity. Design: Surveys were developed to analyze center websites of all transplant programs in the United States. Those with incomplete information about their nephrology or surgical teams were excluded, resulting in 174 (73%) sites in 2013 and 185 (76%) in 2018. Results: Few websites were available in a language other than English, 6.3% in 2013 and 9.7% in 2018 (P = 0.24). Only 3 websites (1.3%) in 2013 and 7 (3.7%) in 2018 reported any evidence of a culturally targeted initiative (P = 0.23). In 2018, 35% of centers employed a Hispanic transplant physician, 77% had a transplant physician who spoke a language other than English, and 39% had a transplant physician who spoke Spanish. Discussion: Although minority patients are expected to grow in the United States, decreased access to transplantation continues to vex the transplant community. Very little progress has been made in the development of multilingual websites and culturally targeted initiatives.
MeSH term(s)	Hispanic Americans ; Humans ; Kidney Transplantation ; Minority Groups ; Transplants ; United States ; Waiting Lists
Language	English
Publishing date	2020-12-23
Publishing country	United States
Document type	Journal Article
ZDB-ID	2864264-8
ISSN	2164-6708 ; 1526-9248
ISSN (online)	2164-6708
ISSN	1526-9248
DOI	10.1177/1526924820978593
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Article ; Online: Identifying new potential genetic biomarkers for HELLP syndrome using massive parallel sequencing.

Jiménez, Karen Marcela / Morel, Adrien / Parada-Niño, Laura / Alejandra González-Rodriguez, María / Flórez, Stephanie / Bolívar-Salazar, David / Becerra-Bayona, Silvia / Aguirre-García, Angel / Gómez-Murcia, Tatiana / Fernanda Castillo, Luisa / Carlosama, Carolina / Ardila, Javier / Vaiman, Daniel / Serrano, Norma / Laissue, Paul

Pregnancy hypertension

2020 Volume 22, Page(s) 181–190

Abstract: Background: Preeclampsia (PE) is a frequently occurring multisystemic disease affecting ~5% of pregnancies. PE patients may develop HELLP syndrome (haemolysis, elevated liver enzymes, and low platelet), a mother and foetus life-threatening condition. ... ...

Abstract	Background: Preeclampsia (PE) is a frequently occurring multisystemic disease affecting ~5% of pregnancies. PE patients may develop HELLP syndrome (haemolysis, elevated liver enzymes, and low platelet), a mother and foetus life-threatening condition. Research into HELLP's genetic origin has been relatively unsuccessful, mainly because normal placental function and blood pressure regulation involve the fine-regulation of hundreds of genes. Objective: To identify new genes and mutations constituting potential biomarkers for HELLP syndrome. Study design: The present case-control study involved whole-exome sequencing of 79 unrelated HELLP women. Candidate variants were screened in a control population constituted by 176 individuals. Stringent bioinformatics filters were used for selecting potentially etiological sequence variants in a subset of 487 genes. We used robust in silico mutation modelling for predicting the potential effect on protein structure. Results: We identified numerous sequence variants in genes related to angiogenesis/coagulation/blood pressure regulation, cell differentiation/communication/adhesion, cell cycle and transcriptional gene regulation, extracellular matrix biology, lipid metabolism and immunological response. Five sequence variants generated premature stop codons in genes playing an essential role in placental physiology (STOX1, PDGFD, IGF2, MMP1 and DNAH11). Six variants (ERAP1- p.Ile915Thr, ERAP2- p.Leu837Ser, COMT-p.His192Gln, CSAD-p.Pro418Ser, CDH1- p.Ala298Thr and CCR2-p.Met249Lys) led to destabilisation of protein structure as they had significant energy and residue interaction-related changes. We identified at least two mutations in 57% of patients, arguing in favour of a polygenic origin for the HELLP syndrome. Conclusion: Our results provide novel evidence regarding PE/HELLP's genetic origin, leading to new biomarkers, having potential clinical usefulness, being proposed.
MeSH term(s)	Case-Control Studies ; Female ; Genetic Markers ; HELLP Syndrome/blood ; HELLP Syndrome/genetics ; Humans ; Pregnancy ; Whole Exome Sequencing/methods
Chemical Substances	Genetic Markers
Language	English
Publishing date	2020-09-21
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	2584464-7
ISSN	2210-7797 ; 2210-7789
ISSN (online)	2210-7797
ISSN	2210-7789
DOI	10.1016/j.preghy.2020.09.003
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