Article ; Online: TIM-3 signaling contributes to the suppressive capacity of Tregs from people with HIV on antiretroviral therapy.
2023 Volume 114, Issue 4, Page(s) 368–372
Abstract: TIM-3 expression is increased on peripheral regulatory T cells (Tregs) of virally suppressed persons with HIV-1 on antiretroviral therapy (PWH-ART). However, the relevance of TIM-3 expression in this setting is unclear. We used flow cytometry to evaluate ...
| Abstract | TIM-3 expression is increased on peripheral regulatory T cells (Tregs) of virally suppressed persons with HIV-1 on antiretroviral therapy (PWH-ART). However, the relevance of TIM-3 expression in this setting is unclear. We used flow cytometry to evaluate the suppressive phenotype and signaling pathways in peripheral TIM-3- vs TIM-3+ Tregs in PWH-ART. TIM-3+ Tregs showed increased expression of IL-10 compared with persons without HIV-1. In addition, TIM-3+ Tregs displayed elevated signaling and activation, relative to TIM-3- Tregs from the same PWH-ART. Dramatically, TIM-3 blockade restrained the in vitro suppressive capacity of peripheral Tregs. Therefore, our data demonstrate not only that TIM-3 expression by Tregs is associated with an immunosuppressive response among PWH-ART, but also that TIM-3 contributes directly to the enhanced suppressive activity of Tregs in this setting. |
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| MeSH term(s) | Humans ; Hepatitis A Virus Cellular Receptor 2/metabolism ; T-Lymphocytes, Regulatory/metabolism ; HIV Infections/drug therapy ; HIV Infections/metabolism | |||||
| Chemical Substances | Hepatitis A Virus Cellular Receptor 2 | |||||
| Language | English | |||||
| Publishing date | 2023-06-07 | |||||
| Publishing country | England | |||||
| Document type | Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't | |||||
| ZDB-ID | 605722-6 | |||||
| ISSN | 1938-3673 ; 0741-5400 | |||||
| ISSN (online) | 1938-3673 | |||||
| ISSN | 0741-5400 | |||||
| DOI | 10.1093/jleuko/qiad068 | |||||
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| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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