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  1. Artikel ; Online: Pediatric P-ANCA vasculitis following COVID-19.

    Fireizen, Yaron / Shahriary, Cyrus / Imperial, Maria E / Randhawa, Inderpal / Nianiaris, Nastasia / Ovunc, Bugsu

    Pediatric pulmonology

    2021  Band 56, Heft 10, Seite(n) 3422–3424

    Abstract: Background: Perinuclear anti-neutrophil cytoplasmic antibodies (P-ANCA) are associated with a multisystem vasculitis affecting small blood vessels in the body. A handful of adult patients who developed vasculitis post-COVID-19 have been reported. ... ...

    Abstract Background: Perinuclear anti-neutrophil cytoplasmic antibodies (P-ANCA) are associated with a multisystem vasculitis affecting small blood vessels in the body. A handful of adult patients who developed vasculitis post-COVID-19 have been reported. Although SARS-CoV-2 has been shown to drive an exaggerated immune response in the pediatric population, such as in Multisystem Inflammatory Syndrome in Children (MIS-C), only one case of vasculitis following COVID-19 has been reported previously in children.
    Case presentation: Seventeen-year-old male with a past medical history of COVID-19 pneumonia two months prior presented with acute kidney injury and diffuse alveolar hemorrhage. Rheumatologic workup revealed P-ANCA and Myeloperoxidase (MPO) positivity. Kidney biopsy showed necrotizing glomerulonephritis with limited immune complex deposition. Subsequently, he was treated with steroids and plasmapheresis, and ultimately started on cyclophosphamide.
    Conclusions: To our knowledge, this report presents the second reported pediatric case of P-ANCA/MPO vasculitis following COVID-19.
    Mesh-Begriff(e) Adolescent ; Adult ; Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis/complications ; Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis/diagnosis ; Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis/drug therapy ; Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis/immunology ; Antibodies, Antineutrophil Cytoplasmic ; COVID-19/diagnosis ; COVID-19/immunology ; COVID-19/virology ; Child ; Humans ; Male ; Peroxidase ; SARS-CoV-2/immunology ; SARS-CoV-2/pathogenicity ; Systemic Inflammatory Response Syndrome ; Treatment Outcome ; Vasculitis/diagnosis ; Vasculitis/etiology
    Chemische Substanzen Antibodies, Antineutrophil Cytoplasmic ; Peroxidase (EC 1.11.1.7)
    Sprache Englisch
    Erscheinungsdatum 2021-08-11
    Erscheinungsland United States
    Dokumenttyp Case Reports
    ZDB-ID 632784-9
    ISSN 1099-0496 ; 8755-6863
    ISSN (online) 1099-0496
    ISSN 8755-6863
    DOI 10.1002/ppul.25612
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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    Jg. 1995 - 2021: Lesesall (1.OG)
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  2. Artikel ; Online: Dual systemic tumor targeting with ligand-directed phage and Grp78 promoter induces tumor regression.

    Kia, Azadeh / Przystal, Justyna M / Nianiaris, Nastasia / Mazarakis, Nicholas D / Mintz, Paul J / Hajitou, Amin

    Molecular cancer therapeutics

    2012  Band 11, Heft 12, Seite(n) 2566–2577

    Abstract: The tumor-specific Grp78 promoter is overexpressed in aggressive tumors. Cancer patients would benefit greatly from application of this promoter in gene therapy and molecular imaging; however, clinical benefit is limited by lack of strategies to target ... ...

    Abstract The tumor-specific Grp78 promoter is overexpressed in aggressive tumors. Cancer patients would benefit greatly from application of this promoter in gene therapy and molecular imaging; however, clinical benefit is limited by lack of strategies to target the systemic delivery of Grp78-driven transgenes to tumors. This study aims to assess the systemic efficacy of Grp78-guided expression of therapeutic and imaging transgenes relative to the standard cytomegalovirus (CMV) promoter. Combination of ligand and Grp78 transcriptional targeting into a single vector would facilitate systemic applications of the Grp78 promoter. We generated a dual tumor-targeted phage containing the arginine-glycine-aspartic acid tumor homing ligand and Grp78 promoter. Next, we combined flow cytometry, Western blot analysis, bioluminescence imaging of luciferase, and HSVtk/ganciclovir gene therapy and compared efficacy to conventional phage carrying the CMV promoter in vitro and in vivo in subcutaneous models of rat and human glioblastoma. We show that double-targeted phage provides persistent transgene expression in vitro and in tumors in vivo after systemic administration compared with conventional phage. Next, we showed significant tumor killing in vivo using the HSVtk/ganciclovir gene therapy and found a systemic antitumor effect of Grp78-driven HSVtk against therapy-resistant tumors. Finally, we uncovered a novel mechanism of Grp78 promoter activation whereby HSVtk/ganciclovir therapy upregulates Grp78 and transgene expression via the conserved unfolded protein response signaling cascade. These data validate the potential of Grp78 promoter in systemic cancer gene therapy and report the efficacy of a dual tumor targeting phage that may prove useful for translation into gene therapy and molecular imaging applications.
    Mesh-Begriff(e) Animals ; Bacteriophages/genetics ; Endoplasmic Reticulum Chaperone BiP ; Ganciclovir/administration & dosage ; Ganciclovir/pharmacokinetics ; Gene Expression ; Genes, Transgenic, Suicide ; Genetic Therapy/methods ; Genetic Vectors/genetics ; HEK293 Cells ; Heat-Shock Proteins/genetics ; Herpesvirus 1, Human/enzymology ; Herpesvirus 1, Human/genetics ; Humans ; Ligands ; MCF-7 Cells ; Mice ; Mice, Nude ; Neoplasms/drug therapy ; Neoplasms/enzymology ; Neoplasms/genetics ; Neoplasms/therapy ; Promoter Regions, Genetic ; Rats ; Thymidine Kinase/biosynthesis ; Thymidine Kinase/genetics ; Thymidine Kinase/metabolism ; Transfection ; Transgenes ; Xenograft Model Antitumor Assays
    Chemische Substanzen Endoplasmic Reticulum Chaperone BiP ; GRP78 protein, rat ; HSPA5 protein, human ; Heat-Shock Proteins ; Hspa5 protein, mouse ; Ligands ; Thymidine Kinase (EC 2.7.1.21) ; Ganciclovir (P9G3CKZ4P5)
    Sprache Englisch
    Erscheinungsdatum 2012-10-10
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2063563-1
    ISSN 1538-8514 ; 1535-7163
    ISSN (online) 1538-8514
    ISSN 1535-7163
    DOI 10.1158/1535-7163.MCT-12-0587
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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    Verfügbar in ZB MED Köln/Königswinter

    Zs.A 5750: Hefte anzeigen Standort:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

    Über subito bestellen

    Dieser Service ist kostenpflichtig (siehe Lieferbedingungen von subito). Bestellungen, die einen Artikel nebst Supplementary Material umfassen, werden grundsätzlich wie mehrfache Bestellungen bearbeitet. Gebühren fallen in diesen Fällen für jede einzelne Bestellung an.

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