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Article ; Online: Sixteen-year trends in fruit consumption and related socioeconomic inequalities among adolescents in Western European countries.

Nicolas, Charlotte / Rouche, Manon / Dierckens, Maxim / Kelly, Colette / Fismen, Anne-Siri / Nardone, Paola / Castetbon, Katia / Chatelan, Angeline

European journal of nutrition

2023 Volume 62, Issue 8, Page(s) 3287–3296

Abstract: Purpose: To investigate time trends in daily fruit consumption among Western European adolescents and in related socioeconomic inequalities.: Methods: We used nationally representative data from 18 countries participating in five rounds (2002 to 2018) ...

Abstract	Purpose: To investigate time trends in daily fruit consumption among Western European adolescents and in related socioeconomic inequalities. Methods: We used nationally representative data from 18 countries participating in five rounds (2002 to 2018) of the cross-sectional "Health Behaviour in School-aged Children" (HBSC) survey (n = 458,973). The questionnaire, standardised across countries and rounds, was self-administered at school by 11-, 13- and 15-year-old adolescents. Daily fruit consumption was assessed using a short food frequency questionnaire (sFFQ). Socioeconomic inequalities were measured using the Family Affluence Scale (FAS). Multilevel logistic regressions were applied to study linear time trends in daily fruit consumption, overall, by country and by FAS. Results: Between 2002 and 2018, daily fruit consumption increased in 10 countries (OR range, 1.04 to 1.13, p < 0.05) and decreased in 3 (OR range 0.96 to 0.98, p < 0.05). In all survey years combined, prevalence of daily fruit consumption was significantly higher among high FAS groups (42.6%) compared to medium (36.1%) and low FAS groups (31.7%; all countries: p < 0.001). Between 2002 and 2018, socioeconomic inequalities in fruit consumption increased in Austria, Germany, Italy, Netherlands, Scotland, Sweden, and Switzerland. Only in Norway FAS inequalities decreased while the prevalence increased. Conclusion: The prevalence of daily fruit consumption generally increased among adolescents between 2002 and 2018 in Western European countries, yet socioeconomic inequalities increased in some countries. Public health interventions should continue to promote fruit consumption with special attention to lower socioeconomic groups.
MeSH term(s)	Child ; Humans ; Adolescent ; Socioeconomic Factors ; Fruit ; Cross-Sectional Studies ; Surveys and Questionnaires ; Norway
Language	English
Publishing date	2023-08-16
Publishing country	Germany
Document type	Journal Article
ZDB-ID	1466536-0
ISSN	1436-6215 ; 1436-6207
ISSN (online)	1436-6215
ISSN	1436-6207
DOI	10.1007/s00394-023-03199-5
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Article ; Online: Création et évaluation d’un MOOC sur le syndrome confusionnel en oncogériatrie.

Antoine, Valery / Nicolas, Charlotte / Albarède, Julie / Azria, David / Cristol, Laurence / Jeandel, Claude / Ferreira, Ernestine / Morel, Charlotte / Mourey, Loïc / Balardy, Laurent

Bulletin du cancer

2021 Volume 108, Issue 12, Page(s) 1101–1111

Abstract: Introduction: Among the themes to be addressed by a Massive Open Online Course (MOOC) on geriatric oncology, one of the priorities was delirium, due to its frequency, complications and difficulties encountered by healthcare professionals in diagnosing ... ...

Title translation	Development and assessment of a MOOC about delirium in geriatric oncology.
Abstract	Introduction: Among the themes to be addressed by a Massive Open Online Course (MOOC) on geriatric oncology, one of the priorities was delirium, due to its frequency, complications and difficulties encountered by healthcare professionals in diagnosing and managing delirium. Our study aims to evaluate professional practices in the area of education, regarding the evaluation of the content of a MOOC module about delirium syndrome in geriatric oncology. Methods: We created a multidisciplinary group to define the scientific content, the pedagogical objectives, the scriptwriting and the development of a training module. The quality of instructional design was then evaluated according to eleven MOOC design principles to promote learning. Participants were studied. Results: Seven of the eleven criteria for evaluating pedagogical quality were documented. Among the 1020 participants, 455 (44.6%) completed the final test concerning delirium: 417 (40.8%) passed the final test; 406 documented their profession and the region of France where they worked: 146 (32%) nurses (confirming the participation of the targeted audience), 103 (22.6%) doctors/pharmacists (illustrating the multi-professional interest of the thematic), with a wide distribution of the participants over the national territory. Discussion: The multidisciplinary team's investment in developing these teaching materials strengthened the group's cohesion and valuated its professional skills. All teaching resources developed for access via the internet must be accompanied by an evaluation of the quality of the scientific content, objectives and teaching methods, before being able to appreciate its use in the field and assess its real impact on the participants' learning and practice.
MeSH term(s)	Aged ; Clinical Competence/statistics & numerical data ; Curriculum ; Delirium/diagnosis ; Delirium/etiology ; Delirium/therapy ; Education, Distance/organization & administration ; Educational Measurement/statistics & numerical data ; Female ; France ; Geriatrics/education ; Humans ; Male ; Medical Oncology/education ; Nurses/statistics & numerical data ; Pharmacists/statistics & numerical data ; Physicians/statistics & numerical data ; Program Development/methods ; Risk Factors ; Students, Health Occupations/statistics & numerical data ; Syndrome ; Teaching
Language	French
Publishing date	2021-10-21
Publishing country	France
Document type	Journal Article
ZDB-ID	213270-9
ISSN	1769-6917 ; 0007-4551
ISSN (online)	1769-6917
ISSN	0007-4551
DOI	10.1016/j.bulcan.2021.05.014
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Article ; Online: Reply to: "Shunt dysfunction: is it suitable as the primary end point in transjugular intrahepatic portosystemic shunt trials?".

Nicolas, Charlotte / d'Alteroche, Louis / Perarnau, Jean-Marc

Journal of hepatology

2015 Volume 62, Issue 1, Page(s) 247–248

MeSH term(s)	Esophageal and Gastric Varices/surgery ; Female ; Humans ; Male ; Portasystemic Shunt, Transjugular Intrahepatic/instrumentation ; Stents
Language	English
Publishing date	2015-01
Publishing country	Netherlands
Document type	Comment ; Letter
ZDB-ID	605953-3
ISSN	1600-0641 ; 0168-8278
ISSN (online)	1600-0641
ISSN	0168-8278
DOI	10.1016/j.jhep.2014.09.017
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Article ; Online: Spreading geriatric oncology culture through professional caregivers: Results of a French massive open online course (MOOC).

Nicolas, Charlotte / Balardy, Laurent / Antoine, Valery / Albarède, Julie / Azria, David / Cristol, Laurence / Ferreira, Ernestine / Gérard, Stéphane / Jeandel, Claude / Louit, Camille / Tranier, Alexandrine / Ufkes, Rosanne / Bauvin, Eric / Morel, Charlotte / Mourey, Loïc

Journal of geriatric oncology

2021 Volume 13, Issue 1, Page(s) 94–99

Abstract: Geriatric oncology is based on the synergy between several professionals whose common goal is to improve care for older patients with cancer. This requires sharing a common core of knowledge to facilitate collaboration between them. To date, training in ... ...

Abstract	Geriatric oncology is based on the synergy between several professionals whose common goal is to improve care for older patients with cancer. This requires sharing a common core of knowledge to facilitate collaboration between them. To date, training in geriatric oncology has been limited in scope and difficult to access for caregivers, particularly nurses and healthcare aides. To meet this need, a massive open online course (MOOC), in geriatric oncology has been developed in France. This kind of course aims to provide simultaneous access for a large number of participants and to foster communication with the pedagogical team through discussion forums. The first session of the MOOC, which has been set up in the Occitania region of France, went online nationwide from March 6 to June 23, 2020. Despite the SARS CoV-2 global health crisis, 1020 people subscribed to the first session and 417 (40.9%) were certified at the end of the course. Most are nurses (35.2%) and work outside Occitania (56.3%). A survey revealed a high satisfaction level regarding relevance of lessons (97.9%), pedagogical quality of teaching team (97.9%), knowledge acquisition (93.6%), meeting learners' needs (90.4%) and practical value of the course (88.3%). This preliminary experience demonstrates the ability of this MOOC to spread the culture of geriatric oncology and the educational potential of this new type of online training.
MeSH term(s)	Aged ; COVID-19 ; Caregivers ; Education, Distance ; Humans ; Neoplasms ; SARS-CoV-2
Language	English
Publishing date	2021-08-27
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	2556813-9
ISSN	1879-4076 ; 1879-4068
ISSN (online)	1879-4076
ISSN	1879-4068
DOI	10.1016/j.jgo.2021.08.002
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Article ; Online: Ten-year experience of transjugular intrahepatic portosystemic shunt for noncirrhotic portal hypertension.

Regnault, David / d'Alteroche, Louis / Nicolas, Charlotte / Dujardin, Fanny / Ayoub, Jean / Perarnau, Jean Marc

European journal of gastroenterology & hepatology

2017 Volume 30, Issue 5, Page(s) 557–562

Abstract: Background: Transjugular intrahepatic portosystemic shunt (TIPS) is considered to be well suited for the treatment of noncirrhotic portal hypertension (NCPHT) because of a usually severe portal hypertension (PHT) and a mild liver failure, but very less ... ...

Abstract	Background: Transjugular intrahepatic portosystemic shunt (TIPS) is considered to be well suited for the treatment of noncirrhotic portal hypertension (NCPHT) because of a usually severe portal hypertension (PHT) and a mild liver failure, but very less data are available. Patients and methods: Records of patients referred for TIPS between 2004 and 2015 for NCPHT were reviewed. No patient should have clinical or biological or histological features of cirrhosis. Results: Twenty-five patients with a wide variety of histological lesions (sinusoidal dilatations, granulomatosis, regenerative nodular hyperplasia, obliterative portal venopathy, or subnormal liver) and a wide variety of associated diseases (thrombophilia, sarcoidosis, common variable immunodeficiency, scleroderma, Castleman's disease, early primitive biliary cirrhosis, congenital liver fibrosis, chemotherapy, purinethol intake, and congenital varices) were included. Two complications occurred during the procedure: one periprosthetic hematoma and the other misposition of a covered stent. During the first month, two other patients had an early thrombosis, another had induced encephalopathy, and one died of early rebleeding. Two of these complications occurred in patients with cavernoma. With a mean follow-up of 39 months, 10 patients experienced at least one episode of spontaneous encephalopathy, with three of these patients requiring a stent reduction. Five patients had a recurrence of their initial symptoms, and one had an asymptomatic hemodynamic dysfunction. Conclusion: TIPS is effective in NCPHT but can be technically difficult, especially in the case of cavernoma. Good liver function does not prevent the occurrence of long-term encephalopathy.
MeSH term(s)	Adult ; Aged ; Brain Diseases/etiology ; Female ; Humans ; Hypertension, Portal/etiology ; Hypertension, Portal/surgery ; Liver Cirrhosis/complications ; Male ; Middle Aged ; Portasystemic Shunt, Transjugular Intrahepatic/adverse effects ; Portasystemic Shunt, Transjugular Intrahepatic/methods ; Postoperative Complications ; Retrospective Studies ; Stents/adverse effects
Language	English
Publishing date	2017-12-27
Publishing country	England
Document type	Journal Article
ZDB-ID	1034239-4
ISSN	1473-5687 ; 0954-691X
ISSN (online)	1473-5687
ISSN	0954-691X
DOI	10.1097/MEG.0000000000001067
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Article ; Online: Severe infections due to Francisella tularensis ssp. holarctica in solid organ transplant recipient: report of two cases and review of literature.

Bahuaud, Olivier / Le Brun, Cécile / Chalopin, Thomas / Lacasse, Marion / Le Marec, Julien / Pantaleon, Clémence / Nicolas, Charlotte / Barbier, Louise / Bernard, Louis / Lemaignen, Adrien

BMC infectious diseases

2019 Volume 19, Issue 1, Page(s) 238

Abstract: Background: Tularemia is a rare zoonotic infection caused by bacterium Francisella tularensis. It has been well described in immunocompetent patients but poorly described in immunocompromised patients notably in solid organ transplant recipients.: ... ...

Abstract	Background: Tularemia is a rare zoonotic infection caused by bacterium Francisella tularensis. It has been well described in immunocompetent patients but poorly described in immunocompromised patients notably in solid organ transplant recipients. Case presentations: We report here two cases of tularemia in solid organ transplant recipients including first case after heart transplant. We also carried out an exhaustive review of literature describing characteristics of this infection in solid organ transplant recipients.
MeSH term(s)	Animals ; Anti-Bacterial Agents/therapeutic use ; Drug Therapy, Combination ; Francisella tularensis/isolation & purification ; Humans ; Magnetic Resonance Imaging ; Male ; Middle Aged ; Organ Transplantation ; Severity of Illness Index ; Transplant Recipients ; Tularemia/diagnosis ; Tularemia/drug therapy ; Tularemia/parasitology ; Tularemia/pathology ; Zoonoses/diagnosis ; Zoonoses/drug therapy ; Zoonoses/parasitology ; Zoonoses/pathology
Chemical Substances	Anti-Bacterial Agents
Language	English
Publishing date	2019-03-08
Publishing country	England
Document type	Case Reports ; Journal Article
ISSN	1471-2334
ISSN (online)	1471-2334
DOI	10.1186/s12879-019-3863-0
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Article ; Online: Pregnancies after transjugular intrahepatic portosystemic shunt for noncirrhotic portal hypertension.

Nicolas, Charlotte / Ferrand, Emma / d'Alteroche, Louis / Ayoub, Jean / Bastides, Frederic / Potin, Jerome / Perarnau, Jean-Marc

European journal of gastroenterology & hepatology

2014 Volume 26, Issue 4, Page(s) 488–490

Abstract: With the growing role of transjugular intrahepatic portosystemic shunt (TIPS) in the management of portal hypertension complications, a number of women of childbearing age are now being treated with TIPS. However, if pregnancy is unusual in patients with ...

Abstract	With the growing role of transjugular intrahepatic portosystemic shunt (TIPS) in the management of portal hypertension complications, a number of women of childbearing age are now being treated with TIPS. However, if pregnancy is unusual in patients with cirrhosis, it can occur in the case of noncirrhotic portal hypertension. To our knowledge, there are no data on pregnancy safety after TIPS insertion. We report the first case of a patient with noncirrhotic portal hypertension treated by TIPS who had two successful pregnancies. She presented with HIV-associated obliterative portopathy with recurrent variceal bleeding treated by TIPS. Pregnancies occurred later and progressed normally without maternal or fetal morbidity. There was no effect on TIPS patency, but only a moderate increase in the flow velocity in the portal vein, the stent, and the hepatic artery. Thus, TIPS does not seem to impair progression of pregnancy.
MeSH term(s)	Adult ; Female ; HIV Infections/complications ; Humans ; Hypertension, Portal/diagnosis ; Hypertension, Portal/etiology ; Hypertension, Portal/surgery ; Live Birth ; Portasystemic Shunt, Transjugular Intrahepatic ; Pregnancy
Language	English
Publishing date	2014-04
Publishing country	England
Document type	Case Reports ; Journal Article
ZDB-ID	1034239-4
ISSN	1473-5687 ; 0954-691X
ISSN (online)	1473-5687
ISSN	0954-691X
DOI	10.1097/MEG.0000000000000048
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Article: Evaluation of Doppler-ultrasonography in the diagnosis of transjugular intrahepatic portosystemic shunt dysfunction: A prospective study.

Nicolas, Charlotte / Le Gouge, Amélie / d'Alteroche, Louis / Ayoub, Jean / Georgescu, Monica / Vidal, Vincent / Castaing, Denis / Cercueil, Jean-Pierre / Chevallier, Patrick / Roumy, Jérôme / Trillaud, Hervé / Boyer, Louis / Le Pennec, Vincent / Perret, Christophe / Giraudeau, Bruno / Perarnau, Jean-Marc / Stic-Tips Group

World journal of hepatology

2017 Volume 9, Issue 27, Page(s) 1125–1132

Abstract: Aim: To prospectively evaluate the performance of Doppler-ultrasonography (US) for the detection of transjugular intrahepatic portosystemic shunt (TIPS) dysfunction within a multicenter cohort of cirrhotic patients.: Methods: This study was conducted ...

Abstract	Aim: To prospectively evaluate the performance of Doppler-ultrasonography (US) for the detection of transjugular intrahepatic portosystemic shunt (TIPS) dysfunction within a multicenter cohort of cirrhotic patients. Methods: This study was conducted in 10 french teaching hospitals. After TIPS insertion, angiography and liver Doppler-US were carried out every six months to detect dysfunction (defined by a portosystemic gradient ≥ 12 mmHg and/or a stent stenosis ≥ 50%). The association between ultrasonographic signs and dysfunction was studied by logistic random-effects models, and the diagnostic performance of each Doppler criterion was estimated by the bootstrap method. This study was approved by the ethics committee of Tours. Results: Two hundred and eighteen pairs of examinations performed on 87 cirrhotic patients were analyzed. Variables significantly associated with dysfunction were: The speed of flow in the portal vein ( Conclusion: The performance of Doppler-US for the detection of TIPS dysfunction is poor compared to angiography. New tools are needed to improve diagnosis of TIPS dysfunction.
Language	English
Publishing date	2017-09-08
Publishing country	United States
Document type	Journal Article
ZDB-ID	2573703-X
ISSN	1948-5182
ISSN	1948-5182
DOI	10.4254/wjh.v9.i27.1125
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Article ; Online: Covered vs. uncovered stents for transjugular intrahepatic portosystemic shunt: a randomized controlled trial.

Perarnau, Jean Marc / Le Gouge, Amélie / Nicolas, Charlotte / d'Alteroche, Louis / Borentain, Patrick / Saliba, Faouzi / Minello, Anne / Anty, Rodolphe / Chagneau-Derrode, Carine / Bernard, Pierre Henri / Abergel, Armand / Ollivier-Hourmand, Isabelle / Gournay, Jérome / Ayoub, Jean / Gaborit, Christophe / Rusch, Emmanuel / Giraudeau, Bruno

Journal of hepatology

2014 Volume 60, Issue 5, Page(s) 962–968

Abstract: Background & aims: The first studies comparing covered stents (CS) and bare stents (BS) to achieve Transjugular Intrahepatic Portosystemic Shunt (TIPS) were in favor of CS, but only one randomized study has been performed. Our aim was to compare the ... ...

Abstract	Background & aims: The first studies comparing covered stents (CS) and bare stents (BS) to achieve Transjugular Intrahepatic Portosystemic Shunt (TIPS) were in favor of CS, but only one randomized study has been performed. Our aim was to compare the primary patency of TIPS performed with CS and BS. Methods: The study was planned as a multicenter, pragmatic (with centers different in size and experience), randomized, single-blinded (with blinding of patients only), parallel group trial. The primary endpoint was TIPS dysfunction defined as either a portocaval gradient ⩾12mmHg, or a stent lumen stenosis ⩾50%. A transjugular angiography with portosystemic pressure gradient measurement was scheduled every 6months after TIPS insertion. Results: 137 patients were randomized: 66 to receive CS, and 71 BS. Patients who were found to have a hepato-cellular carcinoma, or whose procedure was cancelled were excluded, giving a sample of 129 patients (62 vs. 67). Median follow-up for CS and BS were 23.6 and 21.8months, respectively. Compared to BS, the risk of TIPS dysfunction with CS was 0.60 95% CI [0.38-0.96], (p=0.032). The 2-year rate of shunt dysfunction was 44.0% for CS vs. 63.6% for BS. Early post TIPS complications (22.4% vs. 34.9%), risk of hepatic encephalopathy (0.89 [0.53-1.49]) and 2-year survival (70% vs. 67.5%) did not differ in the two groups. The 2-year cost/patient was 20k€ [15.9-27.5] for CS vs. 23.4k€ [18-37] for BS (p=0.52). Conclusions: CS provided a significant 39% reduction in dysfunction compared to BS. We did not observe any significant difference with regard to hepatic encephalopathy or death.
MeSH term(s)	Aged ; Ascites/etiology ; Ascites/surgery ; Carcinoma, Hepatocellular/etiology ; Esophageal and Gastric Varices/etiology ; Esophageal and Gastric Varices/surgery ; Female ; Hepatic Encephalopathy/etiology ; Humans ; Hypertension, Portal/complications ; Hypertension, Portal/surgery ; Kaplan-Meier Estimate ; Liver Neoplasms/etiology ; Liver Transplantation ; Male ; Middle Aged ; Portasystemic Shunt, Transjugular Intrahepatic/adverse effects ; Portasystemic Shunt, Transjugular Intrahepatic/instrumentation ; Portasystemic Shunt, Transjugular Intrahepatic/methods ; Recurrence ; Single-Blind Method ; Stents/adverse effects ; Treatment Outcome
Language	English
Publishing date	2014-05
Publishing country	Netherlands
Document type	Journal Article ; Multicenter Study ; Pragmatic Clinical Trial ; Randomized Controlled Trial ; Research Support, Non-U.S. Gov't
ZDB-ID	605953-3
ISSN	1600-0641 ; 0168-8278
ISSN (online)	1600-0641
ISSN	0168-8278
DOI	10.1016/j.jhep.2014.01.015
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