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  1. Article ; Online: Single cell RNA-sequencing identified Dec2 as a suppressive factor for spermatogonial differentiation by inhibiting Sohlh1 expression

    Yoshinori Makino / Niels H. Jensen / Naoko Yokota / Moritz J. Rossner / Haruhiko Akiyama / Katsuhiko Shirahige / Yuki Okada

    Scientific Reports, Vol 9, Iss 1, Pp 1-

    2019  Volume 15

    Abstract: Abstract Gonocyte-to-spermatogonia transition is a critical fate determination process to initiate sperm production throughout the lifecycle. However, the molecular dynamics of this process has not been fully elucidated mainly due to the asynchronized ... ...

    Abstract Abstract Gonocyte-to-spermatogonia transition is a critical fate determination process to initiate sperm production throughout the lifecycle. However, the molecular dynamics of this process has not been fully elucidated mainly due to the asynchronized differentiation stages of neonatal germ cells. In this study, we employed single cell RNA sequencing analyses of P1.5–5.5 germ cells to clarify the temporal dynamics of gene expression during gonocyte-to-spermatogonia transition. The analyses identified transcriptional modules, one of which regulates spermatogonial gene network in neonatal germ cells. Among them, we identified Dec2, a bHLH-type transcription factor, as a transcriptional repressor for a spermatogonial differentiation factor Sohlh1. Deficiency of Dec2 in mice induces significant reduction of undifferentiated spermatogonia, and transplantation assay using Dec2-depleted cells also demonstrated the impaired efficiency of engraftment, suggesting its role in maintaining spermatogonial stem cells (SSCs). Collectively, this study revealed the intrinsic role of a new SSC factor Dec2, which protects germ cells from inadequate differentiation during neonatal testis development.
    Keywords Medicine ; R ; Science ; Q
    Subject code 570
    Language English
    Publishing date 2019-04-01T00:00:00Z
    Publisher Nature Publishing Group
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  2. Article ; Online: Soil assessment in Denmark

    Lucas Carvalho Gomes / Amélie Marie Beucher / Anders Bjørn Møller / Bo V. Iversen / Christen Duus Børgesen / Diana Vigah Adetsu / Gasper Laurent Sechu / Goswin Johann Heckrath / Julian Koch / Kabindra Adhikari / Maria Knadel / Mathieu Lamandé / Mette Balslev Greve / Niels H. Jensen / Sebastian Gutierrez / Thomas Balstrøm / Triven Koganti / Yannik Roell / Yi Peng /
    Mogens Humlekrog Greve

    Frontiers in Soil Science, Vol

    Towards soil functional mapping and beyond

    2023  Volume 3

    Abstract: Soil provides essential ecosystem services sustaining and improving human life, but mapping soil functions is an ongoing challenge. Denmark has a long history of carrying out soil assessments − originally in order to determine tax revenues for the king, ... ...

    Abstract Soil provides essential ecosystem services sustaining and improving human life, but mapping soil functions is an ongoing challenge. Denmark has a long history of carrying out soil assessments − originally in order to determine tax revenues for the king, and, more recently, for aiding policymakers and farmers. This knowledge has supported the development of intensive agricultural systems while maintaining the provision of ecosystem services (e.g., clean water). Getting an overview of historical soil surveys and pedological mapping approaches can generate useful information for mapping soil, identifying gaps and proposing directions for future research. In this review, we explore the evolution of soil and environmental inventories, the historical development of soil mapping methods, and how these factors contributed to a better spatial understanding of soil functions. Specifically, we discuss soil functions related to water regulation (e.g., drainage, groundwater and water surface interactions, water table), water filtering (e.g., nitrogen leaching), carbon sequestration (e.g., peatlands), agricultural production (e.g., land suitability, wheat yields), and threats related to soil degradation (e.g., soil erosion). Denmark has benefitted from a government-coordinated approach, promoting detailed and systematic national soil surveys and environmental monitoring programmes. The large databases produced in the surveys formed the basis for mapping several soil properties and functions at increasingly high resolutions over the last many years based on developments in machine learning. In contrast to methodological advances in soil mapping and relevant contributions to pedometric research, we identified a lack of spatial information on soil biodiversity. Detailed spatial information about soil functions is essential to address global issues, such as climate change, food security and water security, and the experience of mapping soil functions in Denmark can be a source of inspiration to other parts of the world.
    Keywords digital soil mapping ; ecosystem services ; sustainable development goals ; machine learning ; soil security ; soil threats ; Chemistry ; QD1-999 ; Engineering geology. Rock mechanics. Soil mechanics. Underground construction ; TA703-712
    Language English
    Publishing date 2023-01-01T00:00:00Z
    Publisher Frontiers Media S.A.
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  3. Article: A statistically based mapping of the influence of geology and land use on soil pH

    Balstrøm, Thomas / Henrik Breuning-Madsen / Johannes Krüger / Niels H. Jensen / Mogens H. Greve

    Geoderma. 2013 Jan., v. 192

    2013  

    Abstract: The purpose of this paper is to investigate the geographical distribution of pH values in Danish soils of different ages representing the main Saalian and Weichselian ice advances. The investigation is based on soil sampling from top- and subsoils in ... ...

    Abstract The purpose of this paper is to investigate the geographical distribution of pH values in Danish soils of different ages representing the main Saalian and Weichselian ice advances. The investigation is based on soil sampling from top- and subsoils in soil profiles located in a nationwide 7-km grid. The data have been analysed using statistical spatial analysis methods, and a model has been erected demonstrating areas of homogeneous low, high, or inhomogeneous pH values relative to deposits from different ice advances and regional variations in land use.The investigation shows that the major part of Jutland is characterized by low pH values in the topsoils and subsoils compared to the islands east of the peninsula. This corresponds with the maximum extension of the Weichselian Young Baltic Ice Cap. A Hot Spot analysis carried out on regional and local scales shows that most of the Danish islands form a homogeneous area of high pH values except Northeast Zealand. And in Jutland a huge area east and north of the maximum extension of the Young Baltic Ice Cap formed a homogeneous area of low pH values. Exceptions are the areas around Mors in the western part of the Limfjord and in the eastern part of Himmerland and on Djursland.
    Keywords case studies ; geographical distribution ; ice ; islands ; land use ; models ; soil pH ; soil profiles ; soil sampling ; Denmark
    Language English
    Dates of publication 2013-01
    Size p. 453-462.
    Publishing place Elsevier B.V.
    Document type Article
    ZDB-ID 281080-3
    ISSN 1872-6259 ; 0016-7061
    ISSN (online) 1872-6259
    ISSN 0016-7061
    DOI 10.1016/j.geoderma.2012.08.024
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  4. Article: Linking climate change mitigation and coastal eutrophication management through biogas technology: Evidence from a new Danish bioenergy concept

    Kaspersen, Bjarke Stoltze / Anders Michael Fredenslund / Henrik Bjarne Møller / Michael Brian Butts / Niels H. Jensen / Thomas Budde Christensen / Tyge Kjaer

    Science of the total environment. 2016 Jan. 15, v. 541

    2016  

    Abstract: The interest in sustainable bioenergy solutions has gained great importance in Europe due to the need to reduce GHG emissions and to meet environmental policy targets, not least for the protection of groundwater and surface water quality. In the ... ...

    Abstract The interest in sustainable bioenergy solutions has gained great importance in Europe due to the need to reduce GHG emissions and to meet environmental policy targets, not least for the protection of groundwater and surface water quality. In the Municipality of Solrød in Denmark, a novel bioenergy concept for anaerobic co-digestion of food industry residues, manure and beach-cast seaweed has been developed and tested in order to quantify the potential for synergies between climate change mitigation and coastal eutrophication management in the Køge Bay catchment. The biogas plant, currently under construction, was designed to handle an annual input of up to 200,000t of biomass based on four main fractions: pectin wastes, carrageenan wastes, manure and beach-cast seaweed. This paper describes how this bioenergy concept can contribute to strengthening the linkages between climate change mitigation strategies and Water Framework Directive (WFD) action planning. Our assessments of the projected biogas plant indicate an annual reduction of GHG emissions of approx. 40,000t CO2 equivalents, corresponding to approx. 1/3 of current total GHG emissions in the Municipality of Solrød. In addition, nitrogen and phosphorous loads to Køge Bay are estimated to be reduced by approx. 63tyr.−1 and 9tyr.−1, respectively, contributing to the achievement of more than 70% of the nutrient reduction target set for Køge Bay in the first WFD river basin management plan. This study shows that anaerobic co-digestion of the specific food industry residues, pig manure and beach-cast seaweed is feasible and that there is a very significant, cost-effective GHG and nutrient loading mitigation potential for this bioenergy concept. Our research demonstrates how an integrated planning process where considerations about the total environment are integrated into the design and decision processes can support the development of this kind of holistic bioenergy solutions.
    Keywords anaerobic digestion ; biogas ; biomass ; carbon dioxide ; carrageenan ; climate change ; cost effectiveness ; environmental policy ; eutrophication ; food industry ; greenhouse gas emissions ; greenhouse gases ; groundwater ; macroalgae ; nitrogen ; pectins ; phosphorus ; pig manure ; planning ; pollution load ; surface water ; water quality ; watersheds ; Denmark
    Language English
    Dates of publication 2016-0115
    Size p. 1124-1131.
    Publishing place Elsevier B.V.
    Document type Article
    ZDB-ID 121506-1
    ISSN 1879-1026 ; 0048-9697
    ISSN (online) 1879-1026
    ISSN 0048-9697
    DOI 10.1016/j.scitotenv.2015.10.015
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  5. Article: Using a map-based assessment tool for the development of cost-effective WFD river basin action programmes in a changing climate

    Kaspersen, Bjarke Stoltze / Eva Boegh / Henrik Gioertz Müller / Lauren Paige Seaby / Michael Brian Butts / Niels H. Jensen / Torsten Vammen Jacobsen / Tyge Kjaer

    Journal of environmental management. 2016 Aug. 01, v. 178

    2016  

    Abstract: For the 2nd and 3rd river basin management cycles (2015–2027) of the Water Framework Directive (WFD), EU Member States are required to fully integrate climate change into the process of river basin management planning (RBMP). Complying with the main ... ...

    Abstract For the 2nd and 3rd river basin management cycles (2015–2027) of the Water Framework Directive (WFD), EU Member States are required to fully integrate climate change into the process of river basin management planning (RBMP). Complying with the main WFD objective of achieving ‘good ecological status’ in all water bodies in Denmark requires Programmes of Measures (PoMs) to reduce nitrogen (N) pollution from point and diffuse sources. Denmark is among the world's most intensively farmed countries and in spite of thirty years of significant policy actions to reduce diffuse nutrient emissions, there is still a need for further reductions. In addition, the impacts of climate change are projected to lead to a situation where nutrient loads will have to be reduced still further in comparison to current climate conditions. There is an urgent need to address this challenge in WFD action programmes in order to develop robust and cost-effective adaptation strategies for the next WFD RBMP cycles. The aim of this paper is to demonstrate and discuss how a map-based PoMs assessment tool can support the development of adaptive and cost-effective strategies to reduce N losses in the Isefjord and Roskilde Fjord River Basin in the north east of Denmark. The tool facilitates assessments of the application of agri-environmental measures that are targeted towards low retention agricultural areas, where limited or no surface and subsurface N reduction takes place. Effects of climate change on nitrate leaching were evaluated using the dynamic agro-ecosystem model ‘Daisy’. Results show that nitrate leaching rates increase by approx. 25% under current management practices. This impact outweighs the expected total N reduction effect of Baseline 2015 and the first RBMP in the case study river basin. The particular PoMs investigated in our study show that WFD N reduction targets can be achieved by targeted land use changes on approx. 4% of the agricultural area under current climate conditions and approx. 9% of the agricultural area, when projected climate change impacts on nitrate leaching rates are included in the assessment. The study highlights the potential of the PoMs assessment tool to assist in evaluation of alternative WFD RBMP scenarios to achieve spatially targeted and cost-effective reductions of N loads at catchment scale in the context of a changing climate.
    Keywords agricultural land ; agri-environmental policy ; agroecosystems ; case studies ; climate ; climate change ; cost effectiveness ; emissions ; European Union ; land use change ; leaching ; models ; nitrates ; nitrogen ; planning ; pollution load ; surface water ; watersheds ; Denmark
    Language English
    Dates of publication 2016-0801
    Size p. 70-82.
    Publishing place Elsevier Ltd
    Document type Article
    ZDB-ID 184882-3
    ISSN 1095-8630 ; 0301-4797
    ISSN (online) 1095-8630
    ISSN 0301-4797
    DOI 10.1016/j.jenvman.2016.04.043
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  6. Article ; Online: Isoquinoline Alkaloids Isolated from Corydalis yanhusuo and Their Binding Affinities at the Dopamine D1 Receptor

    David Y. W. Lee / Lee-Yuan Liu-Chen / Bryan L. Roth / Niels H. Jensen / Wei Xu / Zhong-Ze Ma

    Molecules, Vol 13, Iss 9, Pp 2303-

    2008  Volume 2312

    Abstract: Bioactivity-guided fractionation of Corydalis yanhusuo has resulted in the isolation of eight known isoquinoline alkaloids - tetrahydropalmatine, isocorypalmine, stylopine, corydaline, columbamine, coptisin, 13-methylpalmatine, and dehydrocorybulbine. ... ...

    Abstract Bioactivity-guided fractionation of Corydalis yanhusuo has resulted in the isolation of eight known isoquinoline alkaloids - tetrahydropalmatine, isocorypalmine, stylopine, corydaline, columbamine, coptisin, 13-methylpalmatine, and dehydrocorybulbine. The tertiary alkaloids were further analyzed by chiral HPLC to determine the ratios of d-and l-isomers. The isolated compounds were screened for their binding affinities at the dopamine D1 receptor. Isocorypalmine had the highest affinity (Ki = 83 nM). The structure-affinity relationships of these alkaloids are discussed.
    Keywords Corydalis yanhusuo ; Isoquinoline alkaloids ; d/l Ratio ; Chiral HPLC ; Dopamine receptor ; Organic chemistry ; QD241-441
    Language English
    Publishing date 2008-09-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
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