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Article ; Online: The Impact of Exercise on Telomere Length, DNA Methylation and Metabolic Footprints.

Haupt, Sandra / Niedrist, Tobias / Sourij, Harald / Schwarzinger, Stephan / Moser, Othmar

2022 Volume 11, Issue 1

Abstract: Aging as a major risk factor influences the probability of developing cancer, cardiovascular disease and diabetes, amongst others. The underlying mechanisms of disease are still not fully understood, but research suggests that delaying the aging process ... ...

Abstract	Aging as a major risk factor influences the probability of developing cancer, cardiovascular disease and diabetes, amongst others. The underlying mechanisms of disease are still not fully understood, but research suggests that delaying the aging process could ameliorate these pathologies. A key biological process in aging is cellular senescence which is associated with several stressors such as telomere shortening or enhanced DNA methylation. Telomere length as well as DNA methylation levels can be used as biological age predictors which are able to detect excessive acceleration or deceleration of aging. Analytical methods examining aging are often not suitable, expensive, time-consuming or require a high level of technical expertise. Therefore, research focusses on combining analytical methods which have the potential to simultaneously analyse epigenetic, genomic as well as metabolic changes.
MeSH term(s)	Aged ; Aging/genetics ; Cellular Senescence/genetics ; DNA Methylation/genetics ; Exercise/genetics ; Humans ; Telomere Homeostasis/physiology
Language	English
Publishing date	2022-01-04
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2661518-6
ISSN	2073-4409 ; 2073-4409
ISSN (online)	2073-4409
ISSN	2073-4409
DOI	10.3390/cells11010153
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Comparison of Automated Procalcitonin Immunoassays under Routine Conditions.

Niedrist, Tobias / Mangge, Harald / Herrman, Markus

Clinical laboratory

2021 Volume 67, Issue 1

MeSH term(s)	Calcitonin ; Humans ; Immunoassay ; Procalcitonin
Chemical Substances	Procalcitonin ; Calcitonin (9007-12-9)
Language	English
Publishing date	2021-01-24
Publishing country	Germany
Document type	Letter
ZDB-ID	1307629-2
ISSN	1433-6510 ; 0941-2131
ISSN	1433-6510 ; 0941-2131
DOI	10.7754/Clin.Lab.2020.200457
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Article ; Conference proceedings: Einfluss von sedentärem Verhalten versus physische Aktivität auf den Glukosestoffwechsel bei Personen mit Übergewicht/Adipositas – eine randomisierte kontrollierte Cross-Over-Studie (SEDAKT)

Hoffmann, Sascha / Schierbauer, Janis / Grothoff, Auguste / Wachsmuth, Nadine / Voit, Thomas / Zimmermann, Paul / Lackner, Helmut / Niedrist, Tobias / Moser, Othmar

Diabetologie und Stoffwechsel

(Diabetes Kongress 2024 – 58. Jahrestagung der DDG)

2024 Volume 19, Issue S 01

Event/congress	Diabetes. Umwelt. Leben. Perspektiven aus allen Blickwinkeln, CityCube Berlin, 2024-05-08
Series title	Diabetes Kongress 2024 – 58. Jahrestagung der DDG
Language	German
Publishing date	2024-04-01
Publisher	Georg Thieme Verlag KG
Publishing place	Stuttgart ; New York
Document type	Article ; Conference proceedings
ZDB-ID	2222993-0
ISSN	1861-9010 ; 1861-9002
ISSN (online)	1861-9010
ISSN	1861-9002
DOI	10.1055/s-0044-1785306
Database	Thieme publisher's database

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Zs.A 6479: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular ab Jg. 2022: Lesesaal (EG)
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Article: Soluble Urokinase Plasminogen Activator Receptor (SuPAR) Analysis for Diagnosis of Periprosthetic Joint Infection.

Klim, Sebastian M / Prattes, Jürgen / Amerstorfer, Florian / Niedrist, Tobias / Zurl, Christoph / Stradner, Martin / Dreo, Barbara / Glehr, Gunther / Leithner, Andreas / Glehr, Mathias / Reinbacher, Patrick / Sadoghi, Patrick / Hauer, Georg

Antibiotics (Basel, Switzerland)

2024 Volume 13, Issue 2

Abstract: Soluble urokinase plasminogen activator receptors (suPARs) are a biomarker for inflammatory diseases. This study aims to investigate its diagnostic properties regarding periprosthetic joint infections (PJI). This retrospective cohort study included adult ...

Abstract	Soluble urokinase plasminogen activator receptors (suPARs) are a biomarker for inflammatory diseases. This study aims to investigate its diagnostic properties regarding periprosthetic joint infections (PJI). This retrospective cohort study included adult patients who underwent joint puncture for suspected PJI. The presence of PJI was determined according to the criteria of the European Bone and Joint Infection Society (EBJIS). Laboratory study analyses included the determination of white blood cells (WBC) in whole blood, C-reactive protein (CRP) in blood plasma, and suPAR in both blood plasma and synovial fluid. Appropriate diagnostic cut-off values were identified utilizing Youden's J, and their diagnostic performance was determined by calculating the positive (PPV) and negative predictive value (NPV) for each marker. Sixty-seven cases were included in the final analysis. Forty-three samples (64%) were identified as periprosthetic joint infection (PJI) and twenty-four specimen (36%) were PJI negative cases. The PPV and NPV were 0.80 and 0.70 for synovial suPAR, 0.86 and 0.55 for CRP, 0.84 and 0.31 for WBC and 1.00 and 0.31 for plasma suPAR. Synovial suPAR showed a solid diagnostic performance in this study and has the potential to be an alternative or complementary biomarker for PJI. Further investigations in larger patient collectives are indicated.
Language	English
Publishing date	2024-02-12
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2681345-2
ISSN	2079-6382
ISSN	2079-6382
DOI	10.3390/antibiotics13020179
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Article ; Online: Effects of Different Types of Intermittent Fasting Interventions on Metabolic Health in Healthy Individuals (EDIF): A Randomised Trial with a Controlled-Run in Phase.

Herz, Daniel / Karl, Sebastian / Weiß, Johannes / Zimmermann, Paul / Haupt, Sandra / Zimmer, Rebecca Tanja / Schierbauer, Janis / Wachsmuth, Nadine Bianca / Erlmann, Maximilian Paul / Niedrist, Tobias / Khoramipour, Kayvan / Voit, Thomas / Rilstone, Sian / Sourij, Harald / Moser, Othmar

Nutrients

2024 Volume 16, Issue 8

Abstract: The effects of intermittent fasting (IF) on health promotion in the healthy population remain controversial. Therefore, our study aimed to analyse the efficacy and feasibility of different IF protocols and evaluated the effects within a cohort with a ... ...

Abstract	The effects of intermittent fasting (IF) on health promotion in the healthy population remain controversial. Therefore, our study aimed to analyse the efficacy and feasibility of different IF protocols and evaluated the effects within a cohort with a controlled-run in phase on the body mass index (BMI) as the primary outcome, the body composition, and metabolic and haematological markers in healthy participants. A total of 25 individuals were randomised into three fasting groups: 16/8 fasting (
MeSH term(s)	Humans ; Fasting ; Male ; Female ; Adult ; Body Mass Index ; Body Composition ; Middle Aged ; Young Adult ; Healthy Volunteers ; Body Weight ; Biomarkers/blood ; Blood Glucose/metabolism ; Intermittent Fasting
Chemical Substances	Biomarkers ; Blood Glucose
Language	English
Publishing date	2024-04-10
Publishing country	Switzerland
Document type	Journal Article ; Randomized Controlled Trial
ZDB-ID	2518386-2
ISSN	2072-6643 ; 2072-6643
ISSN (online)	2072-6643
ISSN	2072-6643
DOI	10.3390/nu16081114
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Article ; Online: Decreased response to the mRNA anti-SARS-CoV-2 vaccine in hepatitis B vaccine non-responders and frail patients treated with peritoneal dialysis.

Kolland, Michael / Riedl, Regina / Bachler, Bernhard / Ribitsch, Werner / Niedrist, Tobias / Meissl, Anna-Maria / Rosenkranz, Alexander R / Kirsch, Alexander H

Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association

2022 Volume 37, Issue 6, Page(s) 1188–1190

MeSH term(s)	Aged ; Antibodies, Viral ; COVID-19/prevention & control ; COVID-19 Vaccines/therapeutic use ; Frail Elderly ; Hepatitis B Vaccines ; Humans ; Peritoneal Dialysis ; RNA, Messenger ; Renal Dialysis
Chemical Substances	Antibodies, Viral ; COVID-19 Vaccines ; Hepatitis B Vaccines ; RNA, Messenger
Language	English
Publishing date	2022-02-07
Publishing country	England
Document type	Letter
ZDB-ID	90594-x
ISSN	1460-2385 ; 0931-0509
ISSN (online)	1460-2385
ISSN	0931-0509
DOI	10.1093/ndt/gfac031
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Zs.MO 329: Show issues

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Article: The Impact of a High-Carbohydrate/Low Fat vs. Low-Carbohydrate Diet on Performance and Body Composition in Physically Active Adults: A Cross-Over Controlled Trial

Wachsmuth, Nadine B. / Aberer, Felix / Haupt, Sandra / Schierbauer, Janis R. / Zimmer, Rebecca T. / Eckstein, Max L. / Zunner, Beate / Schmidt, Walter / Niedrist, Tobias / Sourij, Harald / Moser, Othmar

Nutrients. 2022 Jan. 18, v. 14, no. 3

2022

Abstract: Background: Recently, high-carbohydrate or low-carbohydrate (HC/LC) diets have gained substantial popularity, speculated to improve physical performance in athletes; however, the effects of short-term changes of the aforementioned nutritional ... ...

Abstract	Background: Recently, high-carbohydrate or low-carbohydrate (HC/LC) diets have gained substantial popularity, speculated to improve physical performance in athletes; however, the effects of short-term changes of the aforementioned nutritional interventions remain largely unclear. Methods: The present study investigated the impact of a three-week period of HC/low-fat (HC) diet followed by a three-week wash-out-phase and subsequent LC diet on the parameters of physical capacity assessed via cardiopulmonary exercise testing, body composition via bioimpedance analysis and blood profiles, which were assessed after each of the respective diet periods. Twenty-four physically active adults (14 females, age 25.8 ± 3.7 years, body mass index 22.1 ± 2.2 kg/m²), of which six participants served as a control group, were enrolled in the study. Results: After three weeks of each diet, VO₂ₚₑₐₖ was comparable following both interventions (46.8 ± 6.7 (HC) vs. 47.2 ± 6.7 mL/kg/min (LC; p = 0.58)) while a significantly higher peak performance (251 ± 43 W (HC) vs. 240 ± 45 W (LC); (p = 0.0001), longer time to exhaustion (14.5 ± 2.4 min (HC) vs. 14.1 ± 2.4 min (LC); p = 0.002) and greater Watt/kg performance (4.1 ± 0.5 W/kg (HC) vs. 3.9 ± 0.5 W/kg (LC); p = 0.003) was demonstrated after the HC diet. In both trial arms, a significant reduction in body mass (65.2 ± 11.2 to 63.8 ± 11.8 kg (HC) vs. 64.8 ± 11.6 to 63.5 ± 11.3 kg (LC); both p < 0.0001) and fat mass (22.7% to 21.2%; (HC) vs. 22.3% to 20.6% (LC); both p < 0.0001) but not in lean body mass or skeletal muscle mass was shown when compared to baseline. Resting metabolic rate was not different within both groups (p > 0.05). Total cholesterol and LDL-cholesterol significantly decreased after the HC diet (97.9 ± 33.6 mg/dL at baseline to 78.2 ± 23.5 mg/dL; p = 0.02) while triglycerides significantly increased (76 ± 38 mg/dL at baseline to 104 ± 44 mg/dL; p = 0.005). Conclusion: A short-term HC and LC diet showed improvements in various performance parameters in favor of the HC diet. Some parameters of body composition significantly changed during both diets. The HC diet led to a significant reduction in total and LDL-cholesterol while triglycerides significantly increased.
Keywords	bioelectrical impedance ; blood ; body mass index ; body weight ; exercise ; lean body mass ; low carbohydrate diet ; low density lipoprotein cholesterol ; metabolism ; skeletal muscle
Language	English
Dates of publication	2022-0118
Publishing place	Multidisciplinary Digital Publishing Institute
Document type	Article
ZDB-ID	2518386-2
ISSN	2072-6643
ISSN	2072-6643
DOI	10.3390/nu14030423
Database	NAL-Catalogue (AGRICOLA)

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Article: Vancomycin Elution Kinetics of Four Antibiotic Carriers Used in Orthopaedic Surgery: In Vitro Study over 42 Days.

Smolle, Maria Anna / Murtezai, Hana / Niedrist, Tobias / Amerstorfer, Florian / Hörlesberger, Nina / Leitner, Lukas / Klim, Sebastian Martin / Glehr, Reingard / Ahluwalia, Raju / Leithner, Andreas / Glehr, Mathias

Antibiotics (Basel, Switzerland)

2023 Volume 12, Issue 11

Abstract: This study aimed to analyse and compare the vancomycin elution kinetics of four biodegradable, osteoconductive antibiotic carriers used in clinical practice within a 42-day in vitro setting. Carriers A and D already contained vancomycin (1.1 g and 0.247 ... ...

Abstract	This study aimed to analyse and compare the vancomycin elution kinetics of four biodegradable, osteoconductive antibiotic carriers used in clinical practice within a 42-day in vitro setting. Carriers A and D already contained vancomycin (1.1 g and 0.247 g), whereas carriers B and C were mixed with vancomycin according to the manufacturer's recommendations (B: 0.83 g and C: 0.305 g). At nine time points, 50% (4.5 mL) of the elution sample was removed and substituted with the same amount of PBS. Probes were analysed with a kinetic microparticle immunoassay. Time-dependent changes in vancomycin concentrations for each carrier and differences between carriers were analysed. Mean initial antibiotic levels were highest for carrier A (37.5 mg/mL) and lowest for carrier B (5.4 mg/mL). We observed time-dependent, strongly negative linear elution kinetics for carriers A (-0.835;
Language	English
Publishing date	2023-11-17
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2681345-2
ISSN	2079-6382
ISSN	2079-6382
DOI	10.3390/antibiotics12111636
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Article: Changes in cardiac troponins during hemodialysis depend on hemodialysis membrane and modality: a randomized crossover trial.

Kolland, Michael / Amenitsch, Jascha / Schreiber, Nikolaus / Ginthör, Noemi / Schuller, Max / Riedl, Regina / Rainer, Peter P / Schneditz, Daniel / Niedrist, Tobias / Eller, Kathrin / Krietemeyer, Benedikt / Rosenkranz, Alexander R / Kirsch, Alexander H

Clinical kidney journal

2023 Volume 17, Issue 1, Page(s) sfad297

Language	English
Publishing date	2023-12-05
Publishing country	England
Document type	Journal Article
ZDB-ID	2655800-2
ISSN	2048-8513 ; 2048-8505
ISSN (online)	2048-8513
ISSN	2048-8505
DOI	10.1093/ckj/sfad297
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Article ; Online: Soluble urokinase plasminogen activator receptor (suPAR) in bronchoalveolar fluid and blood in critically ill patients-a prospective cohort study.

Reisinger, Alexander C / Hatzl, Stefan / Prattes, Juergen / Hackl, Gerald / Schilcher, Gernot / Eisner, Florian / Niedrist, Tobias / Raggam, Reinhard / Krause, Robert / Eller, Philipp

Infection

2023 Volume 52, Issue 1, Page(s) 249–252

Abstract: Introduction: Soluble urokinase plasminogen activator receptor (suPAR) is a biologically active protein and increased levels are associated with worse outcomes in critically ill patients. suPAR in bronchoalveolar fluid (BALF) may be helpful to ... ...

Abstract	Introduction: Soluble urokinase plasminogen activator receptor (suPAR) is a biologically active protein and increased levels are associated with worse outcomes in critically ill patients. suPAR in bronchoalveolar fluid (BALF) may be helpful to differentiate between types of acute respiratory distress syndrome (ARDS) and may have potential for early detection of fungal infection. Methods: We prospectively investigated levels of suPAR in BALF and serum in critically ill patients who underwent bronchoscopy for any reason at the ICU of the Department of Internal Medicine, Medical University of Graz, Graz, Austria. Results: Seventy-five patients were available for analyses. Median age was 60 [25th-75th percentile: 50-69] years, 27% were female, and median SOFA score was 12 [11-14] points. Serum suPAR levels were significantly associated with ICU mortality in univariable logistic regression analysis. There was no correlation between BALF and serum suPAR. Serum suPAR was higher in ARDS patients at 11.2 [8.0-17.2] ng/mL compared to those without ARDS at 7.1 [3.7-10.1] (p < 0.001). BALF-suPAR was significantly higher in patients with evidence of fungal lung infection compared to patients without fungal infection both in the general cohort (7.6 [3.2-9.4] vs 2.5 [1.1-5.3], p = 0.013) and in the subgroup of ARDS (7.2 [3.1-39.2] vs 2.5 [1.0-5.2], p = 0.022). All patients were classified as putative/probable invasive aspergillosis. Conclusion: We found significant higher levels of serum suPAR in ARDS patients compared to those not fulfilling ARDS criteria. Serum and BALF-suPAR were significantly higher in those patients with evidence for invasive pulmonary aspergillosis. These findings may suggest testing this biomarker for early diagnosis of fungal infection in a greater cohort.
MeSH term(s)	Female ; Humans ; Male ; Middle Aged ; Aspergillosis ; Biomarkers ; Critical Illness ; Prognosis ; Prospective Studies ; Receptors, Urokinase Plasminogen Activator/blood ; Receptors, Urokinase Plasminogen Activator/chemistry ; Respiratory Distress Syndrome/diagnosis
Chemical Substances	Biomarkers ; Receptors, Urokinase Plasminogen Activator
Language	English
Publishing date	2023-11-16
Publishing country	Germany
Document type	Journal Article
ZDB-ID	185104-4
ISSN	1439-0973 ; 0300-8126 ; 0173-2129
ISSN (online)	1439-0973
ISSN	0300-8126 ; 0173-2129
DOI	10.1007/s15010-023-02127-3
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