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  1. AU="Nicola Cirillo"
  2. AU="Lee, Hyung Chul"
  3. AU="Luo, Anping"
  4. AU="Kuosmanen, Pekka"
  5. AU=Wu Feng
  6. AU="Mufti, Hani N"
  7. AU="Przyborski, Stefan"
  8. AU="Helio Garcia Leite"
  9. AU="Chang, Yi-Yao"
  10. AU="Ren, Xiangzhong"
  11. AU="Ha, Van Thi Cam"
  12. AU="Zheng, Jinhong"
  13. AU="Tomatis-Souverbielle, Cristiana"
  14. AU="Al-Jumaily, Adel A"
  15. AU="Marallo, Carmine"
  16. AU="Alshammari, Afraj"
  17. AU="Min, Dong-Joon"
  18. AU=Fattorini Daniele AU=Fattorini Daniele
  19. AU="Lou, L X"
  20. AU="Yadollah Haji-Heydari"
  21. AU="Placidi, A"
  22. AU="Olivé, Claudia"
  23. AU="Türk, Y"
  24. AU="Brosnan, Hannah"
  25. AU="Hardy, Rowan S"
  26. AU="Demirci, Yılmaz Mehmet"
  27. AU="Dlugosz, Andrzej A"

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Treffer 1 - 10 von insgesamt 21

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  1. Artikel ; Online: The Hyaluronan/CD44 Axis

    Nicola Cirillo

    International Journal of Molecular Sciences, Vol 24, Iss 21, p

    A Double-Edged Sword in Cancer

    2023  Band 15812

    Abstract: Hyaluronic acid (HA) receptor CD44 is widely used for identifying cancer stem cells and its activation promotes stemness. Recent evidence shows that overexpression of CD44 is associated with poor prognosis in most human cancers and mediates therapy ... ...

    Abstract Hyaluronic acid (HA) receptor CD44 is widely used for identifying cancer stem cells and its activation promotes stemness. Recent evidence shows that overexpression of CD44 is associated with poor prognosis in most human cancers and mediates therapy resistance. For these reasons, in recent years, CD44 has become a treatment target in precision oncology, often via HA-conjugated antineoplastic drugs. Importantly, HA molecules of different sizes have a dual effect and, therefore, may enhance or attenuate the CD44-mediated signaling pathways, as they compete with endogenous HA for binding to the receptors. The magnitude of these effects could be crucial for cancer progression, as well as for driving the inflammatory response in the tumor microenvironment. The increasingly common use of HA-conjugated drugs in oncology, as well as HA-based compounds as adjuvants in cancer treatment, adds further complexity to the understanding of the net effect of hyaluronan-CD44 activation in cancers. In this review, I focus on the significance of CD44 in malignancy and discuss the dichotomous function of the hyaluronan/CD44 axis in cancer progression.
    Schlagwörter hyaluronic acid ; CD44 ; cancer stem cells ; chemoresistance ; carcinogenesis ; Biology (General) ; QH301-705.5 ; Chemistry ; QD1-999
    Thema/Rubrik (Code) 610
    Sprache Englisch
    Erscheinungsdatum 2023-10-01T00:00:00Z
    Verlag MDPI AG
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  2. Artikel ; Online: Biosynthesis of glucocorticoids in tumors

    Nicola Cirillo

    The Journal of Clinical Investigation, Vol 133, Iss

    2023  Band 21

    Schlagwörter Endocrinology ; Oncology ; Medicine ; R
    Sprache Englisch
    Erscheinungsdatum 2023-11-01T00:00:00Z
    Verlag American Society for Clinical Investigation
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  3. Artikel ; Online: Taste alteration in COVID-19

    Nicola Cirillo

    Journal of Infection and Public Health, Vol 14, Iss 8, Pp 1099-

    Significant geographical differences exist in the prevalence of the symptom

    2021  Band 1105

    Abstract: Early detection of COVID-19 is important for reduction in the spread of the disease and gustatory disturbances (GD) are known to have a strong predictive value. In the present study, we aimed to map the geographical differences in the prevalence of GD in ...

    Abstract Early detection of COVID-19 is important for reduction in the spread of the disease and gustatory disturbances (GD) are known to have a strong predictive value. In the present study, we aimed to map the geographical differences in the prevalence of GD in individuals infected with SARS-CoV-2 during the first wave of COVID-19 in order to improve case identification and to facilitate prioritization. We undertook a rapid scoping review of articles published in the repository of the National Library of Medicine (MEDLINE/PubMed) and medRxiv from their inception until 3rd September, 2020. The minimum requirements for completing a restricted systematic review were fulfilled. Of the 431 articles retrieved, 61 studies (28,374 cases confirmed with COVID-19) from 20 countries were included in the analysis. GD were most prevalent in the Americas [66.78%, 95% CI 54.77–78.79%] compared to Europe [57.18%, 95% CI 52.35–62.01%], the Middle East [38.83%, 95% CI 27.47–50.19%] and East Asia [13.1%, 95% CI 0.14–26.06%]. No differences of GD prevalence were evident between February and August 2020. The data demonstrate that there is a marked geographical distribution of GD in COVID-19 patients which, possibly, might be explained by differences in diagnostic criteria for COVID-19 case definition during the early phase of the pandemic.
    Schlagwörter SARS-CoV-2 ; Dysgeusia ; Taste ; COVID-19 ; Oral diseases ; Infectious and parasitic diseases ; RC109-216 ; Public aspects of medicine ; RA1-1270
    Thema/Rubrik (Code) 610
    Sprache Englisch
    Erscheinungsdatum 2021-08-01T00:00:00Z
    Verlag Elsevier
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  4. Artikel ; Online: The Local Neuropeptide System of Keratinocytes

    Nicola Cirillo

    Biomedicines, Vol 9, Iss 1854, p

    2021  Band 1854

    Abstract: Neuropeptides have been known for over 50 years as chemical signals in the brain. However, it is now well established that the synthesis of this class of peptides is not restricted to neurons. For example, human skin not only expresses several functional ...

    Abstract Neuropeptides have been known for over 50 years as chemical signals in the brain. However, it is now well established that the synthesis of this class of peptides is not restricted to neurons. For example, human skin not only expresses several functional receptors for neuropeptides but, also, can serve as a local source of neuroactive molecules such as corticotropin-releasing hormone, melanocortins, and β-endorphin. In contrast, an equivalent of the hypothalamic-pituitary axis in the oral mucosa has not been well characterized to date. In view of the differences in the morphology and function of oral mucosal and skin cells, in this review I surveyed the existing evidence for a local synthesis of hypothalamic-pituitary, opiate, neurohypophyseal, and neuroendocrine neuropeptides in both epidermal and oral keratinocytes.
    Schlagwörter keratinocytes ; neuropeptides ; hypothalamic-pituitary-adrenal axis ; hypothalamic–pituitary–thyroid axis ; neuroendocrine system ; Biology (General) ; QH301-705.5
    Sprache Englisch
    Erscheinungsdatum 2021-12-01T00:00:00Z
    Verlag MDPI AG
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  5. Artikel ; Online: The Role of Non-Neuronal Acetylcholine in the Autoimmune Blistering Disease Pemphigus Vulgaris

    Delila Pouldar Foulad / Nicola Cirillo / Sergei A. Grando

    Biology, Vol 12, Iss 354, p

    2023  Band 354

    Abstract: The importance of acetylcholine (ACh) in keratinocyte adhesion and acantholysis has been investigated over the last three decades, particularly in the pathophysiology of autoimmune blistering dermatoses. Pemphigus vulgaris (PV) is an autoimmune ... ...

    Abstract The importance of acetylcholine (ACh) in keratinocyte adhesion and acantholysis has been investigated over the last three decades, particularly in the pathophysiology of autoimmune blistering dermatoses. Pemphigus vulgaris (PV) is an autoimmune blistering skin disease where autoantibody-mediated suprabasilar intraepidermal splitting causes flaccid blisters and non-healing erosions of the oral mucosa and sometimes also of the skin. Historically, acantholysis in PV was thought to be driven by anti-desmoglein (Dsg) antibodies. Herein, we describe the role of autoantibodies against keratinocyte muscarinic and nicotinic acetylcholine receptors, as well as the annexin-like molecule pemphaxin that also binds ACh, in the immunopathogenesis of PV. The identification of targets in this disease is important, as they may lead to novel diagnostic and therapeutic options in the future for this potentially deadly disease.
    Schlagwörter pemphigus ; acetylcholine ; keratinocyte adhesion ; acantholysis ; nicotinic receptor ; muscarinic receptor ; Biology (General) ; QH301-705.5
    Sprache Englisch
    Erscheinungsdatum 2023-02-01T00:00:00Z
    Verlag MDPI AG
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  6. Artikel ; Online: Introducing CREATING, a plan for dental higher education in Saudi Arabia

    Nicola Cirillo

    Saudi Dental Journal, Vol 27, Iss 2, Pp 55-

    2015  Band 56

    Schlagwörter Medicine ; R ; Dentistry ; RK1-715
    Sprache Englisch
    Erscheinungsdatum 2015-04-01T00:00:00Z
    Verlag Elsevier
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  7. Artikel ; Online: Heterogeneity of Cancer Stem Cells in Tumorigenesis, Metastasis, and Resistance to Antineoplastic Treatment of Head and Neck Tumours

    Nicola Cirillo / Carmen Wu / Stephen S. Prime

    Cells, Vol 10, Iss 3068, p

    2021  Band 3068

    Abstract: The discovery of a small subset of cancer cells with self-renewal properties that can give rise to phenotypically diverse tumour populations has shifted our understanding of cancer biology. Targeting cancer stem cells (CSCs) is becoming a promising ... ...

    Abstract The discovery of a small subset of cancer cells with self-renewal properties that can give rise to phenotypically diverse tumour populations has shifted our understanding of cancer biology. Targeting cancer stem cells (CSCs) is becoming a promising therapeutic strategy in various malignancies, including head and neck squamous cell carcinoma (HNSCC). Diverse sub-populations of head and neck cancer stem cells (HNCSCs) have been identified previously using CSC specific markers, the most common being CD44, Aldehyde Dehydrogenase 1 (ALDH1), and CD133, or by side population assays. Interestingly, distinct HNCSC subsets play different roles in the generation and progression of tumours. This article aims to review the evidence for a role of specific CSCs in HNSCC tumorigenesis, invasion, and metastasis, together with resistance to treatment.
    Schlagwörter cancer stem cells ; head and neck tumours ; CD44 ; ALDH ; CD133 ; Biology (General) ; QH301-705.5
    Thema/Rubrik (Code) 610
    Sprache Englisch
    Erscheinungsdatum 2021-11-01T00:00:00Z
    Verlag MDPI AG
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  8. Artikel ; Online: Global Burden of Disease Data for Indonesia

    Elizabeth Fitriana Sari / Newell W Johnson / Michael John McCullough / Nicola Cirillo

    The Lancet Global Health, Vol 11, Iss 3, Pp e336- (2023)

    2023  

    Schlagwörter Public aspects of medicine ; RA1-1270
    Sprache Englisch
    Erscheinungsdatum 2023-03-01T00:00:00Z
    Verlag Elsevier
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    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  9. Artikel ; Online: A Critical Interpretive Synthesis of the Role of Arecoline in Oral Carcinogenesis

    Hakan Gocol / Jin Han Zeng / Sara Chang / Buo Yu Koh / Hoang Nguyen / Nicola Cirillo

    Pharmaceuticals, Vol 16, Iss 12, p

    Is the Local Cholinergic Axis a Missing Link in Disease Pathophysiology?

    2023  Band 1684

    Abstract: Arecoline is the primary active carcinogen found in areca nut and has been implicated in the pathogenesis of oral squamous cell carcinoma (OSCC) and oral submucous fibrosis (OSF). For this study, we conducted a stepwise review process by combining ... ...

    Abstract Arecoline is the primary active carcinogen found in areca nut and has been implicated in the pathogenesis of oral squamous cell carcinoma (OSCC) and oral submucous fibrosis (OSF). For this study, we conducted a stepwise review process by combining iterative scoping reviews with a post hoc search, with the aim of identifying the specific mechanisms by which arecoline initiates and promotes oral carcinogenesis. Our initial search allowed us to define the current trends and patterns in the pathophysiology of arecoline-induced OSF and OSCC, which include the induction of cell proliferation, facilitation of invasion, adhesion, and migration, increased collagen deposition and fibrosis, imbalance in immune and inflammatory mechanisms, and genotoxicity. Key molecular pathways comprise the activation of NOTCH1, MYC, PRDX2, WNT, CYR61, EGFR/Pl3K, DDR1 signaling, and cytokine upregulation. Despite providing a comprehensive overview of potential pathogenic mechanisms of OSF, the involvement of molecules functioning as areca alkaloid receptors, namely, the muscarinic and nicotinic acetylcholine receptors (AChRs), was not elucidated with this approach. Accordingly, our search strategy was refined to reflect these evidence gaps. The results of the second round of reviews with the post hoc search highlighted that arecoline binds preferentially to muscarinic AChRs, which have been implicated in cancer. Consistently, AChRs activate the signaling pathways that partially overlap with those described in the context of arecoline-induced carcinogenesis. In summary, we used a theory-driven interpretive review methodology to inform, extend, and supplement the conventional systematic literature assessment workflow. On the one hand, the results of this critical interpretive synthesis highlighted the prevailing trends and enabled the consolidation of data pertaining to the molecular mechanisms involved in arecoline-induced carcinogenesis, and, on the other, brought up knowledge gaps related to the role of the local cholinergic axis in oral ...
    Schlagwörter arecoline ; nicotine ; acetylcholine receptors ; oral submucous fibrosis ; oral cancer ; mouth neoplasms ; Medicine ; R ; Pharmacy and materia medica ; RS1-441
    Thema/Rubrik (Code) 610
    Sprache Englisch
    Erscheinungsdatum 2023-12-01T00:00:00Z
    Verlag MDPI AG
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  10. Artikel ; Online: Molecules and Biomaterial Technologies Affecting Stem Cell Differentiation

    Lorenzo Lo Muzio / Marco Mascitti / Marcella La Noce / Francesca Posa / Yasusei Kudo / Nicola Cirillo

    Stem Cells International, Vol

    2022  Band 2022

    Schlagwörter Internal medicine ; RC31-1245
    Sprache Englisch
    Erscheinungsdatum 2022-01-01T00:00:00Z
    Verlag Hindawi Limited
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