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Article ; Online: Methods of Recruitment for Surgical and Perioperative Randomized Controlled Trials: A Rapid Review.

Ninomiya, Maya Morton / Hiemstra, Jenna / Nicholson, Emma / Isaac, Kathryn V

2023 Volume 47, Issue 11, Page(s) 2659–2667

Abstract: Due to the complex nature of surgical randomized controlled trials (RCTs), reaching target recruitment can be challenging. The primary objective was to report on characteristics of successful pilot surgical and perioperative RCTs and the methodological ... ...

Abstract	Due to the complex nature of surgical randomized controlled trials (RCTs), reaching target recruitment can be challenging. The primary objective was to report on characteristics of successful pilot surgical and perioperative RCTs and the methodological strategies implemented to optimize recruitment. The secondary objective was to provide recommendations for successful recruitment strategies for future surgical RCTs. Ovid MEDLINE, Ovid EMBASE, and Web of Science (via Ovid) databases were searched from 2012 to 2022. This review included surgical and perioperative pilot studies that met their recruitment targets. Study and recruitment characteristics were summarized, and potential relationships between study design and recruitment rate were assessed. Optimized recruitment strategies were extracted when reported. Of 4156 total articles identified, 255 underwent full-text screening, and 52 articles were included. Of the included pilot studies, 21% (n = 11) did not indicate a target sample size or recruitment rate. Recruitment methods were minimally reported in pilot studies for perioperative or surgical RCTs. Strategies to optimize recruitment included internal iterative evaluations of the recorded recruitment appointments and staged introduction of the study. Recruitment rate was not associated with invasiveness of intervention or burden of participation. Patient involvement is absent from current reports on methodological design and offers valuable opportunity to optimize recruitment. Recruitment strategies in perioperative and surgical RCTs can be optimized with iterative qualitative evaluation of the recruitment methods with input from the interdisciplinary research team.
Language	English
Publishing date	2023-08-17
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	224043-9
ISSN	1432-2323 ; 0364-2313
ISSN (online)	1432-2323
ISSN	0364-2313
DOI	10.1007/s00268-023-07124-z
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Zs.A 1336: Show issues

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Article ; Online: Unscheduled healthcare for children with intellectual disabilities: A systematic scoping review.

Nicholson, Emma / Conlon, Ciara / Mimmo, Laurel / Doherty, Edel / Guerin, Suzanne

Journal of applied research in intellectual disabilities : JARID

2022 Volume 35, Issue 3, Page(s) 736–751

Abstract: Background: The provision of unscheduled healthcare for children with intellectual disability is less researched than that focused on hospital settings or for adult services. The aim of the scoping review was to map the evidence base in this area and ... ...

Abstract	Background: The provision of unscheduled healthcare for children with intellectual disability is less researched than that focused on hospital settings or for adult services. The aim of the scoping review was to map the evidence base in this area and identify areas for future study. Method: A five-stage scoping review framework was adopted. CINAHL, PubMed, SCOPUS, PsycINFO, Embase, ProQuest Dissertation & Theses and Google Scholar were searched. Studies published in English after 1/1/2000 were considered eligible for inclusion. Results: A total of 3158 titles and abstracts were screened, 137 full-text articles were reviewed, and 25 papers met the inclusion criteria. Descriptive themes focused on inequities, needs and experiences of families', poor GP training, and limitations of existing evidence. Conclusion: Describing trends in healthcare utilisation by this population is valuable for monitoring quality of healthcare, however, addressing observed inequities will require approaches that recognise specific issues within the health system that result in inequities.
MeSH term(s)	Adult ; Child ; Delivery of Health Care ; Hospitals ; Humans ; Intellectual Disability ; Patient Acceptance of Health Care
Language	English
Publishing date	2022-03-24
Publishing country	England
Document type	Journal Article ; Review ; Systematic Review
ZDB-ID	1326222-1
ISSN	1468-3148 ; 0952-9608 ; 1360-2322
ISSN (online)	1468-3148
ISSN	0952-9608 ; 1360-2322
DOI	10.1111/jar.12994
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Zs.A 4157: Show issues

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Article ; Online: The influence of the BDNF Val66Met genotype on emotional recognition memory in post-traumatic stress disorder.

Nicholson, Emma Louise / Garry, Michael I / Ney, Luke J / Hsu, Chia-Ming K / Zuj, Daniel V / Felmingham, Kim L

Scientific reports

2023 Volume 13, Issue 1, Page(s) 5033

Abstract: Dysregulated consolidation of emotional memories is a core feature of posttraumatic stress disorder (PTSD). Brain Derived Neurotrophic Factor (BDNF) influences synaptic plasticity and emotional memory consolidation. The BDNF Val66Met polymorphism has ... ...

Abstract	Dysregulated consolidation of emotional memories is a core feature of posttraumatic stress disorder (PTSD). Brain Derived Neurotrophic Factor (BDNF) influences synaptic plasticity and emotional memory consolidation. The BDNF Val66Met polymorphism has been associated with PTSD risk and memory deficits respectively, although findings have been inconsistent, potentially due to a failure to control for important confounds such as sex, ethnicity, and the timing/extent of previous trauma experiences. Furthermore, very little research has examined the impact of BDNF genotypes on emotional memory in PTSD populations. This study investigated the interaction effects of Val66Met and PTSD symptomatology in an emotional recognition memory task in 234 participants divided into healthy control (n = 85), trauma exposed (TE: n = 105) and PTSD (n = 44) groups. Key findings revealed impaired negative recognition memory in PTSD compared to control and TE groups and in participants with the Val/Met compared to the Val/Val genotype. There was a group × genotype interaction showing no Met effect in the TE group despite significant effects in PTSD and controls. Results suggest that people previously exposed to trauma who do not develop PTSD may be protected from the BDNF Met effect, however more research is needed to replicate findings and to explore the epigenetic and neural processes involved.
MeSH term(s)	Humans ; Brain-Derived Neurotrophic Factor/genetics ; Emotions ; Genotype ; Memory Disorders ; Polymorphism, Single Nucleotide ; Stress Disorders, Post-Traumatic/genetics
Chemical Substances	Brain-Derived Neurotrophic Factor ; BDNF protein, human (7171WSG8A2)
Language	English
Publishing date	2023-03-28
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-023-30787-6
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Article ; Online: Parent's preferences for unscheduled paediatric healthcare: A discrete choice experiment.

Nicholson, Emma / McDonnell, Thérèse / Conlon, Ciara / De Brún, Aoife / Doherty, Edel / McAuliffe, Eilish

Health expectations : an international journal of public participation in health care and health policy

2023 Volume 26, Issue 5, Page(s) 1931–1940

Abstract: Background: Unscheduled healthcare is a key component of healthcare delivery and makes up a significant proportion of healthcare access, with children being particularly high users of unscheduled healthcare. Understanding the relative importance of ... ...

Abstract	Background: Unscheduled healthcare is a key component of healthcare delivery and makes up a significant proportion of healthcare access, with children being particularly high users of unscheduled healthcare. Understanding the relative importance of factors that influence this behaviour and decision-making is fundamental to ensuring the system is best designed to meet the needs of users and foster appropriate cost-effective usage of health system resources. Objective: The aim of the study was to identify the parent's preferences for unscheduled healthcare for a common mild childhood illness. Design: A discrete choice experiment (DCE) was developed to identify the preferences of parents accessing unscheduled healthcare for their children. Setting and participants: Data were collected from parents in Ireland (N = 458) to elicit preferences across five attributes: timeliness, appointment type, healthcare professional attended, telephone guidance before attending and cost. Results: Using a random parameters logit model, all attributes were statistically significant, cost (β = -5.064, 95% confidence interval, CI [-5.60, -4.53]), same-day (β = 1.386, 95% CI [1.19, 1.58]) or next-day access (β = 0.857, 95% CI [0.73, 0.98]), coupled with care by their own general practitioner (β = 0.748, 95% CI [0.61, 0.89]), identified as the strongest preferences of parents accessing unscheduled healthcare for their children. Discussion: The results have implications for policy development and implementation initiatives that seek to improve unscheduled health services as understanding how parents use these services can maximise their effectiveness. Patient or public contribution: The development of the DCE included a qualitative research component to ensure that the content accurately reflected parents experiences when seeking healthcare. Before data collection, a pilot test was carried out with the target population to gather their views on the survey.
MeSH term(s)	Humans ; Child ; Choice Behavior ; Health Facilities ; Health Services Accessibility ; Parents ; Surveys and Questionnaires ; Patient Preference
Language	English
Publishing date	2023-06-20
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2119434-8
ISSN	1369-7625 ; 1369-6513
ISSN (online)	1369-7625
ISSN	1369-6513
DOI	10.1111/hex.13802
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Article ; Online: Factors that affect GP referral of a child with intellectual disability for a mild illness: A discrete choice experiment.

Nicholson, Emma / McDonnell, Thérèse / Conlon, Ciara / De Brún, Aoife / Doherty, Edel / Collins, Claire / Bury, Gerard / McAuliffe, Eilish

Journal of applied research in intellectual disabilities : JARID

2023 Volume 36, Issue 6, Page(s) 1241–1250

Abstract: Background: General practitioners (GP) report multiple challenges when treating individuals with intellectual disabilities which may influence referral rates. The study aimed to establish factors that influence GP's decision-making when referring a ... ...

Abstract	Background: General practitioners (GP) report multiple challenges when treating individuals with intellectual disabilities which may influence referral rates. The study aimed to establish factors that influence GP's decision-making when referring a child with intellectual disabilities to the emergency department. Method: Discrete choice experiments (DCEs) are increasingly used in health research to further understand complex decision making. A DCE was designed to assess the relative importance of factors that may influence a GP's (N = 157) decision to refer. Results: A random parameters model indicated that perceived limited parental capacity to manage an illness was the most important factor in the decision to refer a child to the ED, followed by a repeat visit, a referral request from the parent, and a Friday afternoon appointment. Conclusion: Understanding the factors that influence referral is important for service improvement and to strengthen primary care provision for this population and their families.
Language	English
Publishing date	2023-07-25
Publishing country	England
Document type	Journal Article
ZDB-ID	1326222-1
ISSN	1468-3148 ; 0952-9608 ; 1360-2322
ISSN (online)	1468-3148
ISSN	0952-9608 ; 1360-2322
DOI	10.1111/jar.13143
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Article ; Online: Outreach nurses critical for delivery of HIV care to women in western Victoria.

Gador-Whyte, Andrew P / Roder, Christine / Hamilton, Rochelle / Fay, Helen / Huning, Emily / Nicholson, Emma / Mackie, Kathryn / Athan, Eugene / Wade, Amanda J

Sexual health

2023 Volume 20, Issue 6, Page(s) 597–598

Abstract: Women living with HIV in regional Victoria face barriers accessing care. We evaluated the care cascade and outreach nurse support required for women attending our service between 2005 and 2020. A total of 33 women attended; 97% (32/33) were on ... ...

Abstract	Women living with HIV in regional Victoria face barriers accessing care. We evaluated the care cascade and outreach nurse support required for women attending our service between 2005 and 2020. A total of 33 women attended; 97% (32/33) were on antiretroviral therapy; 67% (22/33) retained in care, 27% (9/33) transferred and 6% (2/33) lost to follow up. Of women retained in care, 95% (21/22) were on antiretroviral therapy and 91% (20/22) had virological suppression. A total of 91% (30/33) required outreach nurse care (median care episodes 100/woman; IQR 44-179) - most frequently (87%; 26/30) liaising with pharmacies and prescribers. Outreach nurses are critical in achieving UNAIDS targets for women in western Victoria.
MeSH term(s)	Humans ; Female ; HIV Infections/drug therapy ; Anti-HIV Agents/therapeutic use
Chemical Substances	Anti-HIV Agents
Language	English
Publishing date	2023-11-08
Publishing country	Australia
Document type	Journal Article
ZDB-ID	2256731-8
ISSN	1449-8987 ; 1448-5028
ISSN (online)	1449-8987
ISSN	1448-5028
DOI	10.1071/SH23153
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Zs.A 6421: Show issues

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Article ; Online: A Phase I Trial of Allogeneic γδ T Lymphocytes From Haploidentical Donors in Patients With Refractory or Relapsed Acute Myeloid Leukemia.

Vydra, Jan / Cosimo, Emilio / Lesný, Petr / Wanless, Richard Sebastian / Anderson, John / Clark, Alan George / Scott, Angela / Nicholson, Emma Kate / Leek, Michael

Clinical lymphoma, myeloma & leukemia

2023 Volume 23, Issue 5, Page(s) e232–e239

Abstract: Introduction We report the results of a phase I clinical trial NCT03790072 of an adoptive transfer of γδ T lymphocytes from haploidentical donors in patients with refractory/relapsed acute myeloid leukemia after lymphodepletion regimen. Patients and ... ...

Abstract	Introduction We report the results of a phase I clinical trial NCT03790072 of an adoptive transfer of γδ T lymphocytes from haploidentical donors in patients with refractory/relapsed acute myeloid leukemia after lymphodepletion regimen. Patients and methods Healthy donor mononuclear cells collected by leukapheresis were consistently expanded to generate products of 10
MeSH term(s)	Humans ; Pandemics ; Treatment Outcome ; COVID-19 ; Leukemia, Myeloid, Acute/therapy ; T-Lymphocytes ; Hematopoietic Stem Cell Transplantation/methods
Language	English
Publishing date	2023-02-11
Publishing country	United States
Document type	Clinical Trial, Phase I ; Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2540992-X
ISSN	2152-2669 ; 2152-2650
ISSN (online)	2152-2669
ISSN	2152-2650
DOI	10.1016/j.clml.2023.02.003
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Zs.A 5903: Show issues

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Article ; Online: Venetoclax-based salvage for management of relapsed acute leukaemia after allogeneic haematopoetic stem cell transplant: durable remissions only seen following consolidation with donor lymphocyte infusion or second transplant.

Smith, Katy / Fathoala, Dina / Anthias, Chloe / Easdale, Sandra / Ethell, Mark / Mir, Farheen / Pickard, Lucy / Potter, Mike / Taussig, David / Nicholson, Emma

Bone marrow transplantation

2023 Volume 58, Issue 10, Page(s) 1152–1156

Language	English
Publishing date	2023-07-12
Publishing country	England
Document type	Letter
ZDB-ID	632854-4
ISSN	1476-5365 ; 0268-3369 ; 0951-3078
ISSN (online)	1476-5365
ISSN	0268-3369 ; 0951-3078
DOI	10.1038/s41409-023-02029-w
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Zs.A 2168: Show issues

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Article ; Online: The role of contextual factors in decision-making by General Practitioners on paediatric referral to the Emergency Department in Ireland: A Discrete Choice Experiment.

McDonnell, Thérèse / Nicholson, Emma / Bury, Gerard / Collins, Claire / Conlon, Ciara / De Brún, Aoife / Doherty, Edel / McAuliffe, Eilish

Health policy (Amsterdam, Netherlands)

2023 Volume 132, Page(s) 104813

Abstract: A General Practitioner's (GP) decision to refer a patient to the emergency department (ED) requires consideration of a multitude of factors, and significant variation in GP referral patterns to secondary care has been recorded. This study examines the ... ...

Abstract	A General Practitioner's (GP) decision to refer a patient to the emergency department (ED) requires consideration of a multitude of factors, and significant variation in GP referral patterns to secondary care has been recorded. This study examines the contextual factors that influence GPs when referring a paediatric patient with potentially self-limiting clinical symptoms to the ED. Utilizing a discrete choice experiment, survey data was collected from GPs in Ireland (n = 142) to elicit factors influencing this decision across five attributes: time/day of visit, repeat presentation, parents' capacity to cope, parent requesting a referral, and access to a paediatric outpatient clinic/day unit. Using mixed logit models, all attributes were statistically significant, with repeat presentation and parents lacking the capacity to cope identified as the strongest contextual factors leading to the decision to refer to the ED. There has been limited exploration of this decision-making process and this study uses a robust design to identify and rank contextual attributes. Enhanced awareness of contextual factors on referral decision-making is crucial to understanding patterns of paediatric unscheduled healthcare and to planning services that respond to parent's and children's needs, whilst allowing GPs to make decisions in the best interest of the child.
MeSH term(s)	Humans ; Child ; General Practitioners ; Ireland ; Emergency Service, Hospital ; Surveys and Questionnaires ; Referral and Consultation
Language	English
Publishing date	2023-04-05
Publishing country	Ireland
Document type	Journal Article
ZDB-ID	605805-x
ISSN	1872-6054 ; 0168-8510
ISSN (online)	1872-6054
ISSN	0168-8510
DOI	10.1016/j.healthpol.2023.104813
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Article ; Online: Integrated Palliative Care for Patients Referred for Chimeric Antigen Receptor (CAR) T-Cell Therapy: A Service Evaluation.

Williams, Rebekah / Droney, Joanne / Nicholson, Emma / Gonzalez Arias, Carlos / Ellard, Rose / Bradley, Nathalie / Maycock, Celvin / Halley, Angela

Journal of pain and symptom management

2023 Volume 67, Issue 2, Page(s) e157–e159

MeSH term(s)	Humans ; Receptors, Chimeric Antigen/therapeutic use ; Palliative Care ; Immunotherapy, Adoptive ; Hospice and Palliative Care Nursing ; Cell- and Tissue-Based Therapy
Chemical Substances	Receptors, Chimeric Antigen
Language	English
Publishing date	2023-11-08
Publishing country	United States
Document type	Letter
ZDB-ID	639142-4
ISSN	1873-6513 ; 0885-3924
ISSN (online)	1873-6513
ISSN	0885-3924
DOI	10.1016/j.jpainsymman.2023.11.002
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