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  1. AU="Nicolás Gonzalo Núñez"
  2. AU="Hernández Solis, Alejandro"
  3. AU="Jadad, Alejandro R"
  4. AU="Lastres, Palma Rico" AU="Lastres, Palma Rico"
  5. AU="Manes, K"
  6. AU="Baugh, Matthew"
  7. AU="Qu, C"
  8. AU="Flett, Heather"
  9. AU="Shueh Lin Lim"
  10. AU="Schröder, Johann"
  11. AU=Butler Taylor
  12. AU="Yang, Fan"
  13. AU="Giacomo Frati"
  14. AU=Kokhaei P
  15. AU="Charikleia Triantopoulou"
  16. AU="Salil Bhargava"
  17. AU="Jong-Eun Lee"
  18. AU="Vargas C, Laura"

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  1. Artikel ; Online: Oxidation inhibits autophagy protein deconjugation from phagosomes to sustain MHC class II restricted antigen presentation

    Laure-Anne Ligeon / Maria Pena-Francesch / Liliana Danusia Vanoaica / Nicolás Gonzalo Núñez / Deepti Talwar / Tobias P. Dick / Christian Münz

    Nature Communications, Vol 12, Iss 1, Pp 1-

    2021  Band 13

    Abstract: LC3-associated phagocytosis (LAP) is a non-canonical use of the autophagy machinery that can contribute to immune responses. Here, the authors describe the mechanism by which ROS production regulates LAPosome stabilization sustaining MHC II dependent ... ...

    Abstract LC3-associated phagocytosis (LAP) is a non-canonical use of the autophagy machinery that can contribute to immune responses. Here, the authors describe the mechanism by which ROS production regulates LAPosome stabilization sustaining MHC II dependent antigen presentation.
    Schlagwörter Science ; Q
    Sprache Englisch
    Erscheinungsdatum 2021-03-01T00:00:00Z
    Verlag Nature Portfolio
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  2. Artikel ; Online: Downregulation of adaptor protein MyD88 compromises the angiogenic potential of B16 murine melanoma.

    Lucas Daniel Trucco / Emiliano Roselli / Paula Araya / Nicolás Gonzalo Nuñez / Hebe Agustina Mena / José Luis Bocco / Soledad Negrotto / Mariana Maccioni

    PLoS ONE, Vol 12, Iss 6, p e

    2017  Band 0179897

    Abstract: The mechanisms that link inflammatory responses to cancer development remain a subject of intense investigation, emphasizing the need to better understand the cellular and molecular pathways that create a tumor promoting microenvironment. The myeloid ... ...

    Abstract The mechanisms that link inflammatory responses to cancer development remain a subject of intense investigation, emphasizing the need to better understand the cellular and molecular pathways that create a tumor promoting microenvironment. The myeloid differentiation primary response protein MyD88 acts as a main adaptor molecule for the signaling cascades initiated from Toll-like receptors (TLRs) and the interleukin 1 receptor (IL-1R). MyD88 has been shown to contribute to tumorigenesis in many inflammation-associated cancer models. In this study, we sought to better define the role of MyD88 in neoplastic cells using a murine melanoma model. Herein, we have demonstrated that MyD88 expression is required to maintain the angiogenic switch that supports B16 melanoma growth. By knocking down MyD88 we reduced TLR-mediated NF-κB activation with no evident effects over cell proliferation and survival. In addition, MyD88 downregulation was associated with a decrease of HIF1α levels and its target gene VEGF, in correlation with an impaired capability to induce capillary sprouting and tube formation of endothelial cells. Melanomas developed from cells lacking MyD88 showed an enhanced secretion of chemoattractant ligands such as CCL2, CXCL10 and CXCL1 and have an improved infiltration of macrophages to the tumor site. Our results imply that cell-autonomous signaling through MyD88 is required to sustain tumor growth and underscore its function as an important positive modulator of tumor angiogenesis.
    Schlagwörter Medicine ; R ; Science ; Q
    Thema/Rubrik (Code) 570
    Sprache Englisch
    Erscheinungsdatum 2017-01-01T00:00:00Z
    Verlag Public Library of Science (PLoS)
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  3. Artikel ; Online: Induction of anergic or regulatory tumor-specific CD4+ T cells in the tumor-draining lymph node

    Ruby Alonso / Héloïse Flament / Sébastien Lemoine / Christine Sedlik / Emanuel Bottasso / Isabel Péguillet / Virginie Prémel / Jordan Denizeau / Marion Salou / Aurélie Darbois / Nicolás Gonzalo Núñez / Benoit Salomon / David Gross / Eliane Piaggio / Olivier Lantz

    Nature Communications, Vol 9, Iss 1, Pp 1-

    2018  Band 17

    Abstract: Tumor neoantigens can be drained to the lymph nodes, but the nature and the significance of the induced immune responses are still unclear. Here the authors use a mouse genetic tumor model to show that tumor-specific CD4 T cells can become anergic or ... ...

    Abstract Tumor neoantigens can be drained to the lymph nodes, but the nature and the significance of the induced immune responses are still unclear. Here the authors use a mouse genetic tumor model to show that tumor-specific CD4 T cells can become anergic or suppressive in the draining lymph node to modulate tumor immunity.
    Schlagwörter Science ; Q
    Sprache Englisch
    Erscheinungsdatum 2018-05-01T00:00:00Z
    Verlag Nature Publishing Group
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  4. Artikel ; Online: Induction of anergic or regulatory tumor-specific CD4+ T cells in the tumor-draining lymph node

    Ruby Alonso / Héloïse Flament / Sébastien Lemoine / Christine Sedlik / Emanuel Bottasso / Isabel Péguillet / Virginie Prémel / Jordan Denizeau / Marion Salou / Aurélie Darbois / Nicolás Gonzalo Núñez / Benoit Salomon / David Gross / Eliane Piaggio / Olivier Lantz

    Nature Communications, Vol 9, Iss 1, Pp 1-

    2018  Band 17

    Abstract: Tumor neoantigens can be drained to the lymph nodes, but the nature and the significance of the induced immune responses are still unclear. Here the authors use a mouse genetic tumor model to show that tumor-specific CD4 T cells can become anergic or ... ...

    Abstract Tumor neoantigens can be drained to the lymph nodes, but the nature and the significance of the induced immune responses are still unclear. Here the authors use a mouse genetic tumor model to show that tumor-specific CD4 T cells can become anergic or suppressive in the draining lymph node to modulate tumor immunity.
    Schlagwörter Science ; Q
    Sprache Englisch
    Erscheinungsdatum 2018-05-01T00:00:00Z
    Verlag Nature Portfolio
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  5. Artikel ; Online: Tumor invasion in draining lymph nodes is associated with Treg accumulation in breast cancer patients

    Nicolas Gonzalo Núñez / Jimena Tosello Boari / Rodrigo Nalio Ramos / Wilfrid Richer / Nicolas Cagnard / Cyrill Dimitri Anderfuhren / Leticia Laura Niborski / Jeremy Bigot / Didier Meseure / Philippe De La Rochere / Maud Milder / Sophie Viel / Delphine Loirat / Louis Pérol / Anne Vincent-Salomon / Xavier Sastre-Garau / Becher Burkhard / Christine Sedlik / Olivier Lantz /
    Sebastian Amigorena / Eliane Piaggio

    Nature Communications, Vol 11, Iss 1, Pp 1-

    2020  Band 15

    Abstract: Tumor-draining lymph nodes are often the first site of metastasis in breast cancer patients. Here, the authors show that metastatic lymph nodes are characterized by the accumulation of suppressive regulatory T cells with a distinct phenotype compared to ... ...

    Abstract Tumor-draining lymph nodes are often the first site of metastasis in breast cancer patients. Here, the authors show that metastatic lymph nodes are characterized by the accumulation of suppressive regulatory T cells with a distinct phenotype compared to matched non-invaded lymph nodes and tumors.
    Schlagwörter Science ; Q
    Sprache Englisch
    Erscheinungsdatum 2020-06-01T00:00:00Z
    Verlag Nature Publishing Group
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  6. Artikel ; Online: Tumor invasion in draining lymph nodes is associated with Treg accumulation in breast cancer patients

    Nicolas Gonzalo Núñez / Jimena Tosello Boari / Rodrigo Nalio Ramos / Wilfrid Richer / Nicolas Cagnard / Cyrill Dimitri Anderfuhren / Leticia Laura Niborski / Jeremy Bigot / Didier Meseure / Philippe De La Rochere / Maud Milder / Sophie Viel / Delphine Loirat / Louis Pérol / Anne Vincent-Salomon / Xavier Sastre-Garau / Becher Burkhard / Christine Sedlik / Olivier Lantz /
    Sebastian Amigorena / Eliane Piaggio

    Nature Communications, Vol 11, Iss 1, Pp 1-

    2020  Band 15

    Abstract: Tumor-draining lymph nodes are often the first site of metastasis in breast cancer patients. Here, the authors show that metastatic lymph nodes are characterized by the accumulation of suppressive regulatory T cells with a distinct phenotype compared to ... ...

    Abstract Tumor-draining lymph nodes are often the first site of metastasis in breast cancer patients. Here, the authors show that metastatic lymph nodes are characterized by the accumulation of suppressive regulatory T cells with a distinct phenotype compared to matched non-invaded lymph nodes and tumors.
    Schlagwörter Science ; Q
    Sprache Englisch
    Erscheinungsdatum 2020-06-01T00:00:00Z
    Verlag Nature Portfolio
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  7. Artikel ; Online: Heterogeneity of response to immune checkpoint blockade in hypermutated experimental gliomas

    Katrin Aslan / Verena Turco / Jens Blobner / Jana K. Sonner / Anna Rita Liuzzi / Nicolás Gonzalo Núñez / Donatella De Feo / Philipp Kickingereder / Manuel Fischer / Ed Green / Ahmed Sadik / Mirco Friedrich / Khwab Sanghvi / Michael Kilian / Frederik Cichon / Lara Wolf / Kristine Jähne / Anna von Landenberg / Lukas Bunse /
    Felix Sahm / Daniel Schrimpf / Jochen Meyer / Allen Alexander / Gianluca Brugnara / Ralph Röth / Kira Pfleiderer / Beate Niesler / Andreas von Deimling / Christiane Opitz / Michael O. Breckwoldt / Sabine Heiland / Martin Bendszus / Wolfgang Wick / Burkhard Becher / Michael Platten

    Nature Communications, Vol 11, Iss 1, Pp 1-

    2020  Band 14

    Abstract: Modeling patient-individual resistance to immunotherapy is challenging. Here, the authors use a syngeneic experimental hypermutated orthotopic glioma model to define radiological and biological features that can predict or explain the mechanistic ... ...

    Abstract Modeling patient-individual resistance to immunotherapy is challenging. Here, the authors use a syngeneic experimental hypermutated orthotopic glioma model to define radiological and biological features that can predict or explain the mechanistic differences between responders and non-responders to immunotherapy.
    Schlagwörter Science ; Q
    Sprache Englisch
    Erscheinungsdatum 2020-02-01T00:00:00Z
    Verlag Nature Portfolio
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  8. Artikel ; Online: Loss of immune tolerance to IL-2 in type 1 diabetes

    Louis Pérol / John M. Lindner / Pamela Caudana / Nicolas Gonzalo Nunez / Audrey Baeyens / Andrea Valle / Christine Sedlik / Delphine Loirat / Olivier Boyer / Alain Créange / José Laurent Cohen / Ute Christine Rogner / Jun Yamanouchi / Martine Marchant / Xavier Charles Leber / Meike Scharenberg / Marie-Claude Gagnerault / Roberto Mallone / Manuela Battaglia /
    Pere Santamaria / Agnès Hartemann / Elisabetta Traggiai / Eliane Piaggio

    Nature Communications, Vol 7, Iss 1, Pp 1-

    2016  Band 10

    Abstract: Type 1 diabetes is driven by T-cell autoimmunity to pancreatic islet cells. Here the authors show that autoreactive anti-IL-2 T and B cells are present in type 1 diabetes patients, and that anti-IL-2 antibodies precede diabetes onset in mice, suggesting ... ...

    Abstract Type 1 diabetes is driven by T-cell autoimmunity to pancreatic islet cells. Here the authors show that autoreactive anti-IL-2 T and B cells are present in type 1 diabetes patients, and that anti-IL-2 antibodies precede diabetes onset in mice, suggesting their potential as a diagnostic marker.
    Schlagwörter Science ; Q
    Sprache Englisch
    Erscheinungsdatum 2016-10-01T00:00:00Z
    Verlag Nature Portfolio
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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