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  1. Article ; Online: Understanding the barriers and facilitators of vaccine hesitancy towards the COVID-19 vaccine in healthcare workers and healthcare students worldwide: An Umbrella Review.

    McCready, Jemma Louise / Nichol, Bethany / Steen, Mary / Unsworth, John / Comparcini, Dania / Tomietto, Marco

    PloS one

    2023  Volume 18, Issue 4, Page(s) e0280439

    Abstract: Background: Healthcare workers (HCWs) and healthcare students display high levels of vaccine hesitancy with impact on healthcare provision, patient safety, and health promotion. The factors related to vaccine hesitancy have been reported in several ... ...

    Abstract Background: Healthcare workers (HCWs) and healthcare students display high levels of vaccine hesitancy with impact on healthcare provision, patient safety, and health promotion. The factors related to vaccine hesitancy have been reported in several systematic reviews. However, this evidence needs to be synthesised, as interventions to reduce vaccination hesitancy in this population are needed.
    Methods: This Umbrella Review aimed to explore the barriers and facilitators of vaccine hesitancy toward the COVID-19 vaccine for HCWs and healthcare students. The review was performed and reported in accordance with Joanna Briggs Institutes guidelines and the Preferred Reporting Items for Systematic Reviews and Meta-analysis (PRISMA) guidelines. A protocol was preregistered on PROSPERO (CRD42022327354). Eight databases were searched from November 2019 to 23rd May 2022 to identify any systematic reviews that explored factors associated with hesitancy towards the COVID-19 vaccine for HCWs or healthcare students.
    Results: A total of 31 studies were included in the review. The majority of studies (71%) were appraised as strong or moderate quality and there was a slight degree of overlap (<5%) of primary studies between the reviews. Vaccine hesitancy was more common among HCWs and healthcare students in specific occupational roles (e.g. nurses) than others (e.g. physicians). Frequent reasons for hesitancy were related to sociodemographic factors (gender, age, ethnicity), occupational factors (COVID-19 exposure, perceived risk, mandatory vaccination), health factors (vaccination history), vaccine-related factors (concerns about safety, efficacy, side-effects, rapid development, testing, approval and distribution of the vaccine), social factors (social pressure, altruism and collective responsibility), distrust factors (key social actors, pandemic management), information factors (inadequate information and sources, exposure to misinformation).
    Conclusion: The results from this Umbrella Review have wide-reaching implications for the research area, healthcare systems and institutions and governments worldwide. Designing tailored strategies for specific occupational groups is pivotal to increasing vaccine uptake and securing a safe healthcare provision worldwide.
    MeSH term(s) Humans ; COVID-19/epidemiology ; COVID-19/prevention & control ; COVID-19 Vaccines ; Health Facilities ; Health Personnel ; Vaccination ; Vaccination Hesitancy
    Chemical Substances COVID-19 Vaccines
    Language English
    Publishing date 2023-04-12
    Publishing country United States
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 2267670-3
    ISSN 1932-6203 ; 1932-6203
    ISSN (online) 1932-6203
    ISSN 1932-6203
    DOI 10.1371/journal.pone.0280439
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Understanding the barriers and facilitators of COVID-19 vaccine hesitancy amongst healthcare workers and healthcare students worldwide: An umbrella review protocol.

    McCready, Jemma / Comparcini, Dania / Nichol, Bethany / Steen, Mary / Unsworth, John / Tomietto, Marco

    PloS one

    2023  Volume 18, Issue 3, Page(s) e0283897

    Abstract: Healthcare workers (HCWs) and healthcare students are at increased risk of becoming infected with and being a vector of transmission of COVID-19. Vaccination efforts amongst this group of persons have been hampered in some countries by hesitancy to ... ...

    Abstract Healthcare workers (HCWs) and healthcare students are at increased risk of becoming infected with and being a vector of transmission of COVID-19. Vaccination efforts amongst this group of persons have been hampered in some countries by hesitancy to uptake the COVID-19 vaccine. The factors related to vaccine hesitancy have been reported in several systematic reviews. However, a comprehensive overview of barriers and facilitators of COVID-19 vaccine hesitancy is greatly needed to address effective interventions in this population. Understanding and designing effective strategies to promote vaccination among HCWs is pivotal to secure an appropriate and safe healthcare provision. The current protocol describes the methodology for an Umbrella Review that explores the barriers and facilitators of COVID-19 vaccine hesitancy for HCWs and healthcare students. The databases that will be searched are CINAHL, MedLine, Cochrane Library, PubMed, ProQuest, Web of Science, Science Direct, IBSS, Google Scholar, and Epistemonikos. Studies will be eligible for inclusion if they: (i) conducted a systematic review (with or without meta-analysis); (ii) included primary sources utilizing a quantitative methodology; (iii) investigated factors related to COVID-19 vaccine hesitancy; (iv) and included a sub/population of HCWs or healthcare students aged 18-65. The screening processes and data extraction will be conducted independently by two reviewers. The Joanna Briggs Institute (JBI) Critical Appraisal Checklist for Systematic Reviews and Research Syntheses will be used to assess the methodological quality of the included reviews. The degree to which the included reviews contain the same primary studies will also be assessed and reported. The outcomes of this review will have wide-reaching implications for the research area, healthcare systems and institutions, and governments worldwide.
    MeSH term(s) Humans ; COVID-19/epidemiology ; COVID-19/prevention & control ; COVID-19 Vaccines ; Health Personnel ; Review Literature as Topic ; Students
    Chemical Substances COVID-19 Vaccines
    Language English
    Publishing date 2023-03-31
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2267670-3
    ISSN 1932-6203 ; 1932-6203
    ISSN (online) 1932-6203
    ISSN 1932-6203
    DOI 10.1371/journal.pone.0283897
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Barriers and facilitators of vaccine hesitancy for COVID-19, influenza, and pertussis during pregnancy and in mothers of infants under two years: An umbrella review.

    Nichol, Bethany / McCready, Jemma Louise / Steen, Mary / Unsworth, John / Simonetti, Valentina / Tomietto, Marco

    PloS one

    2023  Volume 18, Issue 3, Page(s) e0282525

    Abstract: Background: Vaccination during pregnancy has been repeatedly demonstrated to be safe and effective in protecting against infection and associated harms for the mother, developing baby, and subsequent infant. However, maternal vaccination uptake remains ... ...

    Abstract Background: Vaccination during pregnancy has been repeatedly demonstrated to be safe and effective in protecting against infection and associated harms for the mother, developing baby, and subsequent infant. However, maternal vaccination uptake remains low compared to the general population.
    Objectives: An umbrella review to explore the barriers and facilitators to Influenza, Pertussis and COVID-19 vaccination during pregnancy and within 2 years after childbirth, and to inform interventions to encourage uptake (PROSPERO registration number: CRD42022327624).
    Methods: Ten databases were searched for systematic reviews published between 2009 and April 2022 exploring the predictors of vaccination or effectiveness of interventions to improve vaccination for Pertussis, Influenza, or COVD-19. Both pregnant women and mothers of infants under two years were included. Barriers and facilitators were organised using the WHO model of determinants of vaccine hesitancy through narrative synthesis, the Joanna Briggs Institute checklist assessed review quality, and the degree of overlap of primary studies was calculated.
    Results: 19 reviews were included. Considerable overlap was found especially for intervention reviews, and the quality of the included reviews and their primary studies varied. Sociodemographic factors were specifically researched in the context of COVID-19, exerting a small but consistent effect on vaccination. Concerns around the safety of vaccination particularly for the developing baby were a main barrier. While key facilitators included recommendation from a healthcare professional, previous vaccination, knowledge around vaccination, and communication with and support from social groups. Intervention reviews indicated multi-component interventions involving human interaction to be most effective.
    Conclusion: The main barriers and facilitators for Influenza, Pertussis and COVID-19 vaccination have been identified and constitute the foundation for policy development at the international level. Ethnicity, socioeconomic status, concerns about vaccine safety and side effects, and lack of healthcare professionals' recommendations, are the most relevant factors of vaccine hesitancy. Adapting educational interventions to specific populations, person-to-person interaction, healthcare professionals' involvement, and interpersonal support are important strategies to improve uptake.
    MeSH term(s) Pregnancy ; Humans ; Infant ; Female ; Influenza, Human/prevention & control ; Mothers ; Vaccination Hesitancy ; Whooping Cough/prevention & control ; COVID-19 Vaccines ; COVID-19/prevention & control ; Systematic Reviews as Topic ; Influenza Vaccines/therapeutic use
    Chemical Substances COVID-19 Vaccines ; Influenza Vaccines
    Language English
    Publishing date 2023-03-02
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2267670-3
    ISSN 1932-6203 ; 1932-6203
    ISSN (online) 1932-6203
    ISSN 1932-6203
    DOI 10.1371/journal.pone.0282525
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Exploring the impact of socially assistive robots on health and wellbeing across the lifespan: An umbrella review and meta-analysis.

    Nichol, Bethany / McCready, Jemma / Erfani, Goran / Comparcini, Dania / Simonetti, Valentina / Cicolini, Giancarlo / Mikkonen, Kristina / Yamakawa, Miyae / Tomietto, Marco

    International journal of nursing studies

    2024  Volume 153, Page(s) 104730

    Abstract: Background: Socially assistive robots offer an alternate source of connection for interventions within health and social care amidst a landscape of technological advancement and reduced staff capacity. There is a need to summarise the available ... ...

    Abstract Background: Socially assistive robots offer an alternate source of connection for interventions within health and social care amidst a landscape of technological advancement and reduced staff capacity. There is a need to summarise the available systematic reviews on the health and wellbeing impacts to evaluate effectiveness, explore potential moderators and mediators, and identify recommendations for future research and practice.
    Objective: To explore the effect of socially assistive robots within health and social care on psychosocial, behavioural, and physiological health and wellbeing outcomes across the lifespan (PROSPERO registration number: CRD42023423862).
    Design: An umbrella review utilising meta-analysis, narrative synthesis, and vote counting by direction of effect.
    Methods: 14 databases were searched (ProQuest Health Research Premium collection, Scopus, PubMed, Web of Science, ASM Digital Library, IEEE Xplore, Cochrane Reviews, and EPISTEMONIKOS) from 2005 to May 4, 2023. Systematic reviews including the effects of socially assistive robots on health outcomes were included and a pooled meta-analysis, vote counting by direction of effect, and narrative synthesis were applied. The second version of A MeaSurement Tool to Assess systematic Reviews (AMSTAR-2) was applied to assess quality of included reviews.
    Results: 35 reviews were identified, most focusing on older adults with or without dementia (n = 24). Pooled meta-analysis indicated no effect of socially assistive robots on quality of life (standard mean difference (SMD) = 0.43), anxiety (SMD = -0.02), or depression (SMD = 0.21), although vote counting identified significant improvements in social interaction, mood, positive affect, loneliness, stress, and pain across the lifespan, and narrative synthesis identified an improvement in anxiety in children. However, some reviews reported no significant difference between the effects of socially assistive robots and a plush toy, and there was no effect of socially assistive robots on psychiatric outcomes including agitation, neuropsychiatric symptoms, and medication use.
    Discussion: Socially assistive robots show promise for improving non-psychiatric outcomes such as loneliness, positive affect, stress, and pain, but exert no effect on psychiatric outcomes such as depression and agitation. The main mechanism of effect within group settings appeared to be the stimulation of social interaction with other humans. Limitations include the low quality and high amount of overlap between included reviews.
    Conclusion: Socially assistive robots may help to improve loneliness, social interaction, and positive affect in older adults, decrease anxiety and distress in children, and improve mood, stress, and reduce pain across the lifespan. However, before recommendations for socially assistive robots can be made, a cost-effectiveness analysis of socially assistive robots to improve mood across the lifespan, and a quantitative analysis of the effects on pain, anxiety, and distress in children are required.
    Language English
    Publishing date 2024-02-22
    Publishing country England
    Document type Journal Article
    ZDB-ID 80148-3
    ISSN 1873-491X ; 0020-7489
    ISSN (online) 1873-491X
    ISSN 0020-7489
    DOI 10.1016/j.ijnurstu.2024.104730
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Barriers and facilitators to vaccination for COVID-19, pertussis, and influenza during pregnancy: Protocol for an umbrella review.

    Nichol, Bethany / Simonetti, Valentina / McCready, Jemma / Steen, Mary / Unsworth, John / Tomietto, Marco

    PloS one

    2022  Volume 17, Issue 9, Page(s) e0275105

    Abstract: Pregnant women are particularly vulnerable to infection. Furthermore, infection from pertussis, influenza and COVID-19 increases the likelihood of adverse consequences to the mother and developing baby such as stillbirth, ICU admission, and pre-term ... ...

    Abstract Pregnant women are particularly vulnerable to infection. Furthermore, infection from pertussis, influenza and COVID-19 increases the likelihood of adverse consequences to the mother and developing baby such as stillbirth, ICU admission, and pre-term caesarean birth. Increased rates of transmission and risk of adverse consequences from infection justifies the provision of national maternal vaccination programmes. Additionally, maternal vaccination helps protect the infant until they are able to receive their own vaccinations; a time when they are most at risk of mortality from influenza and pertussis. Vaccination during pregnancy has been repeatedly demonstrated as safe and effective in reducing harm, although rates of uptake remain low compared to the general population. The current protocol describes the methodology for an umbrella review aiming to explore the barriers and facilitators of vaccination during pregnancy for pertussis, influenza, and COVID-19. Systematic reviews that investigate the barriers and facilitators of at least one of either pertussis, influenza, or COVID-19 will be included in this review. Multiple databases will be searched, and included reviews assessed for quality (using the Joanna Briggs Institute (JBI) quality assessment for systematic reviews) and degree of overlap of included primary studies. Included reviews will be analysed according to the WHO SAGE model of determinants of vaccine hesitancy and separated by whether these explore influenza and pertussis, or COVID-19. The outcomes of this review will help inform the development of interventions to increase uptake of vaccination during pregnancy, and on whether interventions need to be tailored depending on the infectious disease. The key findings will identify the specific barriers and facilitators of vaccination hesitancy by considering contextual influences (e.g. sociodemographic variables), individual/social group influences (e.g. trust in the institutions), and vaccine-specific issues (e.g. safety and recommendations).
    MeSH term(s) COVID-19/prevention & control ; Female ; Humans ; Infant ; Influenza Vaccines ; Influenza, Human/chemically induced ; Influenza, Human/epidemiology ; Influenza, Human/prevention & control ; Pertussis Vaccine/therapeutic use ; Pregnancy ; Pregnancy Complications, Infectious/prevention & control ; Review Literature as Topic ; Systematic Reviews as Topic ; Vaccination ; Whooping Cough/epidemiology ; Whooping Cough/prevention & control
    Chemical Substances Influenza Vaccines ; Pertussis Vaccine
    Language English
    Publishing date 2022-09-26
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2267670-3
    ISSN 1932-6203 ; 1932-6203
    ISSN (online) 1932-6203
    ISSN 1932-6203
    DOI 10.1371/journal.pone.0275105
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: The effect of COVID rehabilitation for ongoing symptoms Post HOSPitalisation with COVID-19 (PHOSP-R): protocol for a randomised parallel group controlled trial on behalf of the PHOSP consortium.

    Daynes, Enya / Baldwin, Molly / Greening, Neil J / Yates, Thomas / Bishop, Nicolette C / Mills, George / Roberts, Matthew / Hamrouni, Malik / Plekhanova, Tatiana / Vogiatzis, Ioannis / Echevarria, Carlos / Nathu, Rashmita / McAuley, Hamish J C / Latimer, Lorna / Glennie, Jennifer / Chambers, Francesca / Penfold, Ruth / Hume, Emily / Megaritis, Dimitrios /
    Alexiou, Charikleia / Potthoff, Sebastian / Hogg, Mitchell James / Haighton, Catherine / Nichol, Bethany / Leavy, Olivia C / Richardson, Matthew / Elneima, Omer / Singapuri, Amisha / Sereno, Marco / Saunders, Ruth M / Harris, Victoria C / Nolan, Claire M / Bolton, Charlotte / Houchen-Wolloff, Linzy / Harrison, Ewen M / Lone, Nazir / Quint, Jennifer / Chalmers, James D / Ho, Ling-Pei / Horsley, Alex / Marks, Michael / Poinasamy, Krisnah / Ramen, Betty / Wain, Louise V / Brightling, Christopher / Man, William D-C / Evans, Rachael / Singh, Sally J

    Trials

    2023  Volume 24, Issue 1, Page(s) 61

    Abstract: Introduction: Many adults hospitalised with COVID-19 have persistent symptoms such as fatigue, breathlessness and brain fog that limit day-to-day activities. These symptoms can last over 2 years. Whilst there is limited controlled studies on ... ...

    Abstract Introduction: Many adults hospitalised with COVID-19 have persistent symptoms such as fatigue, breathlessness and brain fog that limit day-to-day activities. These symptoms can last over 2 years. Whilst there is limited controlled studies on interventions that can support those with ongoing symptoms, there has been some promise in rehabilitation interventions in improving function and symptoms either using face-to-face or digital methods, but evidence remains limited and these studies often lack a control group.
    Methods and analysis: This is a nested single-blind, parallel group, randomised control trial with embedded qualitative evaluation comparing rehabilitation (face-to-face or digital) to usual care and conducted within the PHOSP-COVID study. The aim of this study is to determine the effectiveness of rehabilitation interventions on exercise capacity, quality of life and symptoms such as breathlessness and fatigue. The primary outcome is the Incremental Shuttle Walking Test following the eight week intervention phase. Secondary outcomes include measures of function, strength and subjective assessment of symptoms. Blood inflammatory markers and muscle biopsies are an exploratory outcome. The interventions last eight weeks and combine symptom-titrated exercise therapy, symptom management and education delivered either in a face-to-face setting or through a digital platform ( www.yourcovidrecovery.nhs.uk ). The proposed sample size is 159 participants, and data will be intention-to-treat analyses comparing rehabilitation (face-to-face or digital) to usual care.
    Ethics and dissemination: Ethical approval was gained as part of the PHOSP-COVID study by Yorkshire and the Humber Leeds West Research NHS Ethics Committee, and the study was prospectively registered on the ISRCTN trial registry (ISRCTN13293865). Results will be disseminated to stakeholders, including patients and members of the public, and published in appropriate journals. Strengths and limitations of this study • This protocol utilises two interventions to support those with ongoing symptoms of COVID-19 • This is a two-centre parallel-group randomised controlled trial • The protocol has been supported by patient and public involvement groups who identified treatments of symptoms and activity limitation as a top priority.
    MeSH term(s) Adult ; Humans ; COVID-19 ; Quality of Life ; Single-Blind Method ; Dyspnea ; Fatigue/diagnosis ; Fatigue/etiology ; Randomized Controlled Trials as Topic
    Language English
    Publishing date 2023-01-26
    Publishing country England
    Document type Clinical Trial Protocol ; Journal Article
    ZDB-ID 2040523-6
    ISSN 1745-6215 ; 1468-6694 ; 1745-6215
    ISSN (online) 1745-6215
    ISSN 1468-6694 ; 1745-6215
    DOI 10.1186/s13063-023-07093-7
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Correction: The effect of COVID rehabilitation for ongoing symptoms Post HOSPitalisation with COVID-19 (PHOSP-R): protocol for a randomised parallel group controlled trial on behalf of the PHOSP consortium.

    Daynes, Enya / Baldwin, Molly / Greening, Neil J / Yates, Thomas / Bishop, Nicolette C / Mills, George / Roberts, Matthew / Hamrouni, Malik / Plekhanova, Tatiana / Vogiatzis, Ioannis / Echevarria, Carlos / Nathu, Rashmita / McAuley, Hamish J C / Latimer, Lorna / Glennie, Jennifer / Chambers, Francesca / Penfold, Ruth / Hume, Emily / Megaritis, Dimitrios /
    Alexiou, Charikleia / Potthof, Sebastian / Hogg, Mitchell James / Haighton, Catherine / Nichol, Bethany / Leavy, Olivia C / Richardson, Matthew / Elneima, Omer / Singapuri, Amisha / Sereno, Marco / Saunders, Ruth M / Harris, Victoria C / Nolan, Claire M / Bolton, Charlotte / Houchen-Wolloff, Linzy / Harrison, Ewen M / Lone, Nazir / Quint, Jennifer / Chalmers, James D / Ho, Ling-Pei / Horsley, Alex / Marks, Michael / Poinasamy, Krisnah / Ramen, Betty / Wain, Louise V / Brightling, Christopher / Man, William D-C / Evans, Rachael / Singh, Sally J

    Trials

    2023  Volume 24, Issue 1, Page(s) 98

    Language English
    Publishing date 2023-02-07
    Publishing country England
    Document type Published Erratum
    ZDB-ID 2040523-6
    ISSN 1745-6215 ; 1468-6694 ; 1745-6215
    ISSN (online) 1745-6215
    ISSN 1468-6694 ; 1745-6215
    DOI 10.1186/s13063-023-07132-3
    Database MEDical Literature Analysis and Retrieval System OnLINE

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