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  1. Article ; Online: Response to "Co-infections in COVID-19 critically ill and antibiotic management: a prospective cohort analysis".

    Nieuwenhuis, Marieke B / Van Biesen, Stefaan / Juffermans, Nicole P

    Critical care (London, England)

    2020  Volume 24, Issue 1, Page(s) 591

    MeSH term(s) Anti-Bacterial Agents ; Betacoronavirus ; COVID-19 ; Cohort Studies ; Coinfection ; Coronavirus Infections ; Critical Illness ; Humans ; Pandemics ; Pneumonia, Viral ; Prospective Studies ; SARS-CoV-2
    Chemical Substances Anti-Bacterial Agents
    Keywords covid19
    Language English
    Publishing date 2020-09-29
    Publishing country England
    Document type Letter ; Comment
    ZDB-ID 2041406-7
    ISSN 1466-609X ; 1364-8535
    ISSN (online) 1466-609X
    ISSN 1364-8535
    DOI 10.1186/s13054-020-03308-4
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 5517: Show issues Location:
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  2. Article: Response to "Co-infections in COVID-19 critically ill and antibiotic management: a prospective cohort analysis"

    Nieuwenhuis, Marieke B / Van Biesen, Stefaan / Juffermans, Nicole P

    Crit Care

    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #802410
    Database COVID19

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  3. Article ; Online: Response to “Co-infections in COVID-19 critically ill and antibiotic management

    Nieuwenhuis, Marieke B. / Van Biesen, Stefaan / Juffermans, Nicole P.

    Critical Care

    a prospective cohort analysis”

    2020  Volume 24, Issue 1

    Keywords Critical Care and Intensive Care Medicine ; covid19
    Language English
    Publisher Springer Science and Business Media LLC
    Publishing country us
    Document type Article ; Online
    ZDB-ID 2041406-7
    ISSN 1364-8535
    ISSN 1364-8535
    DOI 10.1186/s13054-020-03308-4
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Article ; Online: A 43-Year-Old Female with Multifocal Cerebral Lesions. Histiocytic Sarcoma.

    Nieuwenhuis, Marieke B B / van der Salm, Sandra M A / Verhoeff, Joost J C / van der Kooi, Anneke J / Slavujecvic-Letic, Ivana / Pals, Steven T / Vos, Josephine M I

    Brain pathology (Zurich, Switzerland)

    2015  Volume 25, Issue 3, Page(s) 371–372

    MeSH term(s) Adult ; Brain Neoplasms/diagnosis ; Brain Neoplasms/drug therapy ; Cerebral Cortex/pathology ; Female ; Histiocytic Sarcoma/diagnosis ; Histiocytic Sarcoma/drug therapy ; Humans
    Language English
    Publishing date 2015-06-18
    Publishing country Switzerland
    Document type Case Reports ; Letter
    ZDB-ID 1051484-3
    ISSN 1750-3639 ; 1015-6305
    ISSN (online) 1750-3639
    ISSN 1015-6305
    DOI 10.1111/bpa.12260
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    Zs.A 3585: Show issues Location:
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  5. Article ; Online: Outcomes of infrainguinal revascularizations with endovascular first strategy in critical limb ischemia.

    Jens, Sjoerd / Conijn, Anne P / Frans, Franceline A / Nieuwenhuis, Marieke B B / Met, Rosemarie / Koelemay, Mark J W / Legemate, Dink A / Bipat, Shandra / Reekers, Jim A

    Cardiovascular and interventional radiology

    2015  Volume 38, Issue 3, Page(s) 552–559

    Abstract: Purpose: This study was designed to study the outcome of infrainguinal revascularization in patients with critical limb ischemia (CLI) in an institution with a preference towards endovascular intervention first in patients with poor condition, ... ...

    Abstract Purpose: This study was designed to study the outcome of infrainguinal revascularization in patients with critical limb ischemia (CLI) in an institution with a preference towards endovascular intervention first in patients with poor condition, unfavourable anatomy for surgery, no venous material for bypass, and old age.
    Methods: A prospective, observational cohort study was conducted between May 2007 and May 2010 in patients presenting with CLI. At baseline, the optimal treatment was selected, i.e., endovascular or surgical treatment. In case of uncertainty about the preferred treatment, a multidisciplinary team (MDT) was consulted. Primary endpoints were quality of life and functional status 6 and 12 months after initial intervention, assessed by the VascuQol and AMC Linear Disability Score questionnaires, respectively.
    Results: In total, 113 patients were included; 86 had an endovascular intervention and 27 had surgery. During follow-up, 41 % underwent an additional ipsilateral revascularisation procedure. For the total population, and endovascular and surgery subgroups, the VascuQol sum scores improved after 6 and 12 months (p < 0.01 for all outcomes) compared with baseline. The functional status improved (p = 0.043) after 12 months compared with baseline for the total population. Functional status of the surgery subgroup improved significantly after 6 (p = 0.031) and 12 (p = 0.044) months, but not that of the endovascular subgroup.
    Conclusions: Overall, the strategy of performing endovascular treatment first in patients with poor condition, unfavourable anatomy for surgery, no venous material for bypass, and old age has comparable or even slightly better results compared with the BASIL trial and other cohort studies. All vascular groups should discuss whether their treatment strategy should be directed at treating CLI patients preferably endovascular first and consider implementing an MDT to optimize patient outcomes.
    MeSH term(s) Activities of Daily Living ; Aged ; Amputation/statistics & numerical data ; Angioplasty, Balloon ; Cohort Studies ; Disease-Free Survival ; Female ; Follow-Up Studies ; Humans ; Ischemia/physiopathology ; Ischemia/surgery ; Ischemia/therapy ; Lower Extremity/blood supply ; Lower Extremity/physiopathology ; Lower Extremity/surgery ; Male ; Middle Aged ; Prospective Studies ; Quality of Life ; Risk Factors ; Surveys and Questionnaires ; Treatment Outcome ; Vascular Patency/physiology
    Language English
    Publishing date 2015-06
    Publishing country United States
    Document type Journal Article ; Observational Study ; Research Support, Non-U.S. Gov't
    ZDB-ID 603082-8
    ISSN 1432-086X ; 0342-7196 ; 0174-1551
    ISSN (online) 1432-086X
    ISSN 0342-7196 ; 0174-1551
    DOI 10.1007/s00270-014-0955-5
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 1378: Show issues Location:
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  6. Article ; Online: The costimulatory molecule CD27 maintains clonally diverse CD8(+) T cell responses of low antigen affinity to protect against viral variants.

    van Gisbergen, Klaas P J M / Klarenbeek, Paul L / Kragten, Natasja A M / Unger, Peter-Paul A / Nieuwenhuis, Marieke B B / Wensveen, Felix M / ten Brinke, Anja / Tak, Paul P / Eldering, Eric / Nolte, Martijn A / van Lier, Rene A W

    Immunity

    2011  Volume 35, Issue 1, Page(s) 97–108

    Abstract: CD70 and CD27 are costimulatory molecules that provide essential signals for the expansion and differentiation of CD8(+) T cells. Here, we show that CD27-driven costimulation lowered the threshold of T cell receptor activation on CD8(+) T cells and ... ...

    Abstract CD70 and CD27 are costimulatory molecules that provide essential signals for the expansion and differentiation of CD8(+) T cells. Here, we show that CD27-driven costimulation lowered the threshold of T cell receptor activation on CD8(+) T cells and enabled responses against low-affinity antigens. Using influenza infection to study in vivo consequences, we found that CD27-driven costimulation promoted a CD8(+) T cell response of overall low affinity. These qualitative effects of CD27 on T cell responses were maintained into the memory phase. On a clonal level, CD27-driven costimulation established a higher degree of variety in memory CD8(+) T cells. The benefit became apparent when mice were reinfected, given that CD27 improved CD8(+) T cell responses against reinfection with viral variants, but not with identical virus. We propose that CD27-driven costimulation is a strategy to generate memory clones that have potential reactivity to a wide array of mutable pathogens.
    MeSH term(s) Animals ; Antigenic Variation ; Antigens, Viral/immunology ; CD8-Positive T-Lymphocytes/immunology ; CD8-Positive T-Lymphocytes/metabolism ; CD8-Positive T-Lymphocytes/pathology ; CD8-Positive T-Lymphocytes/virology ; Clone Cells ; Humans ; Immunologic Memory ; Influenza A virus/immunology ; Influenza A virus/pathogenicity ; Lymphocyte Activation/genetics ; Mice ; Mice, Inbred C57BL ; Mice, Knockout ; Orthomyxoviridae Infections/immunology ; T-Cell Antigen Receptor Specificity/genetics ; Tumor Necrosis Factor Receptor Superfamily, Member 7/genetics ; Tumor Necrosis Factor Receptor Superfamily, Member 7/immunology ; Tumor Necrosis Factor Receptor Superfamily, Member 7/metabolism
    Chemical Substances Antigens, Viral ; Tumor Necrosis Factor Receptor Superfamily, Member 7
    Language English
    Publishing date 2011-07-22
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1217235-2
    ISSN 1097-4180 ; 1074-7613
    ISSN (online) 1097-4180
    ISSN 1074-7613
    DOI 10.1016/j.immuni.2011.04.020
    Database MEDical Literature Analysis and Retrieval System OnLINE

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