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  1. Article ; Online: Correction to

    Angelos G. Kolias / Ellie Edlmann / Eric P. Thelin / Diederik Bulters / Patrick Holton / Nigel Suttner / Kevin Owusu-Agyemang / Yahia Z. Al-Tamimi / Daniel Gatt / Simon Thomson / Ian A. Anderson / Oliver Richards / Peter Whitfield / Monica Gherle / Karen Caldwell / Carol Davis-Wilkie / Silvia Tarantino / Garry Barton / Hani J. Marcus /
    Aswin Chari / Paul Brennan / Antonio Belli / Simon Bond / Carole Turner / Lynne Whitehead / Ian Wilkinson / Peter J. Hutchinson / British Neurosurgical Trainee Research Collaborative (BNTRC) and Dex-CSDH Trial Collaborators

    Trials, Vol 20, Iss 1, Pp 1-

    Dexamethasone for adult patients with a symptomatic chronic subdural haematoma (Dex-CSDH) trial: study protocol for a randomised controlled trial

    2019  Volume 1

    Abstract: After publication of the original article [1], the authors notified that that one of the BNTRC institutional collaborator names was misspelled. ...

    Abstract After publication of the original article [1], the authors notified that that one of the BNTRC institutional collaborator names was misspelled.
    Keywords Medicine (General) ; R5-920
    Language English
    Publishing date 2019-03-01T00:00:00Z
    Publisher BMC
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  2. Article ; Online: Dexamethasone for adult patients with a symptomatic chronic subdural haematoma (Dex-CSDH) trial

    Angelos G. Kolias / Ellie Edlmann / Eric P. Thelin / Diederik Bulters / Patrick Holton / Nigel Suttner / Kevin Owusu-Agyemang / Yahia Z. Al-Tamimi / Daniel Gatt / Simon Thomson / Ian A. Anderson / Oliver Richards / Peter Whitfield / Monica Gherle / Karen Caldwell / Carol Davis-Wilkie / Silvia Tarantino / Garry Barton / Hani J. Marcus /
    Aswin Chari / Paul Brennan / Antonio Belli / Simon Bond / Carole Turner / Lynne Whitehead / Ian Wilkinson / Peter J. Hutchinson / British Neurosurgical Trainee Research Collaborative (BNTRC) and Dex-CSDH Trial Collaborators

    Trials, Vol 19, Iss 1, Pp 1-

    study protocol for a randomised controlled trial

    2018  Volume 14

    Abstract: Abstract Background Chronic subdural haematoma (CSDH) is a common neurosurgical condition, typically treated with surgical drainage of the haematoma. However, surgery is associated with mortality and morbidity, including up to 20% recurrence of the CSDH. ...

    Abstract Abstract Background Chronic subdural haematoma (CSDH) is a common neurosurgical condition, typically treated with surgical drainage of the haematoma. However, surgery is associated with mortality and morbidity, including up to 20% recurrence of the CSDH. Steroids, such as dexamethasone, have been identified as a potential therapy for reducing recurrence risk in surgically treated CSDHs. They have also been used as a conservative treatment option, thereby avoiding surgery altogether. The hypothesis of the Dex-CSDH trial is that a two-week course of dexamethasone in symptomatic patients with CSDH will lead to better functional outcome at six months. This is anticipated to occur through reduced number of hospital admissions and surgical interventions. Methods Dex-CSDH is a UK multi-centre, double-blind randomised controlled trial of dexamethasone versus placebo for symptomatic adult patients diagnosed with CSDH. A sample size of 750 patients has been determined, including an initial internal pilot phase of 100 patients to confirm recruitment feasibility. Patients must be recruited within 72 h of admission to a neurosurgical unit and exclusions include patients already on steroids or with steroid contraindications, patients who have a cerebrospinal fluid shunt and those with a history of psychosis. The decision regarding surgical intervention will be made by the clinical team and patients can be included in the trial regardless of whether operative treatment is planned or has been performed. The primary outcome measure is the modified Rankin Scale (mRS) at six months. Secondary outcomes include the number of CSDH-related surgical interventions during follow-up, length of hospital stay, mRS at three months, EQ-5D at three and six months, adverse events, mortality and a health-economic analysis. Discussion This multi-centre trial will provide high-quality evidence as to the effectiveness of dexamethasone in the treatment of CSDH. This has implications for patient morbidity and mortality as well as a potential economic impact on the overall health service burden from this condition. Trial registration ISRCTN, ISRCTN80782810. Registered on 7 November 2014. EudraCT, 2014-004948-35. Registered on 20 March 2015. Dex-CSDH trial protocol version 3, 27 Apr 2017. This protocol was developed in accordance with the SPIRIT checklist. Available as a separate document on request.
    Keywords Chronic subdural haematoma ; Dexamethasone ; Neurosurgery ; Neurology ; Randomised control trial ; Medicine (General) ; R5-920
    Subject code 610
    Language English
    Publishing date 2018-12-01T00:00:00Z
    Publisher BMC
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  3. Article ; Online: Dex-CSDH randomised, placebo-controlled trial of dexamethasone for chronic subdural haematoma

    Ellie Edlmann / Eric P. Thelin / Karen Caldwell / Carole Turner / Peter Whitfield / Diederik Bulters / Patrick Holton / Nigel Suttner / Kevin Owusu-Agyemang / Yahia Z. Al-Tamimi / Daniel Gatt / Simon Thomson / Ian A. Anderson / Oliver Richards / Monica Gherle / Emma Toman / Dipankar Nandi / Phillip Kane / Beatrice Pantaleo /
    Carol Davis-Wilkie / Silvia Tarantino / Garry Barton / Hani J. Marcus / Aswin Chari / Antonio Belli / Simon Bond / Rafael Gafoor / Sarah Dawson / Lynne Whitehead / Paul Brennan / Ian Wilkinson / Angelos G Kolias / Peter J. A. Hutchinson / Dex-CSDH trial collaborative and BNTRC collaborative.

    Scientific Reports, Vol 9, Iss 1, Pp 1-

    report of the internal pilot phase

    2019  Volume 13

    Abstract: Abstract The Dex-CSDH trial is a randomised, double-blind, placebo-controlled trial of dexamethasone for patients with a symptomatic chronic subdural haematoma. The trial commenced with an internal pilot, whose primary objective was to assess the ... ...

    Abstract Abstract The Dex-CSDH trial is a randomised, double-blind, placebo-controlled trial of dexamethasone for patients with a symptomatic chronic subdural haematoma. The trial commenced with an internal pilot, whose primary objective was to assess the feasibility of multi-centre recruitment. Primary outcome data collection and safety were also assessed, whilst maintaining blinding. We aimed to recruit 100 patients from United Kingdom Neurosurgical Units within 12 months. Trial participants were randomised to a 2-week course of dexamethasone or placebo in addition to receiving standard care (which could include surgery). The primary outcome measure of the trial is the modified Rankin Scale at 6 months. This pilot recruited ahead of target; 100 patients were recruited within nine months of commencement. 47% of screened patients consented to recruitment. The primary outcome measure was collected in 98% of patients. No safety concerns were raised by the independent data monitoring and ethics committee and only five patients were withdrawn from drug treatment. Pilot trial data can inform on the design and resource provision for substantive trials. This internal pilot was successful in determining recruitment feasibility. Excellent follow-up rates were achieved and exploratory outcome measures were added to increase the scientific value of the trial.
    Keywords Medicine ; R ; Science ; Q
    Subject code 610
    Language English
    Publishing date 2019-04-01T00:00:00Z
    Publisher Nature Publishing Group
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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    Inter-library loan at ZB MED

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  4. Article ; Online: External validation and recalibration of an incidental meningioma prognostic model – IMPACT

    Julie Woodfield / Boris Krischek / Giles Critchley / Damian Holliman / Angelos Kolias / Thomas Santarius / Ola Rominiyi / Michael McDermott / Michael D Jenkinson / Jörg-Christian Tonn / Mohsen Javadpour / Andrea Saladino / Tiit Illimar Mathiesen / Rory Piper / Michael Vogelbaum / Chaya Brodie / Sara Venturini / Daniel M Fountain / Roland Goldbrunner /
    Elliot Tilling / Felix Sahm / Priscilla Brastianos / Rory J Piper / Antonio Santoro / Sylvia Kurz / Pierfrancesco Lapolla / Andrea Mingoli / Jennifer Brown / Debraj Mukherjee / Simon Walling / Andrew Morokoff / Patrick Wen / Ghazaleh Tabatabai / Jill Barnholtz-Sloan / Ryan K Mathew / Alexander Smedley / Helen Shih / William Taylor / Minh Nguyen / Bryony Ford / Samantha J Mills / Tamara Ali / Ruwanthi Kolamunnage-Dona / Josephine Jung / Muhammed Elhadi / Erminia Albanese / Aswin Chari / David Rowland / Melissa Gough / Michael Cearns / Simon Lammy / Yasir Chowdhury / Christian Mawrin / Mahmoud Saleh / Jens Schittenhelm / Farshad Nassiri / Raymond Huang / Pietro Familiari / Manfred Westphal / Warren Selman / Daniel Brown / Nathan McSorley / Oliver Hanemann / Richard Pullicino / Francesco Gaillard / Mirjam Renovanz / Chris Barrett / Christine Jungk / Aaron Cohen-Gadol / Javier Martín-Alonso / Gelareh Zadeh / Hytham Hamid / Abdurrahman I Islim / Christopher P Millward / Shaveta Mehta / Usama Ali / Shelli Diane Koszdin / Theo Georgious / Andrew R Brodbelt / Mohamed Abdelsadg / Suhaib Abualsaud / Amro Abuleil / Kevin Agyemang / Hanan Akbari / Likhith Alakandy / Clarissa Alfonso / Arousa Ali / Michael Amoo / Mohamed A. R. Arbab / Mutiu Asha / Kareem Austin / Khaled Badran / Jarnail Bal / Parameswaran Bhattathiri / Paul M. Brennan / Andrew R. Brodbelt / Ferran Brugada-Bellsolà / Placido Bruzzaniti / Annabel Butcher / Rory S. Cairns / Michael Canty / Sachiv Chakravarti / Rebecca Chave-Cox / Anna Craig-McQuade / Peter Crossley / Elizabeth Culpin / Alessia D'Amico / Bassam Dabbous / Pedro David Delgado-López / Mohamed Draz / Katharine J. Drummond / Rusiru T. Ekanayaka / Ibrahim Elmaadawi / Omar Elmandouh / Mazin Elsharif / Daisy Evans / Andreas Fahlström / Fleur L. Fisher / Daniel M. Fountain / Keiko Fox / Chloé Gelder / Shamayitri Ghosh / Aimee Goel / Athanasios Grivas / Andrew Gvozdanovic / Allan Hall / Liv Hartrick / Samih Hassan / Jack Henry / Abdurrahman I. Islim / Asgeir S. Jakola / Michael D. Jenkinson / Sanjeeva Jeyaretna / Adrian Jimenez / Andranik Kahramanian / Neeraj Kalra / David O. Kamson / Oliver Kennion / Adham M. Khalafallah / Sarah Kingdon / Howra Ktayen / Aditaya Kumar / Jun Yi Lau / Jing Xian Lee / Ryan Leyden / Patricia Littlechild / Sophie Liu / Darmanin Lora-Kay / Vivia Lung / Stephen T. Magill / Hani J. Marcus / Fawaz E. Marhoom / Ryan K. Mathew / Calan Mathieson / Tobias Mederer / Torstien R. Meling / Samantha J. Mills / Christopher P. Millward / Mujtaba Mohammad / Amir H. Zamanipoor Najafabadi / Olivia Näslund / Imran Noorani / Gildas Patet / Omar N. Pathmanaban / Andrea Perera / Amit Persad / See Yung Phang / Rory J. Piper / Jonathan Pollock / Benjamin Price / Martin Proescholdt / James Robins / Bobby Sachdev / Fozia Saeed / Ieva Sataite / Antony Kevin Scafa / Verena Schadewaldt / Syed Wajahat Shah / Mustafa El Sheikh / Zenab Sher / Bente Sandvei Skeie / Agbolahan Sofela / Jerome St George / Torbjørn Strømsnes / Nigel Suttner / Philip Theodosopoulos / Manjul Tripathi / Ismail Ughratdar / James Ulrich / Adithya Varma / Anil Varma / Maria Velicu / Esther Wu / Jacob Young / Giuseppa Zancana / Catherine Zhang / Karolyn Au / Felix Behling / Linda Bi / Nicholas Butowski / Ana Castro / Marta Couce / Francesco Dimeco / Katherine J. Drummond / Ian Dunn / Craig Erker / Michelle Felicella / Eva Galanis / Norbert Galldiks / Caterina Giannini / Christel Herold-Mende / Luke Hnenny / Craig Horbinski / Gerhard Jungwirth / Timothy Kaufmann / Daniel Lachance / Christian Lafougere / Katrin Lamszus / Serge Makarenko / Tathiana Malta / Jennifer Moliterno-Gunel / HK Ng / Houtan Noushmehr / Arie Perry / Laila Poisson / Bianco Pollo / Aditya Ragunathan / David Raleigh / Franz Ricklefs / Antonio Santacroce / Christian Schichor / Nils Schimdt / Andrew Sloan / Matija Snuderl / Jim Snyder / Erik Sulman / Suganth Suppiah / Marcos Tatagiba / Marco Timmer / Andreas Von Deimling / Tobias Walbert / Justin Z. Wang / Stephen Yip / Gabriel Zada / Viktor Zherebitskiy / Michael T.C. Poon

    BMJ Open, Vol 12, Iss

    protocol for an international multicentre retrospective cohort study

    2022  Volume 1

    Keywords Medicine ; R
    Language English
    Publishing date 2022-01-01T00:00:00Z
    Publisher BMJ Publishing Group
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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