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  1. Article: Clinicopathological Study of Males with Lupus Nephritis: Pathologist's Experience at a Tertiary-Care Center.

    Patel, Rashmi D / Vanikar, Aruna V / Nigam, Lovelesh K / Kanodia, Kamal V / Suthar, Kamlesh S

    Indian journal of nephrology

    2022  Volume 32, Issue 2, Page(s) 145–150

    Abstract: Background: Systemic lupus erythematosus (SLE) is an autoimmune systemic disorder, more common in females of reproductive age-group as compared with males. There are very few studies regarding lupus nephritis (LN) in males. Hence, we decided to study ... ...

    Abstract Background: Systemic lupus erythematosus (SLE) is an autoimmune systemic disorder, more common in females of reproductive age-group as compared with males. There are very few studies regarding lupus nephritis (LN) in males. Hence, we decided to study the clinical and pathological findings of LN in males.
    Materials and methods: We carried out a retrospective study over a period of 5 years (January 2014-December 2018) on indicated native renal biopsies from male patients with LN. We analyzed the clinical, laboratory, and histological findings of these patients.
    Results: Renal biopsies were performed on 228 patients with LN, of which 29 (12.72%) biopsies were in male patients. The mean age at presentation was 28.3 ± 12.98 years. Edema (65.5%) was the most common clinical feature followed by arthritis (27.58%), fever (27.58%), and skin rash (24.1%). The mean values for 24 hours urinary protein, serum double-stranded DNA, serum antinuclear antibody, and serum complement C3 were 4.98 ± 2.91 g, 137.7 ± 91.93 IU/mL, 2.96 ± 1.78, and 65.07 ± 36.30 mg/dL, respectively. On histology, the most common class of LN was Class IV (34.48%) followed by Class V (20.68%), combined Class IV + V (20.68%), Classes II, III, and III + V.
    Conclusion: LN can affect males, although the prevalence is lower than in females. The incidence of LN in our study was 12.7% with the most common histological class being diffuse proliferative LN.
    Language English
    Publishing date 2022-03-11
    Publishing country India
    Document type Journal Article
    ZDB-ID 2134388-3
    ISSN 1998-3662 ; 0971-4065
    ISSN (online) 1998-3662
    ISSN 0971-4065
    DOI 10.4103/ijn.IJN_302_20
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Solitary Fibrous Tumor of the Kidney With Pure Round Cell Features: A Case Report With Review of Literature.

    Lobo, Anandi / Jha, Shilpy / Kapoor, Rahul / Diwaker, Preeti / Akgul, Mahmut / Arora, Samriti / Pradhan, Manas / Sahoo, Biswajit / Nigam, Lovelesh K / Mohanty, Sambit K

    International journal of surgical pathology

    2023  Volume 32, Issue 4, Page(s) 851–855

    Abstract: Solitary fibrous tumor (SFT) is a rare mesenchymal neoplasm known to occur at various soft tissue and visceral locations. Kidney is a rarely reported site for these tumors. Most of the SFTs described in the kidney exhibit a classical CD34-positive ... ...

    Abstract Solitary fibrous tumor (SFT) is a rare mesenchymal neoplasm known to occur at various soft tissue and visceral locations. Kidney is a rarely reported site for these tumors. Most of the SFTs described in the kidney exhibit a classical CD34-positive patternless spindle cell histology. Focal round cell morphology is seldom reported. Herein, we describe a 48-year-old male patient with renal SFT. This tumor had pure round cell morphology with a CD34-/STAT6+ immunophenotype. Fluorescent in situ hybridization and a multiplexed sequencing assay performed on an Illumina® HiSeq 4000 platform revealed
    MeSH term(s) Humans ; Solitary Fibrous Tumors/pathology ; Solitary Fibrous Tumors/diagnosis ; Male ; Kidney Neoplasms/pathology ; Kidney Neoplasms/diagnosis ; Middle Aged ; STAT6 Transcription Factor/genetics ; STAT6 Transcription Factor/analysis ; STAT6 Transcription Factor/metabolism ; Biomarkers, Tumor/analysis ; Biomarkers, Tumor/genetics ; Diagnosis, Differential ; Kidney/pathology ; Gene Rearrangement ; Repressor Proteins/genetics ; Repressor Proteins/metabolism ; In Situ Hybridization, Fluorescence ; Antigens, CD34/metabolism ; Antigens, CD34/analysis ; Nephrectomy
    Chemical Substances STAT6 protein, human ; STAT6 Transcription Factor ; Biomarkers, Tumor ; NAB2 protein, human ; Repressor Proteins ; Antigens, CD34
    Language English
    Publishing date 2023-09-16
    Publishing country United States
    Document type Case Reports ; Journal Article ; Review
    ZDB-ID 1336393-1
    ISSN 1940-2465 ; 1066-8969
    ISSN (online) 1940-2465
    ISSN 1066-8969
    DOI 10.1177/10668969231199165
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4500: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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  3. Article: Collapsing Glomerulopathy: A Single Centre Clinicopathologic Study of Seven Years.

    Kanodia, Kamal V / Vanikar, Aruna V / Patel, Rashmi D / Suthar, Kamlesh S / Nigam, Lovelesh K / Patel, Himanshu V / Kute, Vivek / Trivedi, Hargovind L

    Journal of clinical and diagnostic research : JCDR

    2016  Volume 10, Issue 4, Page(s) EC15–7

    Abstract: Introduction: Collapsing Glomerulopathy (CG) is recognized as distinct pattern of proliferative parenchymal injury with poor response to empirical therapy.: Aim: A single center retrospective study was carried out to find out clinicopathological ... ...

    Abstract Introduction: Collapsing Glomerulopathy (CG) is recognized as distinct pattern of proliferative parenchymal injury with poor response to empirical therapy.
    Aim: A single center retrospective study was carried out to find out clinicopathological features of idiopathic CG.
    Materials and methods: A total of 3335 native renal biopsies were analyzed retrospectively which were performed from 2008 to 2014 with emphasis on clinicopathological correlation and histopathological presentation.
    Results: Idiopathic CG constituted 0.75% incidence (25 out of 3335 biopsies) of all biopsies, adults constituting major study part with 88%. The duration of the symptoms at the time of biopsy was 34.12±26.09 days and 35±22.91 days respectively in adults and children. Hypertension was noted in 9(40.9%) and oliguria in 8(36.4%) in adults. Urinalysis revealed microscopic haematuria 12(54.5%) in adults. Nephrotic range proteinuria was reported in 10 (45.5%) adult patients. Glomerular collapse with hyperplasia/ hypertrophy of podocytes was seen in 4.54±3.11 glomeruli. Tubular microcystic dilation was seen in 16(64%) patients. Tubular atrophy involving mild (t1) in 15(60%), moderate (t2) in 4(16%) and severe (t3) in 6(24%) patients. Interstitial fibrosis was mild (i1) in 17(68%), moderate (i2) in 2(8%) and severe (i3) in 6(24%) patients.
    Conclusion: Idiopathic CG is a morphological pattern of grave podocyte injury with poor prognosis. However, there are chances of remission/ recovery if the tubular atrophy and interstitial fibrosis are of grades ≤ t1 i1.
    Language English
    Publishing date 2016-04-01
    Publishing country India
    Document type Journal Article
    ZDB-ID 2775283-5
    ISSN 0973-709X ; 2249-782X
    ISSN (online) 0973-709X
    ISSN 2249-782X
    DOI 10.7860/JCDR/2016/17297.7646
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Pediatric Renal Biopsies in India: A Single-Centre Experience of Six Years.

    Kanodia, Kamal V / Vanikar, Aruna V / Nigam, Lovelesh K / Patel, Rashmi D / Suthar, Kamlesh S / Gera, Dinesh N / Trivedi, Hargovind L

    Nephro-urology monthly

    2015  Volume 7, Issue 4, Page(s) e25473

    Abstract: Background: Renal biopsy is a well-established diagnostic modality for the assessment of kidney diseases in children. It can provide diagnostic precision and prognostic value and guide in therapeutic options for many renal diseases.: Objectives: This ...

    Abstract Background: Renal biopsy is a well-established diagnostic modality for the assessment of kidney diseases in children. It can provide diagnostic precision and prognostic value and guide in therapeutic options for many renal diseases.
    Objectives: This report describes the indication, histopathological patterns, and epidemiology of renal diseases in children in India.
    Patients and methods: This is a single-center study on renal biopsies performed between January 2008 and December 2013 in 346 children (age ≤ 14 years).
    Results: Eleven (3.17%) biopsies were inadequate, and 335 biopsies were considered for analysis. The mean age was 7.91 ± 3.04 years with a predominance of males (68.1%). Nephrotic syndrome (46.2%) was the most common indication, followed by urinary abnormality (41.19%), acute nephritic syndrome (10.74%), and chronic renal failure (1.79 %). Primary glomerulonephritis (GN) was predominant (81.79%), and secondary GN constituted 16.12% of the biopsies. Primary GN included mesangial proliferative GN (MePGN), IgM nephropathy, focal segmental glomerulosclerosis, minimal change disease, IgA nephropathy, membranoproliferative GN, membranous nephropathy, crescentic GN, and post-infectious GN. Secondary GN revealed lupus nephritis, hemolytic uremic syndrome, amyloidosis, and hypertensive nephropathy. Tubulointerstitial nephritis was observed in 2.08%. The most common histological pattern of primary GN was MePGN (20%) and in secondary GN it was lupus nephritis (7.76%).
    Conclusions: The present study provides data on the epidemiology of renal diseases in children in India and will be helpful for developing a national registry and devising therapeutic guidelines.
    Language English
    Publishing date 2015-06-28
    Publishing country Iran
    Document type Journal Article
    ISSN 2251-7006
    ISSN 2251-7006
    DOI 10.5812/numonthly.25473
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Invasive fungal infections in renal transplant patients: a single center study.

    Patel, Minaxi H / Patel, Rashmi D / Vanikar, Aruna V / Kanodia, Kamal V / Suthar, Kamlesh S / Nigam, Lovelesh K / Patel, Himanshu V / Patel, Ansy H / Kute, Vivek B / Trivedi, Hargovind L

    Renal failure

    2017  Volume 39, Issue 1, Page(s) 294–298

    Abstract: Background: Timely diagnosis of invasive fungal infections (IFI) in renal transplant (RT) patients on immunosuppression is often difficult, jeopardizing their life and graft. We reported IFI and their causative fungal agents in post-RT patients.: ... ...

    Abstract Background: Timely diagnosis of invasive fungal infections (IFI) in renal transplant (RT) patients on immunosuppression is often difficult, jeopardizing their life and graft. We reported IFI and their causative fungal agents in post-RT patients.
    Materials and methods: This was a retrospective 6-year clinical study carried out from 2010 to 2015 on 1900 RT patients. Clinical data included patient-donor demographics, time to onset of infection, risk factors and graft function in terms of serum creatinine (SCr). To identify IFI, we examined bronchoalveolar lavage (BAL), blood, tissue, and wound swab samples by conventional mycological methods.
    Results: IFI were diagnosed in 30 (1.56%) patients on triple immunosuppression, mainly males (n = 25) with mean age of 36.57 ± 11.9 years at 13.12 ± 18.35 months post-RT. Aspergillus species was identified in 11 BAL, one tissue, and one wound specimen each, 30.76% of these were fatal and 15.38% caused graft loss; Candida albicans was in nine BAL, four blood, two wound swab, and one tissue specimens, 25% of these were fatal and 25% had graft loss and one mucor in BAL which was fatal. Seven patients were diabetic, 10 had superadded cytomegalovirus infection, and 15 were anti-rejected.
    Conclusion: IFI are associated with increased morbidity and mortality in RT patients. Triple immunosuppression, broad spectrum antibiotics for ≥ two weeks, diabetes and superadded infection are added risks for these patients. Prevention, early diagnosis, and appropriate management are necessary to improve their prognosis.
    MeSH term(s) Adult ; Amphotericin B/administration & dosage ; Antifungal Agents/administration & dosage ; Aspergillus/isolation & purification ; Candida albicans/isolation & purification ; Female ; Graft Survival ; Humans ; Immunosuppression/adverse effects ; Immunosuppression/methods ; India/epidemiology ; Invasive Fungal Infections/diagnosis ; Invasive Fungal Infections/drug therapy ; Invasive Fungal Infections/etiology ; Kidney Failure, Chronic/surgery ; Kidney Transplantation/adverse effects ; Kidney Transplantation/methods ; Kidney Transplantation/mortality ; Male ; Middle Aged ; Outcome Assessment (Health Care) ; Postoperative Complications/diagnosis ; Postoperative Complications/drug therapy ; Postoperative Complications/microbiology ; Retrospective Studies ; Transplants/microbiology
    Chemical Substances Antifungal Agents ; Amphotericin B (7XU7A7DROE)
    Language English
    Publishing date 2017-11
    Publishing country England
    Document type Journal Article
    ZDB-ID 632949-4
    ISSN 1525-6049 ; 0886-022X
    ISSN (online) 1525-6049
    ISSN 0886-022X
    DOI 10.1080/0886022X.2016.1268537
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 1331: Show issues Location:
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  6. Article ; Online: Reporting Trends, Practices, and Resource Utilization in Neuroendocrine Tumors of the Prostate Gland: A Survey among Thirty-Nine Genitourinary Pathologists.

    Mohanty, Sambit K / Lobo, Anandi / Williamson, Sean R / Shah, Rajal B / Trpkov, Kiril / Varma, Murali / Sirohi, Deepika / Aron, Manju / Kandukari, Shivani R / Balzer, Bonnie L / Luthringer, Daniel L / Ro, Jae / Osunkoya, Adeboye O / Desai, Sangeeta / Menon, Santosh / Nigam, Lovelesh K / Sardana, Rohan / Roy, Paromita / Kaushal, Seema /
    Midha, Divya / Swain, Minakshi / Ambekar, Asawari / Mitra, Suvradeep / Rao, Vishal / Soni, Shailesh / Jain, Kavita / Diwaker, Preeti / Pattnaik, Niharika / Sharma, Shivani / Chakrabarti, Indranil / Sable, Mukund / Jain, Ekta / Jain, Deepika / Samra, Spinder / Vankalakunti, Mahesha / Mohanty, Subhashis / Parwani, Anil V / Sancheti, Sankalp / Kumari, Niraj / Jha, Shilpy / Dixit, Mallika / Malik, Vipra / Arora, Samriti / Munjal, Gauri / Gopalan, Anuradha / Magi-Galluzzi, Cristina / Dhillon, Jasreman

    International journal of surgical pathology

    2022  Volume 31, Issue 6, Page(s) 993–1005

    Abstract: Background. ...

    Abstract Background.
    MeSH term(s) Male ; Humans ; Prostate/pathology ; Neuroendocrine Tumors/diagnosis ; Neuroendocrine Tumors/pathology ; Pathologists ; Prostatic Neoplasms/diagnosis ; Prostatic Neoplasms/pathology ; Carcinoma, Neuroendocrine/pathology ; Carcinoma, Small Cell/pathology ; Carcinoma, Acinar Cell/pathology ; Carcinoma, Large Cell/pathology ; Surveys and Questionnaires
    Language English
    Publishing date 2022-08-09
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1336393-1
    ISSN 1940-2465 ; 1066-8969
    ISSN (online) 1940-2465
    ISSN 1066-8969
    DOI 10.1177/10668969221116629
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4500: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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