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  1. Article ; Online: Is

    Titball, Richard W / Lewis, Nicholas / Nicholas, Richard

    Multiple sclerosis (Houndmills, Basingstoke, England)

    2023  Volume 29, Issue 9, Page(s) 1057–1063

    Abstract: Clostridium ... ...

    Abstract Clostridium perfringens
    MeSH term(s) Humans ; Multiple Sclerosis/metabolism ; Clostridium perfringens ; Central Nervous System ; Brain ; Myelin Sheath/metabolism
    Language English
    Publishing date 2023-07-22
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 1290669-4
    ISSN 1477-0970 ; 1352-4585
    ISSN (online) 1477-0970
    ISSN 1352-4585
    DOI 10.1177/13524585231186899
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 4428: Show issues Location:
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  2. Article ; Online: CORR Insights®: MRI Identification of the Osseous Extent of Pediatric Bone Sarcomas.

    Nicholas, Richard W

    Clinical orthopaedics and related research

    2018  Volume 476, Issue 3, Page(s) 565–567

    MeSH term(s) Bone and Bones ; Child ; Humans ; Magnetic Resonance Imaging ; Osteosarcoma ; Sarcoma
    Language English
    Publishing date 2018-02-15
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 80301-7
    ISSN 1528-1132 ; 0009-921X
    ISSN (online) 1528-1132
    ISSN 0009-921X
    DOI 10.1007/s11999.0000000000000148
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: CORR Insights®: What Are the Complications of Allograft Reconstructions for Sarcoma Resection in Children Younger Than 10 Years at Long-term Followup?

    Nicholas, Richard W

    Clinical orthopaedics and related research

    2018  Volume 476, Issue 3, Page(s) 556–558

    MeSH term(s) Allografts ; Child ; Follow-Up Studies ; Humans ; Limb Salvage ; Reconstructive Surgical Procedures ; Sarcoma/surgery
    Language English
    Publishing date 2018-02-15
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 80301-7
    ISSN 1528-1132 ; 0009-921X
    ISSN (online) 1528-1132
    ISSN 0009-921X
    DOI 10.1007/s11999.0000000000000138
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: University education facilitates uptake of disease-modifying therapies for multiple sclerosis: A community-based study using the UK MS Register.

    Das, Joyutpal / Rog, David J / Middleton, Rod / Rodgers, Jeff W / Nicholas, Richard

    Multiple sclerosis (Houndmills, Basingstoke, England)

    2024  Volume 30, Issue 2, Page(s) 192–199

    Abstract: Background: Higher education is associated with better job opportunities and higher income.: Objectives: Herein, the impact of education on the uptake of disease-modifying therapies (DMTs) for multiple sclerosis (MS) in a publicly funded health care ... ...

    Abstract Background: Higher education is associated with better job opportunities and higher income.
    Objectives: Herein, the impact of education on the uptake of disease-modifying therapies (DMTs) for multiple sclerosis (MS) in a publicly funded health care system was examined using the UK MS Register.
    Methods: All adult participants with relapsing remitting MS diagnosed between 2008 and 2021 were included. Those without data regarding their education levels were excluded. Binary, multinomial and Cox regression models were used to examine the association between education levels and uptake of DMTs.
    Results: A total of 6317 participants fulfilled all inclusion and exclusion criteria. A total of 1826/2923 (62%) participants with a university education were treated with DMTs, compared to 1788/3394 (53%) participants with school/diploma received DMTs with an odds ratio of 1.318 (1.178-1.473). Participants with a university education were more likely to be treated with both moderate- and high-efficacy DMTs, compared to others, with odds ratios of 1.227 (1.087-1.385) and 1.545 (1.325-1.802), respectively. University education was also a positive predictor for faster initiation of DMTs, and, importantly, higher-efficacy DMTs.
    Conclusion: In a publicly funded health care system, despite intended equality of access, university education was associated with a higher uptake of DMTs.
    MeSH term(s) Humans ; Adult ; Multiple Sclerosis/drug therapy ; Universities ; Multiple Sclerosis, Relapsing-Remitting ; Educational Status ; United Kingdom
    Language English
    Publishing date 2024-01-17
    Publishing country England
    Document type Journal Article
    ZDB-ID 1290669-4
    ISSN 1477-0970 ; 1352-4585
    ISSN (online) 1477-0970
    ISSN 1352-4585
    DOI 10.1177/13524585231221411
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Management of carotid atherosclerosis in stroke.

    Evans, Nicholas Richard / Bhakta, Shiv / Chowdhury, Mohammed M / Markus, Hugh / Warburton, Elizabeth

    Practical neurology

    2024  

    Abstract: Internal carotid artery atherosclerosis is a major risk factor for stroke, accounting for 15-20% of ischaemic strokes. Revascularisation procedures-either carotid endarterectomy or carotid artery stenting-can reduce the risk of stroke for those with ... ...

    Abstract Internal carotid artery atherosclerosis is a major risk factor for stroke, accounting for 15-20% of ischaemic strokes. Revascularisation procedures-either carotid endarterectomy or carotid artery stenting-can reduce the risk of stroke for those with significant (>50%) luminal stenosis but particularly for those with more severe (70-99%) stenosis. However, advances in medical pharmacotherapy have implications for the relative benefit from surgery for symptomatic carotid atherosclerosis, as well as our approach to asymptomatic disease. This review considers the evidence underpinning the current medical and surgical management of symptomatic carotid atherosclerosis, the importance of factors beyond the degree of luminal stenosis, and developments in therapeutic strategies. We also discuss the importance of non-stenotic but high-risk carotid atherosclerotic plaques on the cause of stroke, and their implications for clinical practice.
    Language English
    Publishing date 2024-04-08
    Publishing country England
    Document type Journal Article
    ZDB-ID 2170881-2
    ISSN 1474-7766 ; 1474-7758
    ISSN (online) 1474-7766
    ISSN 1474-7758
    DOI 10.1136/pn-2023-003918
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: CORR Insights

    Nicholas, Richard W

    Clinical orthopaedics and related research

    2017  Volume 475, Issue 5, Page(s) 1338–1340

    MeSH term(s) Allografts ; Bone Transplantation ; Fibula/transplantation ; Humans ; Tibia ; Transplantation, Homologous
    Language English
    Publishing date 2017
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 80301-7
    ISSN 1528-1132 ; 0009-921X
    ISSN (online) 1528-1132
    ISSN 0009-921X
    DOI 10.1007/s11999-016-5228-y
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: CORR Insights

    Nicholas, Richard W

    Clinical orthopaedics and related research

    2016  Volume 475, Issue 3, Page(s) 796–798

    MeSH term(s) Bone Transplantation ; Femur ; Hip Joint ; Humans
    Language English
    Publishing date 2016-04-22
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 80301-7
    ISSN 1528-1132 ; 0009-921X
    ISSN (online) 1528-1132
    ISSN 0009-921X
    DOI 10.1007/s11999-016-4850-z
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: CORR Insights(®): Is the Induced-membrane Technique Successful for Limb Reconstruction After Resecting Large Bone Tumors in Children?

    Nicholas, Richard W

    Clinical orthopaedics and related research

    2015  Volume 473, Issue 6, Page(s) 2076–2078

    MeSH term(s) Bone Neoplasms/surgery ; Bone Transplantation/methods ; Female ; Femoral Neoplasms/surgery ; Fibula/transplantation ; Humans ; Humerus/surgery ; Male ; Osteotomy ; Reconstructive Surgical Procedures/methods ; Tibia/surgery
    Language English
    Publishing date 2015-06
    Publishing country United States
    Document type Comment ; Journal Article
    ZDB-ID 80301-7
    ISSN 1528-1132 ; 0009-921X
    ISSN (online) 1528-1132
    ISSN 0009-921X
    DOI 10.1007/s11999-015-4206-0
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

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  9. Article ; Online: Facilitating the Implementation of Standardized Care Plans in Municipal Healthcare.

    Østensen, Elisabeth / Hardiker, Nicholas Richard / Hellesø, Ragnhild

    Computers, informatics, nursing : CIN

    2021  Volume 40, Issue 2, Page(s) 104–112

    Abstract: Standardized care plans have the potential to enhance the quality of nursing records in terms of content and completeness, thereby better supporting workflow, easing the documentation process, facilitating continuity of care, and permitting systematic ... ...

    Abstract Standardized care plans have the potential to enhance the quality of nursing records in terms of content and completeness, thereby better supporting workflow, easing the documentation process, facilitating continuity of care, and permitting systematic data gathering to build evidence from practice. Despite these potential benefits, there may be challenges associated with the successful adoption and use of standardized care plans in municipal healthcare information practices. Using a participatory approach, two workshops were conducted with nurses and nursing leaders (n = 11) in two Norwegian municipalities, with the objective of identifying success criteria for the adoption and integration of standardized care plans into practice. Three themes were found to describe the identified success criteria: (1) "facilitating system level support for nurses' workflow"; (2) "engaged individuals creating a culture for using standardized care plans"; and (3) "developing system level safety nets." The findings suggest success criteria that could be useful to address to facilitate the integration of standardized care plans in municipal healthcare information practice and provide useful knowledge for those working with implementation and further development of standardized care plans.
    MeSH term(s) Delivery of Health Care ; Documentation ; Humans ; Norway ; Nursing Records
    Language English
    Publishing date 2021-08-04
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2078463-6
    ISSN 1538-9774 ; 1538-2931
    ISSN (online) 1538-9774
    ISSN 1538-2931
    DOI 10.1097/CIN.0000000000000798
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.B 3083: Show issues Location:
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  10. Article ; Online: High Levels of Perivascular Inflammation and Active Demyelinating Lesions at Time of Death Associated with Rapidly Progressive Multiple Sclerosis Disease Course: A Retrospective Postmortem Cohort Study.

    Nicholas, Richard / Magliozzi, Roberta / Marastoni, Damiano / Howell, Owain / Roncaroli, Federico / Muraro, Paolo / Reynolds, Richard / Friede, Tim

    Annals of neurology

    2024  Volume 95, Issue 4, Page(s) 706–719

    Abstract: Objective: Analysis of postmortem multiple sclerosis (MS) tissues combined with in vivo disease milestones suggests that whereas perivascular white matter infiltrates are associated with demyelinating activity in the initial stages, leptomeningeal ... ...

    Abstract Objective: Analysis of postmortem multiple sclerosis (MS) tissues combined with in vivo disease milestones suggests that whereas perivascular white matter infiltrates are associated with demyelinating activity in the initial stages, leptomeningeal immune cell infiltration, enriched in B cells, and associated cortical lesions contribute to disease progression. We systematically examine the association of inflammatory features and white matter demyelination at postmortem with clinical milestones.
    Methods: In 269 MS brains, 20 sites were examined using immunohistochemistry for active lesions (ALs) and perivenular inflammation (PVI). In a subset of 22, a detailed count of CD20+ B cells and CD3+ T cells in PVIs was performed.
    Results: ALs were detected in 22%, whereas high levels of PVI were detected in 52% of cases. ALs were present in 35% of cases with high levels of PVI. Shorter time from onset of progression to death was associated with increased prevalence and higher levels of PVI (both p < 0.0001). Shorter time from onset of progression to wheelchair use was associated with higher prevalence of ALs (odds ratio [OR] = 0.921, 95% confidence interval [CI] = 0.858-0.989, p = 0.0230) and higher level of PVI (OR = 0.932, 95% CI = 0.886-0.981, p = 0.0071). High levels of PVI were associated with meningeal inflammation and increased cortical demyelination and significantly higher levels of B lymphocytes within the PVI.
    Interpretation: ALs, a feature of early disease stage, persist up to death in a subgroup with high levels of PVI. These features link to a rapid progressive phase and higher levels of meningeal inflammation and B-cell infiltrates, supporting the hypothesis that chronic inflammation drives progression in MS. ANN NEUROL 2024;95:706-719.
    MeSH term(s) Humans ; Multiple Sclerosis/pathology ; Cohort Studies ; Retrospective Studies ; Inflammation/complications ; Brain/pathology ; Multiple Sclerosis, Chronic Progressive/pathology
    Language English
    Publishing date 2024-01-12
    Publishing country United States
    Document type Journal Article
    ZDB-ID 80362-5
    ISSN 1531-8249 ; 0364-5134
    ISSN (online) 1531-8249
    ISSN 0364-5134
    DOI 10.1002/ana.26870
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