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  1. Article ; Online: A patient-tailored approach for corticosteroid treatment in COVID-19: still not there yet.

    Nigro, Mattia / Chalmers, James D / Aliberti, Stefano

    The European respiratory journal

    2023  Volume 61, Issue 4

    MeSH term(s) Humans ; COVID-19 ; Methylprednisolone ; COVID-19 Drug Treatment ; Adrenal Cortex Hormones/therapeutic use ; Dexamethasone
    Chemical Substances Methylprednisolone (X4W7ZR7023) ; Adrenal Cortex Hormones ; Dexamethasone (7S5I7G3JQL)
    Language English
    Publishing date 2023-04-20
    Publishing country England
    Document type Editorial ; Comment
    ZDB-ID 639359-7
    ISSN 1399-3003 ; 0903-1936
    ISSN (online) 1399-3003
    ISSN 0903-1936
    DOI 10.1183/13993003.00270-2023
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Biologics in Bronchiectasis: A Future Treatment?

    Nigro, Mattia / Simonetta, Edoardo / Martínez-García, Miguel Ángel / Aliberti, Stefano

    Archivos de bronconeumologia

    2022  Volume 59, Issue 3, Page(s) 139–141

    MeSH term(s) Humans ; Biological Products ; Bronchiectasis/therapy ; Anti-Bacterial Agents/therapeutic use
    Chemical Substances Biological Products ; Anti-Bacterial Agents
    Language Spanish
    Publishing date 2022-12-23
    Publishing country Spain
    Document type Editorial
    ZDB-ID 733126-5
    ISSN 1579-2129 ; 0300-2896
    ISSN (online) 1579-2129
    ISSN 0300-2896
    DOI 10.1016/j.arbres.2022.12.008
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Identify Drug-Resistant Pathogens in Patients with Community-Acquired Pneumonia.

    Amati, Francesco / Bindo, Francesco / Stainer, Anna / Gramegna, Andrea / Mantero, Marco / Nigro, Mattia / Bussini, Linda / Bartoletti, Michele / Blasi, Francesco / Aliberti, Stefano

    Advances in respiratory medicine

    2023  Volume 91, Issue 3, Page(s) 224–238

    Abstract: A substantial increase in broad-spectrum antibiotics as empirical therapy in patients with community-acquired pneumonia (CAP) has occurred over the last 15 years. One of the driving factors leading to that has been some evidence showing an increased ... ...

    Abstract A substantial increase in broad-spectrum antibiotics as empirical therapy in patients with community-acquired pneumonia (CAP) has occurred over the last 15 years. One of the driving factors leading to that has been some evidence showing an increased incidence of drug-resistant pathogens (DRP) in patients from a community with pneumonia, including methicillin-resistant
    MeSH term(s) Humans ; Methicillin-Resistant Staphylococcus aureus ; Community-Acquired Infections/drug therapy ; Pneumonia/drug therapy ; Pneumonia/epidemiology ; Anti-Bacterial Agents/therapeutic use
    Chemical Substances Anti-Bacterial Agents
    Language English
    Publishing date 2023-05-31
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2893877-X
    ISSN 2543-6031 ; 2451-4934
    ISSN (online) 2543-6031
    ISSN 2451-4934
    DOI 10.3390/arm91030018
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Vasoactive drugs for the treatment of pulmonary hypertension associated with interstitial lung diseases: a systematic review.

    Bongiovanni, Gabriele / Tonutti, Antonio / Stainer, Anna / Nigro, Mattia / Kellogg, Dean L / Nambiar, Anoop / Gramegna, Andrea / Mantero, Marco / Voza, Antonio / Blasi, Francesco / Aliberti, Stefano / Amati, Francesco

    BMJ open respiratory research

    2024  Volume 11, Issue 1

    Abstract: Objectives: Vasoactive drugs have exhibited clinical efficacy in addressing pulmonary arterial hypertension, manifesting a significant reduction in morbidity and mortality. Pulmonary hypertension may complicate advanced interstitial lung disease (PH-ILD) ...

    Abstract Objectives: Vasoactive drugs have exhibited clinical efficacy in addressing pulmonary arterial hypertension, manifesting a significant reduction in morbidity and mortality. Pulmonary hypertension may complicate advanced interstitial lung disease (PH-ILD) and is associated with high rates of disability, hospitalisation due to cardiac and respiratory illnesses, and mortality. Prior management hinged on treating the underlying lung disease and comorbidities. However, the INCREASE trial of inhaled treprostinil in PH-ILD has demonstrated that PH-ILD can be effectively treated with vasoactive drugs.
    Methods: This comprehensive systematic review examines the evidence for vasoactive drugs in the management of PH-ILD.
    Results: A total of 1442 pubblications were screened, 11 RCTs were considered for quantitative synthesis. Unfortunately, the salient studies are limited by population heterogeneity, short-term follow-up and the selection of outcomes with uncertain clinical significance.
    Conclusions: This systematic review underscores the necessity of establishing a precision medicine-oriented strategy, directed at uncovering and addressing the intricate cellular and molecular mechanisms that underlie the pathophysiology of PH-ILD.
    Prospero registration number: CRD42023457482.
    MeSH term(s) Humans ; Hypertension, Pulmonary/drug therapy ; Hypertension, Pulmonary/etiology ; Lung Diseases, Interstitial/complications ; Lung Diseases, Interstitial/drug therapy ; Lung Diseases, Interstitial/epidemiology ; Comorbidity
    Language English
    Publishing date 2024-03-13
    Publishing country England
    Document type Systematic Review ; Journal Article
    ZDB-ID 2736454-9
    ISSN 2052-4439 ; 2052-4439
    ISSN (online) 2052-4439
    ISSN 2052-4439
    DOI 10.1136/bmjresp-2023-002161
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: COVID-19 follow-up programs across Europe: an ERS END-COVID CRC survey.

    Valenzuela, Claudia / Nigro, Mattia / Chalmers, James D / Wagers, Scott / Avinash, Aujayeb / Hellemons, Merel E / Löffler-Ragg, Judith / Brightling, Christopher E / Aliberti, Stefano

    The European respiratory journal

    2022  

    Language English
    Publishing date 2022-07-21
    Publishing country England
    Document type Letter
    ZDB-ID 639359-7
    ISSN 1399-3003 ; 0903-1936
    ISSN (online) 1399-3003
    ISSN 0903-1936
    DOI 10.1183/13993003.00923-2022
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Long-Term Domiciliary High-Flow Nasal Therapy in Patients with Bronchiectasis: A Preliminary Retrospective Observational Case-Control Study.

    Crimi, Claudia / Nolasco, Santi / Campisi, Raffaele / Nigro, Mattia / Impellizzeri, Pietro / Cortegiani, Andrea / Noto, Alberto / Gramegna, Andrea / Vancheri, Carlo / Blasi, Francesco / Crimi, Nunzio / Aliberti, Stefano / Carlucci, Annalisa

    Journal of clinical medicine

    2022  Volume 11, Issue 24

    Abstract: High-flow nasal therapy (HFNT) provides several pathophysiological benefits in chronic respiratory disorders. We aimed to evaluate the effectiveness of long-term HFNT in patients with bronchiectasis (BE).: Methods: This is a retrospective bicentric ... ...

    Abstract High-flow nasal therapy (HFNT) provides several pathophysiological benefits in chronic respiratory disorders. We aimed to evaluate the effectiveness of long-term HFNT in patients with bronchiectasis (BE).
    Methods: This is a retrospective bicentric case-control study of outpatients with BE on optimized medical treatment with a severe exacerbation requiring hospitalization in the previous year. Patients on long-term home HFNT (cases) and patients on optimized medical treatment alone (controls) were matched by age, sex, bronchiectasis severity index, and exacerbations in the previous year. Data on BE exacerbations, hospitalizations/year, mucus features, respiratory symptoms, and pulmonary function were collected. The primary outcome was the change from baseline in the exacerbation rates at 12 months between groups.
    Results: 20 patients in the HFNT group and 20 controls were included. A significant reduction in exacerbations [-1.9 (-2.8 to -0.9),
    Conclusions: In this preliminary study, long-term domiciliary HFNT improved the clinical course of patients with BE.
    Language English
    Publishing date 2022-12-09
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662592-1
    ISSN 2077-0383
    ISSN 2077-0383
    DOI 10.3390/jcm11247323
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: Diagnostic delay in bronchiectasis: an Italian perspective.

    Chessari, Carlo / Simonetta, Edoardo / Amati, Francesco / Nigro, Mattia / Stainer, Anna / Sotgiu, Giovanni / Puci, Mariangela / Gramegna, Andrea / Blasi, Francesco / Morlacchi, Letizia Corinna / Buscemi, Agata Alba Maria Domenica / Conio, Valentina / Sanci, Vincenzo / Corsico, Angelo G / Faverio, Paola / Michalak, Weronika / Luppi, Fabrizio / Crimi, Claudia / Vancheri, Carlo /
    Campisi, Raffaele / Vulpi, Maria Rosaria / Carpagnano, Giovanna Elisiana / Cicchetti, Marianna / Sekretna, Kseniia / Scichilone, Nicola / Battaglia, Salvatore / Aliberti, Stefano

    ERJ open research

    2024  Volume 10, Issue 2

    Abstract: It takes ∼3.5 years to reach a diagnosis of bronchiectasis from onset of symptoms: the long patient's journey in ... ...

    Abstract It takes ∼3.5 years to reach a diagnosis of bronchiectasis from onset of symptoms: the long patient's journey in Italy
    Language English
    Publishing date 2024-03-18
    Publishing country England
    Document type Journal Article
    ZDB-ID 2827830-6
    ISSN 2312-0541
    ISSN 2312-0541
    DOI 10.1183/23120541.00713-2023
    Database MEDical Literature Analysis and Retrieval System OnLINE

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