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  1. Article: Real-World Safety Data of the Orphan Drug Onasemnogene Abeparvovec (Zolgensma

    Ruggiero, Rosanna / Balzano, Nunzia / Nicoletti, Maria Maddalena / di Mauro, Gabriella / Fraenza, Federica / Campitiello, Maria Rosaria / Rossi, Francesco / Capuano, Annalisa

    Pharmaceuticals (Basel, Switzerland)

    2024  Volume 17, Issue 3

    Abstract: The recent introduction of the innovative therapy, onasemnogene abeparvovec ( ... ...

    Abstract The recent introduction of the innovative therapy, onasemnogene abeparvovec (Zolgensma
    Language English
    Publishing date 2024-03-19
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2193542-7
    ISSN 1424-8247
    ISSN 1424-8247
    DOI 10.3390/ph17030394
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Multiple Foci of Basal Cell Carcinoma Arising in Rhinophyma: A Case Report and Literature Review.

    Faenza, Mario / Molle, Marcello / Ronchi, Andrea / Pagliuca, Francesca / Pelella, Tommaso / Nicoletti, Maria Maddalena / Crisci, Erminia / Pieretti, Gorizio / Ferraro, Giuseppe Andrea

    JPRAS open

    2023  Volume 38, Page(s) 186–192

    Abstract: Background: Rhinophyma is a benign condition caused by the excessive growth of sebaceous glands in the nasal tissue, presenting with symptoms such as nasal hypertrophy, erythema, and papules. Cases of basal cell carcinoma in rhinophyma have been ... ...

    Abstract Background: Rhinophyma is a benign condition caused by the excessive growth of sebaceous glands in the nasal tissue, presenting with symptoms such as nasal hypertrophy, erythema, and papules. Cases of basal cell carcinoma in rhinophyma have been reported in literature, but its etiological role remains unclear. It is uncertain whether rhinophyma is predisposed to neoplasm development or if their coexistence is coincidental.
    Material and method: We conducted a literature survey to identify such cases reported over the years.
    Results: We identified 22 studies reporting a total of 47 cases in the literature, all involving male patients. The most common pattern of occurrence was the rapid growth of a nodular formation within the context of rhinophyma.
    Discussions and conclusion: The elucidation of the association between basal cell carcinoma and rhinophyma remains challenging. The presence of multiple foci supports the theory that rhinophyma may play a role in their development, but larger studies are needed to establish a causal relationship.
    Language English
    Publishing date 2023-10-05
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 2834721-3
    ISSN 2352-5878 ; 2352-5878
    ISSN (online) 2352-5878
    ISSN 2352-5878
    DOI 10.1016/j.jpra.2023.10.001
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Immune Checkpoint Inhibitors and Scleroderma: Data from the European Pharmacovigilance Database.

    Nicoletti, Maria Maddalena / Crisci, Erminia / Cosenza, Vincenzo / Riccardi, Consiglia / Campitiello, Maria Rosaria / Ruggiero, Donatella / Berrino, Pasquale Maria / Docimo, Giovanni / Scavone, Cristina

    Drugs - real world outcomes

    2023  Volume 11, Issue 1, Page(s) 33–41

    Abstract: Background: Immune checkpoint inhibitors (ICIs) can be commonly associated with the occurrence of immune-related adverse drug reactions (irADRs), which can involve any tissue and organ. ICI-induced skin toxicities are common irADRs and they can be a ... ...

    Abstract Background: Immune checkpoint inhibitors (ICIs) can be commonly associated with the occurrence of immune-related adverse drug reactions (irADRs), which can involve any tissue and organ. ICI-induced skin toxicities are common irADRs and they can be a consequence of a rheumatologic ADR, such as in the case of scleroderma. A recent literature review reported that scleroderma and scleroderma mimics represent a group of disorders with significant morbidity that have been described during ICIs' use.
    Objective and methods: Considering the clinical significance of scleroderma cases, the present study aimed to analyze the occurrence of these events in patients receiving ICIs by describing data from individual case safety reports (ICSRs) retrieved from the European spontaneous reporting system, EudraVigilance (EV).
    Results: Until February 2023, 70 ICSRs with at least one ICI as the suspected drug and at least one preferred term (PT) related to scleroderma cases were retrieved from the EV. Pembrolizumab was reported as suspected in 41 ICSRs, nivolumab in 25 ICSRs, ipilimumab in 8 ICSRs and atezolizumab in 3 ICSRs. Patients who experienced scleroderma cases were adults, and no differences were found in terms of sex distribution. Scleroderma cases were mainly classified as serious, while the outcome was mainly reported as favorable. The most reported PTs were scleroderma and morphea.
    Conclusions: Considering the seriousness of ICI-induced scleroderma cases and the recent marketing authorization of some ICIs, we believe that further high-quality clinical studies should be conducted on this topic to better estimate the impact of these events in patients with cancer.
    Language English
    Publishing date 2023-10-31
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2806600-5
    ISSN 2198-9788 ; 2199-1154
    ISSN (online) 2198-9788
    ISSN 2199-1154
    DOI 10.1007/s40801-023-00399-7
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Training in Vascular Microsurgery: The Ex Vivo Biological Model on Domestic Turkey Leg (

    La Torre, Francesca / Manfellotto, Vincenzo / Mazzarella, Vincenzo / Sorbino, Luigi / D'Alessio, Matteo / Petroccione, Carlo / Nicoletti, Maria Maddalena / Ferraro, Giuseppe Andrea / Pieretti, Gorizio

    Plastic and reconstructive surgery. Global open

    2024  Volume 12, Issue 4, Page(s) e5733

    Abstract: There are various models for practicing microsurgical anastomoses, from synthetic to ex vivo and in vivo biological ones. In this study, we present the domestic turkey ( ...

    Abstract There are various models for practicing microsurgical anastomoses, from synthetic to ex vivo and in vivo biological ones. In this study, we present the domestic turkey (
    Language English
    Publishing date 2024-04-10
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2851682-5
    ISSN 2169-7574 ; 2169-7574
    ISSN (online) 2169-7574
    ISSN 2169-7574
    DOI 10.1097/GOX.0000000000005733
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 7091: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
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  5. Article: Preclinical and Clinical Epigenetic-Based Reconsideration of Beckwith-Wiedemann Syndrome.

    Papulino, Chiara / Chianese, Ugo / Nicoletti, Maria Maddalena / Benedetti, Rosaria / Altucci, Lucia

    Frontiers in genetics

    2020  Volume 11, Page(s) 563718

    Abstract: Epigenetics has achieved a profound impact in the biomedical field, providing new experimental opportunities and innovative therapeutic strategies to face a plethora of diseases. In the rare ... ...

    Abstract Epigenetics has achieved a profound impact in the biomedical field, providing new experimental opportunities and innovative therapeutic strategies to face a plethora of diseases. In the rare diseases
    Language English
    Publishing date 2020-09-15
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2606823-0
    ISSN 1664-8021
    ISSN 1664-8021
    DOI 10.3389/fgene.2020.563718
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Skin Toxicities Associated with Botulin Toxin Injection for Aesthetic Procedures: Data from the European Spontaneous Reporting System.

    Nicoletti, Maria Maddalena / Anatriello, Antonietta / Liguori, Valerio / Cantone, Andrea / di Mauro, Gabriella / Izzo, Imma / Lettera, Nicoletta / Della Ragione, Joao Marcos / Campitiello, Maria Rosaria / Cosenza, Vincenzo / Scavone, Cristina

    Pharmaceuticals (Basel, Switzerland)

    2023  Volume 16, Issue 11

    Abstract: Botulinum toxin is a protein deriving from the ... ...

    Abstract Botulinum toxin is a protein deriving from the bacteria
    Language English
    Publishing date 2023-11-15
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2193542-7
    ISSN 1424-8247
    ISSN 1424-8247
    DOI 10.3390/ph16111611
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: HDAC6 Inhibition Extinguishes Autophagy in Cancer: Recent Insights.

    Passaro, Eugenia / Papulino, Chiara / Chianese, Ugo / Toraldo, Antonella / Congi, Raffaella / Del Gaudio, Nunzio / Nicoletti, Maria Maddalena / Benedetti, Rosaria / Altucci, Lucia

    Cancers

    2021  Volume 13, Issue 24

    Abstract: Autophagy is an essential intracellular catabolic mechanism involved in the degradation and recycling of damaged organelles regulating cellular homeostasis and energy metabolism. Its activation enhances cellular tolerance to various stresses and is known ...

    Abstract Autophagy is an essential intracellular catabolic mechanism involved in the degradation and recycling of damaged organelles regulating cellular homeostasis and energy metabolism. Its activation enhances cellular tolerance to various stresses and is known to be involved in drug resistance. In cancer, autophagy has a dual role in either promoting or blocking tumorigenesis, and recent studies indicate that epigenetic regulation is involved in its mechanism of action in this context. Specifically, the ubiquitin-binding histone deacetylase (HDAC) enzyme HDAC6 is known to be an important player in modulating autophagy. Epigenetic modulators, such as HDAC inhibitors, mediate this process in different ways and are already undergoing clinical trials. In this review, we describe current knowledge on the role of epigenetic modifications, particularly HDAC-mediated modifications, in controlling autophagy in cancer. We focus on the controversy surrounding their ability to promote or block tumor progression and explore the impact of HDAC6 inhibitors on autophagy modulation in cancer. In light of the fact that targeted drug therapy for cancer patients is attracting ever increasing interest within the research community and in society at large, we discuss the possibility of using HDAC6 inhibitors as adjuvants and/or in combination with conventional treatments to overcome autophagy-related mechanisms of resistance.
    Language English
    Publishing date 2021-12-14
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2527080-1
    ISSN 2072-6694
    ISSN 2072-6694
    DOI 10.3390/cancers13246280
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Prostaglandin E2/EP4 axis is upregulated in Spondyloarthritis and contributes to radiographic progression.

    Mauro, Daniele / Srinath, Archita / Guggino, Giuliana / Nicolaidou, Vicky / Raimondo, Stefania / Ellis, Jonathan J / Whyte, Jessica / Nicoletti, Maria Maddalena / Romano, Marco / Kenna, Tony John / Cañete, Juan D / Alessandro, Riccardo / Rizzo, Aroldo / Brown, Matthew Arthur / Horwood, Nicole J / Haroon, Nigil / Ciccia, Francesco

    Clinical immunology (Orlando, Fla.)

    2023  Volume 251, Page(s) 109332

    Abstract: Ankylosing spondylitis (AS) is an inflammatory disease leading to spine ankylosis; however, the mechanisms behind new bone formation are still not fully understood. Single Nucleotide Polymorphisms (SNPs) in PTGER4, encoding for the receptor EP4 of ... ...

    Abstract Ankylosing spondylitis (AS) is an inflammatory disease leading to spine ankylosis; however, the mechanisms behind new bone formation are still not fully understood. Single Nucleotide Polymorphisms (SNPs) in PTGER4, encoding for the receptor EP4 of prostaglandin E2 (PGE2), are associated with AS. Since the PGE2-EP4 axis participates in inflammation and bone metabolism, this work aims at investigating the influence of the prostaglandin-E2 axis on radiographic progression in AS. In 185 AS (97 progressors), baseline serum PGE2 predicted progression, and PTGER4 SNP rs6896969 was more frequent in progressors. Increased EP4/PTGER4 expression was observed in AS circulating immune cells, synovial tissue, and bone marrow. CD14highEP4 + cells frequency correlated with disease activity, and when monocytes were cocultured with mesenchymal stem cells, the PGE2/EP4 axis induced bone formation. In conclusion, the Prostaglandin E2 axis is involved in bone remodelling and may contribute to the radiographic progression in AS due to genetic and environmental upregulation.
    MeSH term(s) Humans ; Dinoprostone ; Receptors, Prostaglandin E, EP4 Subtype/genetics ; Receptors, Prostaglandin E, EP4 Subtype/metabolism ; Spondylitis, Ankylosing/diagnostic imaging ; Spondylitis, Ankylosing/genetics
    Chemical Substances Dinoprostone (K7Q1JQR04M) ; Receptors, Prostaglandin E, EP4 Subtype
    Language English
    Publishing date 2023-04-17
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1459903-x
    ISSN 1521-7035 ; 1521-6616
    ISSN (online) 1521-7035
    ISSN 1521-6616
    DOI 10.1016/j.clim.2023.109332
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 880: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  9. Article ; Online: Histone lysine demethylase inhibition reprograms prostate cancer metabolism and mechanics.

    Chianese, Ugo / Papulino, Chiara / Passaro, Eugenia / Evers, Tom Mj / Babaei, Mehrad / Toraldo, Antonella / De Marchi, Tommaso / Niméus, Emma / Carafa, Vincenzo / Nicoletti, Maria Maddalena / Del Gaudio, Nunzio / Iaccarino, Nunzia / Randazzo, Antonio / Rotili, Dante / Mai, Antonello / Cappabianca, Salvatore / Mashaghi, Alireza / Ciardiello, Fortunato / Altucci, Lucia /
    Benedetti, Rosaria

    Molecular metabolism

    2022  Volume 64, Page(s) 101561

    Abstract: Objective: Aberrant activity of androgen receptor (AR) is the primary cause underlying development and progression of prostate cancer (PCa) and castration-resistant PCa (CRPC). Androgen signaling regulates gene transcription and lipid metabolism, ... ...

    Abstract Objective: Aberrant activity of androgen receptor (AR) is the primary cause underlying development and progression of prostate cancer (PCa) and castration-resistant PCa (CRPC). Androgen signaling regulates gene transcription and lipid metabolism, facilitating tumor growth and therapy resistance in early and advanced PCa. Although direct AR signaling inhibitors exist, AR expression and function can also be epigenetically regulated. Specifically, lysine (K)-specific demethylases (KDMs), which are often overexpressed in PCa and CRPC phenotypes, regulate the AR transcriptional program.
    Methods: We investigated LSD1/UTX inhibition, two KDMs, in PCa and CRPC using a multi-omics approach. We first performed a mitochondrial stress test to evaluate respiratory capacity after treatment with MC3324, a dual KDM-inhibitor, and then carried out lipidomic, proteomic, and metabolic analyses. We also investigated mechanical cellular properties with acoustic force spectroscopy.
    Results: MC3324 induced a global increase in H3K4me2 and H3K27me3 accompanied by significant growth arrest and apoptosis in androgen-responsive and -unresponsive PCa systems. LSD1/UTX inhibition downregulated AR at both transcriptional and non-transcriptional level, showing cancer selectivity, indicating its potential use in resistance to androgen deprivation therapy. Since MC3324 impaired metabolic activity, by modifying the protein and lipid content in PCa and CRPC cell lines. Epigenetic inhibition of LSD1/UTX disrupted mitochondrial ATP production and mediated lipid plasticity, which affected the phosphocholine class, an important structural element for the cell membrane in PCa and CRPC associated with changes in physical and mechanical properties of cancer cells.
    Conclusions: Our data suggest a network in which epigenetics, hormone signaling, metabolite availability, lipid content, and mechano-metabolic process are closely related. This network may be able to identify additional hotspots for pharmacological intervention and underscores the key role of KDM-mediated epigenetic modulation in PCa and CRPC.
    MeSH term(s) Androgen Antagonists/therapeutic use ; Androgens/metabolism ; Gene Expression Regulation, Neoplastic ; Histone Demethylases/genetics ; Histone Demethylases/metabolism ; Humans ; Lipids ; Male ; Prostatic Neoplasms, Castration-Resistant/drug therapy ; Prostatic Neoplasms, Castration-Resistant/genetics ; Prostatic Neoplasms, Castration-Resistant/pathology ; Proteomics
    Chemical Substances Androgen Antagonists ; Androgens ; Lipids ; Histone Demethylases (EC 1.14.11.-)
    Language English
    Publishing date 2022-08-06
    Publishing country Germany
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2708735-9
    ISSN 2212-8778 ; 2212-8778
    ISSN (online) 2212-8778
    ISSN 2212-8778
    DOI 10.1016/j.molmet.2022.101561
    Database MEDical Literature Analysis and Retrieval System OnLINE

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