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  1. Article ; Online: Hypoxiebasierte Deeskalation der Radiochemotherapie bei Patienten mit Humanem-Papillomavirus-assoziiertem Oropharynxkarzinom.

    Rühle, Alexander / Nicolay, Nils H

    Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al

    2024  Volume 200, Issue 5, Page(s) 453–456

    Title translation Hypoxia-based de-escalation of radiochemotherapy in patients with human papillomavirus-related oropharyngeal carcinoma.
    MeSH term(s) Humans ; Oropharyngeal Neoplasms/virology ; Oropharyngeal Neoplasms/therapy ; Chemoradiotherapy ; Papillomavirus Infections ; Male ; Middle Aged ; Female ; Aged ; Carcinoma, Squamous Cell/therapy ; Human Papillomavirus Viruses
    Language German
    Publishing date 2024-02-23
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 84983-2
    ISSN 1439-099X ; 0179-7158 ; 0039-2073
    ISSN (online) 1439-099X
    ISSN 0179-7158 ; 0039-2073
    DOI 10.1007/s00066-024-02215-9
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Vorasidenib bei niedriggradigen Gliomen – neues Therapieprinzip mit offenen Fragen zu den Langzeitergebnissen.

    Seidel, Clemens / Nicolay, Nils H

    Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al

    2023  Volume 200, Issue 2, Page(s) 178–180

    Title translation Vorasidenib for low-grade gliomas-new treatment option with unanswered questions regarding long-term outcomes.
    MeSH term(s) Humans ; Brain Neoplasms/drug therapy ; Brain Neoplasms/radiotherapy ; Diamines/adverse effects ; Diamines/therapeutic use ; Glioma/drug therapy ; Pyridines/adverse effects ; Pyridines/therapeutic use
    Chemical Substances Diamines ; Pyridines ; vorasidenib
    Language German
    Publishing date 2023-11-20
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 84983-2
    ISSN 1439-099X ; 0179-7158 ; 0039-2073
    ISSN (online) 1439-099X
    ISSN 0179-7158 ; 0039-2073
    DOI 10.1007/s00066-023-02179-2
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Re-Bestrahlung und Bevacizumab – wirksame Partner bei rezidiviertem Glioblastom.

    Seidel, Clemens / Nicolay, Nils H

    Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al

    2023  Volume 199, Issue 6, Page(s) 604–606

    Title translation Re-irradiation and Bevacizumab - active combination for treatment of recurrent glioblastoma.
    MeSH term(s) Humans ; Bevacizumab/therapeutic use ; Glioblastoma/radiotherapy ; Re-Irradiation ; Neoplasm Recurrence, Local/radiotherapy ; Glioma/therapy ; Brain Neoplasms/radiotherapy ; Chronic Disease
    Chemical Substances Bevacizumab (2S9ZZM9Q9V)
    Language German
    Publishing date 2023-04-20
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 84983-2
    ISSN 1439-099X ; 0179-7158 ; 0039-2073
    ISSN (online) 1439-099X
    ISSN 0179-7158 ; 0039-2073
    DOI 10.1007/s00066-023-02084-8
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  4. Article ; Online: Die Rolle der Chemotherapie im Kontext der Bestrahlung beim Nasopharynxkarzinom: Update der MAC-NPC-Netzwerk-Metaanalyse.

    Rühle, Alexander / Nicolay, Nils H

    Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al

    2023  Volume 200, Issue 1, Page(s) 99–102

    Title translation Role of chemotherapy in radiotherapy-treated nasopharynx carcinoma: update of the MAC-NPC network meta-analysis.
    MeSH term(s) Humans ; Network Meta-Analysis ; Nasopharyngeal Carcinoma ; Nasopharyngeal Neoplasms/radiotherapy ; Nasopharynx
    Language German
    Publishing date 2023-10-19
    Publishing country Germany
    Document type Meta-Analysis ; Journal Article
    ZDB-ID 84983-2
    ISSN 1439-099X ; 0179-7158 ; 0039-2073
    ISSN (online) 1439-099X
    ISSN 0179-7158 ; 0039-2073
    DOI 10.1007/s00066-023-02164-9
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  5. Article ; Online: Deeskalation der adjuvanten Radiotherapie nach transoraler Resektion HPV-positiver Oropharynxkarzinome: Ergebnisse der E3311-Studie.

    Rühle, Alexander / Nicolay, Nils H

    Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al

    2022  Volume 198, Issue 4, Page(s) 400–403

    Title translation De-escalation of adjuvant radiotherapy after transoral surgery of HPV-associated oropharyngeal cancer: results of the E3311 trial.
    MeSH term(s) Humans ; Oropharyngeal Neoplasms/surgery ; Papillomaviridae ; Papillomavirus Infections/complications ; Radiotherapy, Adjuvant/methods
    Language German
    Publishing date 2022-02-08
    Publishing country Germany
    Document type Journal Article ; Comment
    ZDB-ID 84983-2
    ISSN 1439-099X ; 0179-7158 ; 0039-2073
    ISSN (online) 1439-099X
    ISSN 0179-7158 ; 0039-2073
    DOI 10.1007/s00066-022-01907-4
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  6. Article ; Online: Wöchentliche versus dreiwöchentliche Cisplatingabe bei der postoperativen Radiochemotherapie von lokal fortgeschrittenen Kopf-Hals-Plattenepithelkarzinomen – Ergebnisse der JCOG1008-Studie.

    Rühle, Alexander / Nicolay, Nils H

    Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al

    2022  Volume 198, Issue 10, Page(s) 966–969

    Title translation Weekly versus three-weekly cisplatin for the postoperative chemoradiation of locally advanced head-and-neck squamous cell carcinoma: results of the JCOG1008 trial.
    MeSH term(s) Antineoplastic Agents/therapeutic use ; Antineoplastic Combined Chemotherapy Protocols/therapeutic use ; Chemoradiotherapy/methods ; Cisplatin ; Head and Neck Neoplasms ; Humans ; Squamous Cell Carcinoma of Head and Neck/therapy
    Chemical Substances Antineoplastic Agents ; Cisplatin (Q20Q21Q62J)
    Language German
    Publishing date 2022-06-20
    Publishing country Germany
    Document type Clinical Trial ; Journal Article ; Comment
    ZDB-ID 84983-2
    ISSN 1439-099X ; 0179-7158 ; 0039-2073
    ISSN (online) 1439-099X
    ISSN 0179-7158 ; 0039-2073
    DOI 10.1007/s00066-022-01970-x
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  7. Article ; Online: Aggressive Deeskalation der Strahlentherapie bei HPV-assoziierten Oropharynxkarzinomen auf der Basis der Hypoxiedynamik.

    Rühle, Alexander / Nicolay, Nils H

    Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al

    2021  Volume 197, Issue 6, Page(s) 570–573

    Title translation Aggressive radiotherapy de-escalation for HPV-associated oropharyngeal carcinoma based on hypoxia dynamics.
    MeSH term(s) Carcinoma ; Chemoradiotherapy ; Humans ; Hypoxia ; Oropharyngeal Neoplasms ; Papillomavirus Infections
    Language German
    Publishing date 2021-03-25
    Publishing country Germany
    Document type Journal Article ; Comment
    ZDB-ID 84983-2
    ISSN 1439-099X ; 0179-7158 ; 0039-2073
    ISSN (online) 1439-099X
    ISSN 0179-7158 ; 0039-2073
    DOI 10.1007/s00066-021-01765-6
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  8. Article ; Online: Moderate Dosisdeeskalation der definitiven Cisplatin-basierten Radiochemotherapie für HPV-positive Oropharynxkarzinompatienten : Ergebnisse der NRG-HN002-Studie.

    Rühle, Alexander / Nicolay, Nils H

    Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al

    2021  Volume 197, Issue 10, Page(s) 950–952

    Title translation Moderate dose de-escalation of cisplatin-based chemoradiation for HPV-associated oropharyngeal carcinoma : Results of the NRG-HN002 trial.
    MeSH term(s) Carcinoma ; Chemoradiotherapy/methods ; Cisplatin ; Humans ; Oropharyngeal Neoplasms/pathology ; Oropharyngeal Neoplasms/therapy ; Papillomavirus Infections
    Chemical Substances Cisplatin (Q20Q21Q62J)
    Language German
    Publishing date 2021-07-26
    Publishing country Germany
    Document type Journal Article ; Comment
    ZDB-ID 84983-2
    ISSN 1439-099X ; 0179-7158 ; 0039-2073
    ISSN (online) 1439-099X
    ISSN 0179-7158 ; 0039-2073
    DOI 10.1007/s00066-021-01823-z
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  9. Article ; Online: Decision regret of cancer patients after radiotherapy: results from a cross-sectional observational study at a large tertiary cancer center in Germany.

    Rühle, Alexander / Wieland, Leonie / Hinz, Andreas / Mehnert-Theuerkauf, Anja / Nicolay, Nils H / Seidel, Clemens

    Journal of cancer research and clinical oncology

    2024  Volume 150, Issue 3, Page(s) 167

    Abstract: Purpose: The decision-making process regarding cancer treatment is emotionally challenging for patients and families, harboring the risk of decision regret. We aimed to explore prevalence and determinants of decision regret following radiotherapy.: ... ...

    Abstract Purpose: The decision-making process regarding cancer treatment is emotionally challenging for patients and families, harboring the risk of decision regret. We aimed to explore prevalence and determinants of decision regret following radiotherapy.
    Methods: This cross-sectional observational study was conducted at a tertiary cancer center to assess decision regret following radiotherapy. The study employed the German version of the Ottawa Decision Regret Scale (DRS) which was validated in the study population. Decision regret was categorized as absent (0 points), mild (1-25 points), and strong (> 25 points). Various psychosocial outcome measures were collected using validated questionnaires to identify factors that may be associated with decision regret.
    Results: Out of 320 eligible patients, 212 participated, with 207 completing the DRS. Median age at start of radiotherapy was 64 years [interquartile range (IQR), 56-72], genders were balanced (105 female, 102 male), and the most common cancer types were breast (n = 84; 41%), prostate (n = 57; 28%), and head-and-neck cancer (n = 19; 9%). Radiotherapy was applied with curative intention in 188 patients (91%). Median time between last radiotherapy fraction and questionnaire completion was 23 months (IQR, 1-38). DRS comprehensibility was rated as good or very good by 98% (196 of 201) of patients. Decision regret was reported by 43% (n = 90) as absent, 38% (n = 78) as mild, and 18% (n = 38) as strong. In the multiple regression analysis, poor Eastern Cooperative Oncology Group performance status, low social support, and dissatisfaction with care were independent risk factors for higher decision regret after radiotherapy.
    Conclusions: The German version of the DRS could be used to assess decision regret in a diverse cohort of cancer patients undergoing radiotherapy. Decision regret was prevalent in a considerable proportion of patients. Further studies are necessary to validate these findings and obtain causal factors associated with decision regret after radiotherapy.
    MeSH term(s) Female ; Humans ; Male ; Middle Aged ; Cross-Sectional Studies ; Decision Making ; Emotions ; Neoplasms/radiotherapy ; Risk Factors ; Aged
    Language English
    Publishing date 2024-03-28
    Publishing country Germany
    Document type Observational Study ; Journal Article
    ZDB-ID 134792-5
    ISSN 1432-1335 ; 0171-5216 ; 0084-5353 ; 0943-9382
    ISSN (online) 1432-1335
    ISSN 0171-5216 ; 0084-5353 ; 0943-9382
    DOI 10.1007/s00432-024-05638-0
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  10. Article ; Online: Authors' response to the Letter to the Editor by Efsun Somay and Erkan Topkan regarding our study "The influence of antibiotic administration on the outcomes of head-and-neck squamous cell carcinoma patients undergoing definitive (chemo)radiation".

    Rühle, Alexander / Zou, Jiadai / Popp, Ilinca / Nicolay, Nils H

    European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery

    2023  Volume 280, Issue 6, Page(s) 3043–3044

    MeSH term(s) Humans ; Squamous Cell Carcinoma of Head and Neck/therapy ; Head and Neck Neoplasms/radiotherapy ; Carcinoma, Squamous Cell/therapy ; Carcinoma, Squamous Cell/pathology ; Anti-Bacterial Agents
    Chemical Substances Anti-Bacterial Agents
    Language English
    Publishing date 2023-04-13
    Publishing country Germany
    Document type Letter ; Comment
    ZDB-ID 1017359-6
    ISSN 1434-4726 ; 0937-4477
    ISSN (online) 1434-4726
    ISSN 0937-4477
    DOI 10.1007/s00405-023-07960-8
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