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  1. AU="Nicola Sunter"
  2. AU=Dalinka M K
  3. AU="Slim, Marine"
  4. AU=Colby J
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  6. AU=Smarr Cory-Ann
  7. AU="Rende, Mario"
  8. AU="Evans, Leigh"
  9. AU=Brown Erwin
  10. AU=Hehlmann R
  11. AU="Azzopardi, Nicolas"
  12. AU="Surić-Mihić Marija"
  13. AU=Cismasiu Valeriu B
  14. AU="Töpfer, Änne"
  15. AU="Lemcke, Johannes"
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  30. AU="Suzuki, Kenichi G N"
  31. AU="Hu, Yizhong"
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  34. AU="Jung, Hee-Jun"
  35. AU="Struckmann, Stephan"
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  38. AU="Rebecca A Butcher"
  39. AU="Kimberlyn Roosa"
  40. AU=Chian Ri-Cheng
  41. AU="Alzalzalah, Sayed"
  42. AU=Kaufman Jonathan J
  43. AU="Kim, Jin K"
  44. AU="Zevakov, S A"
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  46. AU="Kolomeichuk, Lilia V"
  47. AU="Sabuj Kanti Mistry"
  48. AU="Basurto-Lozada, Daniela"
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  50. AU="Teresinha Leal"
  51. AU="Angélique B van 't Wout"
  52. AU="Roberts, Nicholas J"
  53. AU="Chauhan, Gaurav B"
  54. AU=Hanjaya-Putra Donny
  55. AU=Powell James
  56. AU="Russell, Todd"
  57. AU=Forth Scott
  58. AU="Kreutzer, Susanne" AU="Kreutzer, Susanne"
  59. AU="St John, Maie"
  60. AU=Gerhardy A
  61. AU="Qi, Huixin"
  62. AU="Dobosiewicz, May"
  63. AU="Srivastava, Rakesh"
  64. AU="Grevtsov K.I."

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  1. Artikel ; Online: A comparative study of the capacity of mesenchymal stromal cell lines to form spheroids.

    Margaux Deynoux / Nicola Sunter / Elfi Ducrocq / Hassan Dakik / Roseline Guibon / Julien Burlaud-Gaillard / Lucie Brisson / Florence Rouleux-Bonnin / Louis-Romée le Nail / Olivier Hérault / Jorge Domenech / Philippe Roingeard / Gaëlle Fromont / Frédéric Mazurier

    PLoS ONE, Vol 15, Iss 6, p e

    2020  Band 0225485

    Abstract: Mesenchymal stem cells (MSC)-spheroid models favor maintenance of stemness, ex vivo expansion and transplantation efficacy. Spheroids may also be considered as useful surrogate models of the hematopoietic niche. However, accessibility to primary cells, ... ...

    Abstract Mesenchymal stem cells (MSC)-spheroid models favor maintenance of stemness, ex vivo expansion and transplantation efficacy. Spheroids may also be considered as useful surrogate models of the hematopoietic niche. However, accessibility to primary cells, from bone marrow (BM) or adipose tissues, may limit their experimental use and the lack of consistency in methods to form spheroids may affect data interpretation. In this study, we aimed to create a simple model by examining the ability of cell lines, from human (HS-27a and HS-5) and murine (MS-5) BM origins, to form spheroids, compared to primary human MSCs (hMSCs). Our protocol efficiently allowed the spheroid formation from all cell types within 24 hours. Whilst hMSC-spheroids began to shrink after 24 hours, the size of spheroids from cell lines remained constant during three weeks. The difference was partially explained by the balance between proliferation and cell death, which could be triggered by hypoxia and induced oxidative stress. Our results demonstrate that, like hMSCs, MSC cell lines make reproductible spheroids that are easily handled. Thus, this model could help in understanding mechanisms involved in MSC functions and may provide a simple model by which to study cell interactions in the BM niche.
    Schlagwörter Medicine ; R ; Science ; Q
    Thema/Rubrik (Code) 571
    Sprache Englisch
    Erscheinungsdatum 2020-01-01T00:00:00Z
    Verlag Public Library of Science (PLoS)
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  2. Artikel ; Online: Genome-wide association study identifies risk loci for progressive chronic lymphocytic leukemia

    Wei-Yu Lin / Sarah E. Fordham / Nicola Sunter / Claire Elstob / Thahira Rahman / Elaine Willmore / Colin Shepherd / Gordon Strathdee / Tryfonia Mainou-Fowler / Rachel Piddock / Hannah Mearns / Timothy Barrow / Richard S. Houlston / Helen Marr / Jonathan Wallis / Geoffrey Summerfield / Scott Marshall / Andrew Pettitt / Christopher Pepper /
    Christopher Fegan / Francesco Forconi / Martin J. S. Dyer / Sandrine Jayne / April Sellors / Anna Schuh / Pauline Robbe / David Oscier / James Bailey / Syed Rais / Alison Bentley / Lynn Cawkwell / Paul Evans / Peter Hillmen / Guy Pratt / David J. Allsup / James M. Allan

    Nature Communications, Vol 12, Iss 1, Pp 1-

    2021  Band 8

    Abstract: The clinical course of chronic lymphocytic leukaemia (CLL) is variable and difficult to predict. Here, the authors conduct a genome wide association study meta-analysis for time to first treatment in CLL patients and report two loci associating with ... ...

    Abstract The clinical course of chronic lymphocytic leukaemia (CLL) is variable and difficult to predict. Here, the authors conduct a genome wide association study meta-analysis for time to first treatment in CLL patients and report two loci associating with progressive disease.
    Schlagwörter Science ; Q
    Sprache Englisch
    Erscheinungsdatum 2021-01-01T00:00:00Z
    Verlag Nature Portfolio
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

    Volltext online

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    Kategorien

    Fernleihe an ZB MED

    Sie können sich den gewünschten Titel als lokale Nutzerin oder lokaler Nutzer von ZB MED direkt an den Standort Köln schicken lassen.

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