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Article ; Online: Autoantibody Markers of Increased Risk of Malignancy in Patients with Dermatomyositis.

Marzęcka, Milena / Niemczyk, Anna / Rudnicka, Lidia

Clinical reviews in allergy & immunology

2022 Volume 63, Issue 2, Page(s) 289–296

Abstract: Dermatomyositis is a chronic inflammatory disease involving the skin and muscles. It most commonly occurs in adults with preponderance in females, but pediatric occurrence is also possible. The risk of malignancy in adult patients with dermatomyositis ... ...

Abstract	Dermatomyositis is a chronic inflammatory disease involving the skin and muscles. It most commonly occurs in adults with preponderance in females, but pediatric occurrence is also possible. The risk of malignancy in adult patients with dermatomyositis was reported to be 4.66-fold higher compared to that in the general population. A significantly increased risk of malignancy was reported within the first 12 months following the diagnosis of dermatomyositis (standardized incidence ratio equaled 17). One of the characteristic laboratory findings associated with dermatomyositis is the presence of circulating autoantibodies which are classified into two subgroups: myositis-specific and myositis-associated autoantibodies. It was shown that specific types of antibodies might be associated with an increased risk of malignancy. Current literature data indicate that the strongest correlation with malignant diseases was reported in anti-TIF1-γ-positive patients who were at a 9.37-fold higher risk of cancer. A 3.68-fold increase in the risk of cancer was also reported among patients with anti-NXP2 antibodies. Malignant diseases were reported in 14-57% of patients with anti-SAE antibodies. The presence of other autoantibodies may also be associated with an increased risk of malignancy. These data indicate that patients with circulating anti-TIF1-γ, anti-NXP2, and anti-SAE should be very closely monitored for dermatomyositis-associated malignant comorbidities. The aim of this review is to summarize the current data regarding the link between malignancy and the presence of specific antibodies in patients with dermatomyositis.
MeSH term(s)	Adult ; Autoantibodies ; Biomarkers ; Child ; Dermatomyositis ; Female ; Humans ; Myositis ; Neoplasms/epidemiology
Chemical Substances	Autoantibodies ; Biomarkers
Language	English
Publishing date	2022-02-11
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	1239045-8
ISSN	1559-0267 ; 1080-0549
ISSN (online)	1559-0267
ISSN	1080-0549
DOI	10.1007/s12016-022-08922-4
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Article ; Online: Development of novel air electrode materials for the SOFC and SOEC technologies

Niemczyk Anna / Świerczek Konrad

E3S Web of Conferences, Vol 108, p

2019 Volume 01019

Abstract: One of major goals in the development of solid oxide fuel cells and its reversible mode, solid oxide electrolyzer cells, is related to a decrease of the operating temperature, down to the intermediate range (600-800 °C) or even lower temperatures. ... ...

Abstract	One of major goals in the development of solid oxide fuel cells and its reversible mode, solid oxide electrolyzer cells, is related to a decrease of the operating temperature, down to the intermediate range (600-800 °C) or even lower temperatures. However, this reduction causes an increase of the polarization resistance, especially for the air electrode, which results in a significant decline of the efficiency of the device. Therefore, it is essential to obtain new, thermally and chemically stable materials with the high ionic-electronic conductivity and good catalytic activity for the oxygen reduction reaction working in the decreased temperature range. At the same time, environmental and economic aspects have to be considered in the development of the new compounds. Promising cobalt-free electrode materials can be Cu-based oxides with the perovskite and perovskite-related structures.
Keywords	Environmental sciences ; GE1-350
Subject code	620
Language	English
Publishing date	2019-01-01T00:00:00Z
Publisher	EDP Sciences
Document type	Article ; Online
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Article ; Online: The profile of adipokines associated with fibrosis and impaired microcirculation in systemic sclerosis.

Niemczyk, Anna / Waśkiel-Burnat, Anna / Zaremba, Michał / Czuwara, Joanna / Rudnicka, Lidia

Advances in medical sciences

2023 Volume 68, Issue 2, Page(s) 298–305

Abstract: Purpose: Adipokines belong to a group of molecules mostly produced by adipose tissue. Abnormalities in the secretion of several adipokines have already implicated to play a pathogenic role in systemic sclerosis (SSc). However, the possible role of ... ...

Abstract	Purpose: Adipokines belong to a group of molecules mostly produced by adipose tissue. Abnormalities in the secretion of several adipokines have already implicated to play a pathogenic role in systemic sclerosis (SSc). However, the possible role of numerous molecules still needs to be clarified. The aim of the study was to determine whether the altered level of selected circulating adipokines might correlate with the intensity of fibrosis and vasculopathy in the course of SSc. Materials and methods: Serum concentrations of chemerin, adipsin, retinol-binding protein 4, apelin, visfatin, omentin-1, and vaspin were determined with ELISA in the sera of patients with SSc (n = 55) and healthy controls (n = 25). Results: The serum concentration of adipsin (p = 0.03) and visfatin (p = 0.04) was significantly increased and the level of retinol-binding protein 4 (p = 0.03) was decreased in diffuse compared to limited cutaneous SSc. Moreover, serum adipsin level correlated positively with the intensity of skin fibrosis measured with the modified Rodnan skin score (r = 0.31, p = 0.02) and was significantly higher in patients with pulmonary arterial hypertension than in those without the condition (p = 0.03). The concentrations of adipsin (p = 0.01) and visfatin (p = 0.04) were significantly increased and the level of apelin (p = 0.02) was decreased in patients with active digital ulcerations compared to individuals without this complication. Conclusion: Adipsin may be considered a pivotal protein in the development of both fibrosis and impaired microcirculation. Its abnormal concentration reflects the intensity of skin thickening and the presence of pulmonary arterial hypertension. Adipsin, visfatin, and apelin are adipose tissue-derived molecules associated with digital vasculopathy.
MeSH term(s)	Humans ; Adipokines/metabolism ; Complement Factor D/metabolism ; Apelin/metabolism ; Nicotinamide Phosphoribosyltransferase/metabolism ; Pulmonary Arterial Hypertension ; Microcirculation ; Scleroderma, Systemic ; Vascular Diseases ; Fibrosis ; Retinol-Binding Proteins
Chemical Substances	Adipokines ; Complement Factor D (EC 3.4.21.46) ; Apelin ; Nicotinamide Phosphoribosyltransferase (EC 2.4.2.12) ; Retinol-Binding Proteins
Language	English
Publishing date	2023-09-09
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	2273668-2
ISSN	1898-4002 ; 1896-1126
ISSN (online)	1898-4002
ISSN	1896-1126
DOI	10.1016/j.advms.2023.09.001
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Article ; Online: Feasibility study and techno-economic assessment of power-to-gas (P2G) technology based on solid oxide electrolysis (SOE).

Martsinchyk, Katsiaryna / Martsinchyk, Aliaksandr / Łazor, Monika / Shuhayeu, Pavel / Kupecki, Jakub / Niemczyk, Anna / Błesznowski, Marcin / Milewski, Jarosław

Journal of environmental management

2024 Volume 354, Page(s) 120425

Abstract: Power-to-Gas (P2G) is considered as a promising energy storage technology in a long-time horizon. The rapid growth in the share of intermittent renewables in the energy mix is driving forward research and development in large-scale energy storage. This ... ...

Abstract	Power-to-Gas (P2G) is considered as a promising energy storage technology in a long-time horizon. The rapid growth in the share of intermittent renewables in the energy mix is driving forward research and development in large-scale energy storage. This paper presents a feasibility analysis of a power-to-gas system in terms of various operating points and capacities. The analysis was performed using a system model, which features a solid oxide electrolyzer (SOE), a CO
MeSH term(s)	Feasibility Studies ; Oxides ; Natural Gas ; Electrolysis ; Fluocinolone Acetonide
Chemical Substances	Oxides ; Natural Gas ; Fluocinolone Acetonide (0CD5FD6S2M)
Language	English
Publishing date	2024-02-26
Publishing country	England
Document type	Journal Article
ZDB-ID	184882-3
ISSN	1095-8630 ; 0301-4797
ISSN (online)	1095-8630
ISSN	0301-4797
DOI	10.1016/j.jenvman.2024.120425
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Article: Tuning Cu-Content La

Lach, Jakub / Zheng, Kun / Kluczowski, Ryszard / Niemczyk, Anna / Zhao, Hailei / Chen, Min

Materials (Basel, Switzerland)

2022 Volume 15, Issue 24

Abstract: Cu-content ... ...

Abstract	Cu-content La
Language	English
Publishing date	2022-12-07
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2487261-1
ISSN	1996-1944
ISSN	1996-1944
DOI	10.3390/ma15248737
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Article: Therapeutic and Reconstructive Management Options in Scleroderma (Morphea) en Coup de Sabre in Children and Adults. A Systematic Literature Review.

Ulc, Ewelina / Rudnicka, Lidia / Waśkiel-Burnat, Anna / Warszawik-Hendzel, Olga / Niemczyk, Anna / Olszewska, Małgorzata

Journal of clinical medicine

2021 Volume 10, Issue 19

Abstract: Scleroderma (morphea) en coup de sabre is a localized subtype restricted to the frontoparietal region of the head. Current treatment paradigms rely on low levels of evidence, primarily case reports and case series-supported by expert opinions. The aim of ...

Abstract	Scleroderma (morphea) en coup de sabre is a localized subtype restricted to the frontoparietal region of the head. Current treatment paradigms rely on low levels of evidence, primarily case reports and case series-supported by expert opinions. The aim of this article was to systematically analyze current data related to the treatment of localized scleroderma en coup de sabre. The databases Scopus, PubMed, and EBSCO were searched for all reports discussing the treatment of localized scleroderma en coup de sabre. The keywords en coup de sabre, "facial linear scleroderma", and "morphea linearis", combined with "treatment" or "therapy" were used as search terms. A total of 34 articles analyzed treatment outcomes for patients with localized scleroderma en coup de sabre including 4 retrospective cohort studies, 2 prospective cohort studies, 4 case series, and 24 case reports, representing a total of 69 patients (38 children and 31 adults). Methotrexate was the most commonly investigated treatment (26 patients) with a highest response rate (26/26, 100%). Other treatments included systemic glucocorticosteroids (nine patients), followed by UVA1 (four patients), mycophenolate mofetil (two patients), hydroxychloroquine (five patients), abatacept (two patients), tocilizumab (three patients), cyclosporine (one patient), interferon gamma (one patient), PUVA therapy (two patients), NB-UVB therapy (one patient), and pulsed dye laser (one patient). Reconstructive and surgery treatment was successfully used for lesions with settled disease activity to improve the cosmetic aspect of the lesions. Conclusion: methotrexate is the most often-studied treatment and reported good clinical outcomes in children and adults with localized scleroderma en coup de sabre.
Language	English
Publishing date	2021-09-29
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2662592-1
ISSN	2077-0383
ISSN	2077-0383
DOI	10.3390/jcm10194517
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Article ; Online: Lipocalin-2 and insulin as new biomarkers of alopecia areata.

Waśkiel-Burnat, Anna / Niemczyk, Anna / Chmielińska, Paulina / Muszel, Marta / Zaremba, Michał / Rakowska, Adriana / Olszewska, Małgorzata / Rudnicka, Lidia

PloS one

2022 Volume 17, Issue 5, Page(s) e0268086

Abstract: Lipocalin-2 and visfatin are proinflammatory adipokines involved in the regulation of glucose homeostasis. Their role has been described in numerous inflammatory skin diseases such as atopic dermatitis and psoriasis. Recently, an increased prevalence of ... ...

Abstract	Lipocalin-2 and visfatin are proinflammatory adipokines involved in the regulation of glucose homeostasis. Their role has been described in numerous inflammatory skin diseases such as atopic dermatitis and psoriasis. Recently, an increased prevalence of metabolic abnormalities has been reported in patients with alopecia areata. The aim of the study is to determine the serum levels of lipocalin-2 and visfatin in patients with alopecia areata in comparison with healthy controls. Moreover, the serum levels of total cholesterol, low-density lipoprotein cholesterol (LDL-cholesterol), high-density lipoprotein cholesterol (HDL-cholesterol), triglycerides, fasting glucose, insulin, c-peptide, and homeostasis model assessment for insulin resistance (HOMA-IR) were evaluated. Fifty-two patients with alopecia areata and 17 control subjects were enrolled in the study. The serum levels of lipocalin-2 [mean ± standard deviation, SD: 224.55 ± 53.58 ng/ml vs. 188.64 ± 44.75, p = 0.01], insulin [median (interquartile range, IQR): 6.85 (4.7-9.8) μIU/ml vs. 4.5 (3.5-6.6), p<0.05], c-peptide [median (IQR): 1.63 (1.23-2.36) ng/ml vs. 1.37 (1.1-1.58), p<0.05)], and HOMA-IR [median (IQR): 1.44 (0.98-2.15) vs. 0.92 (0.79-1.44), p<0.05) were significantly higher in patients with alopecia areata compared to the controls. The serum concentration of insulin and HOMA-IR correlated with the number of hair loss episodes (r = 0.300, p<0.05 and r = 0.322, p<0.05, respectively). Moreover, a positive correlation occurred between insulin, HOMA-IR, c-peptide and BMI (r = 0.436, p <0.05; r = 0.384, p<0.05 and r = 0.450, p<0.05, respectively). In conclusion, lipocalin-2 and insulin may serve as biomarkers for alopecia areata. Further studies are needed to evaluate the role of insulin as a prognostic factor in alopecia areata.
MeSH term(s)	Alopecia Areata/diagnosis ; Biomarkers/blood ; C-Peptide ; Cholesterol, HDL ; Glucose ; Humans ; Insulin/blood ; Insulin Resistance ; Lipocalin-2/blood ; Nicotinamide Phosphoribosyltransferase
Chemical Substances	Biomarkers ; C-Peptide ; Cholesterol, HDL ; Insulin ; Lipocalin-2 ; Nicotinamide Phosphoribosyltransferase (EC 2.4.2.12) ; Glucose (IY9XDZ35W2)
Language	English
Publishing date	2022-05-31
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2267670-3
ISSN	1932-6203 ; 1932-6203
ISSN (online)	1932-6203
ISSN	1932-6203
DOI	10.1371/journal.pone.0268086
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Article ; Online: Unveiling the Electrocatalytic Activity of the GdBa

Li, Keyun / Świerczek, Konrad / Winiarz, Piotr / Brzoza-Kos, Agnieszka / Stępień, Anna / Du, Zhihong / Zhang, Yang / Zheng, Kun / Cichy, Kacper / Niemczyk, Anna / Naumovich, Yevgeniy

ACS applied materials & interfaces

2023 Volume 15, Issue 33, Page(s) 39578–39593

Abstract: The A-site cation-ordered ... ...

Abstract	The A-site cation-ordered GdBa
Language	English
Publishing date	2023-08-09
Publishing country	United States
Document type	Journal Article
ISSN	1944-8252
ISSN (online)	1944-8252
DOI	10.1021/acsami.3c08667
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Article: Chemokine C-C Motif Ligand 7 (CCL7), a Biomarker of Atherosclerosis, Is Associated with the Severity of Alopecia Areata: A Preliminary Study.

Waśkiel-Burnat, Anna / Niemczyk, Anna / Blicharz, Leszek / Chmielińska, Paulina / Zaremba, Michał / Gąsecka, Aleksandra / Filipiak, Krzysztof J / Olszewska, Małgorzata / Rudnicka, Lidia

Journal of clinical medicine

2021 Volume 10, Issue 22

Abstract: Alopecia areata is an autoimmune, inflammatory form of non-scarring hair loss that may affect any hair-bearing area. Recently, an increased risk of cardiovascular disorders has been described in patients with alopecia areata. The aim of the study was to ... ...

Abstract	Alopecia areata is an autoimmune, inflammatory form of non-scarring hair loss that may affect any hair-bearing area. Recently, an increased risk of cardiovascular disorders has been described in patients with alopecia areata. The aim of the study was to evaluate the serum concentrations of proinflammatory proteins associated with atherosclerosis (chemokine C-C motif ligand 4; CCL4, chemokine C-C motif ligand 7, CCL7; and sortilin, SORT1), and cardiovascular risk (myeloperoxidase, MPO; interleukin 1 receptor-like 1, IL1RL1; and growth differentiation factor 15, GDF15) in patients with alopecia areata without symptoms or prior cardiovascular disease in comparison with healthy controls. Sixty otherwise healthy patients with alopecia areata and twenty control subjects matched for age, gender, and body mass index (BMI) were enrolled in the study. No significant differences in the serum levels of MPO, IL1RL1, CCL4, CCL7, SORT1, and GDF15 were detected between patients with alopecia areata and healthy controls. A positive correlation was found between the serum concentration of CCL7 and the severity of alopecia areata (r = 0.281,
Language	English
Publishing date	2021-11-19
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2662592-1
ISSN	2077-0383
ISSN	2077-0383
DOI	10.3390/jcm10225418
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Article ; Online: Patients with alopecia areata are at risk of endothelial dysfunction: results of a case-control study.

Waśkiel-Burnat, Anna / Kotowska, Maja / Dorobek, Wioleta / Smyk, Julia Maria / Gąsecka, Aleksandra / Niemczyk, Anna / Blicharz, Leszek / Filipiak, Krzysztof Jerzy / Olszewska, Małgorzata / Rudnicka, Lidia

Clinical and experimental dermatology

2022 Volume 47, Issue 8, Page(s) 1517–1522

Abstract: Background: Alopecia areata (AA) is an autoimmune form of hair loss, which may affect any hair-bearing area. It has been suggested that AA is associated with an increased risk of metabolic and cardiovascular comorbidities.: Aim: To evaluate the early ...

Abstract	Background: Alopecia areata (AA) is an autoimmune form of hair loss, which may affect any hair-bearing area. It has been suggested that AA is associated with an increased risk of metabolic and cardiovascular comorbidities. Aim: To evaluate the early predictors of cardiovascular disease [endothelial function (EF) and arterial stiffness (AS)] in patients with AA without prior cardiovascular disease, and compare with healthy controls (HCs). Methods: In total, 52 patients with AA (38 women and 14 men; mean age 41 years, range 30-52 years) and 34 HCs, matched for age, sex and body mass index, were enrolled in the study. EF, expressed as reactive hyperaemia index (RHI), and AS, identified by augmentation index at 75 beats/min (AI@75) were assessed with the use of the Endo-PAT 2000 device. Endothelial dysfunction (ED) was defined as RHI value ≤1.67. Results: ED was observed in 22 of 52 patients with AA (42%) and in 4 of 34 HCs (12%) (P < 0.01). Moreover, mean RHI was lower in patients with AA compared with HCs (1.90 ± 0.31 vs. 2.11 ± 0.45; P = 0.03). There was no significant difference in AI@75 between patients with AA and HCs. Conclusions: Patients with AA show abnormalities in early predictors of cardiovascular diseases. Regular cardiovascular screening might be appropriate for patients with AA.
MeSH term(s)	Adult ; Alopecia Areata/complications ; Cardiovascular Diseases/complications ; Case-Control Studies ; Female ; Humans ; Male ; Middle Aged ; Vascular Diseases/complications
Language	English
Publishing date	2022-06-06
Publishing country	England
Document type	Journal Article
ZDB-ID	195504-4
ISSN	1365-2230 ; 0307-6938
ISSN (online)	1365-2230
ISSN	0307-6938
DOI	10.1111/ced.15206
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