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Article ; Online: Exploring the evidence behind the comparable impact of the pneumococcal conjugate vaccines PHiD-CV and PCV13 on overall pneumococcal disease.

Izurieta, Patricia / Nieto Guevara, Javier

2021 Volume 18, Issue 1, Page(s) 1872341

Abstract: The worldwide implementation of pneumococcal conjugate vaccines (PCVs) in children has reduced the overall pneumococcal disease burden. Two PCVs are widely available for infant vaccination: the pneumococcal non- ... ...

Abstract	The worldwide implementation of pneumococcal conjugate vaccines (PCVs) in children has reduced the overall pneumococcal disease burden. Two PCVs are widely available for infant vaccination: the pneumococcal non-typeable
MeSH term(s)	Child ; Humans ; Infant ; Pneumococcal Infections/prevention & control ; Pneumococcal Vaccines ; Serogroup ; Streptococcus pneumoniae ; Vaccines, Conjugate ; Viral Vaccines
Chemical Substances	Pneumococcal Vaccines ; Vaccines, Conjugate ; Viral Vaccines
Language	English
Publishing date	2021-02-19
Publishing country	United States
Document type	Journal Article
ZDB-ID	2664176-8
ISSN	2164-554X ; 2164-5515
ISSN (online)	2164-554X
ISSN	2164-5515
DOI	10.1080/21645515.2021.1872341
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Article ; Online: Reply to '

Nieto Guevara, Javier / Izurieta, Patricia

Human vaccines & immunotherapeutics

2020 Volume 16, Issue 9, Page(s) 2307–2308

MeSH term(s)	Child ; Colombia/epidemiology ; Humans ; Pneumococcal Infections/epidemiology ; Pneumococcal Infections/prevention & control ; Pneumococcal Vaccines ; Serogroup ; Streptococcus pneumoniae
Chemical Substances	10-valent pneumococcal conjugate vaccine ; Pneumococcal Vaccines
Language	English
Publishing date	2020-07-09
Publishing country	United States
Document type	Letter ; Research Support, Non-U.S. Gov't ; Comment
ZDB-ID	2664176-8
ISSN	2164-554X ; 2164-5515
ISSN (online)	2164-554X
ISSN	2164-5515
DOI	10.1080/21645515.2020.1784654
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Article ; Online: A systematic review of invasive pneumococcal disease vaccine failures and breakthrough with higher-valency pneumococcal conjugate vaccines in children.

Mungall, Bruce A / Hoet, Bernard / Nieto Guevara, Javier / Soumahoro, Lamine

Expert review of vaccines

2022 Volume 21, Issue 2, Page(s) 201–214

Abstract: Introduction: The pneumococcal non-typeable : Areas covered: We searched Scopus/Medline/EMBASE to retrieve articles/abstracts published between 1/2008-7/2019. We excluded reports only including data from ≥6-year-olds, exclusively assessing PCV7- ... ...

Abstract	Introduction: The pneumococcal non-typeable Areas covered: We searched Scopus/Medline/EMBASE to retrieve articles/abstracts published between 1/2008-7/2019. We excluded reports only including data from ≥6-year-olds, exclusively assessing PCV7-vaccinated children or children with comorbidities. Twenty-six reports (20 PCV13, 1 PCV10, 5 both), covering studies with various designs in six continents, using different schedules, were included. Collectively, they reported 469 VT IPD cases classified as vaccine failures and 403 as breakthrough. Vaccine failure and breakthrough rates were low: 8.4% and 9.3%, respectively, of all IPD in vaccinated children, consistent with the vaccines' high effectiveness. The main serotypes associated with vaccine failure/breakthrough were 19A, 3 and 19F for PCV13 and 14, 6B and vaccine-related 19A and 6A for PCV10. Expert opinion: As we move to vaccines with more serotypes, it is not only important to consider which serotypes are added, but also monitor and address incomplete protection against specific serotypes.
MeSH term(s)	Child ; Child, Preschool ; Haemophilus influenzae ; Humans ; Infant ; Pneumococcal Infections/epidemiology ; Pneumococcal Infections/prevention & control ; Pneumococcal Vaccines ; Serogroup ; Streptococcus pneumoniae ; Vaccines, Conjugate
Chemical Substances	Pneumococcal Vaccines ; Vaccines, Conjugate
Language	English
Publishing date	2022-02-03
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Systematic Review
ZDB-ID	2181284-6
ISSN	1744-8395 ; 1476-0584
ISSN (online)	1744-8395
ISSN	1476-0584
DOI	10.1080/14760584.2022.2012455
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Article ; Online: Laboratory-based surveillance in Latin America: attributes and limitations in evaluation of pneumococcal vaccine impact.

Nieto Guevara, Javier / Guzman-Holst, Adriana

Human vaccines & immunotherapeutics

2021 Volume 17, Issue 11, Page(s) 4667–4672

Abstract: Disease surveillance data are needed to monitor trends in disease activity, inform decision-making in public health and evaluate disease prevention/control measures. The Sistema Regional de Vacunas (SIREVA) supports laboratory-based surveillance of ... ...

Abstract	Disease surveillance data are needed to monitor trends in disease activity, inform decision-making in public health and evaluate disease prevention/control measures. The Sistema Regional de Vacunas (SIREVA) supports laboratory-based surveillance of invasive pneumococcal disease (IPD) in Latin American countries, providing information on identification, distribution, and anti-microbial susceptibility of pneumococcal strains. We estimated the proportion of pneumococcal meningitis and sepsis/bacteremia cases captured by SIREVA, by comparing the number of SIREVA-reported isolates in Argentina, Brazil, Chile, Colombia, Ecuador and Mexico with the estimated expected number of cases based on regional estimates of disease incidence. In all six countries, the number of isolates reported by SIREVA was consistently lower than the number of cases expected, across all years with data available. The proportion of SIREVA-reported isolates was highest in Chile (43-83%) and lowest in Mexico (1.4-3.5%). Passive surveillance systems such as SIREVA are important tools for monitoring circulating strains that could be related to pneumococcal disease, but our results show that SIREVA is likely to underestimate pneumococcal disease incidence. This under-reporting will limit the precision of surveillance data in monitoring changes in the incidence of IPD after vaccine introduction, and this should be considered when assessing the impact of vaccination programs.
MeSH term(s)	Humans ; Incidence ; Infant ; Laboratories ; Latin America/epidemiology ; Meningitis, Pneumococcal ; Pneumococcal Infections/epidemiology ; Pneumococcal Infections/prevention & control ; Pneumococcal Vaccines ; Serotyping
Chemical Substances	Pneumococcal Vaccines
Language	English
Publishing date	2021-10-07
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2664176-8
ISSN	2164-554X ; 2164-5515
ISSN (online)	2164-554X
ISSN	2164-5515
DOI	10.1080/21645515.2021.1972709
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Article ; Online: Systematic review of the efficacy, effectiveness and impact of high-valency pneumococcal conjugate vaccines on otitis media.

Izurieta, Patricia / Scherbakov, Michael / Nieto Guevara, Javier / Vetter, Volker / Soumahoro, Lamine

Human vaccines & immunotherapeutics

2022 Volume 18, Issue 1, Page(s) 2013693

Abstract: Otitis media (OM) is a common disease of childhood and available pneumococcal conjugate vaccines (PCVs), with different compositions, could have different impact on OM reduction. This systematic literature review evaluated available data describing the ... ...

Abstract	Otitis media (OM) is a common disease of childhood and available pneumococcal conjugate vaccines (PCVs), with different compositions, could have different impact on OM reduction. This systematic literature review evaluated available data describing the efficacy, effectiveness, and impact of 10-valent pneumococcal
MeSH term(s)	Child ; Humans ; Otitis Media/prevention & control ; Pneumococcal Infections/prevention & control ; Vaccination ; Vaccines, Conjugate
Chemical Substances	Vaccines, Conjugate
Language	English
Publishing date	2022-01-12
Publishing country	United States
Document type	Journal Article ; Systematic Review ; Research Support, Non-U.S. Gov't
ZDB-ID	2664176-8
ISSN	2164-554X ; 2164-5515
ISSN (online)	2164-554X
ISSN	2164-5515
DOI	10.1080/21645515.2021.2013693
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Article: Assessing the Underestimation of Adult Pertussis Disease in Five Latin American Countries.

Guzman-Holst, Adriana / Gomez, Jorge A / Cintra, Otavio / Van Oorschot, Desirée / Jamet, Nicolas / Nieto-Guevara, Javier

Infectious diseases and therapy

2023 Volume 12, Issue 12, Page(s) 2791–2806

Abstract: Introduction: Pertussis, a contagious respiratory disease, is underreported in adults. The study objective was to quantify underestimation of pertussis cases in adults aged ≥ 50 years in five Latin American countries (Argentina, Brazil, Chile, Mexico, ... ...

Abstract	Introduction: Pertussis, a contagious respiratory disease, is underreported in adults. The study objective was to quantify underestimation of pertussis cases in adults aged ≥ 50 years in five Latin American countries (Argentina, Brazil, Chile, Mexico, Peru). Methods: A previously published probabilistic model was adapted to adjust the number of pertussis cases reported to national surveillance systems by successive multiplication steps (proportion of pertussis cases seeking healthcare; proportion with a specimen collected; proportion sent for confirmatory testing; proportion positive for pertussis; proportion reported to passive surveillance). The proportions at each step were added in a random effects model to produce a pooled overall proportion, and a final multiplier was calculated as the simple inverse of this proportion. This multiplier was applied to the number of cases reported to surveillance to estimate the number of pertussis cases. Monte Carlo simulation with 10,000 iterations estimated median as well as upper and lower 90% values. Input data were obtained from surveillance systems and published sources. Results: The estimated median underestimation factor for pertussis cases in adults ranged from 104 (90% limits 40, 451) in Chile to 114 (90% limits 39, 419) in Argentina. In all five countries, the largest estimated number of cases was in the group aged 50-59 years. The highest number per 100,000 population was in the group aged ≥ 90 years in most countries. The estimated median underestimation factor for pertussis hospitalizations was 2.3 (90% limits 1.8, 3.3) in Brazil and 2.4 (90% limits 1.8, 3.2) in Chile (data not available for other countries). Conclusion: This analysis indicates that the number of pertussis cases in adults aged ≥ 50 years in five Latin American countries is approximately 100 times higher than the number captured in surveillance data. These results could support decision-making in the diagnosis, management, and prevention of pertussis disease in adults.
Language	English
Publishing date	2023-12-14
Publishing country	New Zealand
Document type	Journal Article
ZDB-ID	2701611-0
ISSN	2193-6382 ; 2193-8229
ISSN (online)	2193-6382
ISSN	2193-8229
DOI	10.1007/s40121-023-00895-x
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Article ; Online: Ten years of experience with the pneumococcal non-typeable

Lecrenier, Nicolas / Marijam, Alen / Olbrecht, Jan / Soumahoro, Lamine / Nieto Guevara, Javier / Mungall, Bruce

Expert review of vaccines

2020 Volume 19, Issue 3, Page(s) 247–265

Abstract: ... ...

Abstract	Introduction
MeSH term(s)	Child, Preschool ; Humans ; Infant ; Otitis Media/microbiology ; Otitis Media/prevention & control ; Pneumococcal Infections/prevention & control ; Pneumococcal Vaccines/administration & dosage ; Pneumococcal Vaccines/immunology ; Vaccination ; Vaccination Coverage ; Vaccines, Conjugate
Chemical Substances	PHiD-CV vaccine ; Pneumococcal Vaccines ; Vaccines, Conjugate
Language	English
Publishing date	2020-03-20
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	2181284-6
ISSN	1744-8395 ; 1476-0584
ISSN (online)	1744-8395
ISSN	1476-0584
DOI	10.1080/14760584.2020.1738226
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Article ; Online: Herpes zoster epidemiology in Latin America: A systematic review and meta-analysis.

Bardach, Ariel Esteban / Palermo, Carolina / Alconada, Tomás / Sandoval, Macarena / Balan, Darío Javier / Nieto Guevara, Javier / Gómez, Jorge / Ciapponi, Agustin

PloS one

2021 Volume 16, Issue 8, Page(s) e0255877

Abstract: The epidemiology and burden of Herpes Zoster (HZ) are largely unknown, and there are no recent reviews summarizing the available evidence from the Latin America and Caribbean (LAC) region. We conducted a systematic review and meta-analysis to ... ...

Abstract	The epidemiology and burden of Herpes Zoster (HZ) are largely unknown, and there are no recent reviews summarizing the available evidence from the Latin America and Caribbean (LAC) region. We conducted a systematic review and meta-analysis to characterize the epidemiology and burden of HZ in LAC. Bibliographic databases and grey literature sources were consulted to find studies published (January 2000 -February 2020) with epidemiological endpoints: cumulative incidence and incidence density (HZ cases per 100,000 person-years), prevalence, case-fatality rates, HZ mortality, hospitalization rates, and rates of each HZ complication. Twenty-six studies were included with most studies coming from Brazil. No studies reported the incidence of HZ in the general population. In population at higher risk, the cumulative incidence ranged from 318-3,423 cases of HZ per 100,000 persons per year of follow-up. The incidence density was 6.4-36.5 cases per 1,000 person-years. Age was identified as a major risk factor towards HZ incidence which increase significantly in people >50 years of age. Hospitalization rates ranged from 3%-35.7%. The in-hospital HZ mortality rate ranged from 0%-36%. Overall, HZ mortality rates were found to be higher in females across all age groups and countries. The incidence of HZ complications (such as post-herpetic neuralgia, ophthalmic herpes zoster, and Ramsay Hunt syndrome) was higher in the immunosuppressed compared to the immunocompetent population. Acyclovir was the most frequently used therapy. Epidemiological data from Ministry of Health databases (Argentina, Brazil, Colombia, Chile y Mexico) and Institute for Health Metrics and Evaluation's Global Burden of Disease project reported stable rates of hospitalizations and deaths over the last 10 years. High-risk groups for HZ impose a considerable burden in LAC. They could benefit from directed healthcare initiatives, including adult immunization, to prevent HZ occurrence and its complications.
MeSH term(s)	Cost of Illness ; Databases, Factual ; Herpes Zoster/complications ; Herpes Zoster/economics ; Herpes Zoster/epidemiology ; Herpes Zoster/pathology ; Hospitalization/statistics & numerical data ; Humans ; Immunocompromised Host ; Latin America/epidemiology ; Neuralgia/etiology ; Prevalence
Language	English
Publishing date	2021-08-12
Publishing country	United States
Document type	Journal Article ; Meta-Analysis ; Research Support, Non-U.S. Gov't ; Systematic Review
ISSN	1932-6203
ISSN (online)	1932-6203
DOI	10.1371/journal.pone.0255877
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Article ; Online: CIRCULATING CLONAL COMPLEXES AND SEQUENCE TYPES OF STREPTOCOCCUS PNEUMONIAE SEROTYPE 19A WORLDWIDE: THE IMPORTANCE OF MULTIDRUG RESISTANCE: A SYSTEMATIC LITERATURE REVIEW.

Ruiz García, Yara / Nieto Guevara, Javier / Izurieta, Patricia / Vojtek, Ivo / Ortega-Barría, Eduardo / Guzman-Holst, Adriana

Expert review of vaccines

2021 Volume 20, Issue 1, Page(s) 45–57

Abstract: Introduction: Streptococcus pneumoniae: Areas covered: We performed a systematic literature review to analyze the frequency and clonal distribution of serotype 19A isolates in the pre- and post-PCV era worldwide providing a scientific background on ... ...

Abstract	Introduction: Streptococcus pneumoniae Areas covered: We performed a systematic literature review to analyze the frequency and clonal distribution of serotype 19A isolates in the pre- and post-PCV era worldwide providing a scientific background on the factors that influence multidrug resistance in pneumococcal isolates. Expert commentary: Serotype 19A IPD incidence increased in all regions following the introduction of the 7-valent PCV. The higher-valent PCVs have reduced the rates of 19A IPD isolates, but several circulating strains with diverse antibiotic resistance prevailed. Heterogeneous clonal distribution in serotype 19A was observed within countries and regions, irrespective of higher-valent PCV used. An increase of 19A isolates from pre- to post-vaccination periods were associated with frequently occurring serotype switching events and with the prevalence of multidrug resistant strains. Rational antibiotic policies must be implemented to control the emergence of resistance.
MeSH term(s)	Aged ; Anti-Bacterial Agents/pharmacology ; Child ; Drug Resistance, Multiple, Bacterial ; Humans ; Incidence ; Pneumococcal Infections/drug therapy ; Pneumococcal Infections/microbiology ; Pneumococcal Infections/prevention & control ; Pneumococcal Vaccines/administration & dosage ; Pneumococcal Vaccines/immunology ; Serogroup ; Streptococcus pneumoniae/drug effects ; Streptococcus pneumoniae/immunology ; Streptococcus pneumoniae/isolation & purification ; Vaccination ; Vaccines, Conjugate/administration & dosage
Chemical Substances	Anti-Bacterial Agents ; Pneumococcal Vaccines ; Vaccines, Conjugate
Language	English
Publishing date	2021-02-17
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Systematic Review
ZDB-ID	2181284-6
ISSN	1744-8395 ; 1476-0584
ISSN (online)	1744-8395
ISSN	1476-0584
DOI	10.1080/14760584.2021.1873136
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Article ; Online: Interchangeability between pneumococcal conjugate vaccines for pediatric use: a systematic literature review.

Nieto Guevara, Javier / Borys, Dorota / DeAntonio, Rodrigo / Guzman-Holst, Adriana / Hoet, Bernard

Expert review of vaccines

2019 Volume 19, Issue 11, Page(s) 1011–1022

Abstract: ... ...

Abstract	Introduction
MeSH term(s)	Humans ; Immunity, Herd ; Immunization Programs ; Immunization, Secondary/methods ; Immunogenicity, Vaccine ; Infant ; Pneumococcal Infections/immunology ; Pneumococcal Infections/prevention & control ; Pneumococcal Vaccines/administration & dosage ; Pneumococcal Vaccines/immunology ; Vaccines, Conjugate
Chemical Substances	13-valent pneumococcal vaccine ; PHiD-CV vaccine ; Pneumococcal Vaccines ; Vaccines, Conjugate
Language	English
Publishing date	2019-11-21
Publishing country	England
Document type	Comparative Study ; Journal Article ; Research Support, Non-U.S. Gov't ; Systematic Review
ZDB-ID	2181284-6
ISSN	1744-8395 ; 1476-0584
ISSN (online)	1744-8395
ISSN	1476-0584
DOI	10.1080/14760584.2019.1688148
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