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  1. AU="Nicitra, Emanuele"
  2. AU=Strauss Eric J AU=Strauss Eric J
  3. AU="Andy C. Y. Tse"
  4. AU=Diel J
  5. AU="Teper, Alejandro"
  6. AU="Daniel Cisterna"
  7. AU="Barré-Sinoussi, Françoise"
  8. AU="Siracusa, Massimiliano"
  9. AU="Mishra, Vipin Kumar"
  10. AU=Martinez Victor D.
  11. AU="Seol, Myung Do"
  12. AU="Sato, Keiyu"
  13. AU="Go, Ji Young"
  14. AU="Zhao, Bingjian"
  15. AU="Ringeisen, Bradley R"
  16. AU=Sciascia Savino
  17. AU="Capito, Carmen"
  18. AU=Osman Mahasin

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  1. Artikel ; Online: Interactions of Gram-Positive Bacterial Membrane Vesicles and Hosts: Updates and Future Directions.

    Sangiorgio, Giuseppe / Nicitra, Emanuele / Bivona, Dalida / Bonomo, Carmelo / Bonacci, Paolo / Santagati, Maria / Musso, Nicolò / Bongiorno, Dafne / Stefani, Stefania

    International journal of molecular sciences

    2024  Band 25, Heft 5

    Abstract: Extracellular vesicles (EVs) are lipid bilayers derived from cell membranes, released by both eukaryotic cells and bacteria into the extracellular environment. During production, EVs carry proteins, nucleic acids, and various compounds, which are then ... ...

    Abstract Extracellular vesicles (EVs) are lipid bilayers derived from cell membranes, released by both eukaryotic cells and bacteria into the extracellular environment. During production, EVs carry proteins, nucleic acids, and various compounds, which are then released. While Gram-positive bacteria were traditionally thought incapable of producing EVs due to their thick peptidoglycan cell walls, recent studies on membrane vesicles (MVs) in Gram-positive bacteria have revealed their significant role in bacterial physiology and disease progression. This review explores the current understanding of MVs in Gram-positive bacteria, including the characterization of their content and functions, as well as their interactions with host and bacterial cells. It offers a fresh perspective to enhance our comprehension of Gram-positive bacterial EVs.
    Mesh-Begriff(e) Gram-Positive Bacteria ; Bacteria ; Membranes ; Cell Membrane ; Lipid Bilayers/metabolism ; Extracellular Vesicles/metabolism
    Chemische Substanzen Lipid Bilayers
    Sprache Englisch
    Erscheinungsdatum 2024-03-01
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article ; Review
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms25052904
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  2. Artikel: The molecular detection of carbapenem markers with a two-levels amplification screening protocol: epidemiological and resistome insights.

    Calvo, Maddalena / Migliorisi, Giuseppe / Maugeri, Gaetano / Bongiorno, Dafne / Bonomo, Carmelo / Nicitra, Emanuele / Scalia, Guido / Stefani, Stefania

    Frontiers in microbiology

    2024  Band 15, Seite(n) 1346442

    Abstract: Objectives: Carbapenem-resistance is a challenging healthcare concern and require specific stewardship programs. Monitoring workflows include the identification from surveillance samples, such as rectal swabs. Although culture assays represent the gold ... ...

    Abstract Objectives: Carbapenem-resistance is a challenging healthcare concern and require specific stewardship programs. Monitoring workflows include the identification from surveillance samples, such as rectal swabs. Although culture assays represent the gold standard, data report a significant effectiveness in detecting carbapenemases genes directly from rectal swabs. The aim of this study was to evaluate the REALQUALITY Carba-Screen kit (AB ANALITICA, Padova, Italy) in detecting carbapenemases genes directly from rectal swabs, also comparing its effectiveness to culture assays results. A next-generation sequencing (NGS) was performed to investigate the positive samples about resistance markers and sequence type (ST).
    Methods: A number of 136 rectal swabs were collected from the University Hospital Policlinico of Catania critical wards. The samples simultaneously underwent culture and molecular assays (REALQUALITY Carba-Screen kit). The molecular method included two-steps. The first step (1 h and 6 min) rapidly excluded negative samples, while the second one (1 h and 6 min) included only positive samples for a resistance confirmation. All the positive culture samples underwent NGS analysis.
    Results: Statistical evaluations demonstrated high sensitivity (100%) and detection rates (92.6%) for the REALQUALITY Carba-Screen kit, which mostly correlated to the standard workflow. All the culture positive results matched the positive molecular results, which were mainly confirmed by the NGS resistome analysis. The identified ST appeared to be diversified and different from the clinically significative strains of the same setting, furnishing interesting epidemiological evidence.
    Conclusion: The molecular detection allowed a coordinate approach in a high-prevalence multi-drug-resistance area. The rapid identification with a multi-step procedure accelerated the infection control procedures, while the preliminary negative results reduced the overtreatment episodes. The molecular method efficacy was confirmed through the NGS. In conclusion, the molecular screening could initially lead to a more conservative approach, which may be reevaluated after a culture result about the microorganisms' identification and susceptibility profile.
    Sprache Englisch
    Erscheinungsdatum 2024-02-23
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article
    ZDB-ID 2587354-4
    ISSN 1664-302X
    ISSN 1664-302X
    DOI 10.3389/fmicb.2024.1346442
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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    Dieser Service ist kostenpflichtig (siehe Lieferbedingungen von subito). Bestellungen, die einen Artikel nebst Supplementary Material umfassen, werden grundsätzlich wie mehrfache Bestellungen bearbeitet. Gebühren fallen in diesen Fällen für jede einzelne Bestellung an.

  3. Artikel: Evaluation of the Effects of Heteroaryl Ethylene Molecules in Combination with Antibiotics: A Preliminary Study on Control Strains.

    Bonomo, Carmelo / Bonacci, Paolo Giuseppe / Bivona, Dalida Angela / Mirabile, Alessia / Bongiorno, Dafne / Nicitra, Emanuele / Marino, Andrea / Bonaccorso, Carmela / Consiglio, Giuseppe / Fortuna, Cosimo Gianluca / Stefani, Stefania / Musso, Nicolò

    Antibiotics (Basel, Switzerland)

    2023  Band 12, Heft 8

    Abstract: The discovery of compounds with antibacterial activity is crucial in the ongoing battle against antibiotic resistance. We developed two QSAR models to design six novel heteroaryl drug candidates and assessed their antibacterial properties against nine ... ...

    Abstract The discovery of compounds with antibacterial activity is crucial in the ongoing battle against antibiotic resistance. We developed two QSAR models to design six novel heteroaryl drug candidates and assessed their antibacterial properties against nine ATCC strains, including
    Sprache Englisch
    Erscheinungsdatum 2023-08-10
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article
    ZDB-ID 2681345-2
    ISSN 2079-6382
    ISSN 2079-6382
    DOI 10.3390/antibiotics12081308
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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    Über subito bestellen

    Dieser Service ist kostenpflichtig (siehe Lieferbedingungen von subito). Bestellungen, die einen Artikel nebst Supplementary Material umfassen, werden grundsätzlich wie mehrfache Bestellungen bearbeitet. Gebühren fallen in diesen Fällen für jede einzelne Bestellung an.

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